Overview

Overall Research Goals

To further understand the determinants of outcome from concussion and more serious brain injuries

To advance brain imaging in psychiatric and neurological disorders

To better understand the factors leading to social decline and homelessness in Vancouver’s downtown eastside population

Primary Research Techniques

Advanced neuroimaging, primarily cutting edge MRI techniques

Neurocognitive and psychiatric assessments, both manual and computerized

Publications

Characterizing Traumatic Brain Injury and Its Association with Losing Stable Housing in a Community-based Sample,Caractérisation d’une lésion cérébrale traumatique et de son association avec la perte d’un logement stable dans un échantillon communautaire
Canadian Journal of Psychiatry
Stubbs, J.L. and Thornton, A.E. and Gicas, K.M. and O?Connor, T.A. and Livingston, E.M. and Lu, H.Y. and Mehta, A.K. and Lang, D.J. and Vertinsky, A.T. and Field, T.S. and Heran, M.K. and Leonova, O. and Sahota, C.S. and Buchanan, T. and Barr, A.M. and MacEwan, G.W. and Rauscher, A. and Honer, W.G. and Panenka, W.J.
DOI: 10.1177/07067437211000665
2022

Feasibility of Concussion Rehabilitation Approaches Tailored to Psychological Coping Styles: A Randomized Controlled Trial
Archives of Physical Medicine and Rehabilitation
Silverberg, N.D. and Cairncross, M. and Brasher, P.M.A. and Vranceanu, A.-M. and Snell, D.L. and Yeates, K.O. and Panenka, W.J. and Iverson, G.L. and Debert, C.T. and Bayley, M.T. and Hunt, C. and Baker, A. and Burke, M.J.
DOI: 10.1016/j.apmr.2021.12.005
2022

Traumatic brain injury in precariously housed persons: Incidence and risks
eClinicalMedicine
O'Connor, T.A. and Panenka, W.J. and Livingston, E.M. and Stubbs, J.L. and Askew, J. and Sahota, C.S. and Feldman, S.J. and Buchanan, T. and Xu, L. and Hu, X.J. and Lang, D.J. and Woodward, M.L. and Thornton, W.L. and Gicas, K.M. and Vertinsky, A.T. and Heran, M.K. and Su, W. and MacEwan, G.W. and Barr, A.M. and Honer, W.G. and Thornton, A.E.
DOI: 10.1016/j.eclinm.2022.101277
2022

Expert Panel Survey to Update the American Congress of Rehabilitation Medicine Definition of Mild Traumatic Brain Injury
Archives of Physical Medicine and Rehabilitation
Silverberg, N.D. and Iverson, G.L. and Arciniegas, D.B. and Bayley, M.T. and Bazarian, J.J. and Bell, K.R. and Broglio, S.P. and Cifu, D. and Davis, G.A. and Dvorak, J. and Echemendia, R.J. and Gioia, G.A. and Giza, C.C. and Hinds, S.R. and Katz, D.I. and Kurowski, B.G. and Leddy, J.J. and Le Sage, N. and Lumba-Brown, A. and Maas, A.I.R. and Manley, G.T. and McCrea, M. and McCrory, P. and Menon, D.K. and Putukian, M. and Suskauer, S.J. and van der Naalt, J. and Walker, W.C. and Yeates, K.O. and Zafonte, R. and Zasler, N. and Zemek, R. and Brown, J. and Cogan, A. and Dams-O'Connor, K. and Delmonico, R. and Park Graf, M.J. and Iaccarino, M.A. and Kajankova, M. and Kamins, J. and McCulloch, K.L. and McKinney, G. and Nagele, D. and Panenka, W.J. and Rabinowitz, A.R. and Reed, N. and Wethe, J.V. and Whitehair, V.
DOI: 10.1016/j.apmr.2020.08.022
2021

Development of embedded performance validity indicators in the NIH Toolbox Cognitive Battery.
Psychological Assessment
Abeare, C. and Erdodi, L. and Messa, I. and Terry, D.P. and Panenka, W.J. and Iverson, G.L. and Silverberg, N.D.
DOI: 10.1037/pas0000958
2021

History of functional somatic syndromes and persistent symptoms after mild traumatic brain injury
Journal of Neuropsychiatry and Clinical Neurosciences
Green, K. and Cairncross, M. and Panenka, W.J. and Stubbs, J.L. and Silverberg, N.D.
DOI: 10.1176/appi.neuropsych.20060159
2021

Preseason Vestibular Ocular Motor Screening in Children and Adolescents
Clinical Journal of Sport Medicine
Iverson, G.L. and Cook, N.E. and Howell, D.R. and Collings, L.J. and Kusch, C. and Sun, J. and Virji-Babul, N. and Panenka, W.J.
DOI: 10.1097/JSM.0000000000000767
2021

Dynamic networks of psychotic symptoms in adults living in precarious housing or homelessness
Psychological Medicine
Jones, A.A. and Gicas, K.M. and Mostafavi, S. and Woodward, M.L. and Leonova, O. and Vila-Rodriguez, F. and Procyshyn, R.M. and Cheng, A. and Buchanan, T. and Lang, D.J. and Macewan, G.W. and Panenka, W.J. and Barr, A.M. and Thornton, A.E. and Honer, W.G.
DOI: 10.1017/S0033291720004444
2021

Avoidance and Endurance Coping After Mild Traumatic Brain Injury Are Associated With Disability Outcomes
Rehabilitation Psychology
Cassetta, B.D. and Cairncross, M. and Brasher, P.M.A. and Panenka, W.J. and Silverberg, N.D.
DOI: 10.1037/rep0000372
2021

