A systems biology approach to better understand human tick-borne diseases
Trends in Parasitology
Wenna Lee and Amanda D. Barbosa and Peter J. Irwin and Andrew Currie and Tobias R. Kollmann and Miles Beaman and Amy H. Lee and Charlotte L. Oskam
DOI: 10.1016/j.pt.2022.10.006
01/2023

Implications of Non-Specific Effects for Testing, Approving, and Regulating Vaccines
Drug Safety
DOI: 10.1007/s40264-023-01295-3
2023

The non-specific effects of maternal immunization on birth outcomes: The evidence, mechanisms, and the implications
International Journal of Gynecology and Obstetrics
DOI: 10.1002/ijgo.14795
2023

Randomized Trial of BCG Vaccine to Protect against Covid-19 in Health Care Workers
New England Journal of Medicine
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2023

Mortality Risk Among Frail Neonates and Maternal BCG Vaccine Scar Status: Observational Study From Guinea-Bissau
Journal of Infectious Diseases
DOI: 10.1093/infdis/jiac140
2023

Maternal Vaccination to Prevent Adverse Pregnancy Outcomes: An Underutilized Molecular Immunological Intervention?
Journal of Molecular Biology
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2023

Defining the pediatric response to SARS-CoV-2 variants
Frontiers in Immunology
DOI: 10.3389/fimmu.2023.1200456
2023

BCG-Induced Immune Training: Interplay between Trained Immunity and Emergency Granulopoiesis
Journal of Molecular Biology
DOI: 10.1016/j.jmb.2023.168169
2023

Bacillus Calmette-Guérin vaccination for protection against recurrent herpes labialis: a nested randomised controlled trial
eClinicalMedicine
DOI: 10.1016/j.eclinm.2023.102203
2023

Interferon ß-1a ring prophylaxis to reduce household transmission of SARS-CoV-2: a cluster randomised clinical trial
eClinicalMedicine
DOI: 10.1016/j.eclinm.2023.102082
2023

The PRotective Effect of Maternal Immunisation on preTerm birth: characterising the Underlying mechanisms and Role in newborn immune function: the PREMITUR study protocol
Frontiers in Immunology
DOI: 10.3389/fimmu.2023.1212320
2023

The safety of co-administration of Bacille Calmette-Guérin (BCG) and influenza vaccines
PLOS ONE
Paola Villanueva and Ushma Wadia and Nigel W. Crawford and Nicole L. Messina and Tobias R. Kollmann and Michaela Lucas and Laurens Manning and Peter Richmond and Laure F. Pittet and Nigel Curtis
DOI: 10.1371/journal.pone.0268042
06/2022

Cutaneous CpG adjuvant conditioning to enhance vaccine responses
Vaccine
Douglas A. Carlow and Jacqueline C.Y. Lai and Tobias R. Kollmann and Manish Sadarangani and Jan P. Dutz
DOI: 10.1016/j.vaccine.2021.12.060
03/2022

Off-target effects of bacillus Calmette–Guérin vaccination on immune responses to SARS-CoV-2: implications for protection against severe COVID-19
Clinical and Translational Immunology
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Revaccination with Bacille Calmette-Guérin (BCG) is associated with an increased risk of abscess and lymphadenopathy
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Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells
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A single birth dose of Hepatitis B vaccine induces polyfunctional CD4⁺ T helper cells
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Immunisation with the BCG and DTPw vaccines induces different programs of trained immunity in mice
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2022

FastMix: a versatile data integration pipeline for cell type-specific biomarker inference
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Bacille Calmette-Guérin vaccine reprograms human neonatal lipid metabolism in vivo and in vitro
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Microbial antigen in human milk: a natural vaccine?
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A place for neutrophils in the beneficial pathogen-agnostic effects of the BCG vaccine
Vaccine
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The Troublesome Ticks Research Protocol: Developing a Comprehensive, Multidiscipline Research Plan for Investigating Human Tick-Associated Disease in Australia
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Immunological mechanisms of vaccine-induced protection against COVID-19 in humans
Nature Reviews Immunology
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Biogeography of the Relationship between the Child Gut Microbiome and Innate Immune System.
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BCG vaccination to reduce the impact of COVID-19 in healthcare workers: Protocol for a randomised controlled trial (BRACE trial)
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Searching for a technology-driven acute rheumatic fever test: The START study protocol
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2021

Machine learning-based single cell and integrative analysis reveals that baseline mDC predisposition predicts protective Hepatitis B vaccine response
medRxiv
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2021

Bacille Calmette-Guérin vaccine reprograms human neonatal lipid metabolism in vitro and in vivo
medRxiv
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2021

Machine Learning-Based Single Cell and Integrative Analysis Reveals That Baseline mDC Predisposition Correlates With Hepatitis B Vaccine Antibody Response
Frontiers in Immunology
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2021

Listeriosis in infants: Prospective surveillance studies in Canada and Switzerland
Paediatrics and Child Health (Canada)
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2021

Immediate Bacille Calmette-Guérin Vaccination to Neonates Requiring Perinatal Treatment at the Maternity Ward in Guinea-Bissau: A Randomized Controlled Trial
Journal of Infectious Diseases
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2021

Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life
Cytokine
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2021

FastMix: A versatile multi-omics data integration pipeline for cell type-specific biomarker inference
medRxiv
Zhang, Y. and Sun, H. and Mandava, A. and Aevermann, B.D. and Kollmann, T.R. and Scheuermann, R.H. and Qiu, X. and Qian, Y.
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2021

