Overall Research Goals
To further understand the determinants of outcome from concussion and more serious brain injuries
To advance brain imaging in psychiatric and neurological disorders
To better understand the factors leading to social decline and homelessness in Vancouver’s downtown eastside population
Primary Research Techniques
Advanced neuroimaging, primarily cutting edge MRI techniques
Neurocognitive and psychiatric assessments, both manual and computerized
Avoidance and endurance coping after mild traumatic brain injury are associated with disability outcomes.
Cassetta BD and Cairncross M and Brasher PMA and Panenka WJ and Silverberg ND
History of Functional Somatic Syndromes and Persistent Symptoms After Mild Traumatic Brain Injury.
The Journal of neuropsychiatry and clinical neurosciences
Green K and Cairncross M and Panenka WJ and Stubbs JL and Silverberg ND
Quantification of Neurological Blood-Based Biomarkers in Critically Ill Patients With Coronavirus Disease 2019.
Critical care explorations
Cooper J and Stukas S and Hoiland RL and Fergusson NA and Thiara S and Foster D and Mitra A and Stoessl JA and Panenka WJ and Sekhon MS and Wellington CL
Development of embedded performance validity indicators in the NIH Toolbox Cognitive Battery.
Abeare C and Erdodi L and Messa I and Terry DP and Panenka WJ and Iverson GL and Silverberg ND
Promoting early treatment for mild traumatic brain injury in primary care with a guideline implementation tool: a pilot cluster randomised trial.
Silverberg ND and Panenka WJ and Lizotte PP and Bayley MT and Dance D and Li LC
Expert Panel Survey to Update the American Congress of Rehabilitation Medicine Definition of Mild Traumatic Brain Injury.
Archives of physical medicine and rehabilitation
Silverberg ND and Iverson GL and ACRM Mild TBI Definition Expert Consensus Group and the ACRM Brain Injury Special Interest Group Mild TBI Task Force
Cerebral Small Vessel Disease, Risk Factors, and Cognition in Tenants of Precarious Housing.
Zhou LW and Panenka WJ and Al-Momen G and Gicas KM and Thornton AE and Jones AA and Woodward M and Heran MKS and Vertinsky AT and Su W and Barr AM and MacEwan GW and Lang DJ and Field TS
Differential effects of cannabis exposure during early versus later adolescence on the expression of psychosis in homeless and precariously housed adults.
Progress in neuro-psychopharmacology & biological psychiatry
Gicas KM and Cheng A and Panenka WJ and Kim DD and Yau JC and Procyshyn RM and Stubbs JL and Jones AA and Bains S and Thornton AE and Lang DJ and Vertinsky AT and Rauscher A and Honer WG and Barr AM
De-implementing Prolonged Rest Advice for Concussion in Primary Care Settings: A Pilot Stepped Wedge Cluster Randomized Trial.
The Journal of head trauma rehabilitation
Silverberg ND and Otamendi T and Panenka WJ and Archambault P and Babul S and MacLellan A and Li LC and Canadian TBI Research Consortium
Associations of substance use, psychosis, and mortality among people living in precarious housing or homelessness: A longitudinal, community-based study in Vancouver, Canada.
Jones AA and Gicas KM and Seyedin S and Willi TS and Leonova O and Vila-Rodriguez F and Procyshyn RM and Smith GN and Schmitt TA and Vertinsky AT and Buchanan T and Rauscher A and Honer WG
Amygdala Nuclei Volumes Are Selectively Associated With Social Network Size in Homeless and Precariously Housed Persons.
Frontiers in behavioral neuroscience
Jones PW and Thornton AE and Jones AA and Knerich VM and Lang DJ and Woodward ML and Panenka WJ and Su W and Barr AM and Buchanan T and Honer WG and Gicas KM
M216. ASSOCIATIONS OF EXTRAPYRAMIDAL SYMPTOMS WITH PSYCHOTIC SYMPTOMS IN A COHORT OF HOMELESS OR PRECARIOUSLY HOUSED PERSONS WITH OR WITHOUT SCHIZOPHRENIA.
Kim D and Procyshyn R and Hang Lee L and Panenka W and Leonova O and Honer W and Barr A
Traumatic Brain Injury: An Underappreciated Determinant of Health in Individuals Who are Homeless or Precariously Housed.
Stubbs JL and Thornton AE and Silverberg ND and Sevick JM and Barr AM and Honer WG and Panenka WJ
Cognitive decline and mortality in a community-based sample of homeless and precariously housed adults: 9-year prospective study.
