Wallace Wee

MHSc, MD, PhD, FRCPC

Investigator and Pediatric Respirologist, BC Children's Hospital

Dr. Wallace Wee is a Pediatric Respirologist with a PhD in clinical epidemiology and a unique background that bridges medicine, engineering and clinical epidemiology. Wallace is passionate about innovation in healthcare, improving patient outcomes, exploring AI in medicine and driving research excellence. He envisions and endeavors to develop a research program that improves our understanding of lung disease through the (1) clinical translation of technologies to improve patient care and monitoring of lung diseases, (2) use of clinical epidemiologic approaches in lung diseases to understand patient outcomes and (3) exploration of the use of artificial intelligence in disease management.

Wallace enthusiastically welcomes the opportunity to collaborate with individuals who share his vision of pushing the boundaries of pediatric care.

Academic Affiliations

  • Clinical Assistant Professor, Division of Respiratory Medicine, Department of Pediatrics, Faculty of Medicine, University of British Columbia
  • Research Theme: Evidence to Innovation
  • Research Group(s): Clinical Practice, Outcomes and Innovation; Clinical and Community Data, Analytics and Informatics; Implementing Knowledge for Equity and System Change

Contact Information

Location

4500 Oak Street, Vancouver, British Columbia, Canada, V6H 3N1

Utility of Hyperpolarized 129-Xenon MRI in Primary Ciliary Dyskinesia

ERJ Open Research

Wallace B. Wee and Brandon Zanette and Samal Munidasa and Rachel L. Eddy and Jonathan H Rayment and Teresa To and Felix Ratjen and Giles Santyr and Sharon D. Dell

DOI: 10.1183/23120541.01105-2025

10 / 2025

Comparison of phase-resolved functional lung (PREFUL) and hyperpolarized 129Xe MRI for longitudinal monitoring of lung function in pediatric cystic fibrosis following elexacaftor/tezacaftor/ivacaftor

Pediatric Radiology

Munidasa, S. and Alam, F. and Zanette, B. and Li, D. and Wee, W. and Braganza, S. and Woods, J. and Ratjen, F. and Santyr, G.

DOI: 10.1007/s00247-025-06390-4

Comparison of 3D UTE free-breathing lung MRI with hyperpolarized 129Xe MRI in pediatric cystic fibrosis

Magnetic Resonance in Medicine

Munidasa, S. and Zanette, B. and Dumas, M.-P. and Wee, W. and Braganza, S. and Li, D. and Ratjen, F. and Santyr, G.

DOI: 10.1002/mrm.30299

Primary ciliary dyskinesia phenotypes and correlation with genotype

Current Opinion in Pulmonary Medicine

Horani, A. and Wee, W. and Omran, H. and Ferkol, T.

DOI: 10.1097/MCP.0000000000001212

RPGR regulates motile cilia by interfering with actin dynamics

Biorxiv

Wu, Y. and Tavares, E. and Liang, B. and Wee, W. and Mennella, V. and Feng, H. and Cao, J. and Zheng, J. and He, M. and Stephenson, K. and Hanan, L. and Li, J.M. and Dell, S.D. and Heon, E. and Liu, Z.

DOI: 10.1101/2025.03.13.643176

Repeatability of Multiple Breath Washout in Pediatric Primary Ciliary Dyskinesia

Pediatric Pulmonology

Wee, W.B. and Bashi, L.M. and Jensen, R. and Rayment, J.H. and To, T. and Ratjen, F. and Santyr, G. and Dell, S.D.

DOI: 10.1002/ppul.71107

Estimates of primary ciliary dyskinesia prevalence: a scoping review

ERJ Open Research

Wee, W.B. and Gatt, D. and Seidl, E. and Santyr, G. and To, T. and Dell, S.D.

DOI: 10.1183/23120541.00989-2023

Bronchodilator responsiveness in children with primary ciliary dyskinesia

ERJ Open Research

Seidl, E. and Gatt, D. and Grasemann, H. and Wee, W.B. and Wilson, D. and Ratjen, F.