Pediatric nasal epithelial cells are less permissive to SARS-CoV-2 replication compared to adult cells
bioRxiv
Zhu, Y. and Chew, K.Y. and Karawita, A.C. and Yamamoto, A. and Labzin, L.L. and Yarlagadda, T. and Khromykh, A.A. and Stocks, C.J. and Xia, Y. and Kollmann, T.R. and Martino, D. and Kicic, A. and Joensuu, M. and Meunier, F.A. and Balistreri, G. and Bielefeldt-Ohmann, H. and Bowen, A.C. and Sly, P.D. and Spann, K.M. and Short, K.R.
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2021

A cluster randomized trial of interferon ß-1a for the reduction of transmission of SARS-Cov-2: protocol for the Containing Coronavirus Disease 19 trial (ConCorD-19)
BMC Infectious Diseases
Iturriaga, C. and Eiffler, N. and Aniba, R. and Ben-Othman, R. and Perez-Mateluna, G. and Meyer, J.K.V. and Fish, E.N. and Kollmann, T.R. and Severino, N. and Stick, S. and Borzutzky, A. and Perret, C. and Castro-Rodriguez, J.A. and Garcia-Huidobro, D.
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2021

Plasma Adenosine Deaminase (ADA)-1 and -2 Demonstrate Robust Ontogeny Across the First Four Months of Human Life
Frontiers in Immunology
Odumade, O.A. and Plotkin, A.L. and Pak, J. and Idoko, O.T. and Pettengill, M.A. and Kollmann, T.R. and Ozonoff, A. and Kampmann, B. and Levy, O. and Smolen, K.K.
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2021

The Fifth International Neonatal and Maternal Immunization Symposium (INMIS 2019): Securing Protection for the Next Generation
mSphere
Sadarangani, M. and Kollmann, T. and Bjornson, G. and Heath, P. and Clarke, E. and Marchant, A. and Levy, O. and Leuridan, E. and Ulloa-Gutierrez, R. and Cutland, C.L. and Kampmann, B. and Chaithongwongwatthana, S. and Dinleyici, E. and Damme, P.V. and Munoz, F.M.
DOI: 10.1128/MSPHERE.00862-20
2021

One vaccine for life: Lessons from immune ontogeny
Journal of Paediatrics and Child Health
Brophy-Williams, S. and Fidanza, M. and Marchant, A. and Way, S. and Kollmann, T.R.
DOI: 10.1111/jpc.15511
2021

Bacterial and Fungal Gut Community Dynamics Over the First 5 Years of Life in Predominantly Rural Communities in Ghana
Frontiers in Microbiology
Amenyogbe, N. and Adu-Gyasi, D. and Enuameh, Y. and Asante, K.P. and Konadu, D.G. and Kaali, S. and Dosoo, D. and Panigrahi, P. and Kollmann, T.R. and Mohn, W.W. and Owusu-Agyei, S.
DOI: 10.3389/fmicb.2021.664407
2021

Lactiplantibacillus plantarum–Nomad and Ideal Probiotic
Frontiers in Microbiology
Fidanza, M. and Panigrahi, P. and Kollmann, T.R.
DOI: 10.3389/fmicb.2021.712236
2021

Corrigendum: Clinical Protocol for a Longitudinal Cohort Study Employing Systems Biology to Identify Markers of Vaccine Immunogenicity in Newborn Infants in The Gambia and Papua New Guinea.
Frontiers in pediatrics
Idoko OT and Smolen KK and Wariri O and Imam A and Shannon CP and Dibassey T and Diray-Arce J and Darboe A and Strandmark J and Ben-Othman R and Odumade OA and McEnaney K and Kampmann B
DOI: 10.3389/fped.2020.610461
PubMed: 33313031
11/2020

Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in Adults.
Frontiers in immunology
Ben-Othman R and Cai B and Liu AC and Varankovich N and He D and Blimkie TM and Lee AH and Gill EE and Novotny M and Aevermann B and Drissler S and Shannon CP and McCann S and Marty K and Sadarangani M
DOI: 10.3389/fimmu.2020.580373
PubMed: 33250895
11/2020

Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life
Frontiers in Immunology
Tue Bjerg Bennike and Benoit Fatou and Asimenia Angelidou and Joann Diray-Arce and Reza Falsafi and Rebecca Ford and Erin E. Gill and Simon D. van Haren and Olubukola T. Idoko and Amy H. Lee and Rym Ben-Othman and William S. Pomat and Casey P. Shannon and Kinga K. Smolen and Scott J. Tebbutt and Al Ozonoff and Peter C. Richmond and Anita H. J. van den Biggelaar and Robert E. W. Hancock and Beate Kampmann and Tobias R. Kollmann and Ofer Levy and Hanno Steen
DOI: 10.3389/fimmu.2020.578505
10/2020

Innate Immune Responses and Gut Microbiomes Distinguish HIV-Exposed from HIV-Unexposed Children in a Population-Specific Manner.
Journal of immunology (Baltimore, Md. : 1950)
Amenyogbe N and Dimitriu P and Cho P and Ruck C and Fortuno ES and Cai B and Alimenti A and Côté HCF and Maan EJ and Slogrove AL and Esser M and Marchant A and Goetghebuer T and Smolen KK
DOI: 10.4049/jimmunol.2000040
PubMed: 33067377
10/2020

