Overview

As you read this paragraph, two infants in the world will have died from an infection for which there is an effective vaccine. Worldwide we could save millions of infants every year - if only we could immunize them on time. The work in our lab focuses on part of the science to help solve this problem.

Publications

Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: Effects on allergic diseases.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
DOI: 10.1111/cea.13063
PubMed: 29143385
11/2017

Newborn susceptibility to infection vs. disease depends on complex in vivo interactions of host and pathogen.
Seminars in immunopathology
DOI: 10.1007/s00281-017-0651-z
PubMed: 29098373
11/2017

Immunity and immunopathology in early human life.
Seminars in immunopathology
DOI: 10.1007/s00281-017-0657-6
PubMed: 29170801
11/2017

Modes of Infant Feeding and the Risk of Childhood Asthma: A Prospective Birth Cohort Study.
The Journal of pediatrics
DOI: 10.1016/j.jpeds.2017.07.012
PubMed: 29144244
11/2017

Predicting the atopic march: Results from the Canadian Healthy Infant Longitudinal Development Study.
The Journal of allergy and clinical immunology
DOI: 10.1016/j.jaci.2017.08.024
PubMed: 29153857
11/2017

Cellular immune responses of older adults to four influenza vaccines: Results of a randomized, controlled comparison.
Human vaccines & immunotherapeutics
DOI: 10.1080/21645515.2017.1337615
PubMed: 28635557
09/2017

Timing of food introduction and development of food sensitization in a prospective birth cohort.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
DOI: 10.1111/pai.12739
PubMed: 28557044
08/2017

Maternal immunisation: collaborating with mother nature.
The Lancet. Infectious diseases
DOI: 10.1016/s1473-3099(17)30229-3
PubMed: 28433705
07/2017

Exposure to household furry pets influences the gut microbiota of infant at 3-4 months following various birth scenarios.
Microbiome
DOI: 10.1186/s40168-017-0254-x
PubMed: 28381231
04/2017

Lack of broad functional differences in immunity in fully vaccinated vs. unvaccinated children.
Pediatric research
DOI: 10.1038/pr.2016.272
PubMed: 28024144
04/2017

Protecting the Newborn and Young Infant from Infectious Diseases: Lessons from Immune Ontogeny.
Immunity
DOI: 10.1016/j.immuni.2017.03.009
PubMed: 28329702
03/2017

A Prospective Cohort Study of Common Childhood Infections in South African HIV-exposed Uninfected and HIV-unexposed Infants.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0000000000001391
PubMed: 28081048
02/2017

Environment impacts innate immune ontogeny.
Innate immunity
DOI: 10.1177/1753425916671018
PubMed: 27697850
01/2017

Early-Life Host-Microbiome Interphase: The Key Frontier for Immune Development.
Frontiers in Pediatrics
DOI: 10.3389/fped.2017.00111
PubMed: 28596951
2017

Editorial: Immune Mechanisms Underlying the Increased Morbidity and Mortality of HIV-Exposed Uninfected (HEU) Children.
Frontiers in Immunology
DOI: 10.3389/fimmu.2017.01060
PubMed: 28932223
2017

Cesarean Section, Formula Feeding, and Infant Antibiotic Exposure: Separate and Combined Impacts on Gut Microbial Changes in Later Infancy.
Frontiers in pediatrics
DOI: 10.3389/fped.2017.00200
PubMed: 29018787
2017

Host Defense Mechanisms Against Bacteria
Fetal and Neonatal Physiology
Tobias R. Kollmann, Arnaud Marchant
DOI: 10.1016/b978-0-323-35214-7.00120-7
2017

Endosomal pH modulation by peptide-gold nanoparticle hybrids enables potent anti-inflammatory activity in phagocytic immune cells.
Biomaterials
DOI: 10.1016/j.biomaterials.2016.09.032
PubMed: 27728817
12/2016