DOI: 10.1183/23120541.00611-2023

Situs Ambiguus Is Associated With Adverse Clinical Outcomes in Children With Primary Ciliary Dyskinesia

Chest

Kaspy, K.R. and Dell, S.D. and Davis, S.D. and Ferkol, T.W. and Rosenfeld, M. and Sagel, S.D. and Milla, C. and Olivier, K.N. and Barber, A.T. and Wee, W. and Lin, F.-C. and Li, L. and Rampakakis, E. and Zariwala, M.A. and Knowles, M.R. and Leigh, M.W. and Shapiro, A.J.

DOI: 10.1016/j.chest.2023.12.005

Mortality of Pediatric Surgical Lung Biopsies in Ontario, Canada, 2000"2019

Annals of the American Thoracic Society

Wee, W.B. and Shapera, S. and To, T. and Chiu, P.P.L. and Dell, S.D. and Fisher, J.H.

DOI: 10.1513/AnnalsATS.202304-306OC

Primary Ciliary Dyskinesia

Pediatrics

Wee, W.B. and Kinghorn, B. and Davis, S.D. and Ferkol, T.W. and Shapiro, A.J.

DOI: 10.1542/peds.2023-063064

Exhaled Volatile Organic Compound Profiles Differ between Children with Primary Ciliary Dyskinesia and Cystic Fibrosis

Annals of the American Thoracic Society

Seidl, E. and Licht, J.-C. and Wee, W.B. and Post, M. and Ratjen, F. and Grasemann, H.

DOI: 10.1513/ANNALSATS.202302-165RL

Pulmonary Involvement in the Systemic Inflammatory Diseases of Childhood

Kendig and Wilmott S Disorders of the Respiratory Tract in Children

Dell, S.D. and Wee, W.

DOI: 10.1016/B978-0-323-82915-1.00049-7

Inter- and intravisit repeatability of free-breathing MRI in pediatric cystic fibrosis lung disease

Magnetic Resonance in Medicine

Munidasa, S. and Zanette, B. and Couch, M. and Grimm, R. and Seethamraju, R. and Dumas, M.-P. and Wee, W. and Au, J. and Braganza, S. and Li, D. and Woods, J. and Ratjen, F. and Santyr, G.

DOI: 10.1002/mrm.29566

Efficacy of Antibiotic Eradication Therapy of Early Pseudomonas aeruginosa Infection in Children with Primary Ciliary Dyskinesia

Annals of the American Thoracic Society

Gatt, D. and Shaw, M. and Wee, W. and Solomon, M. and Dell, S.D. and Ratjen, F.

DOI: 10.1513/AnnalsATS.202210-858OC

Going beyond the chest X-ray:Investigating laterality defects in primary ciliary dyskinesia

Pediatric Pulmonology

Wee, W.B. and Kaspy, K.R. and Sawras, M.G. and Knowles, M.R. and Zariwala, M.A. and Leigh, M.W. and Dell, S.D. and Shapiro, A.J.

DOI: 10.1002/ppul.25853

Timing of Antenatal Corticosteroids for Optimal Neonatal Outcomes: A Markov Decision Analysis Model

Journal of Obstetrics and Gynaecology Canada

Lapinsky, S.C. and Wee, W.B. and Penner, M.

DOI: 10.1016/j.jogc.2021.10.016

Granulomatosis with polyangiitis in an adolescent male with chronic cough and pulmonary nodules

BMJ Case Reports

Wee, W. and Mehta, K.D.

DOI: 10.1136/bcr-2022-252257

Association of Neonatal Hospital Length of Stay with Lung Function in Primary Ciliary Dyskinesia

Annals of the American Thoracic Society

Wee, W.B. and Leigh, M.W. and Davis, S.D. and Rosenfeld, M. and Sullivan, K.M. and Sawras, M.G. and Ferkol, T.W. and Knowles, M.R. and Milla, C. and Sagel, S.D. and Zariwala, M.A. and Pullenayegum, E. and Dell, S.D.