Gicas KM and Jones AA and Thornton AE and Petersson A and Livingston E and Waclawik K and Panenka WJ and Barr AM and Lang DJ and Vila-Rodriguez F and Leonova O and Procyshyn RM and Honer WG
Atypical Somatic Symptoms in Adults With Prolonged Recovery From Mild Traumatic Brain Injury.
Frontiers in neurology
Stubbs JL and Green KE and Silverberg ND and Howard A and Dhariwal AK and Brubacher JR and Garraway N and Heran MKS and Sekhon MS and Aquino A and Purcell V and Hutchison JS and Panenka WJ
Myelin water fraction decrease in mild traumatic brain injury
Russell-Schulz B and Vavasour I and Zhang J and MacKay AL and Purcell V and Muller AM and Brucar L and Torres IJ and Panenka W and Virji-Babul N
Traumatic brain injury in homeless and marginally housed individuals: a systematic review and meta-analysis.
The Lancet. Public health
Stubbs JL and Thornton AE and Sevick JM and Silverberg ND and Barr AM and Honer WG and Panenka WJ
Characterization of mental health in cannabis dispensary users, using structured clinical interviews and standardized assessment instruments.
Yau JC and Yu SM and Panenka WJ and Pearce H and Gicas KM and Procyshyn RM and MacCallum C and Honer WG and Barr AM
Management of Concussion and Mild Traumatic Brain Injury: A Synthesis of Practice Guidelines.
Archives of physical medicine and rehabilitation
Silverberg ND and Iaccarino MA and Panenka WJ and Iverson GL and McCulloch KL and Dams-O'Connor K and Reed N and McCrea M and American Congress of Rehabilitation Medicine Brain Injury Interdisciplinary Special Interest Group Mild TBI Task Force
Cognitive Impairment in Marginally Housed Youth: Prevalence and Risk Factors.
Frontiers in public health
Waclawik K and Jones AA and Barbic SP and Gicas KM and O'Connor TA and Smith GN and Leonova O and Mathias S and Barr AM and Procyshyn RM and Lang DJ and Woodward ML and MacEwan GW and Thornton AE
Social and structural factors associated with substance use within the support network of adults living in precarious housing in a socially marginalized neighborhood of Vancouver, Canada.
Knerich V and Jones AA and Seyedin S and Siu C and Dinh L and Mostafavi S and Barr AM and Panenka WJ and Thornton AE and Honer WG and Rutherford AR
Characterizing traumatic brain injury and its association with homelessness in a community-based sample of precariously housed adults and youth
Stubbs JL and Thornton AE and Gicas KM and O'Connor TA and Livingston EM and Lu HY and Mehta AK and Lang DJ and Vertinsky AT and Field TS and Heran MK and Leonova O and Buchanan T and Panenka WJ
Atypical somatic symptoms in adults with prolonged recovery from mild traumatic brain injury
Stubbs JL and Green KE and Silverberg ND and Howard A and Dhariwal A and Brubacher JR and Garraway N and Heran MKS and Sekhon MS and Aquino A and Purcell V and Hutchison JS and CTRC (Canadian traumatic brain injury research...)
Prevalence and Risk Factors of Brain Infarcts and Associations With Cognitive Performance in Tenants of Marginal Housing
Journal of the American Heart Association
Lily W. Zhou and William J. Panenka and Andrea A. Jones and Kristina M. Gicas and Allen E. Thornton and Manraj K. S. Heran and David Volders and Donna J. Lang and Alexandra Talia Vertinsky and Alexander Rauscher and Wayne Su and Alasdair M. Barr and Gordon William MacEwan and William G. Honer and Thalia S. Field
Preseason Vestibular Ocular Motor Screening in Children and Adolescents
Clinical Journal of Sport Medicine
Grant L. Iverson and Nathan E. Cook and David R. Howell and Laurel J. Collings and Cody Kusch and Jonathan Sun and Naznin Virji-Babul and William J. Panenka
A comparison of regional brain volumes and white matter connectivity in subjects with stimulant induced psychosis versus schizophrenia
