Overview

Overall Research Goals

To further understand the determinants of outcome from concussion and more serious brain injuries

To advance brain imaging in psychiatric and neurological disorders

To better understand the factors leading to social decline and homelessness in Vancouver’s downtown eastside population

Primary Research Techniques

Advanced neuroimaging, primarily cutting edge MRI techniques

Neurocognitive and psychiatric assessments, both manual and computerized

Publications

Attention-deficit/hyperactivity disorder is associated with baseline child sport concussion assessment tool third edition scores in child hockey players
Brain Injury
Laurel J. Collings, Nathan E. Cook, Shaun Porter, Cody Kusch, Jonathan Sun, Naznin Virji-Babul, Grant L. Iverson, William J. Panenka
DOI: 10.1080/02699052.2017.1377351
09/2017

Perceived Injustice and its Correlates after Mild Traumatic Brain Injury
Journal of Neurotrauma
Grant L Iverson, Douglas P Terry, Justin E. Karr, William Panenka, Noah D Silverberg
DOI: 10.1089/neu.2017.5402
2017

The effects of enhanced attention and working memory on smooth pursuit eye movement
Experimental Brain Research
Jacob L. Stubbs, Sherryse L. Corrow, Benjamin Kiang, William J. Panenka, Jason J. S. Barton
DOI: 10.1007/s00221-017-5146-6
2017

Work Productivity Loss After Mild Traumatic Brain Injury
Archives of Physical Medicine and Rehabilitation
Silverberg, N.D. and Panenka, W.J. and Iverson, G.L.
DOI: 10.1016/j.apmr.2017.07.006
2017

Systematic Review of Genetic Risk Factors for Sustaining a Mild Traumatic Brain Injury
Journal of Neurotrauma
Panenka, W.J. and Gardner, A.J. and Dretsch, M.N. and Crynen, G.C. and Crawford, F.C. and Iverson, G.L.
DOI: 10.1089/neu.2016.4833
2017

Cogniphobia in Mild Traumatic Brain Injury
Journal of Neurotrauma
Silverberg, N.D. and Iverson, G.L. and Panenka, W.
DOI: 10.1089/neu.2016.4719
2017

A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence
Psychopharmacology
Alexander, P.D. and Gicas, K.M. and Willi, T.S. and Kim, C.N. and Boyeva, V. and Procyshyn, R.M. and Smith, G.N. and Thornton, A.E. and Panenka, W.J. and Jones, A.A. and Vila-Rodriguez, F. and Lang, D.J. and William MacEwan, G. and Honer, W.G. and Barr, A.M.
DOI: 10.1007/s00213-017-4551-7
2017

Traumatic Brain Injury in a Community-Based Cohort of Homeless and Vulnerably Housed Individuals
Journal of Neurotrauma
Toby Schmitt, Allen E. Thornton, Iris Rawtaer, Alasdair M. Barr, Kristina M. Gicas, Donna J. Lang, A. Talia Vertinsky, Alexander Rauscher, Ric M. Procyshyn, Tari Buchanan, Alex Cheng, Sarah MacKay, Olga Leonova, Verena Langheimer, Thalia S. Field, Manraj K. Heran, Fidel Vila-Rodriguez, Tiffany A. O'Connor, G. William MacEwan, William G. Honer, William J. Panenka
DOI: 10.1089/neu.2017.5076
2017

Characterization of white matter integrity deficits in cocaine-dependent individuals with substance-induced psychosis compared with non-psychotic cocaine users
Addiction Biology
Willi, T.S. and Barr, A.M. and Gicas, K. and Lang, D.J. and Vila-Rodriguez, F. and Su, W. and Thornton, A.E. and Leonova, O. and Giesbrecht, C.J. and Procyshyn, R.M. and Rauscher, A. and MacEwan, W.G. and Honer, W.G. and Panenka, W.J.
DOI: 10.1111/adb.12363
2017

Structural brain markers are differentially associated with neurocognitive profiles in socially marginalized people with multimorbid illness
Neuropsychology
Gicas, K.M. and Giesbrecht, C.J. and Panenka, W.J. and Lang, D.J. and Smith, G.N. and Vila-Rodriguez, F. and Leonova, O. and Jones, A.A. and Barr, A.M. and Procyshyn, R.M. and Buchanan, T. and MacEwan, G.W. and Su, W. and Vertinsky, A.T. and Rauscher, A. and Honer, W.G. and Thornton, A.E.
DOI: 10.1037/neu0000304
2017