DOI: 10.1513/AnnalsATS.202202-116OC

COPA Syndrome (Ala239Pro) Presenting with Isolated Follicular Bronchiolitis in Early Childhood: Case Report

Journal of Clinical Immunology

Psarianos, P. and Kwan, J.Y.Y. and Dell, S. and Wee, W.B. and Rey-McIntyre, K. and Chen, H. and Dissanayake, D. and Laxer, R.M. and Shum, A. and Liu, F.-F. and Yip, K.W.

DOI: 10.1007/s10875-021-01082-8

Measurement of forces applied using a Macintosh direct laryngoscope compared with a Glidescope video laryngoscope in patients with predictors of difficult laryngoscopy: A randomised controlled trial

European Journal of Anaesthesiology

Cordovani, D. and Russell, T. and Wee, W. and Suen, A. and Cooper, R.M.

DOI: 10.1097/EJA.0000000000000901

Dry Powder Inhaler Delivery of Tobramycin in In Vitro Models of Tracheostomized Children

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Wee, W.B. and Tavernini, S. and Martin, A.R. and Amirav, I. and Majaesic, C. and Finlay, W.H.

DOI: 10.1089/jamp.2016.1309

Recurrent Diplopia in a Pediatric Patient with Bickerstaff Brainstem Encephalitis.

Case reports in neurological medicine

DOI: 10.1155/2016/5240274 PubMed: 27293928

05 / 2016

Modeling breath-enhanced jet nebulizers to estimate pulmonary drug deposition

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Wee, W.B. and Leung, K. and Coates, A.L.

DOI: 10.1089/jamp.2012.0984

Spatially resolved frequency domain phosphorescence lifetime-based oxygen sensing for photodynamic therapy

Proceedings of SPIE - The International Society for Optical Engineering

Lai, B. and Gurari, M. and Wee, W. and Lilge, L.

DOI: 10.1117/12.806913

Feasibility and repeatability of hyperpolarized 129-Xe MRI in primary ciliary dyskinesia 2. Intra-visit repeatability of multiple breath washout in pediatric primary ciliary dyskinesia

This is a multi-center clinical trial assessing the utility of hyperpolarized 129-xenon MRI (Xe-MRI) in primary ciliary dyskinesia. Specifically, this PCD study aims to (i) evaluate the feasibility of Xe-MRI, (ii) evaluate the same-day repeatability of VDP and (iii) explore the relationship between VDP and other lung function measures (i.e. lung clearance index and forced expiratory volume in 1-second).

Research Methods: clinical trials, clinical epidemiology, measurement theory, biostatistics, medical biophysics, pulmonary imaging

Patient population: rare disease, primary ciliary dyskinesia, pediatrics

Grants

2021 – 2022: Professional Development Grant, Royal College of Physicians and Surgeons of Canada

2020 – 2023: Early Career Investigator Award, Genetic Diseases of Mucociliary Clearance Consortium and Primary Ciliary Dyskinesia Foundation

Honours & Awards

2024 - Beverley Antle Award, SickKids CHES

2024 - ‘PCD On The Move’ Case Reports – Oral Presentation Award, PCD Foundation

2024 - 2nd Place, Lung Health Foundation, 3-MT Thesis Competition

2024 - Better Breathing Student Travel Awards, Lung Health Foundation

2022 – 2023 - CRRN Scholarship, Canadian Respiratory Research Network

2022 - ATS PAR Abstract Scholarship

2021 - SickKids RTC Travel and Education Award

2021 – 2023 - PAL-STAR Award, Canadian Child Health Clinical Scientist Program (CCHCSP)

Our Research

At BC Children’s, we are making discoveries that save lives and transform health care for children in our province and around the world. Our research portfolio includes basic, clinical, population, and public health research.

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