Overview

My research uses new Magnetic Resonance Imaging (MRI) and brain monitoring techniques to identify how early-life brain injury, clinical illness, and social determinants of health impact neurodevelopment in newborns at high risk for developmental disabilities. I am also interested in understanding long-term developmental trajectories in children with early-life brain injury. Understanding what factors impact brain development may point to new strategies for promoting long-term brain health in high-risk infants.

Publications

Size and Location of Preterm Brain Injury and Associations With Neurodevelopmental Outcomes
Neurology
Thiviya Selvanathan and Ting Guo and Steven Ufkes and Vann Chau and Helen Branson and Anne Synnes and Linh G. Ly and Edmond N. Kelly and Ruth E. Grunau and Steven P. Miller
DOI: 10.1212/WNL.0000000000209264
04/2024

Challenging Current Perspectives of Neonatal Hypoxic-Ischemic Encephalopathy
Neurology
Thiviya Selvanathan and Steven P. Miller
DOI: 10.1212/WNL.0000000000209212
03/2024

Pain Exposure and Brain Connectivity in Preterm Infants.
JAMA network open
Selvanathan T and Ufkes S and Guo T and Chau V and Branson HM and Ibrahim GM and Ly LG and Kelly EN and Grunau RE and Miller SP
DOI: 10.1001/jamanetworkopen.2024.2551
PubMed: 38488791
03/2024

Antenatal diagnosis, neonatal brain volumes, and neurodevelopment in transposition of the great arteries
Developmental Medicine & Child Neurology
Thiviya Selvanathan and Connor Mabbott and Stephanie H. Au-Young and Mike Seed and Steven P. Miller and Vann Chau
DOI: 10.1111/dmcn.15840
01/2024

Major Surgery, Brain Injury, and Neurodevelopmental Outcomes in Very Preterm Infants
Neurology
Thiviya Selvanathan and Stephanie H. Au-Young and Ting Guo and Vann Chau and Helen M. Branson and Anne Synnes and Linh Ly and Edmond N. Kelly and Ruth E. Grunau and Steven P. Miller
DOI: 10.1212/WNL.0000000000207848
11/2023

Abstract 14028: Stroke Location, White Matter Disconnections, and Neurodevelopmental Outcomes in Infants With Congenital Heart Disease
Circulation
Thiviya Selvanathan and Ting Guo and Shabnam Peyvandi and Anne Synnes and Vann Chau and Linh Ly and ANTHONY J BARKOVICH and Mike Seed and Patrick S McQuillen and Steven P Miller
DOI: 10.1161/circ.148.suppl_1.14028
11/2023

Child Neurology: Cortical Malformations in Preterm Infants
Neurology
Thiviya Selvanathan and Mireille Guillot and Helen M. Branson and Vann Chau and Edmond N. Kelly and Steven P. Miller
DOI: 10.1212/WNL.0000000000207265
08/2023

Declining Incidence of Postoperative Neonatal Brain Injury in Congenital Heart Disease
Journal of the American College of Cardiology
Peyvandi, S. and Xu, D. and Barkovich, A.J. and Gano, D. and Chau, V. and Reddy, V.M. and Selvanathan, T. and Guo, T. and Gaynor, J.W. and Seed, M. and Miller, S.P. and McQuillen, P.
DOI: 10.1016/j.jacc.2022.10.029
2023

Early-life exposure to analgesia and 18-month neurodevelopmental outcomes in very preterm infants
Pediatric Research
Selvanathan, T. and Zaki, P. and McLean, M.A. and Au-Young, S.H. and Chau, C.M.Y. and Chau, V. and Synnes, A.R. and Ly, L.G. and Kelly, E. and Grunau, R.E. and Miller, S.P.
DOI: 10.1038/s41390-023-02536-y
2023

Neurodevelopment in Children With Congenital Heart Disease: An Opportunity for the Cardiovascular Trainee
Canadian Journal of Cardiology
Chetan, D. and Selvanathan, T. and Alzamil, J. and Chau, V. and Seed, M.
DOI: 10.1016/j.cjca.2023.03.009
2023

