Overview

My research interests relate to underlying mechanisms of nutrition and disease risk. I am eager to contribute to targeted and population-based prevention strategies of chronic diseases. My research specifically focuses on B-vitamins and their functions in human metabolism. B-vitamins are essential nutrients for normal cell growth and the nervous system and thus have an impact on human health from the embryo to the older adult. Low folate and/or vitamin B-12 status may yield pregnancy complications, low birth weight, and cognitive impairment.

The overarching theme of my research is nutrient adequacy. My current research projects focus on maternal-fetal nutrient dependency, periconceptional vitamin adequacy, and the role of maternal and infant nutrition on growth and development. In the UBC Nutritional Biomarker Laboratory that I established, my team has set up a wide array of externally validated analytical methods. One of our goals is to identify sensitive nutritional biomarkers for early diagnosis of micronutrient inadequacies. With the use of stable-isotope-tracer-protocols, we are able to investigate metabolic and functional consequences of nutrient inadequacies and imbalances. The studies help evaluate optimal vitamin intake to maintain biochemical functions. I am specifically interested in the metabolic effects of folic acid and less than optimal vitamin B-12 intake.

Publications

Associations between the Level of Trace Elements and Minerals and Folate in Maternal Serum and Amniotic Fluid and Congenital Abnormalities
Nutrients
Rafal D. Kocylowski and Mariusz Grzesiak and Zuzanna Gaj and Wiktor Lorenc and Ewa Bakinowska and Danuta Baralkiewicz and Constantin S. von Kaisenberg and Yvonne Lamers and Joanna Suliburska
DOI: 10.3390/nu11020328
02/2019

Approaches to improving micronutrient status assessment at the population level
Proceedings of the Nutrition Society
Yvonne Lamers
DOI: 10.1017/s0029665118002781
01/2019

Evaluation of folate concentration in amniotic fluid and maternal and umbilical cord blood during labor
Archives of Medical Science
Joanna Suliburska and Rafal Kocylowski and Mariusz Grzesiak and Zuzanna Gaj and Benny Chan and Constantin von Kaisenberg and Yvonne Lamers
DOI: 10.5114/aoms.2018.78776
2018

Periconceptional intake of folic acid among low-risk women in Canada: summary of a workshop aiming to align prenatal folic acid supplement composition with current expert guidelines
The American Journal of Clinical Nutrition
Yvonne Lamers and Amanda J MacFarlane and Deborah L O'Connor and Bénédicte Fontaine-Bisson
DOI: 10.1093/ajcn/nqy212
2018

Pregnant women of South Asian ethnicity in Canada have substantially lower vitamin B12 status compared with pregnant women of European ethnicity
British Journal of Nutrition
Theresa H. Schroder and Graham Sinclair and Andre Mattman and Benjamin Jung and Susan I. Barr and Hilary D. Vallance and Yvonne Lamers
DOI: 10.1017/s0007114517002331
09/2017

Barriers and facilitators to recruitment of South Asians to health research: a scoping review
BMJ Open
Teo AW Quay and Leora Frimer and Patricia A Janssen and Yvonne Lamers
DOI: 10.1136/bmjopen-2016-014889
05/2017

South Asian Ethnicity Is Related to the Highest Risk of Vitamin B12 Deficiency in Pregnant Canadian Women
Nutrients
Marta Jeruszka-Bielak and Carly Isman and Theresa Schroder and Wangyang Li and Tim Green and Yvonne Lamers
DOI: 10.3390/nu9040317
03/2017

Correlations between Maternal, Breast Milk, and Infant Vitamin B12 Concentrations among Mother–Infant Dyads in Vancouver, Canada and Prey Veng, Cambodia: An Exploratory Analysis
Nutrients
Philip Chebaya and Crystal Karakochuk and Kaitlin March and Nancy Chen and Rosemary Stamm and Hou Kroeun and Prak Sophonneary and Mam Borath and Setareh Shahab-Ferdows and Daniela Hampel and Susan Barr and Yvonne Lamers and Lisa Houghton and Lindsay Allen and Tim Green and Kyly Whitfield
DOI: 10.3390/nu9030270
03/2017

Prevalence and Predictors of Low Vitamin B6 Status in Healthy Young Adult Women in Metro Vancouver
Nutrients
Chia-ling Ho and Teo Quay and Angela Devlin and Yvonne Lamers
DOI: 10.3390/nu8090538
09/2016

