I am involved in diverse studies that include defining clinically relevant pharmacodynamic endpoints for drugs used in paediatric anaesthetic and perioperative care, and providing feedback on aspects of quality of intraoperative care, with the common goal of improving patients' experiences & safety.

Examples of such studies include: examining the effects of anaesthetic drugs on myocardial repolarization, with the aim of producing evidence-based advice on the safety of these agents in children with, or at risk of, long QT syndromes; analyzing intraoperative Code Blue data to help focus preventative strategies; correlating perioperative thermoregulation management with surgical outcomes in scoliosis correction surgery and in the National Surgical Quality Improvement Programme – Pediatrics (NSQIP-P).


Using physiological monitoring data for performance feedback: an initiative using thermoregulation metrics.
Görges M and West NC and Whyte SD
DOI: 10.1007/s12630-016-0762-3
PubMed: 27785761

Preoperative warming and undesired surgical and anesthesia outcomes in pediatric spinal surgery-a retrospective cohort study.
Görges M and West NC and Cheung W and Zhou G and Miyanji F and Whyte SD
DOI: 10.1111/pan.12939
PubMed: 27312044

Changes in QTc associated with a rapid bolus dose of dexmedetomidine in patients receiving TIVA: a retrospective study.
Görges M and Whyte SD and Sanatani S and Dawes J and Montgomery CJ and Ansermino JM
DOI: 10.1111/pan.12780
PubMed: 26507917

The safety of modern anesthesia for children with long QT syndrome.
Whyte SD and Nathan A and Myers D and Watkins SC and Kannankeril PJ and Etheridge SP and Andrade J and Collins KK and Law IH and Hayes J and Sanatani S
DOI: 10.1213/ane.0000000000000389
PubMed: 25076102

ACS national surgical quality improvement program: targeting quality improvement in Canadian pediatric surgery.
Skarsgard ED and Bedford J and Chan T and Whyte S and Afshar K
DOI: 10.1016/j.jpedsurg.2014.02.047
PubMed: 24851748

A retrospective audit to examine the effectiveness of preoperative warming on hypothermia in spine deformity surgery patients.
Görges M and Ansermino JM and Whyte SD
DOI: 10.1111/pan.12204
PubMed: 23738627

Usability and performance characteristics of the pediatric air-Q® intubating laryngeal airway.
Whyte SD and Cooke E and Malherbe S
DOI: 10.1007/s12630-013-9918-6
PubMed: 23519724

Normal Tp-e values in children.
Sanatani S and Whyte S
DOI: 10.1213/ane.0b013e31823554ac
PubMed: 22184612

The effects of droperidol and ondansetron on dispersion of myocardial repolarization in children
Pediatric Anesthesia
DOI: 10.1111/j.1460-9592.2010.03408.x

Total intravenous anesthesia and spontaneous respiration for airway endoscopy in children--a prospective evaluation.
Malherbe S and Whyte S and Singh P and Amari E and King A and Ansermino JM
DOI: 10.1111/j.1460-9592.2010.03290.x
PubMed: 20337953

Audit and feedback: to tell or not to tell? That is not the question
Canadian Journal of Anesthesia/Journal canadien d'anesthésie
Simon Whyte
DOI: 10.1007/s12630-018-1206-z

Surgeon's Guide to Anaesthesia and Perioperative Care

Dexmedetomidine for co-analgesia in chemotherapy-induced severe enterocolitis.
Winton P and Whyte E and Reimer EJ and Davis J and Whyte S
DOI: 10.1111/j.1460-9592.2011.03575.x
PubMed: 21793978

Intubation via the intubating laryngeal airway in two pediatric patients with predicted difficult airways.
Peiris K and Traynor M and Whyte S
DOI: 10.1111/j.1460-9592.2009.03222.x
PubMed: 20078820

Anaesthesia for elective ear, nose and throat surgery in children
Anaesthesia & Intensive Care Medicine
Permendra Singh and Simon Whyte
DOI: 10.1016/j.mpaic.2009.02.002

Perioperative fluid and electrolyte balance in children
Anaesthesia & Intensive Care Medicine
Simon D. Whyte
DOI: 10.1016/j.mpaic.2008.10.006

The effect of propofol concentration on dispersion of myocardial repolarization in children.
Hume-Smith HV and Sanatani S and Lim J and Chau A and Whyte SD
DOI: 10.1213/ane.0b013e3181815ce3
PubMed: 18713888