Pearls & Oy-sters: Genetic Epilepsy
Neurology
Vanna Kazazian and Thiviya Selvanathan and Vann Chau and Emily W.Y. Tam and Steven P. Miller
DOI: 10.1212/WNL.0000000000201229
11/2022

Head circumference, total cerebral volume and neurodevelopment in preterm neonates
Archives of Disease in Childhood - Fetal and Neonatal Edition
Thiviya Selvanathan and Ting Guo and Eddie Kwan and Vann Chau and Rollin Brant and Anne R Synnes and Ruth E Grunau and Steven P Miller
DOI: 10.1136/archdischild-2020-321397
03/2022

Proceedings of the 13th International Newborn Brain Conference: Neuroprotection strategies in the neonate
Journal of neonatal-perinatal medicine
Abou Mehrem, A. and Al Awad, E. and Anninck, K. and Au-Young, S. and Aydinol, N. and Bartmann, P. and Benders, M. and Benlamri, A. and Bolderheij, L. and Celik, Y. and Chan, N. and Chau, C. and Chau, V. and Chen, X. and Chetcuti Ganado, C. and Coetser, A. and Cools, F. and Da Rocha, G. and Deigner, H.-P. and Dereymaeker, A. and Deshmukh, L. and Domonoske, R. and Dossani, S. and Dsouza, J.M. and El Gamal, M. and Eshemokhai, P. and Esser, M. and Fiedrich, E. and Franz, A. and Ghosh, A. and Groenendaal, F. and Grunau, R.E. and Venkata, S.K.R.G. and Hamitoglu, S. and Hellstr{\"o}m-Westas, L. and Irvine, L. and Jansen, K. and Javadyan, A. and Jenkin, G. and Kamanga, N. and Kaur, N. and Keles, E. and Keller, M. and Kelly, E. and Kesting, S.J. and Kgwadi, D. and Kim, B. and Kohl, M. and Kowal, D. and Kricitober, J.D. and Leijser, L. and LePine, M. and Lim, Y.-P. and Lodha, A. and Londhe, A. and Ly, L. and Maes, E. and Malhotra, A. and Marlow, N. and Mathew, J.L. and McDonald, C. and McLean, M. and Metcalfe, C. and Meyer, R. and Miller, S.P. and Miller, S. and Mogajane, T. and Mohammad, K. and Momin, S. and Montpetit, J. and Mukiza, N. and Murthy, P. and Scott, J.N. and Nakibuuka, V. and Nakwa, F. and Naulaers, G. and Noort, J. and Ntuli, N. and Ondongo-Ezhet, C. and Paul, R. and Pepper, M. and Plum, A. and Rombough, B. and Saugstad, O. and Scotland, J. and Scott, J. and Seake, K. and Sebunya, R. and Selvanathan, T. and Sepeng, L. and Simsek, H. and Steins-Rang, C. and Stonestreet, B. and Tang, S. and Taskin, E. and Thewissen, L. and Thomas, S. and Thomas, R. and van Kwawegen, A. and van Rensburg, J. and Velaphi, S. and Wu, Y. and Yaman, A. and Yapicioglu-Yildizdas, H. and Yawno, T. and Zaki, P. and Zein, H. and Zhou, L.
DOI: 10.3233/NPM-229003
2022

Neurodevelopment and Cognition Across the Lifespan in Patients With Single-Ventricle Physiology: Abnormal Brain Maturation and Accumulation of Brain Injuries
Canadian Journal of Cardiology
Selvanathan, T. and Smith, J.M.C. and Miller, S.P. and Field, T.S.
DOI: 10.1016/j.cjca.2022.02.009
2022

Abstract 10072: Stroke Topology and Neurodevelopment in Infants with Congenital Heart Disease: Does it Differ by Cardiac Physiology?
Circulation
Thiviya Selvanathan and Ting Guo and Min Sheng and Mike Seed and Anne Synnes and Shabnam Peyvandi and Liza Pulcine and Vann Chau and Linh G Ly and James Barkovich and Patrick S McQuillen and Steven P Miller
DOI: 10.1161/circ.144.suppl_1.10072
11/2021

