Dr. Goldfarb’s current research focuses primarily on novel diagnostic,management and prevention strategies for pediatric infectious disease in resource limited settings.


Asymptomatic Pharyngeal Carriage of Kingella kingae Among Young Children in Vancouver, British Columbia, Canada.
The Pediatric infectious disease journal
Masud S and Greenman J and Mulpuri K and Hasan MR and Goldfarb DM and Tilley P and Gadkar VJ and Al-Rawahi GN
DOI: 10.1097/inf.0000000000002403
PubMed: 31335573

Dermacoccus sp. isolated from a brain abscess in a 4-year-old child.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Ivaska L and Alyazidi R and Hoang L and Goldfarb DM
DOI: 10.1016/j.jiac.2019.05.033
PubMed: 31253474

New Tools to Test Stool: Managing Travelers' Diarrhea in the Era of Molecular Diagnostics.
Infectious disease clinics of North America
Eckbo EJ and Yansouni CP and Pernica JM and Goldfarb DM
DOI: 10.1016/j.idc.2018.10.012
PubMed: 30712762

Pneumococcal Colonization and the Nasopharyngeal Microbiota of Children in Botswana.
The Pediatric infectious disease journal
Kelly MS and Surette MG and Smieja M and Rossi L and Luinstra K and Steenhoff AP and Goldfarb DM and Pernica JM and Arscott-Mills T and Boiditswe S and Mazhani T and Rawls JF and Seed PC
DOI: 10.1097/inf.0000000000002174
PubMed: 30153231

Diagnostic Interpretation Guidance for Pediatric Enteric Pathogens: A Modified Delphi Consensus Process.
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
Stang AS and Trudeau M and Vanderkooi OG and Lee BE and Chui L and Pang XL and Allen V and Burnham CD and Goldfarb DM and MacDonald J and Parsons B and Petrich A and Pollari F and Tarr PI and Freedman SB
DOI: 10.1155/2018/2589826
PubMed: 30363711

Genetic and epidemiological analysis of norovirus from children with gastroenteritis in Botswana, 2013-2015.
BMC infectious diseases
Makhaola K and Moyo S and Lechiile K and Goldfarb DM and Kebaabetswe LP
DOI: 10.1186/s12879-018-3157-y
PubMed: 29848303

Recovery of cytomegalovirus DNA from newborn saliva samples by different methods.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
Goshen O and Goldfarb DM and Book L and Tilley P and Gantt S
DOI: 10.1016/j.jcv.2018.05.001
PubMed: 29753934

Real-time Detection and Monitoring of Loop Mediated Amplification (LAMP) Reaction Using Self-quenching and De-quenching Fluorogenic Probes.
Scientific reports
Gadkar VJ and Goldfarb DM and Gantt S and Tilley PAG
DOI: 10.1038/s41598-018-23930-1
PubMed: 29615801

The global burden of paediatric and neonatal sepsis: a systematic review.
The Lancet. Respiratory medicine
Fleischmann-Struzek C and Goldfarb DM and Schlattmann P and Schlapbach LJ and Reinhart K and Kissoon N
DOI: 10.1016/s2213-2600(18)30063-8
PubMed: 29508706

Evaluation of the Influence of Gastrointestinal Coinfections on Rotavirus Vaccine Effectiveness in Botswana
The Pediatric Infectious Disease Journal
Margaret Mokomane and Jacqueline E. Tate and Andrew P. Steenhoff and Mathew D. Esona and Michael D. Bowen and Kwana Lechiile and Jeffrey M. Pernica and Ishmael Kasvosve and Umesh D. Parashar and David M. Goldfarb
DOI: 10.1097/inf.0000000000001828

'Finding Gory'-bringing home an unwanted aquatic traveler.
Paediatrics & Child Health
Mijovic H and Henkelman E and Goldfarb DM
DOI: 10.1093/pch/pxx213
PubMed: 30455577

