Overview

A main focus of my academic work involves the development and assessment of clinical programs for children with type 1 diabetes. This includes the development of a diabetes telehealth program to provide improved access to specialist care for children across the province. I am also currently involved in an assessment of the BC Children’s Hospital insulin pump program. I am engaged with Child Health BC in work around provincial planning for type 1 diabetes care, and I have a specific interest in the development and assessment of diabetes care for children in the school setting.

My current diabetes research interests include assessing the effectiveness of coaching for families of children with type 1 diabetes. We have also recently completed a study documenting the prevalence of acute kidney injury in children with diabetic ketoacidosis.

I am currently the site-investigator for several multicenter trials of long-acting growth hormone therapies.

Another recent research area of interest is childhood obesity, with a recently completed study of the autonomic nervous system and inflammation in normal weight and obese children. This research has added to our understanding of the physiologic changes that accompany obesity in children.

Publications

Assessing resting energy expenditure in overweight and obese adolescents in a clinical setting: validity of a handheld indirect calorimeter.
Woo P, Murthy G, Wong C, Hursh B, Chanoine JP, Elango R
DOI: 10.1038/pr.2016.182
PubMed: 27653085
01/2017

Adrenal insufficiency exists for both swallowed budesonide and fluticasone propionate in the treatment of eosinophilic esophagitis.
Harel S, Hursh BE, Chan ES, Avinashi V, Panagiotopoulos C
DOI: 10.1016/j.jpeds.2016.02.056
PubMed: 27004676
07/2016

Cardiac Autonomic Function at Baseline and under Stress and Its Relationship to Circulatory Markers of Inflammation in Obese Compared to Nonobese Children: A Pilot Study.
Hursh BE, Fazeli MS, Wang S, Marchant EA, Woo P, Elango R, Lavoie PM, Chanoine JP, Collet JP
DOI: 10.1159/000445685
PubMed: 27105080
2016

Adrenal Suppression in Children Treated With Oral Viscous Budesonide for Eosinophilic Esophagitis.
Harel S, Hursh BE, Chan ES, Avinashi V, Panagiotopoulos C
DOI: 10.1097/mpg.0000000000000848
PubMed: 25950088
08/2015

Case 2: Generalized swelling in a child with newly diagnosed diabetes mellitus.
Hursh BE, Dedhar A, Panagiotopoulos C
PubMed: 24855422
05/2014

Occurrence of slipped capital femoral epiphysis in children undergoing gonadotropin-releasing hormone agonist therapy for the treatment of central precocious puberty.
Inman M, Hursh BE, Mokashi A, Pinto T, Metzger DL, Cummings EA
DOI: 10.1159/000351028
PubMed: 23859950
2013

A rare cause of hypertension in a healthy 2-year-old female: questions.
Fox DA, Matsell DG, Hursh BE, Mammen C
DOI: 10.1007/s00467-012-2161-5
PubMed: 22534766
11/2012

Research

Inflammation and the autonomic nervous system in childhood obesity
I have recently conducted a pilot study at BC Children's Hospital and CFRI to look for differences in both the autonomic nervous system and inflammation between children with healthy weight and those with obesity. There is evidence that nervous system changes may occur in childhood obesity, and if so this indicates the burden of obesity the nerve pathways that control important functions such as heart rate. In this study we assessed for an association between autonomic nervous system changes and the level of inflammation in these children.

Acute kidney injury in diabetic ketoacidosis
This study recently assessed the proportion of acute kidney injury in children presenting to BC Children's Hospital with diabetic ketoacidosis. Current fluid management in diabetic ketoacidosis is guided in large part by concern for cerebral edema; however, we must also be aware of other possible outcomes of our current standard of care treatment, such as kidney injury. This study is the first large-scale assessment for acute kidney injury in children with diabetic ketoacidosis, and the results of this study will inform our monitoring and treatment of kidney related issues that may arise during the course of treatment of diabetic ketoacidosis.

Coaching for parents of children with type 1 diabetes
This study will evaluate the impact of providing a behavioural approach called coaching for families of children with type 1 diabetes. This novel study brings together the Diabetes Team with the staff of the New Knowledge & Innovation Division to integrate a coach into the diabetes team. The coach will work directly with families of children with type 1 diabetes. We will be looking at the impact of this intervention on the children’s quality of life, family conflict, self-management and blood glucose management.

Grants

Canadian Pediatric Endocrine Group : Fellowship Award, 2013-2014. Salary Support for one year of research fellowship in pediatric endocrinology.Amount: $60,000.

Institute of Coaching Harnisch Grant, 2015

CFRI Canucks for Kids Fund Diabetes Catalyst Grant, 2015

Honours & Awards

BC Children’s Hospital Resident Research Award, December 2012.

Research Group Members

Rohan Kakkar
Alex Fung, Research Coordinator