Selected publications

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor. MacDonald KG, Hoeppli RE, Huang Q, Gillies J, Luciani DS, Orban PC, Broady R, Levings MK. J Clin Invest. 2016 Apr 1;126(4):1413-24. doi: 10.1172/JCI82771. PMID: 26999600 Free PMC Article

T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression. Patterson SJ, Pesenacker AM, Wang AY, Gillies J, Mojibian M, Morishita K, Tan R, Kieffer TJ, Verchere CB, Panagiotopoulos C, Levings MK. J Clin Invest. 2016 Mar 1;126(3):1039-51. doi: 10.1172/JCI83987. PMID: 26854929 Free PMC Article

A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes. Pesenacker AM, Wang AY, Singh A, Gillies J, Kim Y, Piccirillo CA, Nguyen D, Haining WN, Tebbutt SJ, Panagiotopoulos C, Levings MK. Diabetes. 2016 Apr;65(4):1031-9. doi: 10.2337/db15-0572.

Discarded Human Thymus Is a Novel Source of Stable and Long-Lived Therapeutic Regulatory T Cells. Dijke IE, Hoeppli RE, Ellis T, Pearcey J, Huang Q, McMurchy AN, Boer K, Peeters AM, Aubert G, Larsen I, Ross DB, Rebeyka I, Campbell A, Baan CC, Levings MK, West LJ. Am J Transplant. 2016 Jan;16(1):58-71. doi: 10.1111/ajt.13456. PMID: 26414799

Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10-Dependent Mechanism. Yao Y, Vent-Schmidt J, McGeough MD, Wong M, Hoffman HM, Steiner TS, Levings MK. J Immunol. 2015 Jul 15;195(2):488-97. doi: 10.4049/jimmunol.1403225. PMID: 26056255 Free PMC Article

IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+ T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance. Han JM, Wu D, Denroche HC, Yao Y, Verchere CB, Levings MK. J Immunol. 2015 May 15;194(10):4777-83. doi: 10.4049/jimmunol.1500020. PMID: 25870243 Free PMC Article