To view Dr. Megan Levings' Bibliography click here

 

Selected publications

Characterization of Regulatory T Cells in Obese Omental Adipose Tissue in Humans. Wu, D., J. M. Han, X. Yu, A. J. Lam, R. E. Hoeppli, A. M. Pesenacker, . . . M. K. Levings. Eur J Immunol, vol. 49(2), 336-347. (2019)
doi:10.1002/eji.201847570.

Innate Control of Tissue-Reparative Human Regulatory T Cells. Lam, A. J., K. N. MacDonald, A. M. Pesenacker, S. C. Juvet, K. A. Morishita, B. Bressler, . . . M. K. Levings. J Immunol. (2019)
doi:10.4049/jimmunol.1801330.

Methods to Manufacture Regulatory T Cells for Cell Therapy. MacDonald, K. N., J. M. Piret and M. K. Levings. Clin Exp Immunol. (2019)
doi:10.1111/cei.13297.

Systematic Testing and Specificity Mapping of Alloantigen-Specific Chimeric Antigen Receptors in Regulatory T Cells. Dawson, N. A., C. Lamarche, R. E. Hoeppli, P. Bergqvist, V. C. Fung, E. McIver, . . . M. K. Levings. JCI Insight, vol. 4(6). (2019)
doi:10.1172/jci.insight.123672.

Tailoring the Homing Capacity of Human Tregs for Directed Migration to Sites of Th1-Inflammation or Intestinal Regions. Hoeppli, R. E., K. N. MacDonald, P. Leclair, V. C. W. Fung, M. Mojibian, J. Gillies, . . . M. K. Levings. Am J Transplant, vol. 19(1), 62-76. (2019)
doi:10.1111/ajt.14936.

Treg Gene Signatures Predict and Measure Type 1 Diabetes Trajectory. Pesenacker, A. M., V. Chen, J. Gillies, C. Speake, A. K. Marwaha, A. Sun, . . . M. K. Levings. JCI Insight, vol. 4(6). (2019)
doi:10.1172/jci.insight.123879.

Characterization of Regulatory T Cells in Obese Omental Adipose Tissue in Humans. Wu, D., J. M. Han, X. Yu, A. J. Lam, R. E. Hoeppli, A. M. Pesenacker, . . . M. K. Levings. Eur J Immunol. (2018)
doi:10.1002/eji.201847570.

Engineering Therapeutic T Cells to Suppress Alloimmune Responses Using Tcrs, Cars, or Bars. Sicard, A., M. K. Levings and D. W. Scott. Am J Transplant, vol. 18(6), 1305-1311. (2018)
doi:10.1111/ajt.14747.

Guiding Regulatory T Cells to the Allograft. Lamarche, C. and M. K. Levings. Curr Opin Organ Transplant, vol. 23(1), 106-113. (2018)
doi:10.1097/MOT.0000000000000483.

An Optimized Method to Measure Human Foxp3(+) Regulatory T Cells from Multiple Tissue Types Using Mass Cytometry. Dawson, N. A. J., A. J. Lam, L. Cook, R. E. Hoeppli, R. Broady, A. M. Pesenacker and M. K. Levings. Eur J Immunol, vol. 48(8), 1415-1419. (2018)
doi:10.1002/eji.201747407.

Regulatory T-Cells Drive Immune Dysfunction in Cll. Lad, D., R. Hoeppli, Q. Huang, R. Garcia, L. Xu, C. Toze, . . . M. Levings. Leuk Lymphoma, vol. 59(2), 486-489. (2018
doi:10.1080/10428194.2017.1330475.

A Standardized Immune Phenotyping and Automated Data Analysis Platform for Multicenter Biomarker Studies. Ivison, S., M. Malek, R. V. Garcia, R. Broady, A. Halpin, M. Richaud, . . . M. K. Levings. JCI Insight, vol. 3(23). (2018)
doi:10.1172/jci.insight.121867.

Taking Regulatory T-Cell Therapy One Step Further. Sicard, A., D. A. Boardman and M. K. Levings. Curr Opin Organ Transplant, vol. 23(5), 509-515. (2018)
doi:10.1097/MOT.0000000000000566.

Adipose-Tissue Regulatory T Cells: Critical Players in Adipose-Immune Crosstalk. Becker, M., M. K. Levings and C. Daniel. Eur J Immunol. (2017)
doi:10.1002/eji.201646739.

