Overview

My research interests relate to underlying mechanisms of nutrition and chronic disease risk. I am eager to contribute to targeted and population-based prevention strategies of chronic diseases. My research specifically focuses on B-vitamins and their functions in human metabolism. B-vitamins are essential nutrients for normal cell growth and the nervous system and thus have an impact on human health from the embryo to the older adult. Low folate and/or vitamin B-12 status may yield pregnancy complications, low birth weight, cancer, and cognitive impairment.

The overarching theme of my research is nutrient adequacy. My research projects aim to investigate metabolic and functional effects of nutritional inadequacies and micronutrient interactions in various population groups. The studies will help elaborate potential underlying mechanisms responsible for linkages between B-vitamin intake and chronic diseases and in the evaluation of optimal vitamin intake to maintain biochemical functions. I am specifically interested in investigating the metabolic effects of folic acid and less than optimal vitamin B-12 intake.

Publications

Pregnant women of South Asian ethnicity in Canada have substantially lower vitamin B12 status compared with pregnant women of European ethnicity
British Journal of Nutrition
Theresa H. Schroder, Graham Sinclair, Andre Mattman, Benjamin Jung, Susan I. Barr, Hilary D. Vallance, Yvonne Lamers
DOI: 10.1017/s0007114517002331
09/2017

Barriers and facilitators to recruitment of South Asians to health research: a scoping review
BMJ Open
Teo AW Quay, Leora Frimer, Patricia A Janssen, Yvonne Lamers
DOI: 10.1136/bmjopen-2016-014889
05/2017

Correlations between Maternal, Breast Milk, and Infant Vitamin B12 Concentrations among Mother–Infant Dyads in Vancouver, Canada and Prey Veng, Cambodia: An Exploratory Analysis
Nutrients
Philip Chebaya, Crystal Karakochuk, Kaitlin March, Nancy Chen, Rosemary Stamm, Hou Kroeun, Prak Sophonneary, Mam Borath, Setareh Shahab-Ferdows, Daniela Hampel, Susan Barr, Yvonne Lamers, Lisa Houghton, Lindsay Allen, Tim Green, Kyly Whitfield
DOI: 10.3390/nu9030270
03/2017

South Asian Ethnicity Is Related to the Highest Risk of Vitamin B12 Deficiency in Pregnant Canadian Women
Nutrients
Marta Jeruszka-Bielak, Carly Isman, Theresa Schroder, Wangyang Li, Tim Green, Yvonne Lamers
DOI: 10.3390/nu9040317
03/2017

Prevalence and Predictors of Low Vitamin B6 Status in Healthy Young Adult Women in Metro Vancouver
Nutrients
Chia-ling Ho, Teo Quay, Angela Devlin, Yvonne Lamers
DOI: 10.3390/nu8090538
09/2016

Reference interval of methylmalonic acid concentrations in dried blood spots of healthy, term newborns to facilitate neonatal screening of vitamin B12 deficiency
Clinical Biochemistry
Theresa H. Schroder, Andre Mattman, Graham Sinclair, Hilary D. Vallance, Yvonne Lamers
DOI: 10.1016/j.clinbiochem.2016.03.007
09/2016

Low Serum Vitamin B-12 Concentrations Are Prevalent in a Cohort of Pregnant Canadian Women
The Journal of Nutrition
Carly E Visentin, Shannon P Masih, Lesley Plumptre, Theresa H Schroder, Kyoung-Jin Sohn, Anna Ly, Andrea Y Lausman, Howard Berger, Ruth Croxford, Yvonne Lamers, Young-In Kim, Deborah L O'Connor
DOI: 10.3945/jn.115.226845
04/2016

Vitamin B-6 Status in Unsupplemented Pregnant Women Is Associated Positively with Serum Docosahexaenoic Acid and Inversely with the n–6-to-n–3 Fatty Acid Ratio
The Journal of Nutrition
Maria F Mujica-Coopman, Ana B Franco-Sena, Dayana R Farias, Juliana S Vaz, Alex Brito, Gilberto Kac, Yvonne Lamers
DOI: 10.3945/jn.116.239483
2016

High prevalence of suboptimal vitamin B12 status in young adult women of South Asian and European ethnicity
Applied Physiology, Nutrition, and Metabolism
Teo A.W. Quay, Theresa H. Schroder, Marta Jeruszka-Bielak, Wangyang Li, Angela M. Devlin, Susan I. Barr, Yvonne Lamers
DOI: 10.1139/apnm-2015-0200
2015

