- Overview
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My research uses new Magnetic Resonance Imaging (MRI) and brain monitoring techniques to identify how early-life brain injury, clinical illness, and social determinants of health impact neurodevelopment in newborns at high risk for developmental disabilities. I am also interested in understanding long-term developmental trajectories in children with early-life brain injury. Understanding what factors impact brain development may point to new strategies for promoting long-term brain health in high-risk infants.
- Publications
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Head growth trajectories as a window into neurodevelopment in preterm infants
Jornal de Pediatria
DOI: 10.1016/j.jped.2024.07.001
2024Pain Exposure and Brain Connectivity in Preterm Infants
JAMA Network Open
DOI: 10.1001/jamanetworkopen.2024.2551
2024Socioeconomic status moderates associations between hippocampal development and cognition in preterms
Annals of Clinical and Translational Neurology
DOI: 10.1002/acn3.52168
2024Neuromonitoring practices for neonates with congenital heart disease: a scoping review
Pediatric Research
DOI: 10.1038/s41390-024-03484-x
2024Challenging Current Perspectives of Neonatal Hypoxic-Ischemic Encephalopathy: Is Encephalopathy Necessary?
Neurology
DOI: 10.1212/WNL.0000000000209212
2024Size and Location of Preterm Brain Injury and Associations With Neurodevelopmental Outcomes
Neurology
DOI: 10.1212/WNL.0000000000209264
2024Fetal Hemodynamics, Early Survival, and Neurodevelopment in Patients With Cyanotic Congenital Heart Disease
Journal of the American College of Cardiology
DOI: 10.1016/j.jacc.2024.02.005
2024Factors affecting brain maturation trajectories in early childhood
The Lancet Neurology
DOI: 10.1016/S1474-4422(24)00089-9
2024Effects of pain, sedation and analgesia on neonatal brain injury and brain development
Seminars in Perinatology
DOI: 10.1016/j.semperi.2024.151928
2024Brain health in preterm infants: importance of early-life pain and analgesia exposure
Pediatric Research
DOI: 10.1038/s41390-024-03245-w
2024Antenatal diagnosis, neonatal brain volumes, and neurodevelopment in transposition of the great arteries
Developmental Medicine and Child Neurology
DOI: 10.1111/dmcn.15840
2024Change in Volumes and Location of Preterm White Matter Injury over a Period of 15 Years
Journal of Pediatrics
DOI: 10.1016/j.jpeds.2024.114090
2024Perinatal Risk and Later Intellectual and Developmental Disabilities
Contemporary Clinical Neuroscience
DOI: 10.1007/978-3-031-66932-3_9
2024Abstract 14028: Stroke Location, White Matter Disconnections, and Neurodevelopmental Outcomes in Infants With Congenital Heart Disease
Circulation
Thiviya Selvanathan and Ting Guo and Shabnam Peyvandi and Anne Synnes and Vann Chau and Linh Ly and ANTHONY J BARKOVICH and Mike Seed and Patrick S McQuillen and Steven P Miller
DOI: 10.1161/circ.148.suppl_1.14028
11/2023Neurodevelopment in Children With Congenital Heart Disease: An Opportunity for the Cardiovascular Trainee
Canadian Journal of Cardiology
Chetan, D. and Selvanathan, T. and Alzamil, J. and Chau, V. and Seed, M.
DOI: 10.1016/j.cjca.2023.03.009
2023Declining Incidence of Postoperative Neonatal Brain Injury in Congenital Heart Disease
Journal of the American College of Cardiology
Peyvandi, S. and Xu, D. and Barkovich, A.J. and Gano, D. and Chau, V. and Reddy, V.M. and Selvanathan, T. and Guo, T. and Gaynor, J.W. and Seed, M. and Miller, S.P. and McQuillen, P.
DOI: 10.1016/j.jacc.2022.10.029
2023Child Neurology: Cortical Malformations in Preterm Infants: Case From a Prospective Cohort
Neurology
Selvanathan, T. and Guillot, M. and Branson, H.M. and Chau, V. and Kelly, E.N. and Miller, S.P.