Corrigendum: Interferon-a2b Treatment for COVID-19.
Frontiers in immunology
Zhou Q and Chen V and Shannon CP and Wei XS and Xiang X and Wang X and Wang ZH and Tebbutt SJ and Kollmann TR and Fish EN
DOI: 10.3389/fimmu.2020.615275
PubMed: 33193462
10/2020

Bacterial and Fungal Gut Community Dynamics Over the First Five Years of Life in Predominantly Rural Communities in Ghana
Amenyogbe NA and Adu-Gyasi D and Enuameh Y and Asante KP and Konadu DG and Seyram K and Dosoo D and Panigrahi P and Kollmann T and Mohn W and Owusu-Agyei S
DOI: 10.21203/rs.3.rs-78160/v1
09/2020

Immunogenicity of 2 and 3 Doses of the Quadrivalent Human Papillomavirus Vaccine up to 120 Months Postvaccination: Follow-up of a Randomized Clinical Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Donken R and Dobson SRM and Marty KD and Cook D and Sauvageau C and Gilca V and Dionne M and McNeil S and Krajden M and Money D and Kellner J and Scheifele DW and Kollmann T and Ogilvie GS
DOI: 10.1093/cid/ciz887
PubMed: 31617568
08/2020

Feasibility of manual white blood cell counts as a predictor of neonatal sepsis in a low-resource setting.
Transactions of the Royal Society of Tropical Medicine and Hygiene
Golding CN and Schaltz-Buchholzer F and Sanca L and Clipet-Jensen C and Benn CS and Au N and Chipperfield K and Kollmann TR and Amenyogbe NA
DOI: 10.1093/trstmh/traa023
PubMed: 32333010
08/2020

Association of Maternal Factors and HIV Infection With Innate Cytokine Responses of Delivering Mothers and Newborns in Mozambique.
Frontiers in microbiology
Moncunill G and Dobaño C and González R and Smolen KK and Manaca MN and Balcells R and Jairoce C and Cisteró P and Vala A and Sevene E and Rupérez M and Aponte JJ and Macete E and Mayor A
DOI: 10.3389/fmicb.2020.01452
PubMed: 32765436
07/2020

Profiling avidity of antibodies elicited by vaccination using enzyme-linked immunosorbent assay-based elution - Insights into a novel experimental and analytical approach.
Vaccine
Abu-Raya B and Giles ML and Kollmann TR and Sadarangani M
DOI: 10.1016/j.vaccine.2020.06.060
PubMed: 32620372
06/2020

Neonatal BCG Vaccination Reduces Interferon-¿ Responsiveness to Heterologous Pathogens in Infants From a Randomized Controlled Trial.
The Journal of infectious diseases
Freyne B and Messina NL and Donath S and Germano S and Bonnici R and Gardiner K and Casalaz D and Robins-Browne RM and Netea MG and Flanagan KL and Kollmann T and Curtis N and Melbourne Infant Study: BCG for Allergy and Infection Reduction (MIS BAIR) Group
DOI: 10.1093/infdis/jiaa030
PubMed: 31990350
06/2020

Maternal HIV Infection Alters Antimicrobial Immunity in Exposed and Uninfected Infants.
The Pediatric infectious disease journal
Marchant A and Amenyogbe N and Kollmann TR and Goetghebuer T
DOI: 10.1097/inf.0000000000002614
PubMed: 32301922
05/2020

The non-specific and sex-differential effects of vaccines.
Nature reviews. Immunology
Aaby P and Benn CS and Flanagan KL and Klein SL and Kollmann TR and Lynn DJ and Shann F
DOI: 10.1038/s41577-020-0338-x
PubMed: 32461674
05/2020

Interferon-a2b Treatment for COVID-19.
Frontiers in immunology
Zhou Q and Chen V and Shannon CP and Wei XS and Xiang X and Wang X and Wang ZH and Tebbutt SJ and Kollmann TR and Fish EN
DOI: 10.3389/fimmu.2020.01061
PubMed: 32574262
05/2020

BCG vaccination-induced emergency granulopoiesis provides rapid protection from neonatal sepsis.
Science translational medicine
Brook B and Harbeson DJ and Shannon CP and Cai B and He D and Ben-Othman R and Francis F and Huang J and Varankovich N and Liu A and Bao W and Bjerregaard-Andersen M and Amenyogbe N
DOI: 10.1126/scitranslmed.aax4517
PubMed: 32376769
05/2020

Vaccination strategies to enhance immunity in neonates.
Science (New York, N.Y.)
Kollmann TR and Marchant A and Way SS
DOI: 10.1126/science.aaz9447
PubMed: 32381718
05/2020

Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome?
Trends in immunology
Tsang JS and Dobaño C and VanDamme P and Moncunill G and Marchant A and Othman RB and Sadarangani M and Koff WC and Kollmann TR
DOI: 10.1016/j.it.2020.04.001
PubMed: 32340868
04/2020

Interferon-a2b treatment for COVID-19
Zhou Q and Wei X and Xiang X and Wang X and Wang Z and Chen V and Shannon CP and Tebbutt SJ and Kollmann TR and Fish EN
DOI: 10.1101/2020.04.06.20042580
04/2020

