- Overview
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Although the neonate heart is completely responsible for delivering blood to the body, it is still immature in many respects. This is particularly true of the cardiac contractile system and its regulatory mechanisms. The strength of cardiac contraction is determined by the amount of calcium (Ca2+) delivered to the contractile element. Thus the levels of Ca2+ inside each cell (or cardiomyocyte) rise and fall each beat, and peak value can vary substantially in response to physiological needs and/or hormones such as adrenaline. How this is achieved in the neonate heart, although poorly understood, is quite different from the adult heart. This has clinical implications; for example, in children with congenital heart disease (present in 1% of live births), the heart must often be arrested during surgical correction. However, these techniques are largely derived from our understanding of the adult heart. We hope to improve the success rate of surgical correction, and better understand “normal” heart development and the deviations that occur in congenital heart diseases.
- Publications
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Developing a soft micropatterned substrate to enhance maturation of human induced pluripotent stem cell-derived cardiomyocytes
Acta Biomaterialia
Yasaman Maaref and Shayan Jannati and Farah Jayousi and Philipp Lange and Mohsen Akbari and Mu Chiao and Glen F Tibbits
DOI: 10.1016/j.actbio.2024.10.029
10/2024The effect of Mg2+ on Ca2+ binding to cardiac troponin C in hypertrophic cardiomyopathy associated TNNC1 variants
The FEBS Journal
Kaveh Rayani and Eric R. Hantz and Omid Haji-Ghassemi and Alison Y. Li and Anne M. Spuches and Filip Van Petegem and R. John Solaro and Steffen Lindert and Glen F. Tibbits
DOI: 10.1111/febs.16578
12/2022Electrophysiological characterization of the hERG R56Q LQTS variant and targeted rescue by the activator RPR260243
Journal of General Physiology
Jacob M. Kemp and Dominic G. Whittaker and Ravichandra Venkateshappa and ZhaoKai Pang and Raj Johal and Valentine Sergeev and Glen F. Tibbits and Gary R. Mirams and Thomas W. Claydon
DOI: 10.1085/jgp.202112923
10/2021The effect of magnesium on calcium binding to cardiac troponin C related hypertrophic cardiomyopathy mutants
Kaveh Rayani and Eric Hantz and Omid Haji-Ghassemi and Alison Yueh Li and Anne Marie Spuches and Filip Van Petegem and R John Solaro and Steffen Lindert and Glen F Tibbits
DOI: 10.1101/2021.05.12.443789
05/2021Binding of calcium and magnesium to human cardiac troponin C
Journal of Biological Chemistry
Kaveh Rayani and Justin Seffernick and Alison Yueh Li and Jonathan P. Davis and Anne Marie Spuches and Filip Van Petegem and R. John Solaro and Steffen Lindert and Glen F. Tibbits
DOI: 10.1016/j.jbc.2021.100350
01/2021Drug screening platform using human induced pluripotent stem cell-derived atrial cardiomyocytes and optical mapping
STEM CELLS Translational Medicine
Marvin G. Gunawan and Sarabjit S. Sangha and Sanam Shafaattalab and Eric Lin and Danielle A. Heims-Waldron and Vassilios J. Bezzerides and Zachary Laksman and Glen F. Tibbits
DOI: 10.1002/sctm.19-0440
01/2021Binding of Calcium and Magnesium to Cardiac Troponin C
K Rayani and JT Seffernick and YA Li and JP Davis and AM Spuches and F Van Petegem and RJ Solaro and S Lindert and GF Tibbits
DOI: 10.1101/2020.06.14.150854
06/2020In vivo characterization of doxycycline-mediated protection of aortic function and structure in a mouse model of Marfan syndrome-associated aortic aneurysm
Scientific Reports