DOI: 10.1212/WNL.0000000000207265
2023Major Surgery, Brain Injury, and Neurodevelopmental Outcomes in Very Preterm Infants
Neurology
DOI: 10.1212/WNL.0000000000207848
2023Early-life exposure to analgesia and 18-month neurodevelopmental outcomes in very preterm infants
Pediatric Research
Selvanathan, T. and Zaki, P. and McLean, M.A. and Au-Young, S.H. and Chau, C.M.Y. and Chau, V. and Synnes, A.R. and Ly, L.G. and Kelly, E. and Grunau, R.E. and Miller, S.P.
DOI: 10.1038/s41390-023-02536-y
2023Head circumference, total cerebral volume and neurodevelopment in preterm neonates
Archives of Disease in Childhood - Fetal and Neonatal Edition
Thiviya Selvanathan and Ting Guo and Eddie Kwan and Vann Chau and Rollin Brant and Anne R Synnes and Ruth E Grunau and Steven P Miller
DOI: 10.1136/archdischild-2020-321397
03/2022Neurodevelopment and Cognition Across the Lifespan in Patients With Single-Ventricle Physiology: Abnormal Brain Maturation and Accumulation of Brain Injuries
Canadian Journal of Cardiology
Selvanathan, T. and Smith, J.M.C. and Miller, S.P. and Field, T.S.
DOI: 10.1016/j.cjca.2022.02.009
2022Proceedings of the 13th International Newborn Brain Conference: Neuroprotection strategies in the neonate
Journal of neonatal-perinatal medicine
Abou Mehrem, A. and Al Awad, E. and Anninck, K. and Au-Young, S. and Aydinol, N. and Bartmann, P. and Benders, M. and Benlamri, A. and Bolderheij, L. and Celik, Y. and Chan, N. and Chau, C. and Chau, V. and Chen, X. and Chetcuti Ganado, C. and Coetser, A. and Cools, F. and Da Rocha, G. and Deigner, H.-P. and Dereymaeker, A. and Deshmukh, L. and Domonoske, R. and Dossani, S. and Dsouza, J.M. and El Gamal, M. and Eshemokhai, P. and Esser, M. and Fiedrich, E. and Franz, A. and Ghosh, A. and Groenendaal, F. and Grunau, R.E. and Venkata, S.K.R.G. and Hamitoglu, S. and Hellstr{\"o}m-Westas, L. and Irvine, L. and Jansen, K. and Javadyan, A. and Jenkin, G. and Kamanga, N. and Kaur, N. and Keles, E. and Keller, M. and Kelly, E. and Kesting, S.J. and Kgwadi, D. and Kim, B. and Kohl, M. and Kowal, D. and Kricitober, J.D. and Leijser, L. and LePine, M. and Lim, Y.-P. and Lodha, A. and Londhe, A. and Ly, L. and Maes, E. and Malhotra, A. and Marlow, N. and Mathew, J.L. and McDonald, C. and McLean, M. and Metcalfe, C. and Meyer, R. and Miller, S.P. and Miller, S. and Mogajane, T. and Mohammad, K. and Momin, S. and Montpetit, J. and Mukiza, N. and Murthy, P. and Scott, J.N. and Nakibuuka, V. and Nakwa, F. and Naulaers, G. and Noort, J. and Ntuli, N. and Ondongo-Ezhet, C. and Paul, R. and Pepper, M. and Plum, A. and Rombough, B. and Saugstad, O. and Scotland, J. and Scott, J. and Seake, K. and Sebunya, R. and Selvanathan, T. and Sepeng, L. and Simsek, H. and Steins-Rang, C. and Stonestreet, B. and Tang, S. and Taskin, E. and Thewissen, L. and Thomas, S. and Thomas, R. and van Kwawegen, A. and van Rensburg, J. and Velaphi, S. and Wu, Y. and Yaman, A. and Yapicioglu-Yildizdas, H. and Yawno, T. and Zaki, P. and Zein, H. and Zhou, L.
DOI: 10.3233/NPM-229003
2022Pearls & Oy-sters: Genetic Epilepsy: An Important Cause of Neonatal Seizures in Infants with Complex Congenital Heart Disease
Neurology
Kazazian, V. and Selvanathan, T. and Chau, V. and Tam, E.W.Y. and Miller, S.P.
DOI: 10.1212/WNL.0000000000201229
2022Abstract 10072: Stroke Topology and Neurodevelopment in Infants with Congenital Heart Disease: Does it Differ by Cardiac Physiology?