Shifts in Lachnospira and Clostridium sp. in the 3-month stool microbiome are associated with preschool age asthma.
Clinical science (London, England : 1979)
DOI: 10.1042/cs20160349
PubMed: 27634868
12/2016

Towards Predicting Protective Vaccine Responses in the Very Young.
Trends in immunology
DOI: 10.1016/j.it.2016.05.005
PubMed: 27344245
08/2016

Harnessing the beneficial heterologous effects of vaccination.
Nature reviews. Immunology
DOI: 10.1038/nri.2016.43
PubMed: 27157064
06/2016

Impact of maternal intrapartum antibiotics, method of birth and breastfeeding on gut microbiota during the first year of life: a prospective cohort study.
BJOG : an international journal of obstetrics and gynaecology
DOI: 10.1111/1471-0528.13601
PubMed: 26412384
05/2016

Changing oral vaccine to inactivated polio vaccine might increase mortality.
Lancet (London, England)
DOI: 10.1016/s0140-6736(16)00661-9
PubMed: 27025182
03/2016

Infant gut immunity: a preliminary study of IgA associations with breastfeeding.
Journal of developmental origins of health and disease
DOI: 10.1017/s2040174415007862
PubMed: 26690933
02/2016

Linking Susceptibility to Infectious Diseases to Immune System Abnormalities among HIV-Exposed Uninfected Infants.
Frontiers in immunology
DOI: 10.3389/fimmu.2016.00310
PubMed: 27594857
2016

Transfer of Maternal Antimicrobial Immunity to HIV-Exposed Uninfected Newborns.
Frontiers in Immunology
DOI: 10.3389/fimmu.2016.00338
PubMed: 27630640
2016

The Immune System of HIV-Exposed Uninfected Infants.
Frontiers in immunology
PubMed: 27733852
2016

Attenuated innate immune defenses in very premature neonates during the neonatal period.
Pediatric research
DOI: 10.1038/pr.2015.132
PubMed: 26186294
11/2015

The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma.
Thorax
DOI: 10.1136/thoraxjnl-2015-207246
PubMed: 26069286
10/2015

MicroResearch in East Africa: Opportunities for Addressing Gender Inequity.
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
DOI: 10.1016/s1701-2163(16)30025-1
PubMed: 26606704
10/2015

Early infancy microbial and metabolic alterations affect risk of childhood asthma.
Science translational medicine
DOI: 10.1126/scitranslmed.aab2271
PubMed: 26424567
09/2015

Amino Acid-Dependent Attenuation of Toll-like Receptor Signaling by Peptide-Gold Nanoparticle Hybrids.
ACS nano
DOI: 10.1021/nn505634h
PubMed: 26083966
07/2015

MicroResearch--Finding sustainable solutions to local health challenges in East Africa.
The Journal of infection
DOI: 10.1016/j.jinf.2015.04.022
PubMed: 25934328
06/2015

Systems vaccinology: a promise for the young and the poor.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
DOI: 10.1098/rstb.2014.0340
PubMed: 25964462
06/2015

Development of immunity in early life.
The Journal of infection
DOI: 10.1016/j.jinf.2015.04.027
PubMed: 25934325
06/2015

Probiotics to prevent early-life infection.
The Lancet. Infectious diseases
DOI: 10.1016/s1473-3099(15)70088-5
PubMed: 25809893
04/2015

BCG modulates neonatal innate immune cytokine production.
The Journal of infectious diseases
DOI: 10.1093/infdis/jiu509
PubMed: 25210138
03/2015

Infant gut microbiota and food sensitization: associations in the first year of life.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
DOI: 10.1111/cea.12487
PubMed: 25599982
03/2015

The Canadian healthy infant longitudinal development birth cohort study: biological samples and biobanking.
Paediatric and perinatal epidemiology
DOI: 10.1111/ppe.12161
PubMed: 25405552
01/2015

The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study: assessment of environmental exposures.
Journal of exposure science & environmental epidemiology
DOI: 10.1038/jes.2015.7
PubMed: 25805254
2015