Reference interval of methylmalonic acid concentrations in dried blood spots of healthy, term newborns to facilitate neonatal screening of vitamin B12 deficiency
Clinical Biochemistry
Theresa H. Schroder and Andre Mattman and Graham Sinclair and Hilary D. Vallance and Yvonne Lamers
DOI: 10.1016/j.clinbiochem.2016.03.007
09/2016

Low Serum Vitamin B-12 Concentrations Are Prevalent in a Cohort of Pregnant Canadian Women
The Journal of Nutrition
Carly E Visentin and Shannon P Masih and Lesley Plumptre and Theresa H Schroder and Kyoung-Jin Sohn and Anna Ly and Andrea Y Lausman and Howard Berger and Ruth Croxford and Yvonne Lamers and Young-In Kim and Deborah L O'Connor
DOI: 10.3945/jn.115.226845
04/2016

Vitamin B-6 Status in Unsupplemented Pregnant Women Is Associated Positively with Serum Docosahexaenoic Acid and Inversely with the n–6-to-n–3 Fatty Acid Ratio
The Journal of Nutrition
Maria F Mujica-Coopman and Ana B Franco-Sena and Dayana R Farias and Juliana S Vaz and Alex Brito and Gilberto Kac and Yvonne Lamers
DOI: 10.3945/jn.116.239483
2016

High prevalence of suboptimal vitamin B12 status in young adult women of South Asian and European ethnicity
Applied Physiology, Nutrition, and Metabolism
Teo A.W. Quay and Theresa H. Schroder and Marta Jeruszka-Bielak and Wangyang Li and Angela M. Devlin and Susan I. Barr and Yvonne Lamers
DOI: 10.1139/apnm-2015-0200
2015

Genetic Hemoglobin Disorders Rather Than Iron Deficiency Are a Major Predictor of Hemoglobin Concentration in Women of Reproductive Age in Rural Prey Veng, Cambodia
The Journal of Nutrition
Crystal D Karakochuk and Kyly C Whitfield and Susan I Barr and Yvonne Lamers and Angela M Devlin and Suzanne M Vercauteren and Hou Kroeun and Aminuzzaman Talukder and Judy McLean and Timothy J Green
DOI: 10.3945/jn.114.198945
11/2014

Methylmalonic Acid Quantified in Dried Blood Spots Provides a Precise, Valid, and Stable Measure of Functional Vitamin B-12 Status in Healthy Women
The Journal of Nutrition
Theresa H. Schroder and Teo A. W. Quay and Yvonne Lamers
DOI: 10.3945/jn.114.194829
08/2014

Metabolite Profile Analysis Reveals Functional Effects of 28-Day Vitamin B-6 Restriction on One-Carbon Metabolism and Tryptophan Catabolic Pathways in Healthy Men and Women
The Journal of Nutrition
Vanessa R. da Silva and Luisa Rios-Avila and Yvonne Lamers and Maria A. Ralat and Øivind Midttun and Eoin P. Quinlivan and Timothy J. Garrett and Bonnie Coats and Meena N. Shankar and Susan S. Percival and Yueh-Yun Chi and Keith E. Muller and Per Magne Ueland and Peter W. Stacpoole and Jesse F. Gregory
DOI: 10.3945/jn.113.180588
08/2013

Red blood cell folate levels in pregnant women with a history of mood disorders: A case series
Birth Defects Research Part A: Clinical and Molecular Teratology
Elyse Yaremco and Angela Inglis and Sheila M. Innis and Catriona Hippman and Prescilla Carrion and Yvonne Lamers and William G. Honer and Jehannine Austin
DOI: 10.1002/bdra.23144
06/2013

Metabolomic Analysis Reveals Extended Metabolic Consequences of Marginal Vitamin B-6 Deficiency in Healthy Human Subjects
PLoS ONE
Jesse F. Gregory and Youngja Park and Yvonne Lamers and Nirmalya Bandyopadhyay and Yueh-Yun Chi and Kichen Lee and Steven Kim and Vanessa da Silva and Nikolas Hove and Sanjay Ranka and Tamer Kahveci and Keith E. Muller and Robert D. Stevens and Christopher B. Newgard and Peter W. Stacpoole and Dean P. Jones
DOI: 10.1371/journal.pone.0063544
06/2013