Early EEG in neonates with mild hypoxic–ischemic encephalopathy: more than meets the eye
Pediatric Research
Selvanathan, T. and Miller, S.P.
DOI: 10.1038/s41390-021-01514-6
2021

Long-term postnatal outcome of fetuses with prenatally suspected septo-optic dysplasia
Ultrasound in Obstetrics and Gynecology
Shinar, S. and Blaser, S. and Chitayat, D. and Selvanathan, T. and Chau, V. and Shannon, P. and Agrawal, S. and Ryan, G. and Pruthi, V. and Miller, S.P. and Krishnan, P. and Van Mieghem, T.
DOI: 10.1002/uog.22018
2020

Imaging microglial activation in untreated first-episode psychosis: A PET study with [18F]FEPPA
American Journal of Psychiatry
Hafizi, S. and Tseng, H.-H. and Rao, N. and Selvanathan, T. and Kenk, M. and Bazinet, R.P. and Suridjan, I. and Wilson, A.A. and Meyer, J.H. and Remington, G. and Houle, S. and Rusjan, P.M. and Mizrahi, R.
DOI: 10.1176/appi.ajp.2016.16020171
2017

Imaging neuroinflammation in gray and white matter in schizophrenia: An in-vivo PET study with [18 F]-FEPPA
Schizophrenia Bulletin
Kenk, M. and Selvanathan, T. and Rao, N. and Suridjan, I. and Rusjan, P. and Remington, G. and Meyer, J.H. and Wilson, A.A. and Houle, S. and Mizrahi, R.
DOI: 10.1093/schbul/sbu157
2015

Neuroinflammation in healthy aging: A PET study using a novel Translocator Protein 18kDa (TSPO) radioligand, [18F]-FEPPA
NeuroImage
Suridjan, I. and Rusjan, P.M. and Voineskos, A.N. and Selvanathan, T. and Setiawan, E. and Strafella, A.P. and Wilson, A.A. and Meyer, J.H. and Houle, S. and Mizrahi, R.
DOI: 10.1016/j.neuroimage.2013.09.021
2014

Research

The Disconnectome in Neonatal Brain Injury and Associations with Neurodevelopmental Outcomes
Infants with brain injury, such as term infants with hypoxic-ischemic brain injury and preterm infants with white matter injury are at increased risk for neurodevelopmental problems. However, there is considerable variability in outcomes amongst these infants making it difficult for us to predict their long-term outcomes. This project aims to understand how neonatal brain injury in term-born infants impacts structural brain connectivity (the Disconnectome), and how this relates to neurodevelopmental outcomes. This may allow for more accurate identification of high-risk infants who may benefit from early neurodevelopmental interventions.

Intersection of Social Determinants, Brain Injury and Brain Dysmaturation, and Associations with Neurodevelopment in Children with Congenital Heart Disease
Infants with congenital heart disease are at increased risk for brain injury and abnormalities in brain maturation (brain dysmaturation) that contribute to an increased risk for neurodevelopmental problems. However, social disparities have also been linked to poorer childhood neurodevelopmental outcomes. Children with congenital heart disease in whom these factors intersect may be particularly vulnerable. This project aims to understand how social disparity modifies the relationships between brain injury, brain maturation and neurodevelopmental outcomes in children with congenital heart disease. There will be a specific focus on identifying the specific pathways through which social determinants impact neurodevelopment, which may point to potential interventions to more equitably promote brain health in this population.

Honours & Awards

CIHR Canada Graduate Scholarship – Master’s Award (2020-2021)

Ontario Ministry of Health – Clinician Investigator Program (2020-2021)

SickKids RI Clinician Scientist Training Program (2020-2023)

CIHR Canada Graduate Scholarship – Doctoral Award (2022-2023)

Research Group Members

Isha Sekhon, Research Assistant