Autoreactivity to sulfatide by human invariant NKT cells
Journal of Immunology
Stax, A.M. and Tuengel, J. and Girardi, E. and Kitano, N. and Allan, L.L. and Liu, V. and Zheng, D. and Panenka, W.J. and Guillaume, J. and Wong, C.-H. and Van Calenbergh, S. and Zajonc, D.M. and Van Den Elzen, P.
DOI: 10.4049/jimmunol.1601976
2017

The Hotel Study - Clinical and Health Service Effectiveness in a Cohort of Homeless or Marginally Housed Persons
Canadian Journal of Psychiatry
Honer, W.G. and Cervantes-Larios, A. and Jones, A.A. and Vila-Rodriguez, F. and Montaner, J.S. and Tran, H. and Nham, J. and Panenka, W.J. and Lang, D.J. and Thornton, A.E. and Vertinsky, T. and Barr, A.M. and Procyshyn, R.M. and Smith, G.N. and Buchanan, T. and Krajden, M. and Krausz, M. and Macewan, G.W. and Gicas, K.M. and Leonova, O. and Langheimer, V. and Rauscher, A. and Schultz, K.
DOI: 10.1177/0706743717693781
2017

Genetics and Other Risk Factors for Past Concussions in Active-Duty Soldiers
Journal of Neurotrauma
Dretsch, M.N. and Silverberg, N. and Gardner, A.J. and Panenka, W.J. and Emmerich, T. and Crynen, G. and Ait-Ghezala, G. and Chaytow, H. and Mathura, V. and Crawford, F.C. and Iverson, G.L.
DOI: 10.1089/neu.2016.4480
2017

Changes in brain-behavior relationships following a 3-month pilot cognitive intervention program for adults with traumatic brain injury
Heliyon
Porter, S. and Torres, I.J. and Panenka, W. and Rajwani, Z. and Fawcett, D. and Hyder, A. and Virji-Babul, N.
DOI: 10.1016/j.heliyon.2017.e00373
2017

Alcohol consumption does not impede recovery from mild to moderate traumatic brain injury
Journal of the International Neuropsychological Society
Silverberg, N.D. and Panenka, W. and Iverson, G.L. and Brubacher, J.R. and Shewchuk, J.R. and Heran, M.K.S. and Oh, G.C.S. and Honer, W.G. and Lange, R.T.
DOI: 10.1017/S1355617716000692
2016

Subcortical grey matter alterations in cocaine dependent individuals with substance-induced psychosis compared to non-psychotic cocaine users
Schizophrenia Research
Willi, T.S. and Lang, D.J. and Honer, W.G. and Smith, G.N. and Thornton, A.E. and Panenka, W.J. and Procyshyn, R.M. and Vila-Rodriguez, F. and Su, W. and Vertinsky, A.T. and Leonova, O. and Rauscher, A. and MacEwan, G.W. and Barr, A.M.
DOI: 10.1016/j.schres.2016.08.001
2016

The positive and negative syndrome scale (PANSS): A three-factor model of psychopathology in marginally housed persons with substance dependence and psychiatric illness
PLoS ONE
Giesbrecht, C.J., O'Rourke, N., Leonova, O., Strehlau, V., Paquet, K., Vila-Rodriguez, F., Panenka, W.J., MacEwan, G.W., Smith, G.N., Thornton, A.E., Honer, W.G.
DOI: 10.1371/journal.pone.0151648
2016

Factors affecting severity of positive and negative symptoms of psychosis in a polysubstance using population with psychostimulant dependence
Psychiatry Research
Willi, T.S. and Honer, W.G. and Thornton, A.E. and Gicas, K. and Procyshyn, R.M. and Vila-Rodriguez, F. and Panenka, W.J. and Aleksic, A. and Leonova, O. and Jones, A.A. and MacEwan, G.W. and Barr, A.M.
DOI: 10.1016/j.psychres.2016.04.059
2016

The Child Sport Concussion Assessment Tool (Child SCAT3): normative values and correspondence between child and parent symptom scores in male child athletes
BMJ Open Sport & Exercise Medicine
Shaun Porter, Jenna Smith-Forrester, Najah Alhajri, Cody Kusch, Jonathan Sun, Bill Barrable, William J Panenka, Naznin Virji-Babul
DOI: 10.1136/bmjsem-2015-000029
08/2015