Clinical Protocol for a Longitudinal Cohort Study Employing Systems Biology to Identify Markers of Vaccine Immunogenicity in Newborn Infants in The Gambia and Papua New Guinea.
Frontiers in pediatrics
Idoko OT and Smolen KK and Wariri O and Imam A and Shannon CP and Dibassey T and Diray-Arce J and Darboe A and Strandmark J and Ben-Othman R and Odumade OA and McEnaney K and Kampmann B
DOI: 10.3389/fped.2020.00197
PubMed: 32426309
04/2020

A teenager with migrating leg pains and anemia
Pediatrics in Review
Eckbo, E.J. and Mijovic, H. and Rathgeber, S. and Armstrong, K. and Kollmann, T.R.
DOI: 10.1542/pir.2018-0042
2020

Multi-Omic Data Integration Allows Baseline Immune Signatures to Predict Hepatitis B Vaccine Response in a Small Cohort
Frontiers in Immunology
Shannon, C.P. and Blimkie, T.M. and Ben-Othman, R. and Gladish, N. and Amenyogbe, N. and Drissler, S. and Edgar, R.D. and Chan, Q. and Krajden, M. and Foster, L.J. and Kobor, M.S. and Mohn, W.W. and Brinkman, R.R. and Le Cao, K.-A. and Scheuermann, R.H. and Tebbutt, S.J. and Hancock, R.E.W. and Koff, W.C. and Kollmann, T.R. and Sadarangani, M. and Lee, A.H.-Y.
DOI: 10.3389/fimmu.2020.578801
2020

The Effect of Timing of Tetanus-Diphtheria-Acellular Pertussis Vaccine Administration in Pregnancy on the Avidity of Pertussis Antibodies.
Frontiers in immunology
Abu-Raya B and Giles ML and Kollmann TR and Sadarangani M
DOI: 10.3389/fimmu.2019.02423
PubMed: 31681310
10/2019

Measles Maternal Antibodies With Low Avidity Do Not Interfere With the Establishment of Robust Quantity and Quality Antibody Responses After the Primary Dose of Measles, Mumps, and Rubella Vaccine Administered at 12-Months of Age.
Journal of the Pediatric Infectious Diseases Society
Collins CA and Gelinas L and Yasukawa LL and Audet S and Abu-Raya B and Turvey SE and Beeler JA and Kollmann TR and Gans HA
DOI: 10.1093/jpids/piz074
PubMed: 31644795
10/2019

Biological sex influences antibody responses to routine vaccinations in the first year of life.
Acta paediatrica (Oslo, Norway : 1992)
Zimmermann P and Perrett KP and Ritz N and Flanagan KL and Robins-Browne R and van der Klis FRM and Curtis N and MIS BAIR group
DOI: 10.1111/apa.14932
PubMed: 31610635
07/2019

AIDS Vaccine Research Subcommittee (AVRS) Consultation: Early-Life Immunization Strategies against HIV Acquisition.
mSphere
Singh A and Permar S and Kollmann TR and Levy O and Marovich M and De Paris K
DOI: 10.1128/mSphere.00320-19
PubMed: 31315966
07/2019

Malt1 deficient mice develop osteoporosis independent of osteoclast-intrinsic effects of Malt1 deficiency.
Journal of leukocyte biology
Monajemi M and Fisk S and Pang YCF and Leung J and Menzies SC and Ben-Othman R and Cai B and Kollmann TR and Rozmus J and Sly LM
DOI: 10.1002/jlb.5vma0219-054r
PubMed: 31313375
07/2019

Reduced genetic potential for butyrate fermentation in the gut microbiome of infants who develop allergic sensitization.
The Journal of allergy and clinical immunology
Cait A and Cardenas E and Dimitriu P and Amenyogbe N and Dai D and Cait J and Sbihi H and Stiemsma L and Subbarao P and Mandhane PJ and Becker AB and Moraes TJ and Sears MR and Mohn WW
DOI: 10.1016/j.jaci.2019.06.029
PubMed: 31279007
07/2019

Robust health-score based survival prediction for a neonatal mouse model of polymicrobial sepsis.
PloS one
Brook B and Harbeson D and Amenyogbe N and Ben-Othman R and Kollmann TR and Aniba R
DOI: 10.1371/journal.pone.0218714
PubMed: 31233529
06/2019

Reply to Slogrove et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Goetghebuer T and Smolen KK and Adler C and Das J and McBride T and Smits G and Lecomte S and Haelterman E and Barlow P and Piedra PA and Van der Klis F and Kollmann TR and Marchant A
DOI: 10.1093/cid/ciy1058
PubMed: 30535371
05/2019

Dynamic molecular changes during the first week of human life follow a robust developmental trajectory.
Nature communications
Lee AH and Shannon CP and Amenyogbe N and Bennike TB and Diray-Arce J and Idoko OT and Gill EE and Ben-Othman R and Pomat WS and van Haren SD and Cao KL and Cox M and Darboe A and Kollmann TR
DOI: 10.1038/s41467-019-08794-x
PubMed: 30862783
03/2019

Initiation of Antiretroviral Therapy Before Pregnancy Reduces the Risk of Infection-related Hospitalization in Human Immunodeficiency Virus-exposed Uninfected Infants Born in a High-income Country.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Goetghebuer T and Smolen KK and Adler C and Das J and McBride T and Smits G and Lecomte S and Haelterman E and Barlow P and Piedra PA and van der Klis F and Kollmann TR and Marchant A
DOI: 10.1093/cid/ciy673
PubMed: 30215689
03/2019