Understanding the ontogeny of the immune system to promote immune-mediated health for life.
Frontiers in immunology
DOI: 10.3389/fimmu.2015.00077
PubMed: 25755655
2015

Age-Related Gene Expression Differences in Monocytes from Human Neonates, Young Adults, and Older Adults.
PloS one
DOI: 10.1371/journal.pone.0132061
PubMed: 26147648
2015

Ponseti clubfoot management: Experience with the Steenbeek foot abduction brace.
Paediatrics & child health
DOI: 10.1093/pch/19.10.513
PubMed: 25587223
12/2014

Nonspecific effects of neonatal and infant vaccination: public-health, immunological and conceptual challenges.
Nature immunology
DOI: 10.1038/ni.2961
PubMed: 25232810
10/2014

Single-cell analysis of innate cytokine responses to pattern recognition receptor stimulation in children across four continents.
Journal of immunology (Baltimore, Md. : 1950)
DOI: 10.4049/jimmunol.1400895
PubMed: 25135829
09/2014

Perinatal Immunization With Vaccine-Grade Listeria monocytogenes Provides Protection Against Murine Th2 Airway Inflammation.
Allergy, asthma & immunology research
DOI: 10.4168/aair.2014.6.4.341
PubMed: 24991458
07/2014

Altered innate immune development in HIV-exposed uninfected infants.
Journal of acquired immune deficiency syndromes (1999)
DOI: 10.1097/qai.0000000000000161
PubMed: 24732876
07/2014

Maturation of innate responses to mycobacteria over the first nine months of life.
Journal of immunology (Baltimore, Md. : 1950)
DOI: 10.4049/jimmunol.1400062
PubMed: 24733845
05/2014

Associations between bacterial communities of house dust and infant gut.
Environmental research
DOI: 10.1016/j.envres.2014.02.005
PubMed: 24637181
05/2014

Case 2: A nine-year-old girl with prolonged fever and headache.
Paediatrics & child health
DOI: 10.1093/pch/19.4.177a
PubMed: 24855412
04/2014

Pattern recognition receptor-mediated cytokine response in infants across 4 continents.
The Journal of allergy and clinical immunology
DOI: 10.1016/j.jaci.2013.09.038
PubMed: 24290283
03/2014

Topical CpG adjuvantation of a protein-based vaccine induces protective immunity to Listeria monocytogenes.
Clinical and vaccine immunology : CVI
DOI: 10.1128/cvi.00734-13
PubMed: 24391136
03/2014

Assessment of HPV 16 and HPV 18 antibody responses by pseudovirus neutralization, Merck cLIA and Merck total IgG LIA immunoassays in a reduced dosage quadrivalent HPV vaccine trial.
Vaccine
DOI: 10.1016/j.vaccine.2013.09.007
PubMed: 24055350
01/2014

The early life gut microbiota and atopic disease.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
DOI: 10.1186/1710-1492-10-s2-a63
2014

Harnessing microbiome and probiotic research in sub-Saharan Africa: recommendations from an African workshop.
Microbiome
DOI: 10.1186/2049-2618-2-12
PubMed: 24739094
2014

Listeria monocytogenes: a promising vehicle for neonatal vaccination.
Human vaccines & immunotherapeutics
DOI: 10.4161/hv.27999
PubMed: 24513715
2014

The role of environmental factors in modulating immune responses in early life.
Frontiers in immunology
DOI: 10.3389/fimmu.2014.00434
PubMed: 25309535
2014

Recurrent subacute post-viral onset of ataxia associated with a PRF1 mutation.
European journal of human genetics : EJHG
DOI: 10.1038/ejhg.2013.20
PubMed: 23443029
11/2013

Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine.
The Journal of biological chemistry
DOI: 10.1074/jbc.m113.484212
PubMed: 23897810
09/2013