A comparison of the effect on dispersion of repolarization of age-adjusted MAC values of sevoflurane in children.
Whyte SD and Sanatani S and Lim J and Booker PD
DOI: 10.1213/01.ane.0000252417.23986.6e
PubMed: 17242080

Torsades de pointes with sevoflurane.
Whyte SD and Sanatani S and Booker PD
DOI: 10.1111/j.1460-9592.2006.01994.x
PubMed: 17040316

Anesthetic considerations in the management of Wilms' tumor.
Whyte SD and Mark Ansermino J
DOI: 10.1111/j.1460-9592.2006.01866.x
PubMed: 16677259

The effects of propofol and sevoflurane on the QT interval and transmural dispersion of repolarization in children.
Whyte SD and Booker PD and Buckley DG
DOI: 10.1213/01.ane.0000140781.18391.41
PubMed: 15616054

Newborn life support and the anaesthetist
Current Anaesthesia & Critical Care
Simon Whyte
DOI: 10.1016/j.cacc.2004.08.005

Bispectral index during isoflurane anesthesia in pediatric patients.
Whyte SD and Booker PD
DOI: 10.1213/01.ane.0000117223.84646.36
PubMed: 15155318

Usefulness of the Minute Ventilation Test in Predicting Successful Extubation in Newborn Infants: A Randomized Controlled Trial
Journal of Perinatology
Lorna M Gillespie and Simon D White and Sunil K Sinha and Steven M Donn
DOI: 10.1038/sj.jp.7210886

Long QT syndrome and anaesthesia.
Booker PD and Whyte SD and Ladusans EJ
DOI: 10.1093/bja/aeg061
PubMed: 12594150

Monitoring the depth of anaesthesia
British Journal of Anaesthesia

Paediatric applications of concentration-orientated anaesthesia
Best Practice & Research Clinical Anaesthesiology
Peter Driscoll Booker and Simon David Whyte
DOI: 10.1053/bean.2000.0138

Premedication before intubation in UK neonatal units.
Whyte S and Birrell G and Wyllie J
DOI: 10.1136/fn.82.1.f38
PubMed: 10634840

Paediatric basic life support: a practical assessment.
Whyte SD and Wyllie JP
DOI: 10.1016/s0300-9572(99)00056-8
PubMed: 10488937

Patient-controlled analgesia: epidural fentanyl and i.v. morphine compared after caesarean section.
Cooper DW and Saleh U and Taylor M and Whyte S and Ryall D and Kokri MS and Desira WR and Day H and McArthur E
DOI: 10.1093/bja/82.3.366
PubMed: 10434817

Neonatal resuscitation--a practical assessment.
Whyte SD and Sinha AK and Wyllie JP
DOI: 10.1016/s0300-9572(98)00143-9
PubMed: 10321844


Canadian Paediatric Difficult Intubation Database
The first stage of this work has been to establish a local difficult intubation database in our operating rooms. This went live in July 2017. The next stage will be to expand the database to allow other Canadian tertiary paediatric anaesthesia departments to contribute data.

Dexmedetomidine & Myocardial Repolarization Dynamics
This randomised, double-blinded clinical trial will investigate the effect of three clinically relevant doses of dexmedetomidine on the dispersion of myocardial repolarization. Increases in dispersion of repolarization are pro-arrhythmogenic and facilitate torsades de pointes in patients with or at risk of long QT syndromes. As many of these patients are undiagnosed, and as the peri-operative period represents a time of increased risk for them, identifying anaesthetic agents that do not further increase this risk is an important undertaking.


2016-2017 Evidence to Innovation Seed Grant

“BCCH Pediatric Anesthesia Difficult Airway Database

A Quality Improvement Initiative to Improve Safety in Patients with Difficult Airways”

Honours & Awards

Child & Family Research Institute Innovations in Acute Care & Technology Trainee Clinical Investigator Seed Grant - Project

"The effect of preoperative warming on surgical complications in pediatric scoliosis repair," $5,000. 2013.

Child & Family Research Institute Pharmaceutical Outcomes and Policy Innovations - Project

"5-HT3 Antagonists and Cardiac Safety," $42,667. 2014/15.

Research Group Members

Victoria McCann, Summer Research Student
Andrew Poznikoff, Clinical Research Coordinator