A Controlled Mouse Model for Neonatal Polymicrobial Sepsis.
Journal of visualized experiments : JoVE
Brook B and Amenyogbe N and Ben-Othman R and Cai B and Harbeson D and Francis F and Liu AC and Varankovich N and Wynn J and Kollmann TR
DOI: 10.3791/58574
PubMed: 30741260
01/2019

Prenatal depression and birth mode sequentially mediate maternal education's influence on infant sleep duration.
Sleep medicine
Matenchuk BA and Tamana SK and Lou WYW and Lefebvre DL and Sears MR and Becker AB and Azad MB and Moraes TJ and Turvey SE and Subbarao P and Kozyrskyj AL and Mandhane PJ and CHILD Study Investigators
DOI: 10.1016/j.sleep.2019.01.015
PubMed: 31153013
01/2019

Probiotic Studies in Neonatal Mice Using Gavage.
Journal of visualized experiments : JoVE
Francis F and Varankovich N and Brook B and Amenyogbe N and Ben-Othman R and Cai B and Harbeson D and Liu AC and Dai B and McErlane S and Andrews K and Kollmann TR and Panigrahi P
DOI: 10.3791/59074
PubMed: 30741256
01/2019

Residential green space and pathways to term birth weight in the Canadian Healthy Infant Longitudinal Development (CHILD) Study.
International journal of health geographics
Cusack L and Sbihi H and Larkin A and Chow A and Brook JR and Moraes T and Mandhane PJ and Becker AB and Azad MB and Subbarao P and Kozyrskyj A and Takaro TK and Sears MR and Turvey SE and CHILD Study Investigators
DOI: 10.1186/s12942-018-0160-x
PubMed: 30514315
12/2018

153. The Effect of Timing of Tetanus–Diphtheria and Pertussis Vaccine Administration in Pregnancy on The Avidity of Pertussis Antibodies.
Open forum infectious diseases
Raya BA and Giles M and Kollmann T and Sadarangani M
DOI: 10.1093/ofid/ofy209.023
11/2018

Diagnosing atopic dermatitis in infancy: Questionnaire reports vs criteria-based assessment.
Paediatric and perinatal epidemiology
Dharma C and Lefebvre DL and Tran MM and Lu Z and Lou WYW and Subbarao P and Becker AB and Mandhane PJ and Turvey SE and Moraes TJ and Azad MB and Sears MR and CHILD Study Investigators
DOI: 10.1111/ppe.12525
PubMed: 30461044
11/2018

Predicting the Atopic March: Results From the Canadian Healthy Infant Longitudinal Development Study
Pediatrics
Jennifer A. Dantzer and Robert A. Wood
DOI: 10.1542/peds.2018-2420n
11/2018

Energy Demands of Early Life Drive a Disease Tolerant Phenotype and Dictate Outcome in Neonatal Bacterial Sepsis.
Frontiers in immunology
Harbeson D and Francis F and Bao W and Amenyogbe NA and Kollmann TR
DOI: 10.3389/fimmu.2018.01918
PubMed: 30190719
08/2018

Association of Exposure to Formula in the Hospital and Subsequent Infant Feeding Practices With Gut Microbiota and Risk of Overweight in the First Year of Life
JAMA Pediatrics
DOI: 10.1001/jamapediatrics.2018.1161
07/2018

Neonatal BCG Vaccination Influences Cytokine Responses to Toll-like Receptor Ligands and Heterologous Antigens.
The Journal of infectious diseases
Freyne B and Donath S and Germano S and Gardiner K and Casalaz D and Robins-Browne RM and Amenyogbe N and Messina NL and Netea MG and Flanagan KL and Kollmann T and Curtis N
DOI: 10.1093/infdis/jiy069
PubMed: 29415180
05/2018

Outgrowing the Immaturity Myth: The Cost of Defending From Neonatal Infectious Disease.
Frontiers in immunology
Harbeson D and Ben-Othman R and Amenyogbe N and Kollmann TR
DOI: 10.3389/fimmu.2018.01077
PubMed: 29896192
05/2018

Innate immune responses following Kawasaki disease and toxic shock syndrome.
PloS one
Chen KYH and Messina N and Germano S and Bonnici R and Freyne B and Cheung M and Goldsmith G and Kollmann TR and Levin M and Burgner D and Curtis N
DOI: 10.1371/journal.pone.0191830
PubMed: 29447181
02/2018

Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn.
Frontiers in immunology
Scheid A and Borriello F and Pietrasanta C and Christou H and Diray-Arce J and Pettengill MA and Joshi S and Li N and Bergelson I and Kollmann T and Dowling DJ and Levy O
DOI: 10.3389/fimmu.2018.00029
PubMed: 29416539
01/2018

Case-control study of household contacts to examine immunological protection from Bordetella pertussis transmission - study protocol.
CMAJ open
Bolotin S and Johnson C and Quach S and Ambrose A and DeCoutere S and Deeks SL and Drews S and Faheem A and Green K and Halperin SA and Hoang L and Jamieson F and Kollmann T and Canadian Immunization Research Network Provincial Collaborative Network
DOI: 10.9778/cmajo.20170072
PubMed: 29269437
12/2017