Peter D. Alexander and Kristina M. Gicas and Alex Cheng and Donna J. Lang and Ric M. Procyshyn and Alexandra T. Vertinsky and William J. Panenka and Allen E. Thornton and Alexander Rauscher and Jamie Y. X. Wong and Tasha Chan and Andrea A. Jones and F. Vila-Rodriguez and William G. Honer and Alasdair M. Barr
Cognitive profiles and associated structural brain networks in a multimorbid sample of marginalized adults
Kristina M. Gicas and Andrea A. Jones and William J. Panenka and Chantelle Giesbrecht and Donna J. Lang and Fidel Vila-Rodriguez and Olga Leonova and Alasdair M. Barr and Ric M. Procyshyn and Wayne Su and Alexander Rauscher and A. Talia Vertinsky and Tari Buchanan and G. William MacEwan and Allen E. Thornton and William G. Honer
Returning to Activity After a Concussion
Archives of Physical Medicine and Rehabilitation
Nick Reed and Noah D. Silverberg and Mary Alexis Iaccarino and Michael McCrea and Karen L. McCulloch and William Panenka and Emma Gregory and Kristen Dams-O’Connor and Grant L. Iverson and Chris Weyer Jamora and Heather Belanger and Gary McKinney and Alison M. Cogan and Christine Provvidenza
Diffusion tensor imaging of neurocognitive profiles in a community cohort living in marginal housing
Brain and Behavior
Kristina M. Gicas and Alex Cheng and Iris Rawtaer and Taylor S. Willi and William J. Panenka and Donna J. Lang and Geoff N. Smith and Fidel Vila-Rodriguez and Olga Leonova and Chantelle J. Giesbrecht and Andrea A. Jones and Alasdair M. Barr and Ric M. Procyshyn and Tari Buchanan and G. William MacEwan and Wayne Su and Alexandra T. Vertinsky and Alexander Rauscher and Norm O’Rourke and Wendy Loken Thornton and Allen E. Thornton and William G. Honer
Working memory load improves diagnostic performance of smooth pursuit eye movement in mild traumatic brain injury patients with protracted recovery
Jacob L. Stubbs and Sherryse L. Corrow and Benjamin R. Kiang and Jeffrey C. Corrow and Hadley L. Pearce and Alex Y. Cheng and Jason J. S. Barton and William J. Panenka
Volumes of the Hippocampal Formation Differentiate Component Processes of Memory in a Community Sample of Homeless and Marginally Housed Persons
Archives of Clinical Neuropsychology
Kristina M Gicas and Allen E Thornton and Kristina Waclawik and Nena Wang and Andrea A Jones and William J Panenka and Donna J Lang and Geoff N Smith and Fidel Vila-Rodriguez and Olga Leonova and Alasdair M Barr and Ric M Procyshyn and Tari Buchanan and Wayne Su and Alexandra T Vertinsky and Alexander Rauscher and G William MacEwan and William G Honer
Workplace and non-workplace mild traumatic brain injuries in an outpatient clinic sample: A case-control study
Douglas P. Terry and Grant L. Iverson and William Panenka and Angela Colantonio and Noah D. Silverberg
Effect of depression on cognition after mild traumatic brain injury in adults
The Clinical Neuropsychologist
Douglas P. Terry and Michelle Brassil and Grant L. Iverson and William J. Panenka and Noah D. Silverberg
Clinical and functional characteristics of young adults living in single room occupancy housing: preliminary findings from a 10-year longitudinal study
Canadian Journal of Public Health
Skye P. Barbic and Andrea A. Jones and Melissa Woodward and Matt Piercy and Steve Mathias and Fidel Vila-Rodriguez and Olga Leonova and Geoffrey N. Smith and Tari Buchanan and Alexandra T. Vertinsky and Stephanie Gillingham and William J. Panenka and Alexander Rauscher and Alasdair M. Barr and Ric M. Procyshyn and G. William MacEwan and Donna J. Lang and Allen E. Thornton and Manraj K. Heran and Adelena M. Leon and Michael Krausz and William G. Honer
Rapid Change in Fentanyl Prevalence in a Community-Based, High-Risk Sample
Andrea A. Jones and Kerry Jang and William J. Panenka and Alasdair M. Barr and G. William MacEwan and Allen E. Thornton and William G. Honer
A Systematic Review of the Usefulness of Glial Fibrillary Acidic Protein for Predicting Acute Intracranial Lesions following Head Trauma.
