Overview

I am involved in diverse studies that include defining clinically relevant pharmacodynamic endpoints for drugs used in paediatric anaesthetic and perioperative care, and providing feedback on aspects of quality of intraoperative care, with the common goal of improving patients' experiences & safety.

Examples of such studies include: examining the effects of anaesthetic drugs on myocardial repolarization, with the aim of producing evidence-based advice on the safety of these agents in children with, or at risk of, long QT syndromes; analyzing intraoperative Code Blue data to help focus preventative strategies; correlating perioperative thermoregulation management with surgical outcomes in scoliosis correction surgery and in the National Surgical Quality Improvement Programme – Pediatrics (NSQIP-P).

Publications

Using physiological monitoring data for performance feedback: an initiative using thermoregulation metrics.
Görges M, West NC, Whyte SD
DOI: 10.1007/s12630-016-0762-3
PubMed: 27785761
03/2017

Preoperative warming and undesired surgical and anesthesia outcomes in pediatric spinal surgery-a retrospective cohort study.
Görges M, West NC, Cheung W, Zhou G, Miyanji F, Whyte SD
DOI: 10.1111/pan.12939
PubMed: 27312044
09/2016

Changes in QTc associated with a rapid bolus dose of dexmedetomidine in patients receiving TIVA: a retrospective study.
Görges M, Whyte SD, Sanatani S, Dawes J, Montgomery CJ, Ansermino JM
DOI: 10.1111/pan.12780
PubMed: 26507917
12/2015

The safety of modern anesthesia for children with long QT syndrome.
Whyte SD, Nathan A, Myers D, Watkins SC, Kannankeril PJ, Etheridge SP, Andrade J, Collins KK, Law IH, Hayes J, Sanatani S
DOI: 10.1213/ane.0000000000000389
PubMed: 25076102
10/2014

ACS national surgical quality improvement program: targeting quality improvement in Canadian pediatric surgery.
Skarsgard ED, Bedford J, Chan T, Whyte S, Afshar K
DOI: 10.1016/j.jpedsurg.2014.02.047
PubMed: 24851748
05/2014

A retrospective audit to examine the effectiveness of preoperative warming on hypothermia in spine deformity surgery patients.
Görges M, Ansermino JM, Whyte SD
DOI: 10.1111/pan.12204
PubMed: 23738627
11/2013

Usability and performance characteristics of the pediatric air-Q® intubating laryngeal airway.
Whyte SD, Cooke E, Malherbe S
DOI: 10.1007/s12630-013-9918-6
PubMed: 23519724
06/2013

Normal Tp-e values in children.
Sanatani S, Whyte S
DOI: 10.1213/ane.0b013e31823554ac
PubMed: 22184612
01/2012

The effects of droperidol and ondansetron on dispersion of myocardial repolarization in childrenDROPERIDOL, ONDANSETRON AND MYOCARDIAL REPOLARIZATION IN CHILDREN
Pediatric Anesthesia
DISHA MEHTA, SHUBHAYAN SANATANI, SIMON D. WHYTE
DOI: 10.1111/j.1460-9592.2010.03408.x
09/2010

Total intravenous anesthesia and spontaneous respiration for airway endoscopy in children--a prospective evaluation.
Malherbe S, Whyte S, Singh P, Amari E, King A, Ansermino JM
DOI: 10.1111/j.1460-9592.2010.03290.x
PubMed: 20337953
05/2010

Audit and feedback: to tell or not to tell? That is not the question
Canadian Journal of Anesthesia/Journal canadien d'anesthésie
Simon Whyte
DOI: 10.1007/s12630-018-1206-z
08/2018

PaediatricsChapter 15
Surgeon's Guide to Anaesthesia and Perioperative Care
2014

Dexmedetomidine for co-analgesia in chemotherapy-induced severe enterocolitis.
Winton P, Whyte E, Reimer EJ, Davis J, Whyte S
DOI: 10.1111/j.1460-9592.2011.03575.x
PubMed: 21793978
09/2011

Intubation via the intubating laryngeal airway in two pediatric patients with predicted difficult airways.
Peiris K, Traynor M, Whyte S
DOI: 10.1111/j.1460-9592.2009.03222.x
PubMed: 20078820
02/2010

Anaesthesia for elective ear, nose and throat surgery in children
Anaesthesia & Intensive Care Medicine
Permendra Singh, Simon Whyte
DOI: 10.1016/j.mpaic.2009.02.002
04/2009

Perioperative fluid and electrolyte balance in children
Anaesthesia & Intensive Care Medicine
Simon D. Whyte
DOI: 10.1016/j.mpaic.2008.10.006
02/2009