Jason Z. Cui and Ling Lee and Xiaoye Sheng and Fanny Chu and Christine P. Gibson and Taline Aydinian and David C. Walker and George G. S. Sandor and Pascal Bernatchez and Glen F. Tibbits and Cornelis van Breemen and Mitra Esfandiarei
DOI: 10.1038/s41598-018-38235-6
02/2019Modeling Atrial Fibrillation using Human Embryonic Stem Cell-Derived Atrial Tissue
Scientific Reports
Zachary Laksman and Marianne Wauchop and Eric Lin and Stephanie Protze and Jeehoon Lee and Wallace Yang and Farzad Izaddoustdar and Sanam Shafaattalab and Lior Gepstein and Glen F. Tibbits and Gordon Keller and Peter H. Backx
DOI: 10.1038/s41598-017-05652-y
07/2017Changes in the dynamics of the cardiac troponin C molecule explain the effects of Ca2+-sensitizing mutations
Journal of Biological Chemistry
Charles M. Stevens and Kaveh Rayani and Gurpreet Singh and Bairam Lotfalisalmasi and D.Peter Tieleman and Glen F. Tibbits
DOI: 10.1074/jbc.M116.770776
07/2017Erratum: Functional Assessment of Cardiac Responses of Adult Zebrafish (Danio rerio) to Acute and Chronic Temperature Change Using High-Resolution Echocardiography (PLoS ONE (2016) 11:1 (e0145163) DOI: 10.1371/journal.pone.0145163)
PLoS ONE
Lee, L. and Genge, C.E. and Cua, M. and Sheng, X. and Rayani, K. and Beg, M.F. and Sarunic, M.V. and Tibbits, G.F.
DOI: 10.1371/journal.pone.0149741
2016Functional assessment of cardiac responses of adult zebrafish (danio rerio) to acute and chronic temperature change using high-resolution echocardiography
PLoS ONE
Lee, L. and Genge, C.E. and Cua, M. and Sheng, X. and Rayani, K. and Beg, M.F. and Sarunic, M.V. and Tibbits, G.F.
DOI: 10.1371/journal.pone.0145163
2016Construction and use of a zebrafish heart voltage and calcium optical mapping system, with integrated electrocardiogram and programmable electrical stimulation
American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Lin, E. and Craig, C. and Lamothe, M. and Sarunic, M.V. and Beg, M.F. and Tibbits, G.F.
DOI: 10.1152/ajpregu.00001.2015.
2015Automatic cycle averaging for denoising approximately periodic spatiotemporal signals
IEEE Transactions on Medical Imaging
Ding, W. and Lin, E. and Ribeiro, A. and Sarunic, M.V. and Tibbits, G.F. and Beg, M.F.
DOI: 10.1109/TMI.2014.2323201
2014Optical mapping of the electrical activity of isolated adult zebrafish hearts: Acute effects of temperature
American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Lin, E. and Ribeiro, A. and Ding, W. and Hove-Madsen, L. and Sarunic, M.V. and Beg, M.F. and Tibbits, G.F.
DOI: 10.1152/ajpregu.00002.2014
2014Morphological phenotyping of mouse hearts using optical coherence tomography
Journal of Biomedical Optics
Cua, M. and Lin, E. and Lee, L. and Sheng, X. and Wong, K.S.K. and Tibbits, G.F. and Beg, M.F. and Sarunic, M.V.
DOI: 10.1117/1.JBO.19.11.116007
2014Adult teleost heart expresses two distinct troponin C paralogs: Cardiac TnC and a novel and teleost-specific ssTnC in a chamber- and temperature-dependent manner
Physiological Genomics
Genge, C.E. and Davidson, W.S. and Tibbits, G.F.
DOI: 10.1152/physiolgenomics.00074.2013
2013Familial hypertrophic cardiomyopathy related cardiac troponin C L29Q mutation alters length-dependent activation and functional effects of phosphomimetic troponin I
PLoS ONE
Li, A.Y. and Stevens, C.M. and Liang, B. and Rayani, K. and Little, S. and Davis, J. and Tibbits, G.F.
DOI: 10.1371/journal.pone.0079363
2013The structure of cardiac troponin C regulatory domain with bound Cd 2+ reveals a closed conformation and unique ion coordination
Acta Crystallographica Section D: Biological Crystallography
Zhang, X.L. and Tibbits, G.F. and Paetzel, M.