The Western environment reduces innate immune cytokine production in Chinese immigrants.
The Journal of allergy and clinical immunology
Saiganesh A and Hales BJ and Chen S and Filipovska-Naumovska E and Pereira G and Garand M and Kollmann TR and Currie AJ and Le Souëf PN and Zhang G
DOI: 10.1016/j.jaci.2017.11.031
PubMed: 29274412
12/2017

Traumatic Neonatal Lumbar Punctures: Experience at a Large Pediatric Tertiary Care Center in Canada.
American journal of perinatology
Matettore A and Kollmann TR
DOI: 10.1055/s-0037-1615794
PubMed: 29287293
12/2017

Immunity and immunopathology in early human life.
Seminars in immunopathology
DOI: 10.1007/s00281-017-0657-6
PubMed: 29170801
11/2017

Predicting the atopic march: Results from the Canadian Healthy Infant Longitudinal Development Study.
The Journal of allergy and clinical immunology
DOI: 10.1016/j.jaci.2017.08.024
PubMed: 29153857
11/2017

Modes of Infant Feeding and the Risk of Childhood Asthma: A Prospective Birth Cohort Study.
The Journal of pediatrics
DOI: 10.1016/j.jpeds.2017.07.012
PubMed: 29144244
11/2017

Newborn susceptibility to infection vs. disease depends on complex in vivo interactions of host and pathogen.
Seminars in immunopathology
DOI: 10.1007/s00281-017-0651-z
PubMed: 29098373
11/2017

Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: Effects on allergic diseases.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
DOI: 10.1111/cea.13063
PubMed: 29143385
11/2017

Cellular immune responses of older adults to four influenza vaccines: Results of a randomized, controlled comparison.
Human vaccines & immunotherapeutics
DOI: 10.1080/21645515.2017.1337615
PubMed: 28635557
09/2017

Timing of food introduction and development of food sensitization in a prospective birth cohort.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
DOI: 10.1111/pai.12739
PubMed: 28557044
08/2017

Maternal immunisation: collaborating with mother nature.
The Lancet. Infectious diseases
DOI: 10.1016/s1473-3099(17)30229-3
PubMed: 28433705
07/2017

Exposure to household furry pets influences the gut microbiota of infant at 3-4 months following various birth scenarios.
Microbiome
DOI: 10.1186/s40168-017-0254-x
PubMed: 28381231
04/2017

OMIP-038: Innate immune assessment with a 14 color flow cytometry panel.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Smolen KK and Cai B and Kollmann TR
DOI: 10.1002/cyto.a.23109
PubMed: 28419701
04/2017

Lack of broad functional differences in immunity in fully vaccinated vs. unvaccinated children.
Pediatric research
DOI: 10.1038/pr.2016.272
PubMed: 28024144
04/2017

Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny.
Immunity
DOI: 10.1016/j.immuni.2017.03.009
PubMed: 28329702
03/2017

A Prospective Cohort Study of Common Childhood Infections in South African HIV-exposed Uninfected and HIV-unexposed Infants.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0000000000001391
PubMed: 28081048
02/2017

Environment impacts innate immune ontogeny.
Innate immunity
DOI: 10.1177/1753425916671018
PubMed: 27697850
01/2017

Early-Life Host-Microbiome Interphase: The Key Frontier for Immune Development.
Frontiers in Pediatrics
DOI: 10.3389/fped.2017.00111
PubMed: 28596951
2017

Editorial: Immune Mechanisms Underlying the Increased Morbidity and Mortality of HIV-Exposed Uninfected (HEU) Children.
Frontiers in Immunology
DOI: 10.3389/fimmu.2017.01060
PubMed: 28932223
2017

Hepatitis B Virus Vaccine–Induced Cell-Mediated Immunity Correlates with Humoral Immune Response following Primary Vaccination during Infancy
ImmunoHorizons
Gelinas, L. and Abu-Raya, B. and Ruck, C. and Cai, B. and Kollmann, T.R.
DOI: 10.4049/immunohorizons.1700015
2017

Sex-specific impact of asthma during pregnancy on infant gut microbiota
European Respiratory Journal
Koleva, P.T. and Tun, H.M. and Konya, T. and Guttman, D.S. and Becker, A.B. and Mandhane, P.J. and Turvey, S.E. and Subbarao, P. and Sears, M.R. and Scott, J.A. and Kozyrskyj, A.L. and Anand, S.S. and Azad, M.B. and Becker, A.B. and Befus, A.D. and Brauer, M. and Brook, J.R. and Chen, E. and Cyr, M.M. and Daley, D. and Dell, S.D. and Denburg, J.A. and Duan, Q.L. and Eiwegger, T. and Grasemann, H. and HayGlass, K. and Hegele, R.G. and Holness, D.L. and Hystad, P. and Kobor, M. and Kollmann, T.R. and Laprise, C. and Lou, W.Y.W. and Macri, J. and Mandhane, P.J. and Miller, G. and Moraes, T.J. and Paré, P. and Ramsey, C. and Ratjen, F. and Sandford, A. and Scott, J. and Scott, J.A. and Sears, M.R. and Silverman, F. and Simons, E. and Subbarao, P. and Takaro, T. and Tebbutt, S.J. and To, T. and Turvey, S.E.
DOI: 10.1183/13993003.00280-2017
2017

Host Defense Mechanisms Against Bacteria
Fetal and Neonatal Physiology
Tobias R. Kollmann and Arnaud Marchant
DOI: 10.1016/b978-0-323-35214-7.00120-7
2017