White matter deficits assessed by diffusion tensor imaging and cognitive dysfunction in psychostimulant users with comorbid human immunodeficiency virus infection Psychiatry
BMC Research Notes
Tang, V.M. and Lang, D.J. and Giesbrecht, C.J. and Panenka, W.J. and Willi, T. and Procyshyn, R.M. and Vila-Rodriguez, F. and Jenkins, W. and Lecomte, T. and Boyda, H.N. and Aleksic, A. and Macewan, G.W. and Honer, W.G. and Barr, A.M.
DOI: 10.1186/s13104-015-1501-5
2015

Mortality from treatable illnesses in marginally housed adults: A prospective cohort study
BMJ Open
Jones, A.A. and Vila-Rodriguez, F. and Leonova, O. and Langheimer, V. and Lang, D.J. and Barr, A.M. and Procyshyn, R.M. and Smith, G.N. and Schultz, K. and Buchanan, T. and Krausz, M. and Montaner, J.S. and Macewan, G.W. and Rauscher, A. and Panenka, W.J. and Thornton, A.E. and Honer, W.G.
DOI: 10.1136/bmjopen-2015-008876
2015

Neuropsychological outcome and diffusion tensor imaging in complicated versus uncomplicated mild traumatic brain injury
PLoS ONE
Panenka, W.J. and Lange, R.T. and Bouix, S. and Shewchuk, J.R. and Heran, M.K.S. and Brubacher, J.R. and Eckbo, R. and Shenton, M.E. and Iverson, G.L.
DOI: 10.1371/journal.pone.0122746
2015

Diffusion tensor imaging findings and postconcussion symptom reporting six weeks following mild traumatic brain injury
Archives of Clinical Neuropsychology
Lange, R.T. and Panenka, W.J. and Shewchuk, J.R. and Heran, M.K.S. and Brubacher, J.R. and Bioux, S. and Eckbo, R. and Shenton, M.E. and Iverson, G.L.
DOI: 10.1093/arclin/acu060
2015

Systematic review of multivariable prognostic models for mild traumatic brain injury
Journal of Neurotrauma
Silverberg, N.D. and Gardner, A.J. and Brubacher, J.R. and Panenka, W.J. and Li, J.J. and Iverson, G.L.
DOI: 10.1089/neu.2014.3600
2015

Prevalence and patterns of antipsychotic use in youth at the time of admission and discharge from an inpatient psychiatric facility
Journal of Clinical Psychopharmacology
Procyshyn, R.M. and Su, J. and Elbe, D. and Liu, A.Y. and Panenka, W.J. and Davidson, J. and Honer, W.G. and Barr, A.M.
DOI: 10.1097/JCP.0b013e3182a607dd
2014

Neurocognitive profiles of marginally housed persons with comorbid substance dependence, viral infection, and psychiatric illness
Journal of Clinical and Experimental Neuropsychology
Gicas, K.M. and Vila-Rodriguez, F. and Paquet, K. and Barr, A.M. and Procyshyn, R.M. and Lang, D.J. and Smith, G.N. and Baitz, H.A. and Giesbrecht, C.J. and Montaner, J.S. and Krajden, M. and Krausz, M. and MacEwan, G.W. and Panenka, W.J. and Honer, W.G. and Thornton, A.E.
DOI: 10.1080/13803395.2014.963519
2014

Towards clinical management of traumatic brain injury: A review of models and mechanisms from a biomechanical perspective
DMM Disease Models and Mechanisms
Namjoshi, D.R. and Good, C. and Cheng, W.H. and Panenka, W. and Richards, D. and Cripton, P.A. and Wellington, C.L.
DOI: 10.1242/dmm.011320
2013

Personalized risk assessment of drug-related harm is associated with health outcomes
PLoS ONE
Jones, A.A. and Vila-Rodriguez, F. and Panenka, W.J. and Leonova, O. and Strehlau, V. and Lang, D.J. and Thornton, A.E. and Wong, H. and Barr, A.M. and Procyshyn, R.M. and Smith, G.N. and Buchanan, T. and Krajden, M. and Krausz, M. and Montaner, J.S. and MacEwan, G.W. and Nutt, D.J. and Honer, W.G.
DOI: 10.1371/journal.pone.0079754
2013

Methamphetamine use: A comprehensive review of molecular, preclinical and clinical findings
Drug and Alcohol Dependence
Panenka, W.J. and Procyshyn, R.M. and Lecomte, T. and MacEwan, G.W. and Flynn, S.W. and Honer, W.G. and Barr, A.M.
DOI: 10.1016/j.drugalcdep.2012.11.016
2013