The global problem of childhood diarrhoeal diseases: emerging strategies in prevention and management.
Therapeutic advances in infectious disease
Mokomane M and Kasvosve I and de Melo E and Pernica JM and Goldfarb DM
DOI: 10.1177/2049936117744429
PubMed: 29344358

Correction: Rapid enteric testing to permit targeted antimicrobial therapy, with and without Lactobacillus reuteri probiotics, for paediatric acute diarrhoeal disease in Botswana: A pilot, randomized, factorial, controlled trial.
PloS one
Pernica JM and Steenhoff AP and Mokomane M and Moorad B and Lechiile K and Smieja M and Mazhani L and Cheng J and Kelly MS and Loeb M and Stordal K and Goldfarb DM
DOI: 10.1371/journal.pone.0194957
PubMed: 29561910

Phylogenetic analyses and antimicrobial resistance profiles of Campylobacter spp. from diarrhoeal patients and chickens in Botswana.
PloS one
de Vries SPW and Vurayai M and Holmes M and Gupta S and Bateman M and Goldfarb D and Maskell DJ and Matsheka MI and Grant AJ
DOI: 10.1371/journal.pone.0194481
PubMed: 29561903

In reference to should infants who fail their newborn hearing screen undergo cytomegalovirus testing?
The Laryngoscope
Gantt S and Goldfarb DM and Dionne F and Bulman D and Doutré SM
DOI: 10.1002/lary.27032
PubMed: 29266275

The Nasopharyngeal Microbiota of Children with Respiratory Infections in Botswana
Pediatric Infectious Disease Journal
DOI: 10.1097/INF.0000000000001607

Rapid enteric testing to permit targeted antimicrobial therapy, with and without Lactobacillus reuteri probiotics, for paediatric acute diarrhoeal disease in Botswana: A pilot, randomized, factorial, controlled trial.
PloS one
Pernica JM and Steenhoff AP and Mokomane M and Moorad B and Lechiile K and Smieja M and Mazhani L and Cheng J and Kelly MS and Loeb M and Stordal K and Goldfarb DM
DOI: 10.1371/journal.pone.0185177
PubMed: 28991918

Hospital-acquired gastroenteritis at a referral hospital in Gaborone, Botswana
International Journal of Infection Control
Henry Welch and David M. Goldfarb and Banno Moorad and Margaret Mokomane and Marek Smieja and Unoda Chakalisa and Andrew P Steenhoff and Rodney Finalle and Susan E Coffin
DOI: 10.3396/ijic.v13i2.006.17

Pneumococcal Colonization and the Nasopharyngeal Microbiota of Children in Botswana
Open Forum Infectious Diseases
Matthew Kelly and Michael Surette and Marek Smieja and Laura Rossi and Kathy Luinstra and Andrew Steenhoff and David Goldfarb and Tonya Arscott-Mills and Sefelani Boiditswe and Ikanyeng Rulaganyang and Charles Muthoga and Kwana Lechiile and Tiny Mazhani and John Rawls and Coleen Cunningham and Samir Shah and Kristen Feemster and Patrick Seed
DOI: 10.1093/ofid/ofx163.490

Correlation of clinical outcomes with multiplex molecular testing of stool from children admitted to hospital with gastroenteritis in Botswana
Journal of the Pediatric Infectious Diseases Society
DOI: 10.1093/jpids/piv028

Cost-effectiveness of universal and targeted newborn screening for congenital cytomegalovirus infection
JAMA Pediatrics
DOI: 10.1001/jamapediatrics.2016.2016

Enteric Parasites in Arctic Communities: Tip of the Iceberg?
Trends in Parasitology
DOI: 10.1016/j.pt.2016.08.004

Effectiveness of Monovalent Rotavirus Vaccine after Programmatic Implementation in Botswana: A Multisite Prospective Case-Control Study
Clinical Infectious Diseases
DOI: 10.1093/cid/civ1207

Molecular Detection of Diarrheal Pathogens
Clinical Microbiology Newsletter
DOI: 10.1016/j.clinmicnews.2016.08.001