Frontiers in neurology
Attention-deficit/hyperactivity disorder is associated with baseline child sport concussion assessment tool third edition scores in child hockey players
Laurel J. Collings and Nathan E. Cook and Shaun Porter and Cody Kusch and Jonathan Sun and Naznin Virji-Babul and Grant L. Iverson and William J. Panenka
Traumatic Brain Injury in a Community-Based Cohort of Homeless and Vulnerably Housed Individuals
Journal of Neurotrauma
Toby Schmitt and Allen E. Thornton and Iris Rawtaer and Alasdair M. Barr and Kristina M. Gicas and Donna J. Lang and A. Talia Vertinsky and Alexander Rauscher and Ric M. Procyshyn and Tari Buchanan and Alex Cheng and Sarah MacKay and Olga Leonova and Verena Langheimer and Thalia S. Field and Manraj K. Heran and Fidel Vila-Rodriguez and Tiffany A. O'Connor and G. William MacEwan and William G. Honer and William J. Panenka
Perceived Injustice and its Correlates after Mild Traumatic Brain Injury
Journal of Neurotrauma
Grant L Iverson and Douglas P Terry and Justin E. Karr and William Panenka and Noah D Silverberg
The effects of enhanced attention and working memory on smooth pursuit eye movement
Experimental Brain Research
Jacob L. Stubbs and Sherryse L. Corrow and Benjamin Kiang and William J. Panenka and Jason J. S. Barton
Characterization of white matter integrity deficits in cocaine-dependent individuals with substance-induced psychosis compared with non-psychotic cocaine users
Alcohol consumption does not impede recovery from mild to moderate traumatic brain injury
Journal of the International Neuropsychological Society
The positive and negative syndrome scale (PANSS): A three-factor model of psychopathology in marginally housed persons with substance dependence and psychiatric illness
Factors affecting severity of positive and negative symptoms of psychosis in a polysubstance using population with psychostimulant dependence
Subcortical grey matter alterations in cocaine dependent individuals with substance-induced psychosis compared to non-psychotic cocaine users
The Child Sport Concussion Assessment Tool (Child SCAT3): normative values and correspondence between child and parent symptom scores in male child athletes
BMJ Open Sport & Exercise Medicine
Shaun Porter and Jenna Smith-Forrester and Najah Alhajri and Cody Kusch and Jonathan Sun and Bill Barrable and William J Panenka and Naznin Virji-Babul
White matter deficits assessed by diffusion tensor imaging and cognitive dysfunction in psychostimulant users with comorbid human immunodeficiency virus infection Psychiatry
BMC Research Notes
Neurocognitive profiles of marginally housed persons with comorbid substance dependence, viral infection, and psychiatric illness
Journal of Clinical and Experimental Neuropsychology
Prevalence and patterns of antipsychotic use in youth at the time of admission and discharge from an inpatient psychiatric facility
Journal of Clinical Psychopharmacology
Excessive antipsychotic dosing in a canadian outpatient population
The need for speed: An update on methamphetamine addiction
Journal of Psychiatry and Neuroscience
MAP kinases contribute to IL-8 secretion by intestinal epithelial cells via a posttranscriptional mechanism
American Journal of Physiology - Cell Physiology
P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase
Journal of Neuroscience
Mitogen-activated protein and tyrosine kinases in the activation of astrocyte volume-activated chloride current
Journal of Neuroscience
As a clinical researcher my main goals over the next five years are to continue my work with the homelessness in Vancouver’s downtown eastside, and set up a mild traumatic brain injury research program at the University of British Columbia.
Vancouver’s downtown eastside is home to our most vulnerable population, characterized by a mixture of primary psychiatric illness and refractory addictions. As part of a large team led by Dr. Bill Honer (Head of Psychiatry) we recruit individuals housed in single room occupancy hotels who then undergo detailed medical and psychiatric testing, including brain MRI. This is a longitudinal study that follows approximately 500 individuals for up to 5 years. The data generated is important to policy makers and to science. There are a multitude of opportunities to explore psychiatric and neurological illness from many angels within this study.
My lab is concurrently engaged in the study of traumatic brain injury. We are building a strong team that includes multiple researchers from multiple disciplines here at UBC and abroad. Under the umbrella of the BC Neuropsychiatry program we have recently started the “Neuropsychiatry Concussion Clinic” for those individuals with symptoms that do are not resolving following head trauma. This clinic and others serve as recruitment sites for research studies that focus on the development of biomarkers in concussion, which simply put means finding cognitive, imaging, and blood markers that may predict outcome and response to treatment in those with brain injuries.Research Group Members
Imad Ahmad, Co-op student
Angela Aquino, Research Coordinator
Julia Askew, Research Volunteer
Ryan Chan, Research Assistant
Mikaela Correa, Research Assistant
Alana Guidry, Research Assistant
Yasmin Hamzah, Research Assistant
Kassia Hayek, Research Assistant
Hiresh Hiresh, Co-op Student
Martina Knappett, Research Assistant
Lexynn Kwan, Coop Student - Medicine
Louise Meddings, Research Assistant
Amiti Mehta, Research Assistant
Victoria Purcell, Research Assistant
Shannon Reid, Coop Student - Medicine
Jacob Scamvougeras, Research Volunteer
Jacob Stubbs, PhD Student, Research trainee
Daniel Wolfman, Volunteer
Lauren Zung, Research Assistant