Clostridium difficile vertebral osteomyelitis.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0b013e318296b424
PubMed: 23594589
09/2013

Elevated inflammatory mediators in adults with oculorespiratory syndrome following influenza immunization: a public health agency of Canada/Canadian Institutes of Health Research Influenza Research Network Study.
Clinical and vaccine immunology : CVI
DOI: 10.1128/cvi.00659-12
PubMed: 23697573
08/2013

Implications of Age-Dependent Immune Responses to Enterovirus 71 Infection for Disease Pathogenesis and Vaccine Design.
Journal of the Pediatric Infectious Diseases Society
DOI: 10.1093/jpids/pit017
PubMed: 26619463
06/2013

Association of common single-nucleotide polymorphisms in innate immune genes with differences in TLR-induced cytokine production in neonates.
Genes and immunity
DOI: 10.1038/gene.2013.5
PubMed: 23466493
06/2013

Immune response to vaccine adjuvants during the first year of life.
Vaccine
DOI: 10.1016/j.vaccine.2012.10.016
PubMed: 23085363
05/2013

Vaccine-induced immunity in early life.
Vaccine
DOI: 10.1016/j.vaccine.2013.04.025
PubMed: 23588085
05/2013

Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in young women: a randomized clinical trial.
JAMA
DOI: 10.1001/jama.2013.1625
PubMed: 23632723
05/2013

Unusual patterns of IgG avidity in some young children following two doses of the adjuvanted pandemic H1N1 (2009) influenza virus vaccine.
Clinical and vaccine immunology : CVI
DOI: 10.1128/cvi.00619-12
PubMed: 23345582
04/2013

Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia.
Journal of immunology (Baltimore, Md. : 1950)
DOI: 10.4049/jimmunol.1201015
PubMed: 23487427
04/2013

Critical assessment of automated flow cytometry data analysis techniques.
Nature methods
DOI: 10.1038/nmeth.2365
PubMed: 23396282
03/2013

Gut microbiota of healthy Canadian infants: profiles by mode of delivery and infant diet at 4 months.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
DOI: 10.1503/cmaj.121189
PubMed: 23401405
03/2013

Antibody responses to vaccination among South African HIV-exposed and unexposed uninfected infants during the first 2 years of life.
Clinical and vaccine immunology : CVI
DOI: 10.1128/cvi.00557-12
PubMed: 23114697
01/2013

Variation between Populations in the Innate Immune Response to Vaccine Adjuvants.
Frontiers in immunology
DOI: 10.3389/fimmu.2013.00081
PubMed: 23565115
2013

Age-dependent differences in systemic and cell-autonomous immunity to L. monocytogenes.
Clinical and Developmental Immunology
DOI: 10.1155/2013/917198
PubMed: 23653659
2013

Host defense against common early life-threatening infections.
Clinical and Developmental Immunology
DOI: 10.1155/2013/350808
PubMed: 24093045
2013

HIV-exposed uninfected infants are at increased risk for severe infections in the first year of life.
Journal of tropical pediatrics
DOI: 10.1093/tropej/fms019
PubMed: 22555385
12/2012

Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly.
Immunity
DOI: 10.1016/j.immuni.2012.10.014
PubMed: 23159225
11/2012

Safety and immunogenicity of 2010-2011 H1N12009-containing trivalent inactivated influenza vaccine in children 12-59 months of age previously given AS03-adjuvanted H1N12009 pandemic vaccine: a PHAC/CIHR Influenza Research Network (PCIRN) study.
Vaccine
DOI: 10.1016/j.vaccine.2012.03.046
PubMed: 22469860
05/2012

Age of recipient and number of doses differentially impact human B and T cell immune memory responses to HPV vaccination.
Vaccine
DOI: 10.1016/j.vaccine.2012.03.051
PubMed: 22469863
05/2012

Uninfected but not unaffected: chronic maternal infections during pregnancy, fetal immunity, and susceptibility to postnatal infections.
The Lancet. Infectious diseases
DOI: 10.1016/s1473-3099(11)70341-3
PubMed: 22364680
04/2012