DOI: 10.1107/S0907444913001182
2013On identification of sinoatrial node in zebrafish heart based on functional time series from optical mapping
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
Ding, W. and Lin, E. and Ribeiro, A. and Sarunic, M.V. and Tibbits, G.F. and Beg, M.F.
DOI: 10.1109/EMBC.2013.6611048
2013Isolation and characterization of atrioventricular nodal cells from neonate rabbit heart
Circulation: Arrhythmia and Electrophysiology
Sheng, X.Y. and Qu, Y. and Dan, P. and Lin, E. and Korthout, L. and Bradford, A. and Hove-Madsen, L. and Sanatani, S. and Tibbits, G.F.
DOI: 10.1161/CIRCEP.111.964056
2011Colocalization of voltage-gated Na+ channels with the Na +/Ca2+ exchanger in rabbit cardiomyocytes during development
American Journal of Physiology - Heart and Circulatory Physiology
Gershome, C. and Lin, E. and Kashihara, H. and Hove-Madsen, L. and Tibbits, G.F.
DOI: 10.1152/ajpheart.00798.2010
2011Crystal structure of cardiac troponin C regulatory domain in complex with cadmium and deoxycholic acid reveals novel conformation
Journal of Molecular Biology
Li, A.Y. and Lee, J. and Borek, D. and Otwinowski, Z. and Tibbits, G.F. and Paetzel, M.
DOI: 10.1016/j.jmb.2011.08.049
2011Calcium handling in zebrafish ventricular myocytes
American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Zhang, P.-C. and Llach, A. and Sheng, X.Y. and Hove-Madsen, L. and Tibbits, G.F.
DOI: 10.1152/ajpregu.00377.2010
2011Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of iks
Journal of General Physiology
Eldstrom, J. and Xu, H. and Werry, D. and Kang, C. and Loewen, M.E. and Degenhardt, A. and Sanatani, S. and Tibbits, G.F. and Sanders, C. and Fedida, D.
DOI: 10.1085/jgp.200910351
2010Characterization of zebrafish (Danio rerio) NCX4: A novel NCX with distinct electrophysiological properties
American Journal of Physiology - Cell Physiology
On, C. and Marshall, C.R. and Perry, S.F. and Hoa, D.L. and Yurkov, V. and Omelchenko, A. and Hnatowich, M. and Hryshko, L.V. and Tibbits, G.F.
DOI: 10.1152/ajpcell.00455.2008
2009Distribution patterns of the Na+-Ca2+ exchanger and caveolin-3 in developing rabbit cardiomyocytes
Cell Calcium
Lin, E. and Hung, V.H.Y. and Kashihara, H. and Dan, P. and Tibbits, G.F.
DOI: 10.1016/j.ceca.2009.01.001
2009Ontogeny of Ca2+-induced Ca2+ release in rabbit ventricular myocytes
American Journal of Physiology - Cell Physiology
Huang, J. and Hove-Madsen, L. and Tibbits, G.F.
DOI: 10.1152/ajpcell.00417.2007
2008Hyperpolarization-activated cyclic nucleotide-modulated 'HCN' channels confer regular and faster rhythmicity to beating mouse embryonic stem cells
Journal of Physiology
Qu, Y. and Whitaker, G.M. and Hove-madsen, L. and Tibbits, G.F. and Accili, E.A.
DOI: 10.1113/jphysiol.2007.144329
2008Gene structure evolution of the Na+-Ca2+ exchanger (NCX) family
BMC Evolutionary Biology
On, C. and Marshall, C.R. and Chen, N. and Moyes, C.D. and Tibbits, G.F.
DOI: 10.1186/1471-2148-8-127
2008Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility
Physiological Genomics
Liang, B. and Chung, F. and Qu, Y. and Pavlov, D. and Gillis, T.E. and Tikunova, S.B. and Davis, J.P. and Tibbits, G.F.
DOI: 10.1152/physiolgenomics.00154.2007
2008A KCNQ1 V205M missense mutation causes a high rate of long QT syndrome in a First Nations community of northern British Columbia: A community-based approach to understanding the impact
Genetics in Medicine
Arbour, L. and Rezazadeh, S. and Eldstrom, J. and Weget-Simms, G. and Rupps, R. and Dyer, Z. and Tibbits, G. and Accili, E. and Casey, B. and Kmetic, A. and Sanatani, S. and Fedida, D.