Marginal Vitamin B-6 Deficiency Decreases Plasma (n-3) and (n-6) PUFA Concentrations in Healthy Men and Women
The Journal of Nutrition
Mei Zhao and Yvonne Lamers and Maria A. Ralat and Bonnie S. Coats and Yueh-Yun Chi and Keith E. Muller and James R. Bain and Meena N. Shankar and Christopher B. Newgard and Peter W. Stacpoole and Jesse F. Gregory
DOI: 10.3945/jn.112.163246
09/2012

Indicators and methods for folate, vitamin B-12, and vitamin B-6 status assessment in humans
Current Opinion in Clinical Nutrition and Metabolic Care
Yvonne Lamers
DOI: 10.1097/mco.0b013e328349f9a7
09/2011

Moderate Vitamin B-6 Restriction Does Not Alter Postprandial Methionine Cycle Rates of Remethylation, Transmethylation, and Total Transsulfuration but Increases the Fractional Synthesis Rate of Cystathionine in Healthy Young Men and Women
The Journal of Nutrition
Yvonne Lamers and Bonnie Coats and Maria Ralat and Eoin P. Quinlivan and Peter W. Stacpoole and Jesse F. Gregory
DOI: 10.3945/jn.110.134197
03/2011

Folate Recommendations for Pregnancy, Lactation, and Infancy
Annals of Nutrition and Metabolism
Yvonne Lamers
DOI: 10.1159/000332073
2011

Global hypothesis testing for high-dimensional repeated measures¿outcomes
Statistics in Medicine
Yueh-Yun Chi and Matthew Gribbin and Yvonne Lamers and Jesse F. Gregory and Keith E. Muller
DOI: 10.1002/sim.4435
2011

Kinetics of Folate and One-Carbon Metabolism
Folate in Health and Disease, Second Edition
Jesse Gregory III and Vanessa da Silva and Yvonne Lamers
DOI: 10.1201/9781420071252-c20
11/2009

Vitamin B-6 restriction tends to reduce the red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and women
The American Journal of Clinical Nutrition
Yvonne Lamers and Bruce O’Rourke and Lesa R Gilbert and Christine Keeling and Dwight E Matthews and Peter W Stacpoole and Jesse F Gregory
DOI: 10.3945/ajcn.2009.27747
06/2009

Supplementation with a multivitamin containing 800 µg of folic acid shortens the time to reach the preventive red blood cell folate concentration in healthy women
International Journal for Vitamin and Nutrition Research
Susanne Brämswig and Reinhild Prinz-Langenohl and Yvonne Lamers and Oliver Tobolski and Eva Wintergerst and Heiner K. Berthold and Klaus Pietrzik
DOI: 10.1024/0300-9831.79.2.61
03/2009

Production of 1-Carbon Units from Glycine Is Extensive in Healthy Men and Women
The Journal of Nutrition
Yvonne Lamers and Jerry Williamson and Douglas W. Theriaque and Jonathan J. Shuster and Lesa R. Gilbert and Christine Keeling and Peter W. Stacpoole and Jesse F. Gregory
DOI: 10.3945/jn.108.103580
02/2009

A Mathematical Model Gives Insights into the Effects of Vitamin B-6 Deficiency on 1-Carbon and Glutathione Metabolism
The Journal of Nutrition
H. Frederik Nijhout and Jesse F. Gregory and Courtney Fitzpatrick and Eugenia Cho and K. Yvonne Lamers and Cornelia M. Ulrich and Michael C. Reed
DOI: 10.3945/jn.109.104265
02/2009

Moderate Dietary Vitamin B-6 Restriction Raises Plasma Glycine and Cystathionine Concentrations While Minimally Affecting the Rates of Glycine Turnover and Glycine Cleavage in Healthy Men and Women
The Journal of Nutrition
Yvonne Lamers and Jerry Williamson and Maria Ralat and Eoin P. Quinlivan and Lesa R. Gilbert and Christine Keeling and Robert D. Stevens and Christopher B. Newgard and Per M. Ueland and Klaus Meyer and Ase Fredriksen and Peter W. Stacpoole and Jesse F. Gregory
DOI: 10.3945/jn.108.099184
01/2009