Cesarean Section, Formula Feeding, and Infant Antibiotic Exposure: Separate and Combined Impacts on Gut Microbial Changes in Later Infancy.
Frontiers in pediatrics
DOI: 10.3389/fped.2017.00200
PubMed: 29018787
2017

Endosomal pH modulation by peptide-gold nanoparticle hybrids enables potent anti-inflammatory activity in phagocytic immune cells.
Biomaterials
DOI: 10.1016/j.biomaterials.2016.09.032
PubMed: 27728817
12/2016

Shifts in Lachnospira and Clostridium sp. in the 3-month stool microbiome are associated with preschool age asthma.
Clinical science (London, England : 1979)
DOI: 10.1042/cs20160349
PubMed: 27634868
12/2016

Proceedings of the Canadian society of allergy and clinical immunology annual scientific meeting 2015.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
Côté M and Boulay M and Plante S and Chakir J and Boulet L and Ahmed H and Ospina M and Sideri K and Vliagoftis H and Johnson SF and Woodgate RL and Cros G and Teira P and Cellot S and Conway EM
08/2016

Towards Predicting Protective Vaccine Responses in the Very Young.
Trends in immunology
DOI: 10.1016/j.it.2016.05.005
PubMed: 27344245
08/2016

Association Between Artificially Sweetened Beverage Consumption During Pregnancy and Infant Body Mass Index.
JAMA pediatrics
DOI: 10.1001/jamapediatrics.2016.0301
PubMed: 27159792
07/2016

Harnessing the beneficial heterologous effects of vaccination.
Nature reviews. Immunology
DOI: 10.1038/nri.2016.43
PubMed: 27157064
06/2016

Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study.
BJOG : an international journal of obstetrics and gynaecology
DOI: 10.1111/1471-0528.13601
PubMed: 26412384
05/2016

Changing oral vaccine to inactivated polio vaccine might increase mortality.
Lancet (London, England)
DOI: 10.1016/s0140-6736(16)00661-9
PubMed: 27025182
03/2016

Infant gut immunity: a preliminary study of IgA associations with breastfeeding.
Journal of developmental origins of health and disease
DOI: 10.1017/s2040174415007862
PubMed: 26690933
02/2016

Transfer of Maternal Antimicrobial Immunity to HIV-Exposed Uninfected Newborns.
Frontiers in Immunology
DOI: 10.3389/fimmu.2016.00338
PubMed: 27630640
2016

The Immune System of HIV-Exposed Uninfected Infants.
Frontiers in immunology
PubMed: 27733852
2016