A ganglionic blocker and adrenoceptor ligands modify clozapine-induced insulin resistance
Psychoneuroendocrinology
Yuen, J.W.Y. and Wu, C. and Wang, C.K. and Kim, D.D. and Procyshyn, R.M. and Panenka, W.G. and Honer, W.G. and Barr, A.M.
DOI: 10.1016/j.psyneuen.2021.105257
2021

Longitudinal changes in brain parenchyma due to mild traumatic brain injury during the first year after injury
Brain and Behavior
Muller, A.M. and Panenka, W.J. and Lange, R.T. and Iverson, G.L. and Brubacher, J.R. and Virji-Babul, N.
DOI: 10.1002/brb3.2410
2021

A Focused Review of the Metabolic Side-Effects of Clozapine
Frontiers in Endocrinology
Yuen, J.W.Y. and Kim, D.D. and Procyshyn, R.M. and Panenka, W.J. and Honer, W.G. and Barr, A.M.
DOI: 10.3389/fendo.2021.609240
2021

Characterization of Bodily Pain and Use of Both Prescription and Non-Prescription Opioids in Tenants of Precarious Housing
Substance Use and Misuse
Lei, M. and Rintoul, K. and Stubbs, J.L. and Kim, D.D. and Jones, A.A. and Hamzah, Y. and Procyshyn, R.M. and Gicas, K.M. and Cho, L.L. and Panenka, W.J. and Thornton, A.E. and Lang, D.J. and MacEwan, G.W. and Honer, W.G. and Barr, A.M.
DOI: 10.1080/10826084.2021.1958865
2021

Myelin water fraction decrease in individuals with chronic mild traumatic brain injury and persistent symptoms
Heliyon
Russell-Schulz, B. and Vavasour, I.M. and Zhang, J. and MacKay, A.L. and Purcell, V. and Muller, A.M. and Brucar, L.R. and Torres, I.J. and Panenka, W.J. and Virji-Babul, N.
DOI: 10.1016/j.heliyon.2021.e06709
2021

De-implementing Prolonged Rest Advice for Concussion in Primary Care Settings: A Pilot Stepped Wedge Cluster Randomized Trial
Journal of Head Trauma Rehabilitation
Silverberg, N.D. and Otamendi, T. and Panenka, W.J. and Archambault, P. and Babul, S. and MacLellan, A. and Li, L.C.
DOI: 10.1097/HTR.0000000000000609
2021

Component Processes of Decision Making in a Community Sample of Precariously Housed Persons: Associations With Learning and Memory, and Health-Risk Behaviors
Frontiers in Psychology
Baitz, H.A. and Jones, P.W. and Campbell, D.A. and Jones, A.A. and Gicas, K.M. and Giesbrecht, C.J. and Loken Thornton, W. and Barone, C.C. and Wang, N.Y. and Panenka, W.J. and Lang, D.J. and Vila-Rodriguez, F. and Leonova, O. and Barr, A.M. and Procyshyn, R.M. and Buchanan, T. and Rauscher, A. and MacEwan, G.W. and Honer, W.G. and Thornton, A.E.
DOI: 10.3389/fpsyg.2021.571423
2021

Psychometric properties and correlates of the Beck Depression Inventory in a community-based and homeless or precariously housed sample
Journal of Affective Disorders Reports
Cho, L.L. and Jones, A.A. and Barbic, S. and Leonova, O. and Vila-Rodriguez, F. and Buchanan, T. and Lang, D.J. and William MacEwan, G. and Procyshyn, R.M. and Panenka, W.J. and Barr, A.M. and Thornton, A.E. and Gicas, K.M. and Honer, W.G.
DOI: 10.1016/j.jadr.2021.100229
2021

Duration of Neurocognitive Impairment With Medical Cannabis Use: A Scoping Review
Frontiers in Psychiatry
Eadie, L. and Lo, L.A. and Christiansen, A. and Brubacher, J.R. and Barr, A.M. and Panenka, W.J. and MacCallum, C.A.
DOI: 10.3389/fpsyt.2021.638962
2021

Unexpected symptoms after concussion: Potential links to functional neurological and somatic symptom disorders
Journal of Psychosomatic Research
Picon, E.L. and Perez, D.L. and Burke, M.J. and Debert, C.T. and Iverson, G.L. and Panenka, W.J. and Silverberg, N.D.
DOI: 10.1016/j.jpsychores.2021.110661
2021

Differential effects of cannabis exposure during early versus later adolescence on the expression of psychosis in homeless and precariously housed adults
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Gicas, K.M. and Cheng, A. and Panenka, W.J. and Kim, D.D. and Yau, J.C. and Procyshyn, R.M. and Stubbs, J.L. and Jones, A.A. and Bains, S. and Thornton, A.E. and Lang, D.J. and Vertinsky, A.T. and Rauscher, A. and Honer, W.G. and Barr, A.M.
DOI: 10.1016/j.pnpbp.2020.110084
2021

Quantification of Neurological Blood-Based Biomarkers in Critically Ill Patients With Coronavirus Disease 2019.
Critical care explorations
Cooper J and Stukas S and Hoiland RL and Fergusson NA and Thiara S and Foster D and Mitra A and Stoessl JA and Panenka WJ and Sekhon MS and Wellington CL
DOI: 10.1097/cce.0000000000000238
PubMed: 33063038
10/2020

