- Overview
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Dr. Wallace Wee is a Pediatric Respirologist with a PhD in clinical epidemiology and a unique background that bridges medicine, engineering and clinical epidemiology. Wallace is passionate about innovation in healthcare, improving patient outcomes, exploring AI in medicine and driving research excellence. He envisions and endeavors to develop a research program that improves our understanding of lung disease through the (1) clinical translation of technologies to improve patient care and monitoring of lung diseases, (2) use of clinical epidemiologic approaches in lung diseases to understand patient outcomes and (3) exploration of the use of artificial intelligence in disease management.
Wallace enthusiastically welcomes the opportunity to collaborate with individuals who share his vision of pushing the boundaries of pediatric care.
- Publications
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Utility of Hyperpolarized 129-Xenon MRI in Primary Ciliary Dyskinesia
ERJ Open Research
Wallace B. Wee and Brandon Zanette and Samal Munidasa and Rachel L. Eddy and Jonathan H Rayment and Teresa To and Felix Ratjen and Giles Santyr and Sharon D. Dell
DOI: 10.1183/23120541.01105-2025
10/2025Comparison of phase-resolved functional lung (PREFUL) and hyperpolarized 129Xe MRI for longitudinal monitoring of lung function in pediatric cystic fibrosis following elexacaftor/tezacaftor/ivacaftor
Pediatric Radiology
Munidasa, S. and Alam, F. and Zanette, B. and Li, D. and Wee, W. and Braganza, S. and Woods, J. and Ratjen, F. and Santyr, G.
DOI: 10.1007/s00247-025-06390-4
2025Comparison of 3D UTE free-breathing lung MRI with hyperpolarized 129Xe MRI in pediatric cystic fibrosis
Magnetic Resonance in Medicine
Munidasa, S. and Zanette, B. and Dumas, M.-P. and Wee, W. and Braganza, S. and Li, D. and Ratjen, F. and Santyr, G.
DOI: 10.1002/mrm.30299
2025Primary ciliary dyskinesia phenotypes and correlation with genotype
Current Opinion in Pulmonary Medicine
Horani, A. and Wee, W. and Omran, H. and Ferkol, T.
DOI: 10.1097/MCP.0000000000001212
2025RPGR regulates motile cilia by interfering with actin dynamics
Biorxiv
Wu, Y. and Tavares, E. and Liang, B. and Wee, W. and Mennella, V. and Feng, H. and Cao, J. and Zheng, J. and He, M. and Stephenson, K. and Hanan, L. and Li, J.M. and Dell, S.D. and Heon, E. and Liu, Z.
DOI: 10.1101/2025.03.13.643176
2025Repeatability of Multiple Breath Washout in Pediatric Primary Ciliary Dyskinesia
Pediatric Pulmonology
Wee, W.B. and Bashi, L.M. and Jensen, R. and Rayment, J.H. and To, T. and Ratjen, F. and Santyr, G. and Dell, S.D.
DOI: 10.1002/ppul.71107
2025Estimates of primary ciliary dyskinesia prevalence: a scoping review
ERJ Open Research
Wee, W.B. and Gatt, D. and Seidl, E. and Santyr, G. and To, T. and Dell, S.D.
DOI: 10.1183/23120541.00989-2023
2024Bronchodilator responsiveness in children with primary ciliary dyskinesia
ERJ Open Research
Seidl, E. and Gatt, D. and Grasemann, H. and Wee, W.B. and Wilson, D. and Ratjen, F.
DOI: 10.1183/23120541.00611-2023
2024Situs Ambiguus Is Associated With Adverse Clinical Outcomes in Children With Primary Ciliary Dyskinesia
Chest
Kaspy, K.R. and Dell, S.D. and Davis, S.D. and Ferkol, T.W. and Rosenfeld, M. and Sagel, S.D. and Milla, C. and Olivier, K.N. and Barber, A.T. and Wee, W. and Lin, F.-C. and Li, L. and Rampakakis, E. and Zariwala, M.A. and Knowles, M.R. and Leigh, M.W. and Shapiro, A.J.
DOI: 10.1016/j.chest.2023.12.005
2024Mortality of Pediatric Surgical Lung Biopsies in Ontario, Canada, 2000–2019
Annals of the American Thoracic Society
Wee, W.B. and Shapera, S. and To, T. and Chiu, P.P.L. and Dell, S.D. and Fisher, J.H.
DOI: 10.1513/AnnalsATS.202304-306OC
2024Primary Ciliary Dyskinesia
Pediatrics
Wee, W.B. and Kinghorn, B. and Davis, S.D. and Ferkol, T.W. and Shapiro, A.J.
DOI: 10.1542/peds.2023-063064
2024Exhaled Volatile Organic Compound Profiles Differ between Children with Primary Ciliary Dyskinesia and Cystic Fibrosis
Annals of the American Thoracic Society
Seidl, E. and Licht, J.-C. and Wee, W.B. and Post, M. and Ratjen, F. and Grasemann, H.
DOI: 10.1513/ANNALSATS.202302-165RL
2023Pulmonary Involvement in the Systemic Inflammatory Diseases of Childhood
Kendig and Wilmott S Disorders of the Respiratory Tract in Children
Dell, S.D. and Wee, W.
DOI: 10.1016/B978-0-323-82915-1.00049-7
2023Inter- and intravisit repeatability of free-breathing MRI in pediatric cystic fibrosis lung disease
Magnetic Resonance in Medicine
Munidasa, S. and Zanette, B. and Couch, M. and Grimm, R. and Seethamraju, R. and Dumas, M.-P. and Wee, W. and Au, J. and Braganza, S. and Li, D. and Woods, J. and Ratjen, F. and Santyr, G.
