I recently completed a research project looking at changes in cardiac output, how much blood the heart pumps around the body per minute, when teenagers are turned onto their front prior to operations to fix the curvature of their back. We found that the amount of blood is significantly reduced on turning on to their front.

This is leading on to further studies as I would like to look at how changes in anesthesia, for example the amount of fluid that we give these teenagers can affect their cardiac output. I am hoping to collaborate with the orthopediac surgeons and nephrologists to examine the incidence of kidney damage after surgery which may be related to changes in cardiac output.


Impact of pediatric near-miss perioperative events: A survey of anesthesiology residents
Pediatric Anesthesia
James D. Taylor and Nicholas West and Theresa Newlove and Zoë Brown
DOI: 10.1111/pan.14616

The effect of intraoperative lidocaine infusion on postoperative opioid consumption in adolescents undergoing posterior spinal instrumentation and fusion for idiopathic scoliosis
Spine Journal
Lin, R. and Zhu, K. and Poznikoff, A.K. and Görges, M. and Brown, Z.E.
DOI: 10.1016/j.spinee.2021.03.024

Update on ENT anaesthesia in children
Anaesthesia and Intensive Care Medicine
Brown, Z.E. and Chadha, N.K.
DOI: 10.1016/j.mpaic.2021.07.019

Reducing preoperative anxiety with Child Life preparation prior to intravenous induction of anesthesia: A randomized controlled trial
Pediatric Anesthesia
Nicholas West and Nancy Christopher and Kirsten Stratton and Matthias Görges and Zoë Brown
DOI: 10.1111/pan.13802

Update on ENT anaesthesia in children
Anaesthesia and Intensive Care Medicine
Ridgway, R. and Dumbarton, T. and Brown, Z.
DOI: 10.1016/j.mpaic.2018.11.003

A comparison of linear and logarithmic auditory tones in pulse oximeters.
Brown Z and Edworthy J and Sneyd JR and Schlesinger J
DOI: 10.1016/j.apergo.2015.06.006
PubMed: 26154232

Update on ENT anaesthesia
Anaesthesia & Intensive Care Medicine
Peter Harper and Lindsay Rawling and Zoë Brown
DOI: 10.1016/j.mpaic.2015.09.005

Changes in cardiac index and blood pressure on positioning children prone for scoliosis surgery.
Brown ZE and Görges M and Cooke E and Malherbe S and Dumont GA and Ansermino JM
DOI: 10.1111/anae.12310
PubMed: 23710730

A Comparison of the Anaesthetic Costs of Day Case Surgery: Propofol Total Intravenous Anaesthesia and Volatile Anaesthesia
Journal One Day Surgery

Anaesthesia for elective ear, nose and throat surgery in children
Anaesthesia & Intensive Care Medicine
Zoë Brown and Simon Whyte
DOI: 10.1016/j.mpaic.2012.02.010

Biological signals and their measurement
Update in Anaesthesia
Brown, Z. and Gupta, B.


Current Project
I have just become part of a collaboration between orthopedics, nephrology and anesthesia, looking initially at the incidence of acute kidney injury (AKI) post-operatively, and then at different alterations to anesthesia management that could help reduce the incidence of AKI in the orthopedic population. Potentially this will involve changes in fluid management, possibly being guided by a cardiac output monitor, and observing the effects of non-steroidal drugs.


Innovation in Acute Care and Technology Research Grant

Honours & Awards

Best presentation by a Fellow, University of British Columbia, Anaesthesia, Pharmacology and Therapeutics Research Day

Research Group Members

James Taylor, Summer Research Student
Denise Taylor, Administrative Assistant, Pediatric Anesthesia