Promoting early treatment for mild traumatic brain injury in primary care with a guideline implementation tool: a pilot cluster randomised trial.
BMJ open
Silverberg ND and Panenka WJ and Lizotte PP and Bayley MT and Dance D and Li LC
DOI: 10.1136/bmjopen-2019-035527
PubMed: 33082178
10/2020

Cerebral Small Vessel Disease, Risk Factors, and Cognition in Tenants of Precarious Housing.
Stroke
Zhou LW and Panenka WJ and Al-Momen G and Gicas KM and Thornton AE and Jones AA and Woodward M and Heran MKS and Vertinsky AT and Su W and Barr AM and MacEwan GW and Lang DJ and Field TS
DOI: 10.1161/strokeaha.120.030446
PubMed: 33019899
10/2020

De-implementing Prolonged Rest Advice for Concussion in Primary Care Settings: A Pilot Stepped Wedge Cluster Randomized Trial.
The Journal of head trauma rehabilitation
Silverberg ND and Otamendi T and Panenka WJ and Archambault P and Babul S and MacLellan A and Li LC and Canadian TBI Research Consortium
DOI: 10.1097/htr.0000000000000609
PubMed: 32898029
09/2020

Associations of substance use, psychosis, and mortality among people living in precarious housing or homelessness: A longitudinal, community-based study in Vancouver, Canada.
PLoS medicine
Jones AA and Gicas KM and Seyedin S and Willi TS and Leonova O and Vila-Rodriguez F and Procyshyn RM and Smith GN and Schmitt TA and Vertinsky AT and Buchanan T and Rauscher A and Honer WG
DOI: 10.1371/journal.pmed.1003172
PubMed: 32628679
07/2020

Amygdala Nuclei Volumes Are Selectively Associated With Social Network Size in Homeless and Precariously Housed Persons.
Frontiers in behavioral neuroscience
Jones PW and Thornton AE and Jones AA and Knerich VM and Lang DJ and Woodward ML and Panenka WJ and Su W and Barr AM and Buchanan T and Honer WG and Gicas KM
DOI: 10.3389/fnbeh.2020.00097
PubMed: 32612516
06/2020

M216. ASSOCIATIONS OF EXTRAPYRAMIDAL SYMPTOMS WITH PSYCHOTIC SYMPTOMS IN A COHORT OF HOMELESS OR PRECARIOUSLY HOUSED PERSONS WITH OR WITHOUT SCHIZOPHRENIA.
Schizophrenia bulletin
Kim D and Procyshyn R and Hang Lee L and Panenka W and Leonova O and Honer W and Barr A
05/2020

Traumatic Brain Injury: An Underappreciated Determinant of Health in Individuals Who are Homeless or Precariously Housed.
World neurosurgery
Stubbs JL and Thornton AE and Silverberg ND and Sevick JM and Barr AM and Honer WG and Panenka WJ
DOI: 10.1016/j.wneu.2020.02.133
PubMed: 32365435
05/2020

Atypical Somatic Symptoms in Adults With Prolonged Recovery From Mild Traumatic Brain Injury.
Frontiers in neurology
Stubbs JL and Green KE and Silverberg ND and Howard A and Dhariwal AK and Brubacher JR and Garraway N and Heran MKS and Sekhon MS and Aquino A and Purcell V and Hutchison JS and Panenka WJ
DOI: 10.3389/fneur.2020.00043
PubMed: 32117012
02/2020

Myelin water fraction decrease in mild traumatic brain injury
Russell-Schulz B and Vavasour I and Zhang J and MacKay AL and Purcell V and Muller AM and Brucar L and Torres IJ and Panenka W and Virji-Babul N
DOI: 10.1101/2020.02.05.934430
02/2020

Cognitive decline and mortality in a community-based sample of homeless and precariously housed adults: 9-year prospective study.
BJPsych open
Gicas KM and Jones AA and Thornton AE and Petersson A and Livingston E and Waclawik K and Panenka WJ and Barr AM and Lang DJ and Vila-Rodriguez F and Leonova O and Procyshyn RM and Honer WG
DOI: 10.1192/bjo.2020.3
PubMed: 32043436
02/2020

Cerebral small vessel disease, risk factors, and cognition in tenants of precarious housing
Stroke
Zhou, L.W. and Panenka, W.J. and Al-Momen, G. and Gicas, K.M. and Thornton, A.E. and Jones, A.A. and Woodward, M. and Heran, M.K.S. and Vertinsky, A.T. and Su, W. and Barr, A.M. and Macewan, G.W. and Lang, D.J. and Rauscher, A. and Honer, W.G. and Field, T.S.
DOI: 10.1161/STROKEAHA.120.030446
2020

Traumatic brain injury in homeless and marginally housed individuals: a systematic review and meta-analysis
The Lancet Public Health
Stubbs, J.L. and Thornton, A.E. and Sevick, J.M. and Silverberg, N.D. and Barr, A.M. and Honer, W.G. and Panenka, W.J.
DOI: 10.1016/S2468-2667(19)30188-4
2020

Management of Concussion and Mild Traumatic Brain Injury: A Synthesis of Practice Guidelines
Archives of Physical Medicine and Rehabilitation
Silverberg, N.D. and Iaccarino, M.A. and Panenka, W.J. and Iverson, G.L. and McCulloch, K.L. and Dams-O'Connor, K. and Reed, N. and McCrea, M. and Cogan, A.M. and Park Graf, M.J. and Kajankova, M. and McKinney, G. and Weyer Jamora, C.
DOI: 10.1016/j.apmr.2019.10.179
2020