Optimization of a whole blood intracellular cytokine assay for measuring innate cell responses to mycobacteria.
Journal of immunological methods
DOI: 10.1016/j.jim.2011.11.011
PubMed: 22155193
02/2012

GLA-SE, a synthetic toll-like receptor 4 agonist, enhances T-cell responses to influenza vaccine in older adults.
The Journal of infectious diseases
DOI: 10.1093/infdis/jir769
PubMed: 22147791
02/2012

Staphylococcus aureus nasal septal abscess complicated by extradural abscess in an infant.
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
PubMed: 22498276
02/2012

Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life.
PloS one
DOI: 10.1371/journal.pone.0044763
PubMed: 23028609
2012

Humanized TLR4/MD-2 mice reveal LPS recognition differentially impacts susceptibility to Yersinia pestis and Salmonella enterica.
PLoS Pathogens
DOI: 10.1371/journal.ppat.1002963
PubMed: 23071439
2012

Management of Multidrug-resistant Tuberculosis (MDR-TB) in Children
European Infectious Disease Journal
2012

Primary peritonitis due to group A Streptococcus in a previously healthy pediatric patient.
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
DOI: 10.1155/2012/105850
PubMed: 23997789
2012

An eight-month-old child with cervical adenitis.
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
DOI: 10.1155/2012/318463
PubMed: 23997784
2012

Drug-resistant tuberculosis: pediatric guidelines.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0b013e31820b583d
PubMed: 21297522
06/2011

Variables to be controlled in the assessment of blood innate immune responses to Toll-like receptor stimulation.
Journal of immunological methods
DOI: 10.1016/j.jim.2011.01.009
PubMed: 21277305
03/2011

Facilitating the analysis of immunological data with visual analytic techniques.
Journal of visualized experiments : JoVE
DOI: 10.3791/2397
PubMed: 21248691
01/2011

Syphilis
Infectious Diseases of the Fetus and Newborn
Tobias R. Kollmann, Simon Dobson
DOI: 10.1016/b978-1-4160-6400-8.00016-x
2011

Flow cytometry data standards.
BMC research notes
DOI: 10.1186/1756-0500-4-50
PubMed: 21385382
2011

Profound lack of interleukin (IL)-12/IL-23p40 in neonates born early in gestation is associated with an increased risk of sepsis.
The Journal of infectious diseases
DOI: 10.1086/657143
PubMed: 20977341
12/2010

A single immunization near birth elicits immediate and lifelong protective immunity.
Vaccine
DOI: 10.1016/j.vaccine.2010.10.013
PubMed: 21034825
12/2010

Ontogeny of Toll-like receptor mediated cytokine responses of human blood mononuclear cells.
PloS one
DOI: 10.1371/journal.pone.0015041
PubMed: 21152080
11/2010

Correlation analysis of intracellular and secreted cytokines via the generalized integrated mean fluorescence intensity.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
DOI: 10.1002/cyto.a.20943
PubMed: 20629196
09/2010

Identification of B cells through negative gating-An example of the MIFlowCyt standard applied.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
DOI: 10.1002/cyto.a.20862
PubMed: 20131398
06/2010

A bacterial immune-prophylactic approach against asthma for infants and children.
Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
DOI: 10.1186/1710-1492-6-s3-p20
2010

Functional characterization of human variants of NFKBIA: a key regulator of immune responsiveness implicated in susceptibility to infectious and inflammatory disease.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
DOI: 10.1186/1710-1492-6-s3-p2
2010

Neonatal innate TLR-mediated responses are distinct from those of adults.
Journal of immunology (Baltimore, Md. : 1950)
DOI: 10.4049/jimmunol.0901481
PubMed: 19917677
12/2009