DOI: 10.1097/GIM.0b013e31817c6b19
2008Functional and evolutionary relationships of troponin C
Physiological Genomics
Gillis, T.E. and Marshall, C.R. and Tibbits, G.F.
DOI: 10.1152/physiolgenomics.00197.2007
2007SR Ca2+ refilling upon depletion and SR Ca2+ uptake rates during development in rabbit ventricular myocytes
American Journal of Physiology - Cell Physiology
Huang, J. and Hove-Madsen, L. and Tibbits, G.F.
DOI: 10.1152/ajpcell.00241.2007
2007Real-time monitoring of intracellular calcium dynamic mobilization of a single cardiomyocyte in a microfluidic chip pertaining to drug discovery
Electrophoresis
Li, X. and Huang, J. and Tibbits, G.F. and Li, P.C.H.
DOI: 10.1002/elps.200700312
2007Three-dimensional distribution of cardiac Na+-Ca2+ exchanger and ryanodine receptor during development
Biophysical Journal
Dan, P. and Lin, E. and Huang, J. and Biln, P. and Tibbits, G.F.
DOI: 10.1529/biophysj.107.104943
2007L-type Ca2+ channel function and expression in neonatal rabbit ventricular myocytes
American Journal of Physiology - Heart and Circulatory Physiology
Huang, J. and Xu, L. and Thomas, M. and Whitaker, K. and Hove-Madsen, L. and Tibbits, G.F.
DOI: 10.1152/ajpheart.01093.2005
2006Store-operated Ca2+ entry modulates sarcoplasmic reticulum Ca2+ loading in neonatal rabbit cardiac ventricular myocytes
American Journal of Physiology - Cell Physiology
Huang, J. and Van Breemen, C. and Kuo, K.-H. and Hove-Madsen, L. and Tibbits, G.F.
DOI: 10.1152/ajpcell.00226.2005
2006Increasing mammalian cardiomyocyte contractility with residues identified in trout troponin C
Physiological Genomics
Gillis, T.E. and Liang, B. and Chung, F. and Tibbits, G.F.
DOI: 10.1152/physiolgenomics.00007.2005
2005CDNA cloning and expression of the cardiac Na+/Ca2+ exchanger from mozambique tilapia (Oreochromis mossambicus) reveal a teleost membrane transporter with mammalian temperature dependence
Journal of Biological Chemistry
Marshall, C.R. and Pan, T.-C. and Le, H.D. and Omelchenko, A. and Hwang, P.P. and Hryshko, L.V. and Tibbits, G.F.
DOI: 10.1074/jbc.M504807200
2005Phylogeny of Na+/Ca2+ exchanger (NCX) genes from genomic data identifies new gene duplications and a new family member in fish species
Physiological Genomics
Marshall, C.R. and Fox, J.A. and Butland, S.L. and Ouellette, B.F.F. and Brinkman, F.S.L. and Tibbits, G.F.
DOI: 10.1152/physiolgenomics.00286.2004
2005Na+/Ca2+ exchange activity in neonatal rabbit ventricular myocytes
American Journal of Physiology - Cell Physiology
Huang, J. and Hove-Madsen, L. and Tibbits, G.F.
DOI: 10.1152/ajpcell.00183.2004
2005Deconvolution of confocal images of dihydropyridine and ryanodine receptors in developing cardiomyocytes
Journal of Applied Physiology
Sedarat, F. and Lin, E. and Moore, E.D.W. and Tibbits, G.F.
DOI: 10.1152/japplphysiol.00089.2004
2004Effect of ß-adrenergic stimulation on the relationship between membrane potential, intracellular [Ca2+] and sarcoplasmic reticulum Ca2+ uptake in rainbow trout atrial myocytes
Journal of Experimental Biology
Llach, A. and Huang, J. and Sederat, F. and Tort, L. and Tibbits, G. and Hove-Madsen, L.
DOI: 10.1242/jeb.00884
2004Effect of Temperature on the Structure of Trout Troponin C
Biochemistry
Blumenschein, T.M.A. and Gillis, T.E. and Tibbits, G.F. and Sykes, B.D.