Traumatic brain injury in homeless and marginally housed individuals: a systematic review and meta-analysis.
The Lancet. Public health
Stubbs JL and Thornton AE and Sevick JM and Silverberg ND and Barr AM and Honer WG and Panenka WJ
DOI: 10.1016/s2468-2667(19)30188-4
PubMed: 31806487
12/2019

Characterization of mental health in cannabis dispensary users, using structured clinical interviews and standardized assessment instruments.
BMC psychiatry
Yau JC and Yu SM and Panenka WJ and Pearce H and Gicas KM and Procyshyn RM and MacCallum C and Honer WG and Barr AM
DOI: 10.1186/s12888-019-2324-z
PubMed: 31675939
11/2019

Cognitive Impairment in Marginally Housed Youth: Prevalence and Risk Factors.
Frontiers in public health
Waclawik K and Jones AA and Barbic SP and Gicas KM and O'Connor TA and Smith GN and Leonova O and Mathias S and Barr AM and Procyshyn RM and Lang DJ and Woodward ML and MacEwan GW and Thornton AE
DOI: 10.3389/fpubh.2019.00270
PubMed: 31649909
10/2019

Social and structural factors associated with substance use within the support network of adults living in precarious housing in a socially marginalized neighborhood of Vancouver, Canada.
PloS one
Knerich V and Jones AA and Seyedin S and Siu C and Dinh L and Mostafavi S and Barr AM and Panenka WJ and Thornton AE and Honer WG and Rutherford AR
DOI: 10.1371/journal.pone.0222611
PubMed: 31545818
09/2019

Characterizing traumatic brain injury and its association with homelessness in a community-based sample of precariously housed adults and youth
Stubbs JL and Thornton AE and Gicas KM and O'Connor TA and Livingston EM and Lu HY and Mehta AK and Lang DJ and Vertinsky AT and Field TS and Heran MK and Leonova O and Buchanan T and Panenka WJ
DOI: 10.1101/19004606
08/2019

Atypical somatic symptoms in adults with prolonged recovery from mild traumatic brain injury
Stubbs JL and Green KE and Silverberg ND and Howard A and Dhariwal A and Brubacher JR and Garraway N and Heran MKS and Sekhon MS and Aquino A and Purcell V and Hutchison JS and CTRC (Canadian traumatic brain injury research...)
DOI: 10.1101/19004622
08/2019

Prevalence and Risk Factors of Brain Infarcts and Associations With Cognitive Performance in Tenants of Marginal Housing
Journal of the American Heart Association
Lily W. Zhou and William J. Panenka and Andrea A. Jones and Kristina M. Gicas and Allen E. Thornton and Manraj K. S. Heran and David Volders and Donna J. Lang and Alexandra Talia Vertinsky and Alexander Rauscher and Wayne Su and Alasdair M. Barr and Gordon William MacEwan and William G. Honer and Thalia S. Field
DOI: 10.1161/jaha.118.011412
07/2019

Preseason Vestibular Ocular Motor Screening in Children and Adolescents
Clinical Journal of Sport Medicine
Grant L. Iverson and Nathan E. Cook and David R. Howell and Laurel J. Collings and Cody Kusch and Jonathan Sun and Naznin Virji-Babul and William J. Panenka
DOI: 10.1097/jsm.0000000000000767
06/2019

A comparison of regional brain volumes and white matter connectivity in subjects with stimulant induced psychosis versus schizophrenia
Psychopharmacology
Peter D. Alexander and Kristina M. Gicas and Alex Cheng and Donna J. Lang and Ric M. Procyshyn and Alexandra T. Vertinsky and William J. Panenka and Allen E. Thornton and Alexander Rauscher and Jamie Y. X. Wong and Tasha Chan and Andrea A. Jones and F. Vila-Rodriguez and William G. Honer and Alasdair M. Barr
DOI: 10.1007/s00213-019-05298-w
06/2019

Cognitive profiles and associated structural brain networks in a multimorbid sample of marginalized adults
PLOS ONE
Kristina M. Gicas and Andrea A. Jones and William J. Panenka and Chantelle Giesbrecht and Donna J. Lang and Fidel Vila-Rodriguez and Olga Leonova and Alasdair M. Barr and Ric M. Procyshyn and Wayne Su and Alexander Rauscher and A. Talia Vertinsky and Tari Buchanan and G. William MacEwan and Allen E. Thornton and William G. Honer
DOI: 10.1371/journal.pone.0218201
06/2019

Headache Trigger Sensitivity and Avoidance after Mild Traumatic Brain Injury
Journal of Neurotrauma
Noah D. Silverberg and Paul Martin and William J. Panenka
DOI: 10.1089/neu.2018.6025
05/2019

Returning to Activity After a Concussion
Archives of Physical Medicine and Rehabilitation
Nick Reed and Noah D. Silverberg and Mary Alexis Iaccarino and Michael McCrea and Karen L. McCulloch and William Panenka and Emma Gregory and Kristen Dams-O’Connor and Grant L. Iverson and Chris Weyer Jamora and Heather Belanger and Gary McKinney and Alison M. Cogan and Christine Provvidenza
DOI: 10.1016/j.apmr.2018.11.022
04/2019

Antidepressants for depression after concussion and traumatic brain injury are still best practice
BMC Psychiatry
Noah D. Silverberg and William J. Panenka
DOI: 10.1186/s12888-019-2076-9
03/2019