DOI: 10.1002/mrm.29566
2023Efficacy of Antibiotic Eradication Therapy of Early Pseudomonas aeruginosa Infection in Children with Primary Ciliary Dyskinesia
Annals of the American Thoracic Society
Gatt, D. and Shaw, M. and Wee, W. and Solomon, M. and Dell, S.D. and Ratjen, F.
DOI: 10.1513/AnnalsATS.202210-858OC
2023Going beyond the chest X-ray: Investigating laterality defects in primary ciliary dyskinesia
Pediatric Pulmonology
Wee, W.B. and Kaspy, K.R. and Sawras, M.G. and Knowles, M.R. and Zariwala, M.A. and Leigh, M.W. and Dell, S.D. and Shapiro, A.J.
DOI: 10.1002/ppul.25853
2022Timing of Antenatal Corticosteroids for Optimal Neonatal Outcomes: A Markov Decision Analysis Model
Journal of Obstetrics and Gynaecology Canada
Lapinsky, S.C. and Wee, W.B. and Penner, M.
DOI: 10.1016/j.jogc.2021.10.016
2022Granulomatosis with polyangiitis in an adolescent male with chronic cough and pulmonary nodules
BMJ Case Reports
Wee, W. and Mehta, K.D.
DOI: 10.1136/bcr-2022-252257
2022Association of Neonatal Hospital Length of Stay with Lung Function in Primary Ciliary Dyskinesia
Annals of the American Thoracic Society
Wee, W.B. and Leigh, M.W. and Davis, S.D. and Rosenfeld, M. and Sullivan, K.M. and Sawras, M.G. and Ferkol, T.W. and Knowles, M.R. and Milla, C. and Sagel, S.D. and Zariwala, M.A. and Pullenayegum, E. and Dell, S.D.
DOI: 10.1513/AnnalsATS.202202-116OC
2022COPA Syndrome (Ala239Pro) Presenting with Isolated Follicular Bronchiolitis in Early Childhood: Case Report
Journal of Clinical Immunology
Psarianos, P. and Kwan, J.Y.Y. and Dell, S. and Wee, W.B. and Rey-McIntyre, K. and Chen, H. and Dissanayake, D. and Laxer, R.M. and Shum, A. and Liu, F.-F. and Yip, K.W.
DOI: 10.1007/s10875-021-01082-8
2021Measurement of forces applied using a Macintosh direct laryngoscope compared with a Glidescope video laryngoscope in patients with predictors of difficult laryngoscopy: A randomised controlled trial
European Journal of Anaesthesiology
Cordovani, D. and Russell, T. and Wee, W. and Suen, A. and Cooper, R.M.
DOI: 10.1097/EJA.0000000000000901
2019Dry Powder Inhaler Delivery of Tobramycin in In Vitro Models of Tracheostomized Children
Journal of Aerosol Medicine and Pulmonary Drug Delivery
Wee, W.B. and Tavernini, S. and Martin, A.R. and Amirav, I. and Majaesic, C. and Finlay, W.H.
DOI: 10.1089/jamp.2016.1309
2017Recurrent Diplopia in a Pediatric Patient with Bickerstaff Brainstem Encephalitis.
Case reports in neurological medicine
DOI: 10.1155/2016/5240274
PubMed: 27293928
05/2016Modeling breath-enhanced jet nebulizers to estimate pulmonary drug deposition
Journal of Aerosol Medicine and Pulmonary Drug Delivery
Wee, W.B. and Leung, K. and Coates, A.L.
DOI: 10.1089/jamp.2012.0984
2013Spatially resolved frequency domain phosphorescence lifetime-based oxygen sensing for photodynamic therapy
Proceedings of SPIE - The International Society for Optical Engineering
Lai, B. and Gurari, M. and Wee, W. and Lilge, L.
DOI: 10.1117/12.806913
2008 - Research
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Feasibility and repeatability of hyperpolarized 129-Xe MRI in primary ciliary dyskinesia 2. Intra-visit repeatability of multiple breath washout in pediatric primary ciliary dyskinesia
This is a multi-center clinical trial assessing the utility of hyperpolarized 129-xenon MRI (Xe-MRI) in primary ciliary dyskinesia. Specifically, this PCD study aims to (i) evaluate the feasibility of Xe-MRI, (ii) evaluate the same-day repeatability of VDP and (iii) explore the relationship between VDP and other lung function measures (i.e. lung clearance index and forced expiratory volume in 1-second).
Research Methods: clinical trials, clinical epidemiology, measurement theory, biostatistics, medical biophysics, pulmonary imaging
Patient population: rare disease, primary ciliary dyskinesia, pediatricsGrants2021 – 2022: Professional Development Grant, Royal College of Physicians and Surgeons of Canada
2020 – 2023: Early Career Investigator Award, Genetic Diseases of Mucociliary Clearance Consortium and Primary Ciliary Dyskinesia Foundation
Honours & Awards2024 - Beverley Antle Award, SickKids CHES
2024 - ‘PCD On The Move’ Case Reports – Oral Presentation Award, PCD Foundation
2024 - 2nd Place, Lung Health Foundation, 3-MT Thesis Competition
2024 - Better Breathing Student Travel Awards, Lung Health Foundation
2022 – 2023 - CRRN Scholarship, Canadian Respiratory Research Network
2022 - ATS PAR Abstract Scholarship
2021 - SickKids RTC Travel and Education Award
2021 – 2023 - PAL-STAR Award, Canadian Child Health Clinical Scientist Program (CCHCSP)
Ensuring research participation is available to all Canadians
Improving language accessibility in clinical research studies helps pave the way for more equitable health outcomes, and makes research more generalizable to the local population.