DOI: 10.1021/bi035504z
2004Sequence mutations in teleost cardiac troponin C that are permissive of high Ca2+ affinity of site II
American Journal of Physiology - Cell Physiology
Gillis, T.E. and Moyes, C.D. and Tibbits, G.F.
2003Effect of temperature and the F27W mutation on the Ca2+ activated structural transition of trout cardiac troponin C
Biochemistry
Gillis, T.E. and Blumenschein, T.M.A. and Sykes, B.D. and Tibbits, G.F.
DOI: 10.1021/bi0340494
2003Triggering of sarcoplasmic reticulum Ca2+ release and contraction by reverse mode Na+/Ca2+ exchange in trout atrial myocytes
American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Hove-Madsen, L. and Llach, A. and Tibbits, G.F. and Tort, L.
2003Na+/H+ exchange inhibition with HOE 642 improves recovery of the injured neonatal rabbit heart
Canadian Journal of Cardiology
Sett, S.S. and Galanopoulos, P.T. and Kashihara, H. and Talling, D.N. and LeBlanc, J.G. and Tibbits, G.F.
2003Temperature dependence of cardiac Na+/Ca2+ exchanger
Annals of the New York Academy of Sciences
Marshall, C. and Elias, C. and Xue, X.-H. and Le, H.D. and Omelchenko, A. and Hryshko, L.V. and Tibbits, G.F.
2002Determinants of cardiac Na+/Ca2+ exchanger temperature dependence: NH2-terminal transmembrane segments
American Journal of Physiology - Cell Physiology
Marshall, C. and Elias, C. and Xue, X.-H. and Le, H.D. and Omelchenko, A. and Hryshko, L.V. and Tibbits, G.F.
2002Beating the cold: The functional evolution of troponin C in teleost fish
Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Gillis, T.E. and Tibbits, G.F.
DOI: 10.1016/S1095-6433(02)00046-6
2002Ontogeny of excitation - Contraction coupling in the mammalian heart
Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology
Tibbits, G.F. and Xu, L. and Sedarat, F.
DOI: 10.1016/S1095-6433(02)00128-9
2002Temperature dependence of cloned mammalian and salmonid cardiac NA+/CA2+ exchanger isoforms
American Journal of Physiology - Cell Physiology
Elias, C.L. and Xue, X.-H. and Marshall, C.R. and Omelchenko, A. and Hryshko, L.V. and Tibbits, G.F.
2001Effects of diabetes and hypertension on myocardial Na+-Ca2+ exchange
Canadian Journal of Physiology and Pharmacology
Kashihara, H. and Shi, Z.Q. and Yu, J.Z. and McNeill, J.H. and Tibbits, G.F.
2000Evolutionary and physiological variation in cardiac troponin C in relation to thermal strategies of fish
Physiological and Biochemical Zoology
Yang, H. and Velema, J. and Hedrick, M.S. and Tibbits, G.F. and Moyes, C.D.
DOI: 10.1086/318095
2000Colocalization of dihydropyridine and ryanodine receptors in neonate rabbit heart using confocal microscopy
American Journal of Physiology - Heart and Circulatory Physiology
Sedarat, F. and Xu, L. and Moore, E.D.W. and Tibbits, G.F.
2000Ca2+ binding to cardiac troponin C: Effects of temperature and pH on mammalian and salmonid isoforms
American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Gillis, T.E. and Marshall, C.R. and Xue, X.-H. and Borgford, T.J. and Tibbits, G.F.
2000Cloning, expression, and characterization of the trout cardiac Na+/Ca2+ exchanger
American Journal of Physiology - Cell Physiology
Xue, X.-H. and Hryshko, L.V. and Nicoll, D.A. and Philipson, K.D. and Tibbits, G.F.
1999Cloning and sequencing of complementary DNA for fatty acid binding protein from rainbow trout heart
Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
Ando, S. and Xue, X.-H. and Tibbits, G.F. and Haunerland, N.H.