Diffusion tensor imaging of neurocognitive profiles in a community cohort living in marginal housing
Brain and Behavior
Kristina M. Gicas and Alex Cheng and Iris Rawtaer and Taylor S. Willi and William J. Panenka and Donna J. Lang and Geoff N. Smith and Fidel Vila-Rodriguez and Olga Leonova and Chantelle J. Giesbrecht and Andrea A. Jones and Alasdair M. Barr and Ric M. Procyshyn and Tari Buchanan and G. William MacEwan and Wayne Su and Alexandra T. Vertinsky and Alexander Rauscher and Norm O’Rourke and Wendy Loken Thornton and Allen E. Thornton and William G. Honer
DOI: 10.1002/brb3.1233
02/2019

Working memory load improves diagnostic performance of smooth pursuit eye movement in mild traumatic brain injury patients with protracted recovery
Scientific Reports
Jacob L. Stubbs and Sherryse L. Corrow and Benjamin R. Kiang and Jeffrey C. Corrow and Hadley L. Pearce and Alex Y. Cheng and Jason J. S. Barton and William J. Panenka
DOI: 10.1038/s41598-018-36286-3
01/2019

Effect of depression on cognition after mild traumatic brain injury in adults
Clinical Neuropsychologist
Terry, D.P. and Brassil, M. and Iverson, G.L. and Panenka, W.J. and Silverberg, N.D.
DOI: 10.1080/13854046.2018.1459853
2019

Prevalence and risk factors of brain infarcts and associations with cognitive performance in tenants of marginal housing
Journal of the American Heart Association
Zhou, L.W. and Panenka, W.J. and Jones, A.A. and Gicas, K.M. and Thornton, A.E. and Heran, M.K.S. and Volders, D. and Lang, D.J. and Vertinsky, A.T. and Rauscher, A. and Su, W. and Barr, A.M. and Macewan, G.W. and Honer, W.G. and Field, T.S.
DOI: 10.1161/JAHA.118.011412
2019

Volumes of the Hippocampal Formation Differentiate Component Processes of Memory in a Community Sample of Homeless and Marginally Housed Persons
Archives of Clinical Neuropsychology
Gicas, K.M. and Thornton, A.E. and Waclawik, K. and Wang, N. and Jones, A.A. and Panenka, W.J. and Lang, D.J. and Smith, G.N. and Vila-Rodriguez, F. and Leonova, O. and Barr, A.M. and Procyshyn, R.M. and Buchanan, T. and Su, W. and Vertinsky, A.T. and Rauscher, A. and Macewan, G.W. and Honer, W.G.
DOI: 10.1093/arclin/acy066
2019

Fear Avoidance and Clinical Outcomes from Mild Traumatic Brain Injury
Journal of Neurotrauma
Noah D. Silverberg and William J. Panenka and Grant L. Iverson
DOI: 10.1089/neu.2018.5662
08/2018

Workplace and non-workplace mild traumatic brain injuries in an outpatient clinic sample: A case-control study
PLOS ONE
Douglas P. Terry and Grant L. Iverson and William Panenka and Angela Colantonio and Noah D. Silverberg
DOI: 10.1371/journal.pone.0198128
06/2018

Clinical and functional characteristics of young adults living in single room occupancy housing: preliminary findings from a 10-year longitudinal study
Canadian Journal of Public Health
Skye P. Barbic and Andrea A. Jones and Melissa Woodward and Matt Piercy and Steve Mathias and Fidel Vila-Rodriguez and Olga Leonova and Geoffrey N. Smith and Tari Buchanan and Alexandra T. Vertinsky and Stephanie Gillingham and William J. Panenka and Alexander Rauscher and Alasdair M. Barr and Ric M. Procyshyn and G. William MacEwan and Donna J. Lang and Allen E. Thornton and Manraj K. Heran and Adelena M. Leon and Michael Krausz and William G. Honer
DOI: 10.17269/s41997-018-0087-9
05/2018

Rapid Change in Fentanyl Prevalence in a Community-Based, High-Risk Sample
JAMA Psychiatry
Andrea A. Jones and Kerry Jang and William J. Panenka and Alasdair M. Barr and G. William MacEwan and Allen E. Thornton and William G. Honer
DOI: 10.1001/jamapsychiatry.2017.4432
03/2018

Work Productivity Loss After Mild Traumatic Brain Injury
Archives of Physical Medicine and Rehabilitation
Silverberg, N.D. and Panenka, W.J. and Iverson, G.L.
DOI: 10.1016/j.apmr.2017.07.006
2018

The effects of enhanced attention and working memory on smooth pursuit eye movement
Experimental Brain Research
Stubbs, J.L. and Corrow, S.L. and Kiang, B. and Panenka, W.J. and Barton, J.J.S.
DOI: 10.1007/s00221-017-5146-6
2018

Perceived Injustice and Its Correlates after Mild Traumatic Brain Injury
Journal of Neurotrauma
Iverson, G.L. and Terry, D.P. and Karr, J.E. and Panenka, W.J. and Silverberg, N.D.
DOI: 10.1089/neu.2017.5402
2018

A Systematic Review of the Usefulness of Glial Fibrillary Acidic Protein for Predicting Acute Intracranial Lesions following Head Trauma.
Frontiers in neurology
DOI: 10.3389/fneur.2017.00652
PubMed: 29255443
12/2017

Preliminary Validation of the World Health Organization Disability Assessment Schedule 2.0 for Mild Traumatic Brain Injury.
Journal of neurotrauma
DOI: 10.1089/neu.2017.5234
PubMed: 28895491
10/2017