Genetic Hemoglobin Disorders Rather Than Iron Deficiency Are a Major Predictor of Hemoglobin Concentration in Women of Reproductive Age in Rural Prey Veng, Cambodia
The Journal of Nutrition
Crystal D Karakochuk, Kyly C Whitfield, Susan I Barr, Yvonne Lamers, Angela M Devlin, Suzanne M Vercauteren, Hou Kroeun, Aminuzzaman Talukder, Judy McLean, Timothy J Green
DOI: 10.3945/jn.114.198945
11/2014

Methylmalonic Acid Quantified in Dried Blood Spots Provides a Precise, Valid, and Stable Measure of Functional Vitamin B-12 Status in Healthy Women
The Journal of Nutrition
Theresa H. Schroder, Teo A. W. Quay, Yvonne Lamers
DOI: 10.3945/jn.114.194829
08/2014

Metabolite Profile Analysis Reveals Functional Effects of 28-Day Vitamin B-6 Restriction on One-Carbon Metabolism and Tryptophan Catabolic Pathways in Healthy Men and Women
The Journal of Nutrition
Vanessa R. da Silva, Luisa Rios-Avila, Yvonne Lamers, Maria A. Ralat, Øivind Midttun, Eoin P. Quinlivan, Timothy J. Garrett, Bonnie Coats, Meena N. Shankar, Susan S. Percival, Yueh-Yun Chi, Keith E. Muller, Per Magne Ueland, Peter W. Stacpoole, Jesse F. Gregory
DOI: 10.3945/jn.113.180588
08/2013

Red blood cell folate levels in pregnant women with a history of mood disorders: A case seriesMaternal Folate Levels and Mood Disorders
Birth Defects Research Part A: Clinical and Molecular Teratology
Elyse Yaremco, Angela Inglis, Sheila M. Innis, Catriona Hippman, Prescilla Carrion, Yvonne Lamers, William G. Honer, Jehannine Austin
DOI: 10.1002/bdra.23144
06/2013

Metabolomic Analysis Reveals Extended Metabolic Consequences of Marginal Vitamin B-6 Deficiency in Healthy Human Subjects
PLoS ONE
Jesse F. Gregory, Youngja Park, Yvonne Lamers, Nirmalya Bandyopadhyay, Yueh-Yun Chi, Kichen Lee, Steven Kim, Vanessa da Silva, Nikolas Hove, Sanjay Ranka, Tamer Kahveci, Keith E. Muller, Robert D. Stevens, Christopher B. Newgard, Peter W. Stacpoole, Dean P. Jones
DOI: 10.1371/journal.pone.0063544
06/2013

Marginal Vitamin B-6 Deficiency Decreases Plasma (n-3) and (n-6) PUFA Concentrations in Healthy Men and Women
The Journal of Nutrition
Mei Zhao, Yvonne Lamers, Maria A. Ralat, Bonnie S. Coats, Yueh-Yun Chi, Keith E. Muller, James R. Bain, Meena N. Shankar, Christopher B. Newgard, Peter W. Stacpoole, Jesse F. Gregory
DOI: 10.3945/jn.112.163246
09/2012

Indicators and methods for folate, vitamin B-12, and vitamin B-6 status assessment in humans
Current Opinion in Clinical Nutrition and Metabolic Care
Yvonne Lamers
DOI: 10.1097/mco.0b013e328349f9a7
09/2011

Moderate Vitamin B-6 Restriction Does Not Alter Postprandial Methionine Cycle Rates of Remethylation, Transmethylation, and Total Transsulfuration but Increases the Fractional Synthesis Rate of Cystathionine in Healthy Young Men and Women
The Journal of Nutrition
Yvonne Lamers, Bonnie Coats, Maria Ralat, Eoin P. Quinlivan, Peter W. Stacpoole, Jesse F. Gregory
DOI: 10.3945/jn.110.134197
03/2011

Folate Recommendations for Pregnancy, Lactation, and Infancy
Annals of Nutrition and Metabolism
Yvonne Lamers
DOI: 10.1159/000332073
2011

Global hypothesis testing for high-dimensional repeated measures¿outcomes
Statistics in Medicine
Yueh-Yun Chi, Matthew Gribbin, Yvonne Lamers, Jesse F. Gregory, Keith E. Muller
DOI: 10.1002/sim.4435
2011

Kinetics of Folate and One-Carbon Metabolism
Folate in Health and Disease, Second Edition
Jesse Gregory III and Vanessa da Silva and Yvonne Lamers
DOI: 10.1201/9781420071252-c20
11/2009