The immune system of HIV-exposed uninfected infants
Frontiers in Immunology
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Linking Susceptibility to Infectious Diseases to Immune System Abnormalities among HIV-Exposed Uninfected Infants.
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Attenuated innate immune defenses in very premature neonates during the neonatal period.
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Probiotics to prevent early-life infection.
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BCG modulates neonatal innate immune cytokine production.
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The author responds
Paediatrics and Child Health (Canada)
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Age-Related Gene Expression Differences in Monocytes from Human Neonates, Young Adults, and Older Adults.
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Understanding the ontogeny of the immune system to promote immune-mediated health for life.
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Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges.
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Single-cell analysis of innate cytokine responses to pattern recognition receptor stimulation in children across four continents.
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Perinatal Immunization With Vaccine-Grade Listeria monocytogenes Provides Protection Against Murine Th2 Airway Inflammation.
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Altered innate immune development in HIV-exposed uninfected infants.
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Case 2: A nine-year-old girl with prolonged fever and headache.
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Topical CpG adjuvantation of a protein-based vaccine induces protective immunity to Listeria monocytogenes.
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The role of environmental factors in modulating immune responses in early life.
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The early life gut microbiota and atopic disease.
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Listeria monocytogenes: a promising vehicle for neonatal vaccination.
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Elevated inflammatory mediators in adults with oculorespiratory syndrome following influenza immunization: a public health agency of Canada/Canadian Institutes of Health Research Influenza Research Network Study.
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Implications of Age-Dependent Immune Responses to Enterovirus 71 Infection for Disease Pathogenesis and Vaccine Design.
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Immune response to vaccine adjuvants during the first year of life.
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Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in young women: a randomized clinical trial.
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Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia.
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Clinical and vaccine immunology : CVI
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Critical assessment of automated flow cytometry data analysis techniques.
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Antibody responses to vaccination among South African HIV-exposed and unexposed uninfected infants during the first 2 years of life.
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Age-dependent differences in systemic and cell-autonomous immunity to L. monocytogenes.
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Host defense against common early life-threatening infections.
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HIV-exposed uninfected infants are at increased risk for severe infections in the first year of life.
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Age of recipient and number of doses differentially impact human B and T cell immune memory responses to HPV vaccination.
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Safety and immunogenicity of 2010-2011 H1N12009-containing trivalent inactivated influenza vaccine in children 12-59 months of age previously given AS03-adjuvanted H1N12009 pandemic vaccine: a PHAC/CIHR Influenza Research Network (PCIRN) study.
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Optimization of a whole blood intracellular cytokine assay for measuring innate cell responses to mycobacteria.
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Management of multi-drug-resistant tuberculosis in children
European Infectious Disease
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An eight-month-old child with cervical adenitis.
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
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Management of Multidrug-resistant Tuberculosis (MDR-TB) in Children
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Staphylococcus aureus nasal septal abscess complicated by extradural abscess in an infant
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Drug-resistant tuberculosis: pediatric guidelines.
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Variables to be controlled in the assessment of blood innate immune responses to Toll-like receptor stimulation.
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Facilitating the analysis of immunological data with visual analytic techniques.
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Congenital Syphilis
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Flow cytometry data standards.
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A single immunization near birth elicits immediate and lifelong protective immunity.
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Profound lack of interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis.
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Ontogeny of Toll-like receptor mediated cytokine responses of human blood mononuclear cells.
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Correlation analysis of intracellular and secreted cytokines via the generalized integrated mean fluorescence intensity.
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Identification of B cells through negative gating-An example of the MIFlowCyt standard applied.
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Syphilis
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Functional characterization of human variants of NFKBIA: a key regulator of immune responsiveness implicated in susceptibility to infectious and inflammatory disease.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
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A bacterial immune-prophylactic approach against asthma for infants and children.
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Neonatal innate TLR-mediated responses are distinct from those of adults.
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Neonatal immunization with Listeria monocytogenes induces T cells with an adult-like avidity, sensitivity, and TCR-Vbeta repertoire, and does not adversely impact the response to boosting.
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Rhabdomyolysis, acute renal failure, and compartment syndrome in a child with parainfluenza type 1 infection.
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Systems biology evaluation of immune responses induced by human host defence peptide LL-37 in mononuclear cells.
Molecular bioSystems
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Fine-tuning the safety and immunogenicity of Listeria monocytogenes-based neonatal vaccine platforms.
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Anaerobic brain abscess following chronic suppurative otitis media in a child from Uganda.
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MIFlowCyt: the minimum information about a Flow Cytometry Experiment.
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Induction of antigen-specific immunity in human neonates and infants.
Nestle Nutrition workshop series. Paediatric programme
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Imported fatal hantavirus pulmonary syndrome.
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Deficient MHC class I cross-presentation of soluble antigen by murine neonatal dendritic cells.
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Characterization of flagellin expression and its role in Listeria monocytogenes infection and immunity.
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Cutting edge: protective cell-mediated immunity to Listeria monocytogenes in the absence of myeloid differentiation factor 88.
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Addressing parents' concerns: do multiple vaccines overwhelm or weaken the infant's immune system?
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Thy/Liv-SCID-Hu mice implanted with human intestine: an in vivo model for investigation of mucosal transmission of HIV.
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Saquinavir-mediated inhibition of human immunodeficiency virus (HIV) infection in SCID mice implanted with human fetal thymus and liver tissue: an in vivo model for evaluating the effect of drug therapy on HIV infection in lymphoid tissues.
Antimicrobial agents and chemotherapy
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Severe combined immunodeficiency mice engrafted with human T cells, B cells, and myeloid cells after transplantation with human fetal bone marrow or liver cells and implanted with human fetal thymus: a model for studying human gene therapy.
Blood
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Severe combined lmmunodeficiency mice engrafted with human T cells, B cells, and myeloid cells after transplantation with human fetal bone marrow or liver cells and implanted with human fetal thymus: A model for studying human gene therapy
Blood
Yurasov, S. and Kollmann, T.R. and Kim, A. and Raker, C.A. and Hachamovitch, M. and Wong-Staal, F. and Goldstein, H.
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Saquinavir-mediated inhibition of human immunodeficiency virus (HIV) infection in SCID mice implanted with human fetal thymus and liver tissue: An in vivo model for evaluating the effect of drug therapy on HIV infection in lymphoid tissues
Antimicrobial Agents and Chemotherapy
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SCID-hu mice: a model for studying disseminated HIV infection.
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Inhibition of acute in vivo human immunodeficiency virus infection by human interleukin 10 treatment of SCID mice implanted with human fetal thymus and liver.
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In vivo studies on retrovirally mediated gene transfer into fetal hematopoietic stem/precursor cells
Experimental Hematology
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Divergent effects of chronic HIV-1 infection on human thymocyte maturation in SCID-hu mice.
Journal of immunology (Baltimore, Md. : 1950)
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Divergent effects of chronic HIV-1 infection on human thymocyte maturation in SCID-hu mice
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Reconstitution of SCID mice with human lymphoid and myeloid cells after transplantation with human fetal bone marrow without the requirement for exogenous human cytokines.
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03/1993

The concurrent maturation of mouse and human thymocytes in human fetal thymus implanted in NIH-beige-nude-xid mice is associated with the reconstitution of the murine immune system
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Design of polymerase chain reaction primers for the selective amplification of HIV-1 RNA in the presence of HIV-1 DNA.
AIDS (London, England)
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Enhancement of HIV-1 infection by the capsular polysaccharide of Cryptococcus neoformans.
Lancet (London, England)
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Design of polymerase chain reaction primers for the selective amplification of HIV-1 RNA in the presence of HIV-1 DNA
AIDS
Kollmann, T.R. and Zhuangt, X. and Rubinstein, A. and Goldstein, H.
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1992

Inhibition of HIV-1 infection by alkylureas.
AIDS (London, England)
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Characterization of IgG and IgG subclass antibodies present in paired maternal and fetal serum which are directed against HIV-1 proteins.
AIDS research and human retroviruses
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Inhibition of HIV-1 infection by alkylureas
AIDS
Goldstein, H. and Pettoello-Mantovani, M. and Kollmann, T.R. and Calvelli, T.A. and Rubinstein, A.
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1991