DOI: 10.1016/S0305-0491(97)00309-X
1998Cloning and expression of salmon cardiac troponin C: Titration of the low-affinity Ca2+-binding site using a tryptophan mutant
Biochemistry
Moyes, C.D. and Borgford, T. and LeBlanc, L. and Tibbits, G.F.
DOI: 10.1021/bi9607057
1996Dihydropyridine and ryanodine binding in ventricles from rat, trout, dogfish and hagfish
Journal of Experimental Biology
Thomas, M.J. and Hamman, B.N. and Tibbits, G.F.
1996Effects of doxorubicin, 4'-epirubicin, and antioxidant enzymes on the contractility of isolated cardiomyocytes
Canadian Journal of Physiology and Pharmacology
Chan, E.M. and Thomas, M.J. and Bandy, B. and Tibbits, G.F.
DOI: 10.1139/cjpp-74-8-904
1996Towards a molecular explanation of the high performance of the tuna heart
Comparative Biochemistry and Physiology - A Physiology
Tibbits, G.F.
DOI: 10.1016/0300-9629(95)02055-1
1996cGMP elevation does not mediate muscarinic agonist-induced negative inotropy in rat ventricular cardiomyocytes
American Journal of Physiology - Heart and Circulatory Physiology
MacDonell, K.L. and Tibbits, G.F. and Diamond, J.
1995Cellular functions of diabetic cardiomyocytes: Contractility, rapid- cooling contracture, and ryanodine binding
American Journal of Physiology - Heart and Circulatory Physiology
Yu, Z. and Tibbits, G.F. and McNeill, J.H.
1994Effect of temperature and temperature acclimation on the ryanodine sensitivity of the trout myocardium
Journal of Comparative Physiology B
Keen, J.E. and Vianzon, D.-M. and Farrell, A.P. and Tibbits, G.F.
DOI: 10.1007/BF00714580
1994Temperature and pH effects on Ca2+ sensitivity of cardiac myofibrils: A comparison of trout with mammals
American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Churcott, C.S. and Moyes, C.D. and Bressler, B.H. and Baldwin, K.M. and Tibbits, G.F.
1994Temperature dependence of unitary properties of an ATP-dependent potassium channel in cardiac myocytes
Biophysical Journal
McLarnon, J.G. and Hamman, B.N. and Tibbits, G.F.
19936 Excitation-Contraction Coupling in the Teleost Heart
Fish Physiology
Tibbits, G.F. and Moyes, C.D. and Hove-Madsen, L.
DOI: 10.1016/S1546-5098(08)60336-2
1992Characterization of myocardial Na+-Ca2+ exchange in rainbow trout
American Journal of Physiology - Cell Physiology
Tibbits, G.F. and Philipson, K.D. and Kashihara, H.
1992Regulation of myocardial contractility
Medicine and Science in Sports and Exercise
Tibbits, G.F. and Hamman, B.N.
1991Ca2+ transport in myocardial sarcolemma from rainbow trout
American Journal of Physiology - Regulatory Integrative and Comparative Physiology
Tibbits, G.F. and Kashihara, H. and Thomas, M.J. and Keen, J.E. and Farrell, A.P.
1990Ca<sup>2+</sup> transport across the plasma membrane of striated muscle
Medicine and Science in Sports and Exercise
Tibbits, G.F. and Thomas, M.J.
1989Effects of active oxygen generated by DTT Fe2+ on cardiac Na+ Ca2+ exchange and membrane permeability to Ca2+
Journal of Molecular and Cellular Cardiology
Shi, Z.Q. and Davison, A.J. and Tibbits, G.F.
DOI: 10.1016/0022-2828(89)90799-2
1989Na+-Ca2+ exchange in cardiac sarcolemma: modulation of Ca2+ affinity by exercise.
The American journal of physiology
Tibbits, G.F. and Kashihara, H. and O'Reilly, K.
1989Na+-Ca2+ exchange in cardiac sarcolemma: Modulation of Ca2+ affinity by exercise
American Journal of Physiology - Cell Physiology
Tibbits, G.F. and Kashihara, H. and O'Reilly, K.