Antigen-Specific Regulatory T Cells: Are Police Cars the Answer? Dawson, N. A. J. and M. K. Levings. Transl Res, vol. 187, 53-58. (2017)
doi:10.1016/j.trsl.2017.06.009.

Biomarker-Guided Stratification of Autoimmune Patients for Biologic Therapy. Ivison, S., C. des Rosiers, S. Lesage, J. D. Rioux and M. K. Levings. Curr Opin Immunol, vol. 49, 56-63. (2017)
doi:10.1016/j.coi.2017.09.006.

Cd56bright Nk Regulatory Cells in Filgrastim Primed Donor Blood or Marrow Products Regulate Chronic Gvhd: Cbmtg Randomized 0601 Study Results. Kariminia, A., S. Ivison, B. Ng, J. Rozmus, S. Sung, A. Varshney, . . . K. R. Schultz. Haematologica. (2017)
doi:10.3324/haematol.2017.170928.

Circulating Gluten-Specific Foxp3+Cd39+ Regulatory T Cells Have Impaired Suppressive Function in Patients with Celiac Disease. Cook, L., C. M. L. Munier, N. Seddiki, D. van Bockel, N. Ontiveros, M. Y. Hardy, . . . A. D. Kelleher. J Allergy Clin Immunol. (2017)
doi:10.1016/j.jaci.2017.02.015.

Effect of Ex Vivo-Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance across Mhc Barriers in Cynomolgus Macaques. Duran-Struuck, R., H. P. Sondermeijer, L. Buhler, P. Alonso-Guallart, J. Zitsman, Y. Kato, . . . M. Sykes. Transplantation, vol. 101(2), 274-283. (2017)
doi:10.1097/TP.0000000000001559.

Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells. Dawson, N. A. J., J. Vent-Schmidt and M. K. Levings. Front Immunol, vol. 8, 1460. (2017)
doi:10.3389/fimmu.2017.01460.

Guidelines for the Use of Flow Cytometry and Cell Sorting in Immunological Studies. Cossarizza, A., H. D. Chang, A. Radbruch, M. Akdis, I. Andra, F. Annunziato, . . . J. Zimmermann. Eur J Immunol, vol. 47(10), 1584-1797. (2017)
doi:10.1002/eji.201646632.

Harnessing Advances in T Regulatory Cell Biology for Cellular Therapy in Transplantation. Lam, A. J., R. E. Hoeppli and M. K. Levings. Transplantation, vol. 101(10), 2277-2287. (2017)
doi:10.1097/TP.0000000000001757.

The Outstanding Questions in Transplantation: It's About Time... Azzi, J., G. Raimondi, V. Mas, L. V. Riella, N. Elfadawy, K. Safa, . . . M. L. Alegre. Am J Transplant. (2017)
doi:10.1111/ajt.14450.

Thymic Progenitors of Tcralphabeta+ Cd8alphaalpha Intestinal Intraepithelial Lymphocytes Require Rasgrp1 for Development. Golec, D. P., R. E. Hoeppli, L. M. Henao Caviedes, J. McCann, M. K. Levings and T. A. Baldwin. J Exp Med, vol. 214(8), 2421-2435. (2017)
doi:10.1084/jem.20170844.

Alloantigen-Specific Regulatory T Cells Generated with a Chimeric Antigen Receptor. MacDonald, K. G., R. E. Hoeppli, Q. Huang, J. Gillies, D. S. Luciani, P. C. Orban, . . . M. K. Levings. J Clin Invest, vol. 126(4), 1413-1424. (2016)
doi:10.1172/JCI82771.

Discarded Human Thymus Is a Novel Source of Stable and Long-Lived Therapeutic Regulatory T Cells. Dijke, I. E., R. E. Hoeppli, T. Ellis, J. Pearcey, Q. Huang, A. N. McMurchy, . . . L. J. West. Am J Transplant, vol. 16(1), 58-71. (2016)
doi:10.1111/ajt.13456.

Filgrastim-Stimulated Bone Marrow Compared with Filgrastim-Mobilized Peripheral Blood in Myeloablative Sibling Allografting for Patients with Hematologic Malignancies: A Randomized Canadian Blood and Marrow Transplant Group Study. Couban, S., M. Aljurf, S. Lachance, I. Walker, C. Toze, M. Rubinger, . . . K. R. Schultz. Biol Blood Marrow Transplant, vol. 22(8), 1410-1415. (2016)
doi:10.1016/j.bbmt.2016.04.017.