The effect of propofol concentration on dispersion of myocardial repolarization in children.
Hume-Smith HV, Sanatani S, Lim J, Chau A, Whyte SD
DOI: 10.1213/ane.0b013e3181815ce3
PubMed: 18713888
09/2008

A comparison of the effect on dispersion of repolarization of age-adjusted MAC values of sevoflurane in children.
Whyte SD, Sanatani S, Lim J, Booker PD
DOI: 10.1213/01.ane.0000252417.23986.6e
PubMed: 17242080
02/2007

Torsades de pointes with sevoflurane.
Whyte SD, Sanatani S, Booker PD
DOI: 10.1111/j.1460-9592.2006.01994.x
PubMed: 17040316
11/2006

Anesthetic considerations in the management of Wilms' tumor.
Whyte SD, Mark Ansermino J
DOI: 10.1111/j.1460-9592.2006.01866.x
PubMed: 16677259
05/2006

The effects of propofol and sevoflurane on the QT interval and transmural dispersion of repolarization in children.
Whyte SD, Booker PD, Buckley DG
DOI: 10.1213/01.ane.0000140781.18391.41
PubMed: 15616054
01/2005

Newborn life support and the anaesthetist
Current Anaesthesia & Critical Care
Simon Whyte
DOI: 10.1016/j.cacc.2004.08.005
10/2004

Bispectral index during isoflurane anesthesia in pediatric patients.
Whyte SD, Booker PD
DOI: 10.1213/01.ane.0000117223.84646.36
PubMed: 15155318
06/2004

Usefulness of the Minute Ventilation Test in Predicting Successful Extubation in Newborn Infants: A Randomized Controlled Trial
Journal of Perinatology
Lorna M Gillespie, Simon D White, Sunil K Sinha, Steven M Donn
DOI: 10.1038/sj.jp.7210886
04/2003

Long QT syndrome and anaesthesia.
Booker PD, Whyte SD, Ladusans EJ
DOI: 10.1093/bja/aeg061
PubMed: 12594150
03/2003

Monitoring the depth of anaesthesia
British Journal of Anaesthesia
2003

Paediatric applications of concentration-orientated anaesthesia
Best Practice & Research Clinical Anaesthesiology
Peter Driscoll Booker, Simon David Whyte
DOI: 10.1053/bean.2000.0138
03/2001

Premedication before intubation in UK neonatal units.
Whyte S, Birrell G, Wyllie J
DOI: 10.1136/fn.82.1.f38
PubMed: 10634840
01/2000

Paediatric basic life support: a practical assessment.
Whyte SD, Wyllie JP
DOI: 10.1016/s0300-9572(99)00056-8
PubMed: 10488937
07/1999

Patient-controlled analgesia: epidural fentanyl and i.v. morphine compared after caesarean section.
Cooper DW, Saleh U, Taylor M, Whyte S, Ryall D, Kokri MS, Desira WR, Day H, McArthur E
DOI: 10.1093/bja/82.3.366
PubMed: 10434817
03/1999

Neonatal resuscitation--a practical assessment.
Whyte SD, Sinha AK, Wyllie JP
DOI: 10.1016/s0300-9572(98)00143-9
PubMed: 10321844
01/1999

Research

Canadian Paediatric Difficult Intubation Database
The first stage of this work has been to establish a local difficult intubation database in our operating rooms. This went live in July 2017. The next stage will be to expand the database to allow other Canadian tertiary paediatric anaesthesia departments to contribute data.

Dexmedetomidine & Myocardial Repolarization Dynamics
This randomised, double-blinded clinical trial will investigate the effect of three clinically relevant doses of dexmedetomidine on the dispersion of myocardial repolarization. Increases in dispersion of repolarization are pro-arrhythmogenic and facilitate torsades de pointes in patients with or at risk of long QT syndromes. As many of these patients are undiagnosed, and as the peri-operative period represents a time of increased risk for them, identifying anaesthetic agents that do not further increase this risk is an important undertaking.


Grants

2016-2017 Evidence to Innovation Seed Grant: “BCCH Pediatric Anesthesia Difficult Airway Database: A Quality Improvement Initiative to Improve Safety in Patients with Difficult Airways”

Honours & Awards

Child & Family Research Institute Innovations in Acute Care & Technology Trainee Clinical Investigator Seed Grant - Project: "The effect of preoperative warming on surgical complications in pediatric scoliosis repair," $5,000. 2013.

Child & Family Research Institute Pharmaceutical Outcomes and Policy Innovations - Project: "5-HT3 Antagonists and Cardiac Safety," $42,667. 2014/15.

Research Group Members

Andrew Poznikoff, Clinical Research Coordinator