Selected publications

Characterization of Regulatory T Cells in Obese Omental Adipose Tissue in Humans. Wu, D., J. M. Han, X. Yu, A. J. Lam, R. E. Hoeppli, A. M. Pesenacker, . . . M. K. Levings. Eur J Immunol, vol. 49(2), 336-347. (2019)

Innate Control of Tissue-Reparative Human Regulatory T Cells. Lam, A. J., K. N. MacDonald, A. M. Pesenacker, S. C. Juvet, K. A. Morishita, B. Bressler, . . . M. K. Levings. J Immunol. (2019)

Methods to Manufacture Regulatory T Cells for Cell Therapy. MacDonald, K. N., J. M. Piret and M. K. Levings. Clin Exp Immunol. (2019)

Systematic Testing and Specificity Mapping of Alloantigen-Specific Chimeric Antigen Receptors in Regulatory T Cells. Dawson, N. A., C. Lamarche, R. E. Hoeppli, P. Bergqvist, V. C. Fung, E. McIver, . . . M. K. Levings. JCI Insight, vol. 4(6). (2019)

Tailoring the Homing Capacity of Human Tregs for Directed Migration to Sites of Th1-Inflammation or Intestinal Regions. Hoeppli, R. E., K. N. MacDonald, P. Leclair, V. C. W. Fung, M. Mojibian, J. Gillies, . . . M. K. Levings. Am J Transplant, vol. 19(1), 62-76. (2019)

Treg Gene Signatures Predict and Measure Type 1 Diabetes Trajectory. Pesenacker, A. M., V. Chen, J. Gillies, C. Speake, A. K. Marwaha, A. Sun, . . . M. K. Levings. JCI Insight, vol. 4(6). (2019)

Characterization of Regulatory T Cells in Obese Omental Adipose Tissue in Humans. Wu, D., J. M. Han, X. Yu, A. J. Lam, R. E. Hoeppli, A. M. Pesenacker, . . . M. K. Levings. Eur J Immunol. (2018)

Engineering Therapeutic T Cells to Suppress Alloimmune Responses Using Tcrs, Cars, or Bars. Sicard, A., M. K. Levings and D. W. Scott. Am J Transplant, vol. 18(6), 1305-1311. (2018)

Guiding Regulatory T Cells to the Allograft. Lamarche, C. and M. K. Levings. Curr Opin Organ Transplant, vol. 23(1), 106-113. (2018)

An Optimized Method to Measure Human Foxp3(+) Regulatory T Cells from Multiple Tissue Types Using Mass Cytometry. Dawson, N. A. J., A. J. Lam, L. Cook, R. E. Hoeppli, R. Broady, A. M. Pesenacker and M. K. Levings. Eur J Immunol, vol. 48(8), 1415-1419. (2018)

Regulatory T-Cells Drive Immune Dysfunction in Cll. Lad, D., R. Hoeppli, Q. Huang, R. Garcia, L. Xu, C. Toze, . . . M. Levings. Leuk Lymphoma, vol. 59(2), 486-489. (2018

A Standardized Immune Phenotyping and Automated Data Analysis Platform for Multicenter Biomarker Studies. Ivison, S., M. Malek, R. V. Garcia, R. Broady, A. Halpin, M. Richaud, . . . M. K. Levings. JCI Insight, vol. 3(23). (2018)

Taking Regulatory T-Cell Therapy One Step Further. Sicard, A., D. A. Boardman and M. K. Levings. Curr Opin Organ Transplant, vol. 23(5), 509-515. (2018)

Adipose-Tissue Regulatory T Cells: Critical Players in Adipose-Immune Crosstalk. Becker, M., M. K. Levings and C. Daniel. Eur J Immunol. (2017)

Antigen-Specific Regulatory T Cells: Are Police Cars the Answer? Dawson, N. A. J. and M. K. Levings. Transl Res, vol. 187, 53-58. (2017)

Biomarker-Guided Stratification of Autoimmune Patients for Biologic Therapy. Ivison, S., C. des Rosiers, S. Lesage, J. D. Rioux and M. K. Levings. Curr Opin Immunol, vol. 49, 56-63. (2017)

Cd56bright Nk Regulatory Cells in Filgrastim Primed Donor Blood or Marrow Products Regulate Chronic Gvhd: Cbmtg Randomized 0601 Study Results. Kariminia, A., S. Ivison, B. Ng, J. Rozmus, S. Sung, A. Varshney, . . . K. R. Schultz. Haematologica. (2017)

Circulating Gluten-Specific Foxp3+Cd39+ Regulatory T Cells Have Impaired Suppressive Function in Patients with Celiac Disease. Cook, L., C. M. L. Munier, N. Seddiki, D. van Bockel, N. Ontiveros, M. Y. Hardy, . . . A. D. Kelleher. J Allergy Clin Immunol. (2017)

Effect of Ex Vivo-Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance across Mhc Barriers in Cynomolgus Macaques. Duran-Struuck, R., H. P. Sondermeijer, L. Buhler, P. Alonso-Guallart, J. Zitsman, Y. Kato, . . . M. Sykes. Transplantation, vol. 101(2), 274-283. (2017)

Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells. Dawson, N. A. J., J. Vent-Schmidt and M. K. Levings. Front Immunol, vol. 8, 1460. (2017)

Guidelines for the Use of Flow Cytometry and Cell Sorting in Immunological Studies. Cossarizza, A., H. D. Chang, A. Radbruch, M. Akdis, I. Andra, F. Annunziato, . . . J. Zimmermann. Eur J Immunol, vol. 47(10), 1584-1797. (2017)