Heterogeneity of Chronic Graft-Versus-Host Disease Biomarkers: Association with Cxcl10 and Cxcr3+ Nk Cells. Kariminia, A., S. G. Holtan, S. Ivison, J. Rozmus, M. J. Hebert, P. J. Martin, . . . K. R. Schultz. Blood, vol. 127(24), 3082-3091. (2016)
doi:10.1182/blood-2015-09-668251.

How Antigen Specificity Directs Regulatory T-Cell Function: Self, Foreign and Engineered Specificity. Hoeppli, R. E., K. G. MacDonald, M. K. Levings and L. Cook. HLA, vol. 88(1-2), 3-13. (2016)
doi:10.1111/tan.12822.

Obesity-Associated Adipose Tissue Inflammation and Transplantation. Wu, D., N. A. Dawson and M. K. Levings. Am J Transplant, vol. 16(3), 743-750. (2016)
doi:10.1111/ajt.13578.

A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children with New-Onset Type 1 Diabetes. Pesenacker, A. M., A. Y. Wang, A. Singh, J. Gillies, Y. Kim, C. A. Piccirillo, . . . M. K. Levings. Diabetes, vol. 65(4), 1031-1039. (2016)
doi:10.2337/db15-0572.

The Role of Foxp3 in Autoimmunity. Pesenacker, A. M., L. Cook and M. K. Levings. Curr Opin Immunol, vol. 43, 16-23. (2016)
doi:10.1016/j.coi.2016.07.004.

T Regulatory Cell Chemokine Production Mediates Pathogenic T Cell Attraction and Suppression. Patterson, S. J., A. M. Pesenacker, A. Y. Wang, J. Gillies, M. Mojibian, K. Morishita, . . . M. K. Levings. J Clin Invest, vol. 126(3), 1039-1051. (2016)
doi:10.1172/JCI83987.

Ccl22 Prevents Rejection of Mouse Islet Allografts and Induces Donor-Specific Tolerance. Montane, J., M. Obach, S. Alvarez, L. Bischoff, D. L. Dai, G. Soukhatcheva, . . . C. B. Verchere. Cell Transplant, vol. 24(10), 2143-2154. (2015)
doi:10.3727/096368914X685249.

Control of Tissue-Localized Immune Responses by Human Regulatory T Cells. Pesenacker, A. M., R. Broady and M. K. Levings. Eur J Immunol, vol. 45(2), 333-343. (2015)
doi:10.1002/eji.201344205.

The Environment of Regulatory T Cell Biology: Cytokines, Metabolites, and the Microbiome. Hoeppli, R. E., D. Wu, L. Cook and M. K. Levings. Front Immunol, vol. 6, 61. (2015)
doi:10.3389/fimmu.2015.00061.

IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue St2+ T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance. Han, J. M., D. Wu, H. C. Denroche, Y. Yao, C. B. Verchere and M. K. Levings. J Immunol, vol. 194(10), 4777-4783. (2015)
doi:10.4049/jimmunol.1500020.

Regulatory T Cells Produce Profibrotic Cytokines in the Skin of Patients with Systemic Sclerosis. MacDonald, K. G., N. A. Dawson, Q. Huang, J. V. Dunne, M. K. Levings and R. Broady. J Allergy Clin Immunol, vol. 135(4), 946- e949. (2015)
doi:10.1016/j.jaci.2014.12.1932.

Restimulation after Cryopreservation and Thawing Preserves the Phenotype and Function of Expanded Baboon Regulatory T Cells. Weiner, J., R. Duran-Struuck, J. Zitsman, L. Buhler, H. Sondermeijer, A. N. McMurchy, . . . A. Griesemer. Transplant Direct, vol. 1(1), 1-7. (2015)
doi:10.1097/TXD.0000000000000511.

Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress Nlrp3 Inflammasome Activation Via an Il-10-Dependent Mechanism. Yao, Y., J. Vent-Schmidt, M. D. McGeough, M. Wong, H. M. Hoffman, T. S. Steiner and M. K. Levings. J Immunol, vol. 195(2), 488-497. (2015)
doi:10.4049/jimmunol.1403225.