A comparison of flocked swabs and traditional swabs, using multiplex real-time PCR for detection of common gastroenteritis pathogens in Botswana
Diagnostic Microbiology and Infectious Disease
DOI: 10.1016/j.diagmicrobio.2016.07.007

Impact of Rotavirus Vaccination on Hospitalizations and Deaths from Childhood Gastroenteritis in Botswana
Clinical Infectious Diseases
DOI: 10.1093/cid/civ1210

Prevalence and molecular characterization of Cryptosporidium spp. and Giardia duodenalis in diarrhoeic patients in the Qikiqtani Region, Nunavut, Canada
International Journal of Circumpolar Health
DOI: 10.3402/ijch.v74.27713

Optimizing Management of Pediatric Diarrhoeal Disease in Botswana: A Pilot, Factorial, Randomized, Placebo-Controlled Trial of Rapid Enteric Diagnostics and Probiotic Therapy
Open Forum Infectious Diseases
Jeffrey Pernica and Andrew Steenhoff and Margaret Mokomane and Kwana Lechiile and Banno Moorad and Marek Smieja and Loeto Mazhani and Mark Loeb and Ketil Stordal and David Goldfarb
DOI: 10.1093/ofid/ofv133.1177

Association of respiratory viruses with outcomes of severe childhood pneumonia in Botswana
DOI: 10.1371/journal.pone.0126593

Bordetella species other than bordetella pertussis
Clinical Microbiology Newsletter
DOI: 10.1016/j.clinmicnews.2015.03.004

Risk factors for measles in HIV-infected children and adolescents in Botswana
Pediatric Infectious Disease Journal
DOI: 10.1097/INF.0000000000000816

Early childhood diarrhoeal diseases and cognition: Are we missing the rest of the iceberg?
Paediatrics and International Child Health
DOI: 10.1179/2046905514Y.0000000141

CT before lumbar puncture in suspected meningitis in Botswana: How established guidelines may not apply
African Journal of Emergency Medicine
DOI: 10.1016/j.afjem.2013.07.004

Evaluation of anatomically designed flocked rectal swabs for molecular detection of enteric pathogens in children admitted to hospital with severe gastroenteritis in botswana
Journal of Clinical Microbiology
DOI: 10.1128/JCM.01894-14

Hospital-Based Surveillance for Rotavirus Gastroenteritis using Molecular Testing and Immunoassay During the 2011 Season in Botswana
The Pediatric Infectious Disease Journal
Henry Welch and Andrew P. Steenhoff and Unoda Chakalisa and Tonya Arscott-Mills and Loeto Mazhani and Margaret Mokomane and Sara Foster-Fabiano and Kathleen E. Wirth and Andrew Skinn and Jeffrey M. Pernica and Marek Smieja and David M. Goldfarb
DOI: 10.1097/inf.0b013e3182847295

Microbiology of Urinary Tract Infections in Gaborone, Botswana
Andrew J. Renuart and David M. Goldfarb and Margaret Mokomane and Ephraim O. Tawanana and Mohan Narasimhamurthy and Andrew P. Steenhoff and Jonathan A. Silverman
DOI: 10.1371/journal.pone.0057776

Severe late-onset multisystem cytomegalovirus infection in a premature neonate previously treated for congenital infection
BMC Pediatrics
DOI: 10.1186/1471-2431-13-142

Hospital-based surveillance for rotavirus gastroenteritis using molecular testing and immunoassay during the 2011 season in Botswana
Pediatric Infectious Disease Journal
DOI: 10.1097/INF.0b013e3182847295

Yield of contact tracing from pediatric tuberculosis index cases in Gaborone, Botswana
International Journal of Tuberculosis and Lung Disease
DOI: 10.5588/ijtld.12.0933

Development and evaluation of global child health educational modules
DOI: 10.1542/peds.2013-1534