Reply to EP Quinlivan
The American Journal of Clinical Nutrition
Yvonne Lamers and Klaus Pietrzik
DOI: 10.1093/ajcn/87.5.1538
05/2008

Calculation of red blood cell folate steady state conditions and elimination kinetics after daily supplementation with various folate forms and doses in women of childbearing age
The American Journal of Clinical Nutrition
Klaus Pietrzik and Yvonne Lamers and Susanne Brämswig and Reinhild Prinz-Langenohl
DOI: 10.1093/ajcn/86.5.1414
11/2007

Glycine Turnover and Decarboxylation Rate Quantified in Healthy Men and Women Using Primed, Constant Infusions of [1,2-13C2]Glycine and [2H3]Leucine
The Journal of Nutrition
Yvonne Lamers and Jerry Williamson and Lesa R. Gilbert and Peter W. Stacpoole and Jesse F. Gregory
DOI: 10.1093/jn/137.12.2647
2007

Red blood cell folate concentrations increase more after supplementation with [6 S]-5-methyltetrahydrofolate than with folic acid in women of childbearing age
The American Journal of Clinical Nutrition
Yvonne Lamers and Reinhild Prinz-Langenohl and Susanne Brämswig and Klaus Pietrzik
DOI: 10.1093/ajcn/84.1.156
06/2006

Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women
The American Journal of Clinical Nutrition
Yvonne Lamers and Reinhild Prinz-Langenohl and Rudolf Moser and Klaus Pietrzik
DOI: 10.1093/ajcn/79.3.473
03/2004

Research

DERiVE: DEvelopment of Riboflavin biomarkers to relate dietary sources with status, gene-nutrient Interactions and Validated health Effects in adult cohorts (JPI-HDHL)
Vitamin B2 plays a crucial role in human development and health across the lifespan. Recently, an increase in vitamin B2
intake was suggested to having a reducing effect on blood pressure. In most countries, there is little or no knowledge about
the vitamin B2 nutrition status of the population due to the lack of convenient blood indicators and assessment tools. Dietary
records are the sole source of information for most countries; however these do not reflect the biochemical status of the
population which is a better indicator of health effects.
In this international and multidisciplinary project, we aim to develop accessible blood indicators for vitamin B2 status
assessment and identify which most sensitively reflect dietary intakes and food sources of vitamin B2 in Irish and Canadian
adults. We will also demonstrate an important health effect of vitamin B2 by investigating its role in modulating blood
pressure via a novel gene-nutrient interactive effect.
In summary, sub-optimal vitamin B2 status may be more widespread than is generally recognized across the developed
world, because of the reliance on dietary data only in nutrition surveys, without blood indicator evidence. This project will
address this gap by developing accessible vitamin B2 blood indicators for use in population surveys globally, and by
demonstrating important functional, gene-nutrient and health effects of optimal vitamin B2 status in Canadian, Irish and UK
cohorts.
JPI-HDHL Call "Biomarkers in Nutrition and Health"; CIHR Team Grant (PI: Yvonne Lamers)
Webpage: www.derive-riboflavin.com

Research Group Members

Alisha Buttar, Undergraduate Student
Chloe Chong, Research Assistant
Amira Friedman, Volunteer
Gillian Hayes, Volunteer
Gloria Ho, Clinical Research Assistant
Alyssa Kowbel, Volunteer
Lucy Lee, Volunteer
Vivian Liang, Volunteer
Jon Lin, Volunteer
Cara Mayer, Research Assistant
Larisse Melo, Master's Student & Clinical Trainee
Kate Merchant, Research Assistant
Sarah Montgomery, Doctoral Trainee
Nadia Moran Garcia, Postdoctoral Fellow
Maria Fernanda Mujica, Doctoral Student, Doctoral Student
Clementine Ng, Clinical Trainee, Co-Op Student
Rachelyn Ritchie, Research Assitant
Larissa Rossen, Volunteer
Monique Sanhdu, Work Learn Student
Nasime Sarbar, Research Assistant
Carolina Sasai, Volunteer
Ricky Singh, Research Assistant
Mikaela Stewart
Amy Tan, Graduate Student
Ricky Tsang, Volunteer
Ilona Ugortsev, Clinical Research Assistant
Elena Wang, Research Assistant
Maggie Yuan, Volunteer
Deborah Zibrik, Study Coordinator