I am involved in diverse studies that include defining clinically relevant pharmacodynamic endpoints for drugs used in paediatric anaesthetic and perioperative care, and providing feedback on aspects of quality of intraoperative care, with the common goal of improving patients' experiences & safety.
Examples of such studies include: examining the effects of anaesthetic drugs on myocardial repolarization, with the aim of producing evidence-based advice on the safety of these agents in children with, or at risk of, long QT syndromes; analyzing intraoperative Code Blue data to help focus preventative strategies; correlating perioperative thermoregulation management with surgical outcomes in scoliosis correction surgery and in the National Surgical Quality Improvement Programme – Pediatrics (NSQIP-P).
Preoperative warming and undesired surgical and anesthesia outcomes in pediatric spinal surgery-a retrospective cohort study.
Görges M and West NC and Cheung W and Zhou G and Miyanji F and Whyte SD
Changes in QTc associated with a rapid bolus dose of dexmedetomidine in patients receiving TIVA: a retrospective study.
Görges M and Whyte SD and Sanatani S and Dawes J and Montgomery CJ and Ansermino JM
The safety of modern anesthesia for children with long QT syndrome.
Whyte SD and Nathan A and Myers D and Watkins SC and Kannankeril PJ and Etheridge SP and Andrade J and Collins KK and Law IH and Hayes J and Sanatani S
ACS national surgical quality improvement program: targeting quality improvement in Canadian pediatric surgery.
Skarsgard ED and Bedford J and Chan T and Whyte S and Afshar K
A retrospective audit to examine the effectiveness of preoperative warming on hypothermia in spine deformity surgery patients.
Görges M and Ansermino JM and Whyte SD
The effects of droperidol and ondansetron on dispersion of myocardial repolarization in children
DISHA MEHTA and SHUBHAYAN SANATANI and SIMON D. WHYTE
Total intravenous anesthesia and spontaneous respiration for airway endoscopy in children--a prospective evaluation.
Malherbe S and Whyte S and Singh P and Amari E and King A and Ansermino JM
Audit and feedback: to tell or not to tell? That is not the question
Canadian Journal of Anesthesia/Journal canadien d'anesthésie
Surgeon's Guide to Anaesthesia and Perioperative Care
Intubation via the intubating laryngeal airway in two pediatric patients with predicted difficult airways.
Peiris K and Traynor M and Whyte S
The effect of propofol concentration on dispersion of myocardial repolarization in children.
Hume-Smith HV and Sanatani S and Lim J and Chau A and Whyte SD
A comparison of the effect on dispersion of repolarization of age-adjusted MAC values of sevoflurane in children.
Whyte SD and Sanatani S and Lim J and Booker PD
The effects of propofol and sevoflurane on the QT interval and transmural dispersion of repolarization in children.
Whyte SD and Booker PD and Buckley DG
Usefulness of the Minute Ventilation Test in Predicting Successful Extubation in Newborn Infants: A Randomized Controlled Trial
Journal of Perinatology
Lorna M Gillespie and Simon D White and Sunil K Sinha and Steven M Donn
Monitoring the depth of anaesthesia
British Journal of Anaesthesia
Patient-controlled analgesia: epidural fentanyl and i.v. morphine compared after caesarean section.
Cooper DW and Saleh U and Taylor M and Whyte S and Ryall D and Kokri MS and Desira WR and Day H and McArthur E
Canadian Paediatric Difficult Intubation Database
The first stage of this work has been to establish a local difficult intubation database in our operating rooms. This went live in July 2017. The next stage will be to expand the database to allow other Canadian tertiary paediatric anaesthesia departments to contribute data.
Dexmedetomidine & Myocardial Repolarization Dynamics
This randomised, double-blinded clinical trial will investigate the effect of three clinically relevant doses of dexmedetomidine on the dispersion of myocardial repolarization. Increases in dispersion of repolarization are pro-arrhythmogenic and facilitate torsades de pointes in patients with or at risk of long QT syndromes. As many of these patients are undiagnosed, and as the peri-operative period represents a time of increased risk for them, identifying anaesthetic agents that do not further increase this risk is an important undertaking.Grants
2016-2017 Evidence to Innovation Seed Grant: “BCCH Pediatric Anesthesia Difficult Airway Database: A Quality Improvement Initiative to Improve Safety in Patients with Difficult Airways”Honours & Awards
Child & Family Research Institute Innovations in Acute Care & Technology Trainee Clinical Investigator Seed Grant - Project: "The effect of preoperative warming on surgical complications in pediatric scoliosis repair," $5,000. 2013.
Child & Family Research Institute Pharmaceutical Outcomes and Policy Innovations - Project: "5-HT3 Antagonists and Cardiac Safety," $42,667. 2014/15.Research Group Members
Wesley Chu, Research Volunteer
Andrew Poznikoff, Clinical Research Coordinator
How staying warm and maintaining blood pressure can help children recover from surgery: Q&A with Dr. Matthias Görges and Dr. Simon Whyte
Dr. Matthias Görges and Dr. Simon Whyte jave been digging into patient data routinely collected before, during and after surgery to pinpoint opportunities to improve a child’s recovery.