Overview

A main focus of my academic work involves the development and assessment of clinical programs for children with type 1 diabetes. This includes the development of a diabetes telehealth program to provide improved access to specialist care for children across the province. I am engaged with Child Health BC in work around provincial planning for type 1 diabetes care, and I have a specific interest in the development and assessment of diabetes care for children in the school setting.

My current diabetes research interests include assessing the effectiveness of coaching for families of children with type 1 diabetes as well as understanding the experience of children with celiac disease and type 1 diabetes. We recently completed a study documenting the prevalence of acute kidney injury in children with diabetic ketoacidosis, as well as a study looking at the effect of HbA1c on improvement in glycemic management when initiating insulin pump therapy.

I have a clinical interest in the care of transgender youth, and I am involved in providing education and planning to support care for transgender youth around the province.

Publications

Insulin pump therapy, pre-pump hemoglobin A 1c and metabolic improvement in children with type 1 diabetes at a tertiary Canadian children's hospital
Pediatric Diabetes
Sandra Botros and Nazrul Islam and Brenden Hursh
DOI: 10.1111/pedi.12834
06/2019

Assessing resting energy expenditure in overweight and obese adolescents in a clinical setting: validity of a handheld indirect calorimeter.
Woo P and Murthy G and Wong C and Hursh B and Chanoine JP and Elango R
DOI: 10.1038/pr.2016.182
PubMed: 27653085
01/2017

Acute kidney injury in children with type 1 diabetes hospitalized for diabetic ketoacidosis
JAMA Pediatrics
DOI: 10.1001/jamapediatrics.2017.0020
2017

Adrenal insufficiency exists for both swallowed budesonide and fluticasone propionate in the treatment of eosinophilic esophagitis.
Harel S and Hursh BE and Chan ES and Avinashi V and Panagiotopoulos C
DOI: 10.1016/j.jpeds.2016.02.056
PubMed: 27004676
07/2016

Cardiac Autonomic Function at Baseline and under Stress and Its Relationship to Circulatory Markers of Inflammation in Obese Compared to Nonobese Children: A Pilot Study.
Hursh BE and Fazeli MS and Wang S and Marchant EA and Woo P and Elango R and Lavoie PM and Chanoine JP and Collet JP
DOI: 10.1159/000445685
PubMed: 27105080
2016

Adrenal Suppression in Children Treated With Oral Viscous Budesonide for Eosinophilic Esophagitis.
Harel S and Hursh BE and Chan ES and Avinashi V and Panagiotopoulos C
DOI: 10.1097/mpg.0000000000000848
PubMed: 25950088
08/2015

Adrenal suppression in children treated with oral viscous budesonide for eosinophilic esophagitis
Journal of Pediatric Gastroenterology and Nutrition
DOI: 10.1097/MPG.0000000000000848
2015

Case 2: Generalized swelling in a child with newly diagnosed diabetes mellitus.
Hursh BE and Dedhar A and Panagiotopoulos C
PubMed: 24855422
05/2014

Case 2: Generalized swelling in a child with newly diagnosed diabetes mellitus
Paediatrics and Child Health (Canada)
DOI: 10.1093/pch/19.5.233-b
2014

Occurrence of slipped capital femoral epiphysis in children undergoing gonadotropin-releasing hormone agonist therapy for the treatment of central precocious puberty.
Inman M and Hursh BE and Mokashi A and Pinto T and Metzger DL and Cummings EA
DOI: 10.1159/000351028
PubMed: 23859950
2013

A rare cause of hypertension in a healthy 2-year-old female: questions.
Fox DA and Matsell DG and Hursh BE and Mammen C
DOI: 10.1007/s00467-012-2161-5
PubMed: 22534766
11/2012

A rare cause of hypertension in a healthy 2-year-old female: Answers
Pediatric Nephrology
DOI: 10.1007/s00467-012-2164-2
2012

Research

Acute kidney injury in diabetic ketoacidosis
This study recently assessed the proportion of acute kidney injury in children presenting to BC Children's Hospital with diabetic ketoacidosis. Current fluid management in diabetic ketoacidosis is guided in large part by concern for cerebral edema; however, we must also be aware of other possible outcomes of our current standard of care treatment, such as kidney injury. This study is the first large-scale assessment for acute kidney injury in children with diabetic ketoacidosis, and the results of this study will inform our monitoring and treatment of kidney related issues that may arise during the course of treatment of diabetic ketoacidosis.

Coaching for parents of children with type 1 diabetes
This study will evaluate the impact of providing a behavioural approach called coaching for families of children with type 1 diabetes. This novel study brings together the Diabetes Team with the staff of the New Knowledge & Innovation Division to integrate a coach into the diabetes team. The coach will work directly with families of children with type 1 diabetes. We will be looking at the impact of this intervention on the children’s quality of life, family conflict, self-management and blood glucose management.

Grants

Canadian Pediatric Endocrine Group : Fellowship Award, 2013-2014. Salary Support for one year of research fellowship in pediatric endocrinology.Amount: $60,000.

Institute of Coaching Harnisch Grant, 2015

CFRI Canucks for Kids Fund Diabetes Catalyst Grant, 2015

Honours & Awards

BC Children’s Hospital Resident Research Award, December 2012.

Research Group Members

Alex Fung, Research Coordinator