Attention-deficit/hyperactivity disorder is associated with baseline child sport concussion assessment tool third edition scores in child hockey players
Brain Injury
Laurel J. Collings and Nathan E. Cook and Shaun Porter and Cody Kusch and Jonathan Sun and Naznin Virji-Babul and Grant L. Iverson and William J. Panenka
DOI: 10.1080/02699052.2017.1377351
09/2017

Traumatic Brain Injury in a Community-Based Cohort of Homeless and Vulnerably Housed Individuals
Journal of Neurotrauma
Toby Schmitt and Allen E. Thornton and Iris Rawtaer and Alasdair M. Barr and Kristina M. Gicas and Donna J. Lang and A. Talia Vertinsky and Alexander Rauscher and Ric M. Procyshyn and Tari Buchanan and Alex Cheng and Sarah MacKay and Olga Leonova and Verena Langheimer and Thalia S. Field and Manraj K. Heran and Fidel Vila-Rodriguez and Tiffany A. O'Connor and G. William MacEwan and William G. Honer and William J. Panenka
DOI: 10.1089/neu.2017.5076
2017

Systematic Review of Genetic Risk Factors for Sustaining a Mild Traumatic Brain Injury
Journal of Neurotrauma
Panenka, W.J. and Gardner, A.J. and Dretsch, M.N. and Crynen, G.C. and Crawford, F.C. and Iverson, G.L.
DOI: 10.1089/neu.2016.4833
2017

Characterization of white matter integrity deficits in cocaine-dependent individuals with substance-induced psychosis compared with non-psychotic cocaine users
Addiction Biology
Willi, T.S. and Barr, A.M. and Gicas, K. and Lang, D.J. and Vila-Rodriguez, F. and Su, W. and Thornton, A.E. and Leonova, O. and Giesbrecht, C.J. and Procyshyn, R.M. and Rauscher, A. and MacEwan, W.G. and Honer, W.G. and Panenka, W.J.
DOI: 10.1111/adb.12363
2017

Autoreactivity to sulfatide by human invariant NKT cells
Journal of Immunology
Stax, A.M. and Tuengel, J. and Girardi, E. and Kitano, N. and Allan, L.L. and Liu, V. and Zheng, D. and Panenka, W.J. and Guillaume, J. and Wong, C.-H. and Van Calenbergh, S. and Zajonc, D.M. and Van Den Elzen, P.
DOI: 10.4049/jimmunol.1601976
2017

Genetics and Other Risk Factors for Past Concussions in Active-Duty Soldiers
Journal of Neurotrauma
Dretsch, M.N. and Silverberg, N. and Gardner, A.J. and Panenka, W.J. and Emmerich, T. and Crynen, G. and Ait-Ghezala, G. and Chaytow, H. and Mathura, V. and Crawford, F.C. and Iverson, G.L.
DOI: 10.1089/neu.2016.4480
2017

The Hotel Study - Clinical and Health Service Effectiveness in a Cohort of Homeless or Marginally Housed Persons
Canadian Journal of Psychiatry
Honer, W.G. and Cervantes-Larios, A. and Jones, A.A. and Vila-Rodriguez, F. and Montaner, J.S. and Tran, H. and Nham, J. and Panenka, W.J. and Lang, D.J. and Thornton, A.E. and Vertinsky, T. and Barr, A.M. and Procyshyn, R.M. and Smith, G.N. and Buchanan, T. and Krajden, M. and Krausz, M. and Macewan, G.W. and Gicas, K.M. and Leonova, O. and Langheimer, V. and Rauscher, A. and Schultz, K.
DOI: 10.1177/0706743717693781
2017

Structural brain markers are differentially associated with neurocognitive profiles in socially marginalized people with multimorbid illness
Neuropsychology
Gicas, K.M. and Giesbrecht, C.J. and Panenka, W.J. and Lang, D.J. and Smith, G.N. and Vila-Rodriguez, F. and Leonova, O. and Jones, A.A. and Barr, A.M. and Procyshyn, R.M. and Buchanan, T. and MacEwan, G.W. and Su, W. and Vertinsky, A.T. and Rauscher, A. and Honer, W.G. and Thornton, A.E.
DOI: 10.1037/neu0000304
2017

A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence
Psychopharmacology
Alexander, P.D. and Gicas, K.M. and Willi, T.S. and Kim, C.N. and Boyeva, V. and Procyshyn, R.M. and Smith, G.N. and Thornton, A.E. and Panenka, W.J. and Jones, A.A. and Vila-Rodriguez, F. and Lang, D.J. and William MacEwan, G. and Honer, W.G. and Barr, A.M.
DOI: 10.1007/s00213-017-4551-7
2017

Changes in brain-behavior relationships following a 3-month pilot cognitive intervention program for adults with traumatic brain injury
Heliyon
Porter, S. and Torres, I.J. and Panenka, W. and Rajwani, Z. and Fawcett, D. and Hyder, A. and Virji-Babul, N.
DOI: 10.1016/j.heliyon.2017.e00373
2017

Cogniphobia in Mild Traumatic Brain Injury
Journal of Neurotrauma
Silverberg, N.D. and Iverson, G.L. and Panenka, W.
DOI: 10.1089/neu.2016.4719
2017

Alcohol consumption does not impede recovery from mild to moderate traumatic brain injury
Journal of the International Neuropsychological Society
Silverberg, N.D. and Panenka, W. and Iverson, G.L. and Brubacher, J.R. and Shewchuk, J.R. and Heran, M.K.S. and Oh, G.C.S. and Honer, W.G. and Lange, R.T.
DOI: 10.1017/S1355617716000692
2016