Neonatal immunization with Listeria monocytogenes induces T cells with an adult-like avidity, sensitivity, and TCR-Vbeta repertoire, and does not adversely impact the response to boosting.
Vaccine
DOI: 10.1016/j.vaccine.2009.09.091
PubMed: 19796722
12/2009

Rhabdomyolysis, acute renal failure, and compartment syndrome in a child with parainfluenza type 1 infection.
The Pediatric infectious disease journal
DOI: 10.1097/inf.0b013e3181a33522
PubMed: 19684526
09/2009

Systems biology evaluation of immune responses induced by human host defence peptide LL-37 in mononuclear cells.
Molecular bioSystems
DOI: 10.1039/b813787k
PubMed: 19381363
05/2009

Fine-tuning the safety and immunogenicity of Listeria monocytogenes-based neonatal vaccine platforms.
Vaccine
DOI: 10.1016/j.vaccine.2008.11.047
PubMed: 19059297
02/2009

Anaerobic brain abscess following chronic suppurative otitis media in a child from Uganda.
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
DOI: 10.1155/2009/407139
PubMed: 20808460
2009

MIFlowCyt: the minimum information about a Flow Cytometry Experiment.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
DOI: 10.1002/cyto.a.20623
PubMed: 18752282
10/2008

Polychromatic flow cytometric high-throughput assay to analyze the innate immune response to Toll-like receptor stimulation.
Journal of immunological methods
DOI: 10.1016/j.jim.2008.04.013
PubMed: 18565537
07/2008

Induction of antigen-specific immunity in human neonates and infants.
Nestle Nutrition workshop series. Paediatric programme
DOI: 10.1159/000113493
PubMed: 18196952
2008

Imported fatal hantavirus pulmonary syndrome.
Emerging Infectious Diseases
DOI: 10.3201/eid1309.070708
PubMed: 18252129
09/2007

Induction of protective immunity to Listeria monocytogenes in neonates.
Journal of immunology (Baltimore, Md. : 1950)
DOI: 10.4049/jimmunol.178.6.3695
PubMed: 17339467
03/2007

Deficient MHC class I cross-presentation of soluble antigen by murine neonatal dendritic cells.
Blood
DOI: 10.1182/blood-2003-11-3805
PubMed: 14982880
06/2004

Characterization of flagellin expression and its role in Listeria monocytogenes infection and immunity.
Cellular microbiology
DOI: 10.1046/j.1462-5822.2004.00360.x
PubMed: 14764107
03/2004

Cutting edge: protective cell-mediated immunity to Listeria monocytogenes in the absence of myeloid differentiation factor 88.
Journal of immunology (Baltimore, Md. : 1950)
DOI: 10.4049/jimmunol.171.2.533
PubMed: 12847214
07/2003

Addressing parents' concerns: do multiple vaccines overwhelm or weaken the infant's immune system?
Pediatrics
DOI: 10.1542/peds.109.1.124
PubMed: 11773551
01/2002

Purified protein derivative anergy in Kawasaki disease.
The Pediatric infectious disease journal
DOI: 10.1097/00006454-200101000-00018
PubMed: 11176575
01/2001

thy/liv-SCID-hu mice: a system for investigating the in vivo effects of multidrug therapy on plasma viremia and human immunodeficiency virus replication in lymphoid tissues.
The Journal of infectious diseases
DOI: 10.1086/514214
PubMed: 9466519
02/1998

Thy/Liv-SCID-Hu mice implanted with human intestine: an in vivo model for investigation of mucosal transmission of HIV.
AIDS research and human retroviruses
DOI: 10.1089/aid.1997.13.1453
PubMed: 9390744
11/1997

Saquinavir-mediated inhibition of human immunodeficiency virus (HIV) infection in SCID mice implanted with human fetal thymus and liver tissue: an in vivo model for evaluating the effect of drug therapy on HIV infection in lymphoid tissues.
Antimicrobial agents and chemotherapy
PubMed: 9303378
09/1997