Circulation
Thiviya Selvanathan and Ting Guo and Min Sheng and Mike Seed and Anne Synnes and Shabnam Peyvandi and Liza Pulcine and Vann Chau and Linh G Ly and James Barkovich and Patrick S McQuillen and Steven P Miller
DOI: 10.1161/circ.144.suppl_1.10072
11/2021Early EEG in neonates with mild hypoxic–ischemic encephalopathy: more than meets the eye
Pediatric Research
Selvanathan, T. and Miller, S.P.
DOI: 10.1038/s41390-021-01514-6
2021Long-term postnatal outcome of fetuses with prenatally suspected septo-optic dysplasia
Ultrasound in Obstetrics and Gynecology
Shinar, S. and Blaser, S. and Chitayat, D. and Selvanathan, T. and Chau, V. and Shannon, P. and Agrawal, S. and Ryan, G. and Pruthi, V. and Miller, S.P. and Krishnan, P. and Van Mieghem, T.
DOI: 10.1002/uog.22018
2020Imaging microglial activation in untreated first-episode psychosis: A PET study with [18F]FEPPA
American Journal of Psychiatry
Hafizi, S. and Tseng, H.-H. and Rao, N. and Selvanathan, T. and Kenk, M. and Bazinet, R.P. and Suridjan, I. and Wilson, A.A. and Meyer, J.H. and Remington, G. and Houle, S. and Rusjan, P.M. and Mizrahi, R.
DOI: 10.1176/appi.ajp.2016.16020171
2017Imaging neuroinflammation in gray and white matter in schizophrenia: An in-vivo PET study with [18 F]-FEPPA
Schizophrenia Bulletin
Kenk, M. and Selvanathan, T. and Rao, N. and Suridjan, I. and Rusjan, P. and Remington, G. and Meyer, J.H. and Wilson, A.A. and Houle, S. and Mizrahi, R.
DOI: 10.1093/schbul/sbu157
2015Neuroinflammation in healthy aging: A PET study using a novel Translocator Protein 18kDa (TSPO) radioligand, [18F]-FEPPA
NeuroImage
Suridjan, I. and Rusjan, P.M. and Voineskos, A.N. and Selvanathan, T. and Setiawan, E. and Strafella, A.P. and Wilson, A.A. and Meyer, J.H. and Houle, S. and Mizrahi, R.
DOI: 10.1016/j.neuroimage.2013.09.021
2014 - Research
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The Disconnectome in Neonatal Brain Injury and Associations with Neurodevelopmental Outcomes
Infants with brain injury, such as term infants with hypoxic-ischemic brain injury and preterm infants with white matter injury are at increased risk for neurodevelopmental problems. However, there is considerable variability in outcomes amongst these infants making it difficult for us to predict their long-term outcomes. This project aims to understand how neonatal brain injury in term-born infants impacts structural brain connectivity (the Disconnectome), and how this relates to neurodevelopmental outcomes. This may allow for more accurate identification of high-risk infants who may benefit from early neurodevelopmental interventions.Intersection of Social Determinants, Brain Injury and Brain Dysmaturation, and Associations with Neurodevelopment in Children with Congenital Heart Disease
Infants with congenital heart disease are at increased risk for brain injury and abnormalities in brain maturation (brain dysmaturation) that contribute to an increased risk for neurodevelopmental problems. However, social disparities have also been linked to poorer childhood neurodevelopmental outcomes. Children with congenital heart disease in whom these factors intersect may be particularly vulnerable. This project aims to understand how social disparity modifies the relationships between brain injury, brain maturation and neurodevelopmental outcomes in children with congenital heart disease. There will be a specific focus on identifying the specific pathways through which social determinants impact neurodevelopment, which may point to potential interventions to more equitably promote brain health in this population.Honours & AwardsCIHR Canada Graduate Scholarship – Master’s Award (2020-2021)
Ontario Ministry of Health – Clinician Investigator Program (2020-2021)
SickKids RI Clinician Scientist Training Program (2020-2023)
CIHR Canada Graduate Scholarship – Doctoral Award (2022-2023)
Research Group MembersKate Kim, Medical Student
Isha Sekhon, Research Assistant
Rahul Vivekanandan, Student Volunteer
Congratulations CIHR Spring 2024 Project Grant recipients
Congratulations to the BC Children’s Hospital Research Institute (BCCHR) and Women’s Health Research Institute (WHRI) investigators and their teams who were awarded $5 million in funding through the Canadian Institutes of Health Research (CIHR) Spring 2024 Project Grant competition.