Vitamin B-6 restriction tends to reduce the red blood cell glutathione synthesis rate without affecting red blood cell or plasma glutathione concentrations in healthy men and women
The American Journal of Clinical Nutrition
Yvonne Lamers, Bruce O’Rourke, Lesa R Gilbert, Christine Keeling, Dwight E Matthews, Peter W Stacpoole, Jesse F Gregory
DOI: 10.3945/ajcn.2009.27747
06/2009

Supplementation with a multivitamin containing 800 µg of folic acid shortens the time to reach the preventive red blood cell folate concentration in healthy women
International Journal for Vitamin and Nutrition Research
Susanne Brämswig, Reinhild Prinz-Langenohl, Yvonne Lamers, Oliver Tobolski, Eva Wintergerst, Heiner K. Berthold, Klaus Pietrzik
DOI: 10.1024/0300-9831.79.2.61
03/2009

A Mathematical Model Gives Insights into the Effects of Vitamin B-6 Deficiency on 1-Carbon and Glutathione Metabolism
The Journal of Nutrition
H. Frederik Nijhout, Jesse F. Gregory, Courtney Fitzpatrick, Eugenia Cho, K. Yvonne Lamers, Cornelia M. Ulrich, Michael C. Reed
DOI: 10.3945/jn.109.104265
02/2009

Production of 1-Carbon Units from Glycine Is Extensive in Healthy Men and Women
The Journal of Nutrition
Yvonne Lamers, Jerry Williamson, Douglas W. Theriaque, Jonathan J. Shuster, Lesa R. Gilbert, Christine Keeling, Peter W. Stacpoole, Jesse F. Gregory
DOI: 10.3945/jn.108.103580
02/2009

Moderate Dietary Vitamin B-6 Restriction Raises Plasma Glycine and Cystathionine Concentrations While Minimally Affecting the Rates of Glycine Turnover and Glycine Cleavage in Healthy Men and Women
The Journal of Nutrition
Yvonne Lamers, Jerry Williamson, Maria Ralat, Eoin P. Quinlivan, Lesa R. Gilbert, Christine Keeling, Robert D. Stevens, Christopher B. Newgard, Per M. Ueland, Klaus Meyer, Ase Fredriksen, Peter W. Stacpoole, Jesse F. Gregory
DOI: 10.3945/jn.108.099184
01/2009

Reply to EP Quinlivan
The American Journal of Clinical Nutrition
Yvonne Lamers, Klaus Pietrzik
DOI: 10.1093/ajcn/87.5.1538
05/2008

Calculation of red blood cell folate steady state conditions and elimination kinetics after daily supplementation with various folate forms and doses in women of childbearing age
The American Journal of Clinical Nutrition
Klaus Pietrzik, Yvonne Lamers, Susanne Brämswig, Reinhild Prinz-Langenohl
DOI: 10.1093/ajcn/86.5.1414
11/2007

Glycine Turnover and Decarboxylation Rate Quantified in Healthy Men and Women Using Primed, Constant Infusions of [1,2-13C2]Glycine and [2H3]Leucine
The Journal of Nutrition
Yvonne Lamers, Jerry Williamson, Lesa R. Gilbert, Peter W. Stacpoole, Jesse F. Gregory
DOI: 10.1093/jn/137.12.2647
2007

Red blood cell folate concentrations increase more after supplementation with [6 S]-5-methyltetrahydrofolate than with folic acid in women of childbearing age
The American Journal of Clinical Nutrition
Yvonne Lamers, Reinhild Prinz-Langenohl, Susanne Brämswig, Klaus Pietrzik
DOI: 10.1093/ajcn/84.1.156
06/2006

Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women
The American Journal of Clinical Nutrition
Yvonne Lamers, Reinhild Prinz-Langenohl, Rudolf Moser, Klaus Pietrzik
DOI: 10.1093/ajcn/79.3.473
03/2004

Research
Research Group Members

Maria Fernanda Mujica, Doctoral Student
Lynda Soberanes
Deborah Zibrik, Study Coordinator
Gloria Ho
Amy Tan, Graduate Student
Larisse Melo
Mikaela Stewart
Yuqi Duan
Sarah Montgomery, Doctoral Trainee
Danica Davies, Undergraduate Student
Joshua Lam, Student
Queena Chung, Student
Jessica Liao, Undergraduate Student
Alisha Buttar, Undergraduate Student
Rachelyn Ritchie
Natalie Cryderman, Undergraduate Student
Nadia Moran Garcia, Postdoctoral Fellow