Severe combined immunodeficiency mice engrafted with human T cells, B cells, and myeloid cells after transplantation with human fetal bone marrow or liver cells and implanted with human fetal thymus: a model for studying human gene therapy.
Blood
PubMed: 9057666
03/1997

SCID-hu mice: a model for studying disseminated HIV infection.
Seminars in immunology
DOI: 10.1006/smim.1996.0028
PubMed: 8883145
08/1996

Inhibition of acute in vivo human immunodeficiency virus infection by human interleukin 10 treatment of SCID mice implanted with human fetal thymus and liver.
Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.93.7.3126
PubMed: 8610180
04/1996

Divergent effects of chronic HIV-1 infection on human thymocyte maturation in SCID-hu mice.
Journal of immunology (Baltimore, Md. : 1950)
PubMed: 7814892
01/1995

Reconstitution of SCID mice with human lymphoid and myeloid cells after transplantation with human fetal bone marrow without the requirement for exogenous human cytokines.
Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.91.17.8032
PubMed: 7914701
08/1994

Disseminated human immunodeficiency virus 1 (HIV-1) infection in SCID-hu mice after peripheral inoculation with HIV-1.
The Journal of experimental medicine
DOI: 10.1084/jem.179.2.513
PubMed: 8294863
02/1994

The concurrent maturation of mouse and human thymocytes in human fetal thymus implanted in NIH-beige-nude-xid mice is associated with the reconstitution of the murine immune system.
The Journal of experimental medicine
DOI: 10.1084/jem.177.3.821
PubMed: 8436912
03/1993

Design of polymerase chain reaction primers for the selective amplification of HIV-1 RNA in the presence of HIV-1 DNA.
AIDS (London, England)
PubMed: 1388875
06/1992

Enhancement of HIV-1 infection by the capsular polysaccharide of Cryptococcus neoformans.
Lancet (London, England)
DOI: 10.1016/0140-6736(92)90142-p
PubMed: 1370335
01/1992

Inhibition of HIV-1 infection by alkylureas.
AIDS (London, England)
PubMed: 1726039
12/1991

Characterization of IgG and IgG subclass antibodies present in paired maternal and fetal serum which are directed against HIV-1 proteins.
AIDS research and human retroviruses
DOI: 10.1089/aid.1991.7.847
PubMed: 1742077
10/1991

Research

Current Projects
Our lab uses state-of-the-art wet-lab technology and bioinformatic approaches (systems biology) to get the most information out of the smallest samples from newborns and infants around the world. Parallel to these obervational human cohort studies, we are developing in vitro (culture) and in vivo (animal) models where we establish concrete cause & effect of the relationships identified in our systems biological studies. This combined approach allows us to systematically dissect the key cellular and molecular mechanisms important in the human neonatal and infant response to infection or vaccination. Based on that knowledge, we are identifying immune modulators that help protect newborns from disease, and aid in their immune response to vaccines important for global health. This work is done in close collaboration with several large national (e.g. CHILD) and international research groups from Africa and Asia, to Europe, North America and Australia.

Grants

“Systemic immunity: the missing link between gut microbiome and asthma”. CIHR Operating. Co-PI: Drs. William Mohn, Pedro Dimitriu & Tobias Kollmann.

CIHR Operating Grant - Project: "Lower GBP1 expression reduces human host defense against Listeria monocytogenes." PI: Dr. Tobias Kollmann.

Honours & Awards

Michael Smith Foundation for Health Research Career Investigator Award

Burroughs Wellcome Career Award in the Biomedical Sciences

Canadian Child Health Clinician Scientist Career Development Award

Research Group Members

Byron Brook, PhD Student
Ben Dai, Research Assistant
Bing Cai, Lab Manager
Carolyn Smith
Bahaa Abu Raya
Daniel He, Research Technician
Daniel Harbeson
Guravneet Gill
Joe Huang
Winnie Bao, Undergraduate Student
Edward Ssebuliba, Undergraduate Student