Nanolitre real-time PCR detection of bacterial, parasitic, and viral agents from patients with diarrhoea in Nunavut, Canada
International Journal of Circumpolar Health
DOI: 10.3402/ijch.v72i0.19903

Rapid PCR detection of group a streptococcus from flocked throat swabs: A retrospective clinical study
Annals of Clinical Microbiology and Antimicrobials
DOI: 10.1186/1476-0711-10-33

Prevalence of methicillin-resistant Staphylococcus aureus colonization in children and adolescents admitted to CHEO
Paediatrics and Child Health

Detection of plasmid-mediated KPC-producing Klebsiella pneumoniae in Ottawa, Canada: Evidence of intrahospital transmission
Journal of Clinical Microbiology
DOI: 10.1128/JCM.00098-09

Assessment of flocked swabs for use in identification of streptococcal pharyngitis
Journal of Clinical Microbiology
DOI: 10.1128/JCM.01163-09

Protocol for management of imported pediatric malaria decreases time to medication administration
Pediatric Infectious Disease Journal
DOI: 10.1097/INF.0b013e3181a3d12f

Index of suspicion.
Pediatrics in review / American Academy of Pediatrics

Seasonal timing of the Royal College examination in general paediatrics: A survey of residents' preferences
Paediatrics and Child Health

Case 2: Newborn with jaundice and "hyperglycemia"
Paediatrics and Child Health


Gastrointestinal Infections in the Arctic
Nunavut has an unusually high infection rate of cryptosporidium, a parasite that causes abdominal cramps and diarrhea. Children in the region are particularly impacted by these infections. When coupled with malnutrition, the parasite could affect early brain development. I am involved in a registry aimed at documenting enteric infections in the Canadian Arctic and am also leading a prospective study to investigate outcomes of pediatric cryptosporidium infections in Northern communities.

Improving Neonatal Care in Malawi
Malawi has the highest preterm delivery rate (18%) in the world. Inadequate newborn care at the facility level, particularly care of preterm infants, has resulted in an unacceptably high neonatal mortality rate in Malawi. I am a co-principal investigator on a project aimed at implementing various simple, life-saving, evidence-based interventions into routine clinical practice at Malawi hospitals.We hope that our program will result in reduced neonatal mortality and that our knowledge can be applied to other sub-saharan countries.

Point of Care Testing of Gastroenteritis in Botswana:
I am leading a team of collaborators from the University of Pennsylvania, University of Botswana and McMaster that plans to design an innovative, user- and patient-friendly sample collection method that will allow for point of care testing for gastroenteritis. Combined with more recent, highly sensitive detection techniques, this work could have immediate impact in much of the world where diarrheal disease remains deadly and for the large part undiagnosed.


2015 Apr - 2018 Mar. Yansouni, C (PI), Goldfarb, DM (co-PI), Diarrheal Illness and Enteric Infections Among Young Children in Nunavik and Nunavut, ArcticNet PhaseIV, Research - $120,000 (awarded)

2015 Apr - 2020 Mar. Dube, Q (PI), Goldfarb, DM (co-PI), Integrating a Neonatal Health Care Package in Malawi, International Development Research Centre/CIHR - $1,000,000 (awarded)

2015 Jan - 2016 Jan. Goldfarb DM (PI), Building an Arctic Enteric Infections Research Agenda. Canadian Institutes of Health Research Planning and Dissemination Grant, $12,000

Honours & Awards

2008 University of Ottawa, Dept of Pathology & Lab Medicine Annual Research Day - 2nd prize

2008 Children’s Hospital of Eastern Ontario, Popham Fellowship

2008 Children’s Hospital of Eastern Ontario Research Institute, Best Sub-specialty Resident Presentation

Research Group Members

Haya Abuzuluf
Bronwyn Barker
Abdullah Hafeez, Clinical Trainee
Margaret Mokomane, Doctoral student
Moses Vurayai, Master's student
Celia Walker, Research Assistant
Emilia de Melo, Master's student