Harnessing Advances in T Regulatory Cell Biology for Cellular Therapy in Transplantation. Lam, A. J., R. E. Hoeppli and M. K. Levings. Transplantation, vol. 101(10), 2277-2287. (2017)

The Outstanding Questions in Transplantation: It's About Time... Azzi, J., G. Raimondi, V. Mas, L. V. Riella, N. Elfadawy, K. Safa, . . . M. L. Alegre. Am J Transplant. (2017)

Thymic Progenitors of Tcralphabeta+ Cd8alphaalpha Intestinal Intraepithelial Lymphocytes Require Rasgrp1 for Development. Golec, D. P., R. E. Hoeppli, L. M. Henao Caviedes, J. McCann, M. K. Levings and T. A. Baldwin. J Exp Med, vol. 214(8), 2421-2435. (2017)

Alloantigen-Specific Regulatory T Cells Generated with a Chimeric Antigen Receptor. MacDonald, K. G., R. E. Hoeppli, Q. Huang, J. Gillies, D. S. Luciani, P. C. Orban, . . . M. K. Levings. J Clin Invest, vol. 126(4), 1413-1424. (2016)

Discarded Human Thymus Is a Novel Source of Stable and Long-Lived Therapeutic Regulatory T Cells. Dijke, I. E., R. E. Hoeppli, T. Ellis, J. Pearcey, Q. Huang, A. N. McMurchy, . . . L. J. West. Am J Transplant, vol. 16(1), 58-71. (2016)

Filgrastim-Stimulated Bone Marrow Compared with Filgrastim-Mobilized Peripheral Blood in Myeloablative Sibling Allografting for Patients with Hematologic Malignancies: A Randomized Canadian Blood and Marrow Transplant Group Study. Couban, S., M. Aljurf, S. Lachance, I. Walker, C. Toze, M. Rubinger, . . . K. R. Schultz. Biol Blood Marrow Transplant, vol. 22(8), 1410-1415. (2016)

Heterogeneity of Chronic Graft-Versus-Host Disease Biomarkers: Association with Cxcl10 and Cxcr3+ Nk Cells. Kariminia, A., S. G. Holtan, S. Ivison, J. Rozmus, M. J. Hebert, P. J. Martin, . . . K. R. Schultz. Blood, vol. 127(24), 3082-3091. (2016)

How Antigen Specificity Directs Regulatory T-Cell Function: Self, Foreign and Engineered Specificity. Hoeppli, R. E., K. G. MacDonald, M. K. Levings and L. Cook. HLA, vol. 88(1-2), 3-13. (2016)

Obesity-Associated Adipose Tissue Inflammation and Transplantation. Wu, D., N. A. Dawson and M. K. Levings. Am J Transplant, vol. 16(3), 743-750. (2016)

A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children with New-Onset Type 1 Diabetes. Pesenacker, A. M., A. Y. Wang, A. Singh, J. Gillies, Y. Kim, C. A. Piccirillo, . . . M. K. Levings. Diabetes, vol. 65(4), 1031-1039. (2016)

The Role of Foxp3 in Autoimmunity. Pesenacker, A. M., L. Cook and M. K. Levings. Curr Opin Immunol, vol. 43, 16-23. (2016)

T Regulatory Cell Chemokine Production Mediates Pathogenic T Cell Attraction and Suppression. Patterson, S. J., A. M. Pesenacker, A. Y. Wang, J. Gillies, M. Mojibian, K. Morishita, . . . M. K. Levings. J Clin Invest, vol. 126(3), 1039-1051. (2016)

Ccl22 Prevents Rejection of Mouse Islet Allografts and Induces Donor-Specific Tolerance. Montane, J., M. Obach, S. Alvarez, L. Bischoff, D. L. Dai, G. Soukhatcheva, . . . C. B. Verchere. Cell Transplant, vol. 24(10), 2143-2154. (2015)

Control of Tissue-Localized Immune Responses by Human Regulatory T Cells. Pesenacker, A. M., R. Broady and M. K. Levings. Eur J Immunol, vol. 45(2), 333-343. (2015)

The Environment of Regulatory T Cell Biology: Cytokines, Metabolites, and the Microbiome. Hoeppli, R. E., D. Wu, L. Cook and M. K. Levings. Front Immunol, vol. 6, 61. (2015)

IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue St2+ T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance. Han, J. M., D. Wu, H. C. Denroche, Y. Yao, C. B. Verchere and M. K. Levings. J Immunol, vol. 194(10), 4777-4783. (2015)

Regulatory T Cells Produce Profibrotic Cytokines in the Skin of Patients with Systemic Sclerosis. MacDonald, K. G., N. A. Dawson, Q. Huang, J. V. Dunne, M. K. Levings and R. Broady. J Allergy Clin Immunol, vol. 135(4), 946- e949. (2015)

Restimulation after Cryopreservation and Thawing Preserves the Phenotype and Function of Expanded Baboon Regulatory T Cells. Weiner, J., R. Duran-Struuck, J. Zitsman, L. Buhler, H. Sondermeijer, A. N. McMurchy, . . . A. Griesemer. Transplant Direct, vol. 1(1), 1-7. (2015)

Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress Nlrp3 Inflammasome Activation Via an Il-10-Dependent Mechanism. Yao, Y., J. Vent-Schmidt, M. D. McGeough, M. Wong, H. M. Hoffman, T. S. Steiner and M. K. Levings. J Immunol, vol. 195(2), 488-497. (2015)