The positive and negative syndrome scale (PANSS): A three-factor model of psychopathology in marginally housed persons with substance dependence and psychiatric illness
PLoS ONE
Giesbrecht, C.J. and O'Rourke, N. and Leonova, O. and Strehlau, V. and Paquet, K. and Vila-Rodriguez, F. and Panenka, W.J. and MacEwan, G.W. and Smith, G.N. and Thornton, A.E. and Honer, W.G.
DOI: 10.1371/journal.pone.0151648
2016

Factors affecting severity of positive and negative symptoms of psychosis in a polysubstance using population with psychostimulant dependence
Psychiatry Research
Willi, T.S. and Honer, W.G. and Thornton, A.E. and Gicas, K. and Procyshyn, R.M. and Vila-Rodriguez, F. and Panenka, W.J. and Aleksic, A. and Leonova, O. and Jones, A.A. and MacEwan, G.W. and Barr, A.M.
DOI: 10.1016/j.psychres.2016.04.059
2016

Subcortical grey matter alterations in cocaine dependent individuals with substance-induced psychosis compared to non-psychotic cocaine users
Schizophrenia Research
Willi, T.S. and Lang, D.J. and Honer, W.G. and Smith, G.N. and Thornton, A.E. and Panenka, W.J. and Procyshyn, R.M. and Vila-Rodriguez, F. and Su, W. and Vertinsky, A.T. and Leonova, O. and Rauscher, A. and MacEwan, G.W. and Barr, A.M.
DOI: 10.1016/j.schres.2016.08.001
2016

The Child Sport Concussion Assessment Tool (Child SCAT3): normative values and correspondence between child and parent symptom scores in male child athletes
BMJ Open Sport & Exercise Medicine
Shaun Porter and Jenna Smith-Forrester and Najah Alhajri and Cody Kusch and Jonathan Sun and Bill Barrable and William J Panenka and Naznin Virji-Babul
DOI: 10.1136/bmjsem-2015-000029
08/2015

Diffusion tensor imaging findings and postconcussion symptom reporting six weeks following mild traumatic brain injury
Archives of Clinical Neuropsychology
Lange, R.T. and Panenka, W.J. and Shewchuk, J.R. and Heran, M.K.S. and Brubacher, J.R. and Bioux, S. and Eckbo, R. and Shenton, M.E. and Iverson, G.L.
DOI: 10.1093/arclin/acu060
2015

Systematic review of multivariable prognostic models for mild traumatic brain injury
Journal of Neurotrauma
Silverberg, N.D. and Gardner, A.J. and Brubacher, J.R. and Panenka, W.J. and Li, J.J. and Iverson, G.L.
DOI: 10.1089/neu.2014.3600
2015

Mortality from treatable illnesses in marginally housed adults: A prospective cohort study
BMJ Open
Jones, A.A. and Vila-Rodriguez, F. and Leonova, O. and Langheimer, V. and Lang, D.J. and Barr, A.M. and Procyshyn, R.M. and Smith, G.N. and Schultz, K. and Buchanan, T. and Krausz, M. and Montaner, J.S. and Macewan, G.W. and Rauscher, A. and Panenka, W.J. and Thornton, A.E. and Honer, W.G.
DOI: 10.1136/bmjopen-2015-008876
2015

Neuropsychological outcome and diffusion tensor imaging in complicated versus uncomplicated mild traumatic brain injury
PLoS ONE
Panenka, W.J. and Lange, R.T. and Bouix, S. and Shewchuk, J.R. and Heran, M.K.S. and Brubacher, J.R. and Eckbo, R. and Shenton, M.E. and Iverson, G.L.
DOI: 10.1371/journal.pone.0122746
2015

White matter deficits assessed by diffusion tensor imaging and cognitive dysfunction in psychostimulant users with comorbid human immunodeficiency virus infection Psychiatry
BMC Research Notes
Tang, V.M. and Lang, D.J. and Giesbrecht, C.J. and Panenka, W.J. and Willi, T. and Procyshyn, R.M. and Vila-Rodriguez, F. and Jenkins, W. and Lecomte, T. and Boyda, H.N. and Aleksic, A. and Macewan, G.W. and Honer, W.G. and Barr, A.M.
DOI: 10.1186/s13104-015-1501-5
2015

Neurocognitive profiles of marginally housed persons with comorbid substance dependence, viral infection, and psychiatric illness
Journal of Clinical and Experimental Neuropsychology
Gicas, K.M. and Vila-Rodriguez, F. and Paquet, K. and Barr, A.M. and Procyshyn, R.M. and Lang, D.J. and Smith, G.N. and Baitz, H.A. and Giesbrecht, C.J. and Montaner, J.S. and Krajden, M. and Krausz, M. and MacEwan, G.W. and Panenka, W.J. and Honer, W.G. and Thornton, A.E.
DOI: 10.1080/13803395.2014.963519
2014

Prevalence and patterns of antipsychotic use in youth at the time of admission and discharge from an inpatient psychiatric facility
Journal of Clinical Psychopharmacology
Procyshyn, R.M. and Su, J. and Elbe, D. and Liu, A.Y. and Panenka, W.J. and Davidson, J. and Honer, W.G. and Barr, A.M.
DOI: 10.1097/JCP.0b013e3182a607dd
2014