The hotel study: Multimorbidity in a community sample living in marginal housing
American Journal of Psychiatry
Vila-Rodriguez, F. and Panenka, W.J. and Lang, D.J. and Thornton, A.E. and Vertinsky, T. and Wong, H. and Barr, A.M. and Procyshyn, R.M. and Sidhu, J.J. and Smith, G.N. and Buchanan, T. and Krajden, M. and Krausz, M. and Montaner, J.S. and MacEwan, G.W. and Honer, W.G.
DOI: 10.1176/appi.ajp.2013.12111439
2013

Excessive antipsychotic dosing in a canadian outpatient population
Psychiatric Services
Barr, A.M. and Panenka, W.J. and Honer, W.G. and Khara, S. and Procyshyn, R.M.
2011

A longitudinal study on the effects of typical versus atypical antipsychotic drugs on hippocampal volume in schizophrenia
Schizophrenia Research
Panenka, W.J. and Khorram, B. and Barr, A.M. and Smith, G.N. and Lang, D.J. and Kopala, L.C. and Vandorpe, R.A. and Honer, W.G.
DOI: 10.1016/j.schres.2007.05.002
2007

The need for speed: An update on methamphetamine addiction
Journal of Psychiatry and Neuroscience
Barr, A.M. and Panenka, W.J. and MacEwan, G.W. and Thornton, A.E. and Lang, D.J. and Honer, W.G. and Lecomte, T.
2006

ATP released from astrocytes during swelling activates chloride channels
Journal of Neurophysiology
Darby, M. and Kuzmiski, J.B. and Panenka, W. and Feighan, D. and MacVicar, B.A.
DOI: 10.1152/jn.00510.2002
2003

MAP kinases contribute to IL-8 secretion by intestinal epithelial cells via a posttranscriptional mechanism
American Journal of Physiology - Cell Physiology
Jijon, H.B. and Panenka, W.J. and Madsen, K.L. and Parsons, H.G.
2002

P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase
Journal of Neuroscience
Panenka, W. and Jijon, H. and Herx, L.M. and Armstrong, J.N. and Feighan, D. and Wei, T. and Yong, V.W. and Ransohoff, R.M. and MacVicar, B.A.
2001

Mitogen-activated protein and tyrosine kinases in the activation of astrocyte volume-activated chloride current
Journal of Neuroscience
Crépel, V., Panenka, W., Kelly, M.E.M., MacVicar, B.A.
1998

Research

Current Projects
As a clinical researcher my main goals over the next five years are to continue my work with the homelessness in Vancouver’s downtown eastside, and set up a mild traumatic brain injury research program at the University of British Columbia.

Vancouver’s downtown eastside is home to our most vulnerable population, characterized by a mixture of primary psychiatric illness and refractory addictions. As part of a large team led by Dr. Bill Honer (Head of Psychiatry) we recruit individuals housed in single room occupancy hotels who then undergo detailed medical and psychiatric testing, including brain MRI. This is a longitudinal study that follows approximately 500 individuals for up to 5 years. The data generated is important to policy makers and to science. There are a multitude of opportunities to explore psychiatric and neurological illness from many angels within this study.

My lab is concurrently engaged in the study of traumatic brain injury. We are building a strong team that includes multiple researchers from multiple disciplines here at UBC and abroad. Under the umbrella of the BC Neuropsychiatry program we have recently started the “Neuropsychiatry Concussion Clinic” for those individuals with symptoms that do are not resolving following head trauma. This clinic and others serve as recruitment sites for research studies that focus on the development of biomarkers in concussion, which simply put means finding cognitive, imaging, and blood markers that may predict outcome and response to treatment in those with brain injuries.

Research Group Members

Julia Askew, Research Volunteer
Hadley Pearce, Research Staff
Angela Muller, Postdoctoral Fellow
Lisa Zhang, Student
Qing Zhang, Student
Kassia Hayek, Research Staff
Angela Aquino, Research Coordinator
Alex Cheng
Toby Schmitt, Research Assistant
Jamie Wong, Research Assistant
Martina Knappett, Research Assistant
Sarah Wong, Student
Devine Calanog
Tasha Chan
Shannon Reid
Jacob Stubbs, PhD Student, Research trainee
Victoria Purcell, Research Assistant
Rita de Cássia Almeida Vieira, Postdoctoral Fellow
Amiti Mehta , Research Assistant
Yomna Takieldeen