1989Active oxygen in neuromuscular disorders
Molecular and Cellular Biochemistry
Davison, A. and Tibbits, G. and Shi, Z. and Moon, J.
DOI: 10.1007/BF00421055
1988The effect of activity on calcium-mediated events in striated muscle
Exercise and Sport Sciences Reviews
Klug, G.A. and Tibbits, G.F.
1988Na+-dependent alkaline earth metal uptake in cardiac sarcolemmal vesicles
BBA - Biomembranes
Tibbits, G.F. and Philipson, K.D.
DOI: 10.1016/0005-2736(85)90035-5
1985Regulation of myocardial contractility in exhaustive exercise
Medicine and Science in Sports and Exercise
Tibbits, G.F.
1985Cardiac sarcolemma: Compositional adaptation to exercise
Science
Tibbits, G.F. and Nagatomo, T. and Sasaki, M. and Barnard, R.J.
1981Influence of exercise on excitation-contraction coupling in rat myocardium
American Journal of Physiology - Heart and Circulatory Physiology
Tibbits, G.F. and Barnard, R.J. and Baldwin, K.M.
1981Influence of exercise on excitation-contraction coupling in rat myocardium.
The American journal of physiology
Tibbits, G.F. and Barnard, R.J. and Baldwin, K.M. and Cugalj, N. and Roberts, N.K.
1981Characterization of rat myocardial sarcolemma
Journal of Molecular and Cellular Cardiology
Tibbits, G.F. and Sasaki, M. and Ikeda, M. and Shimada, K. and Tsuruhara, T. and Nagatomo, T.
DOI: 10.1016/0022-2828(81)90295-9
1981Adaptation of the rat myocardium to endurance training
Journal of Applied Physiology Respiratory Environmental and Exercise Physiology
Tibbits, G. and Koziol, B.J. and Roberts, N.K. and Baldwin, K.M. and Barnard, R.J.
1978 - Research
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Regulation of cardiac myofilament sensitivity to calcium
Heart and Stroke Foundation funded project that addresses the structure function relationship of troponin C and its ability to bind Ca2+, a primary determinant of cardiac contractility. The research involves making mutations of troponin C and understanding how the structural changes that result affect Ca2+ binding to the regulatory domain of the molecule. Information from this project will be directed to the development of a novel class of Ca2+-senstizing drugs which may be used to treat heart failure.Ontogeny of myocardial excitation- contraction coupling mechanisms
CIHR funded project with the objectives of determining the molecular and cellular changes in cardiomyocytes from the earliest stages post-partum until adulthood with an eye to understanding certain congenital heart diseases.Molecular mechanisms of electrogenesis in the neonate heart
CIHR funded project focusing on the molecular and cellular mechansms of junctional ectopic tachycardia (JET). JET is an arrhythmia that occurs with relatively high frequency in neonates after open heart surgery. The etiology of JET is poorly understood and as a consequence existing treatments are non-specific and often lack efficacy.GrantsNSERC Discovery Grant - Project: "Regulation of contractility in the teleost heart" (2014)
Honours & AwardsTier I Canada Research Chair in Molecular Cardiac Physiology
Research Group MembersNasim Abrishami Moghaddam, Graduate Student
Alia Arslanova, PhD Student
Parisa Asghari, Research associates
Hosna Babini, Research Assistant
Mariam Butt, Masters Student
Saif Dababneh, Graduate Student (MD/PhD)
Saba Fadaei, Research Assistant
Homa Hamledari
Dina Hosseini, Research Assistant
Kosar Jabbari, Postdoctoral Fellow
Shayan Jannati
Verónica Jiménez Sábado, Postdoctoral Fellow
Yasaman Maaref
Phoebe McNair-Luxon, Co-op Student
Behnam Panahi
Mika Pang, Student volunteer
Sanjana Singh, Master's Student
Brady Surbey, Graduate student
Jing Wang, Lab Manager
Emerson Yu, Volunteer
Crafting beating heart cells to deliver personalized treatments for kids with hypertrophic cardiomyopathy
Researchers at BC Children's Hospital Research Institute are working with human-induced pluripotent stem cells to develop safer and more effective treatments for kids with hypertrophic cardiomyopathy.