Personalized risk assessment of drug-related harm is associated with health outcomes
PLoS ONE
Jones, A.A. and Vila-Rodriguez, F. and Panenka, W.J. and Leonova, O. and Strehlau, V. and Lang, D.J. and Thornton, A.E. and Wong, H. and Barr, A.M. and Procyshyn, R.M. and Smith, G.N. and Buchanan, T. and Krajden, M. and Krausz, M. and Montaner, J.S. and MacEwan, G.W. and Nutt, D.J. and Honer, W.G.
DOI: 10.1371/journal.pone.0079754
2013

Towards clinical management of traumatic brain injury: A review of models and mechanisms from a biomechanical perspective
DMM Disease Models and Mechanisms
Namjoshi, D.R. and Good, C. and Cheng, W.H. and Panenka, W. and Richards, D. and Cripton, P.A. and Wellington, C.L.
DOI: 10.1242/dmm.011320
2013

The hotel study: Multimorbidity in a community sample living in marginal housing
American Journal of Psychiatry
Vila-Rodriguez, F. and Panenka, W.J. and Lang, D.J. and Thornton, A.E. and Vertinsky, T. and Wong, H. and Barr, A.M. and Procyshyn, R.M. and Sidhu, J.J. and Smith, G.N. and Buchanan, T. and Krajden, M. and Krausz, M. and Montaner, J.S. and MacEwan, G.W. and Honer, W.G.
DOI: 10.1176/appi.ajp.2013.12111439
2013

Methamphetamine use: A comprehensive review of molecular, preclinical and clinical findings
Drug and Alcohol Dependence
Panenka, W.J. and Procyshyn, R.M. and Lecomte, T. and MacEwan, G.W. and Flynn, S.W. and Honer, W.G. and Barr, A.M.
DOI: 10.1016/j.drugalcdep.2012.11.016
2013

Excessive antipsychotic dosing in a canadian outpatient population
Psychiatric Services
Barr, A.M. and Panenka, W.J. and Honer, W.G. and Khara, S. and Procyshyn, R.M.
2011

A longitudinal study on the effects of typical versus atypical antipsychotic drugs on hippocampal volume in schizophrenia
Schizophrenia Research
Panenka, W.J. and Khorram, B. and Barr, A.M. and Smith, G.N. and Lang, D.J. and Kopala, L.C. and Vandorpe, R.A. and Honer, W.G.
DOI: 10.1016/j.schres.2007.05.002
2007

The need for speed: An update on methamphetamine addiction
Journal of Psychiatry and Neuroscience
Barr, A.M. and Panenka, W.J. and MacEwan, G.W. and Thornton, A.E. and Lang, D.J. and Honer, W.G. and Lecomte, T.
2006

ATP released from astrocytes during swelling activates chloride channels
Journal of Neurophysiology
Darby, M. and Kuzmiski, J.B. and Panenka, W. and Feighan, D. and MacVicar, B.A.
DOI: 10.1152/jn.00510.2002
2003

MAP kinases contribute to IL-8 secretion by intestinal epithelial cells via a posttranscriptional mechanism
American Journal of Physiology - Cell Physiology
Jijon, H.B. and Panenka, W.J. and Madsen, K.L. and Parsons, H.G.
2002

P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase
Journal of Neuroscience
Panenka, W. and Jijon, H. and Herx, L.M. and Armstrong, J.N. and Feighan, D. and Wei, T. and Yong, V.W. and Ransohoff, R.M. and MacVicar, B.A.
2001

Mitogen-activated protein and tyrosine kinases in the activation of astrocyte volume-activated chloride current
Journal of Neuroscience
Crépel, V. and Panenka, W. and Kelly, M.E.M. and MacVicar, B.A.
1998

Research

Current Projects
As a clinical researcher my main goals over the next five years are to continue my work with the homelessness in Vancouver’s downtown eastside, and set up a mild traumatic brain injury research program at the University of British Columbia.

Vancouver’s downtown eastside is home to our most vulnerable population, characterized by a mixture of primary psychiatric illness and refractory addictions. As part of a large team led by Dr. Bill Honer (Head of Psychiatry) we recruit individuals housed in single room occupancy hotels who then undergo detailed medical and psychiatric testing, including brain MRI. This is a longitudinal study that follows approximately 500 individuals for up to 5 years. The data generated is important to policy makers and to science. There are a multitude of opportunities to explore psychiatric and neurological illness from many angels within this study.

My lab is concurrently engaged in the study of traumatic brain injury. We are building a strong team that includes multiple researchers from multiple disciplines here at UBC and abroad. Under the umbrella of the BC Neuropsychiatry program we have recently started the “Neuropsychiatry Concussion Clinic” for those individuals with symptoms that do are not resolving following head trauma. This clinic and others serve as recruitment sites for research studies that focus on the development of biomarkers in concussion, which simply put means finding cognitive, imaging, and blood markers that may predict outcome and response to treatment in those with brain injuries.

Research Group Members

Alysha Alimohamed
Harneet Bariana, Research Assistant
Ryan Chan, Research Assistant
Mikaela Correa, Research Assistant
Chiara DeMarni
Lea Farah, Research Assistant
Alana Guidry, Research Assistant
Yasmin Hamzah, Research Assistant
Julie Joyce, Volunteer
Lexynn Kwan, Coop Student - Medicine
Breanna Nelson, Graduate Research Assistant
Nishtha Parag, Research Assistant
Michelle Pham, Research Assistant
Jacob Scamvougeras, Research Assistant, Work Learn Summer Student
Jessica Sevick
Catie Song, Research Assistant
Jacob Stubbs, PhD Student, Research trainee
Yomna Takieldeen
Daniel Wolfman, Volunteer