Overview

Dr. Laura Sauvé is a Clinical Assistant Professor and a pediatric infectious disease specialist who has a special interest in Pediatric HIV/AIDS.

Her main research interests include public health surveillance especially with respect to vaccinology, vaccine preventable disease, global child health and pediatric HIV/AIDS.

She joined the Vaccine Evaluation Center in 2007 as the BC site investigator for the Immunization Monitoring Program, Active (IMPAct), a national surveillance system for vaccine preventable diseases and vaccine adverse events in 12 pediatric tertiary care centers across Canada.

She is also the co-primary investigator of the Canadian Perinatal HIV Surveillance Program, which studies vertical transmission of HIV across Canada. As Pediatrics Residency Program Director, she is also involved in a number of medical education research initiatives.

Publications

Inverse relationship between leukocyte telomere length attrition and blood mitochondrial DNA content loss over time.
Aging
Hsieh AYY and Kimmel E and Pick N and Sauvé L and Brophy J and Kakkar F and Bitnun A and Murray MCM and Côté HCF
DOI: 10.18632/aging.103703
PubMed: 32703912
07/2020

Review of pediatric encephalitis and encephalopathy cases following immunization reported to the Canadian Immunization Monitoring Program Active (IMPACT) from 1992 to 2012.
Vaccine
Tam J and Tran D and Bettinger JA and Moore D and Sauvé L and Jadavji T and Tan B and Vaudry W and Halperin SA and Top KA and Canadian Immunization Monitoring Program Active Investigators
DOI: 10.1016/j.vaccine.2020.04.035
PubMed: 32414652
05/2020

Burden of Children Hospitalized With Pertussis in Canada in the Acellular Pertussis Vaccine Era, 1999-2015.
Journal of the Pediatric Infectious Diseases Society
Abu-Raya B and Bettinger JA and Vanderkooi OG and Vaudry W and Halperin SA and Sadarangani M and Members of the Canadian Immunization Monitoring Program and Active (IMPACT)
DOI: 10.1093/jpids/piy128
PubMed: 30535079
04/2020

Challenges to achieving and maintaining viral suppression among children living with HIV.
AIDS (London, England)
Kakkar F and Lee T and Hawkes MT and Brophy J and Lindy S and Singer J and Dieumegard H and Sauve L and Alimenti A and Vaudry W and Seigel S and Tan B and Karatzios C and Lamarre V and EPIC4 Study Group
DOI: 10.1097/qad.0000000000002454
PubMed: 31794519
04/2020

Clinical Correlates of Human Immunodeficiency Virus-1 (HIV-1) DNA and Inducible HIV-1 RNA Reservoirs in Peripheral Blood in Children With Perinatally Acquired HIV-1 Infection With Sustained Virologic Suppression for at Least 5 Years.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Bitnun A and Ransy DG and Brophy J and Kakkar F and Hawkes M and Samson L and Annabi B and Pagliuzza A and Morand JA and Sauve L and Chomont N and Lavoie S and Kim J and Sandstrom P and Early Pediatric Initiation Canada Child Cure Cohort (EPIC4) Research Group
DOI: 10.1093/cid/ciz251
PubMed: 30919879
02/2020

Risk factors for cerebrospinal fluid shunt infections during an outbreak: a case-control study.
The Journal of hospital infection
McAlpine AK and Sauve LJ and Collet JC and Goldfarb DM and Guest E and McDonald PJ and Zheng A and Srigley JA
DOI: 10.1016/j.jhin.2019.12.012
PubMed: 31870886
12/2019

Congenital anomalies following antenatal exposure to dolutegravir: a Canadian surveillance study
BJOG: An International Journal of Obstetrics & Gynaecology
DOI: 10.1111/1471-0528.15838
07/2019

Preventing vertical transmission of HCV in Canada
Canadian Medical Association Journal
DOI: 10.1503/cmaj.181662
06/2019

152 Child development in HIV Exposed, Uninfected Children: Challenges with Accessing Services.
Paediatrics & Child Health
Yang L and Alimenti A and Lipson A and Lanphear N and Sauve L
05/2019

Neurodevelopmental outcomes and in utero antiretroviral exposure in HIV-exposed uninfected children
AIDS
DOI: 10.1097/qad.0000000000001985
08/2018

Missed opportunities for prevention of vertical HIV transmission in Canada, 1997-2016: a surveillance study.
CMAJ open
Bitnun A and Lee T and Brophy J and Samson LM and Kakkar F and Vaudry W and Tan B and Money DM and Singer J and Sauvé LJ and Alimenti A and Canadian Perinatal HIV Surveillance Program
DOI: 10.9778/cmajo.20180016
PubMed: 29759976
05/2018

The Oak Tree Clinic: The Envisioned Model of Care for Women Living with Human Immunodeficiency Virus in Canada
Women's Health Issues
Mary Kestler and Melanie Murray and Deborah Money and Laura Sauve and Neora Pick
DOI: 10.1016/j.whi.2017.11.007
03/2018

Ten-year-old traveller with fever and an exceptional exanthem.
Journal of paediatrics and child health
Osowicki J and Badawi M and Al-Rawahi GN and Rehmus WE and Sauvé L
DOI: 10.1111/jpc.1_13703
PubMed: 29314380
01/2018

Hospitalization for Influenza A Versus B.
Pediatrics
DOI: 10.1542/peds.2015-4643
PubMed: 27535144
08/2016

Enteric Fever in a Multicultural Canadian Tertiary Care Pediatric Setting: A 28-Year Review.
Zhou K and Sauve LJ and Richardson SE and Ford-Jones EL and Morris SK
PubMed: 26952095
03/2016

Enteric Fever in a Multicultural Canadian Tertiary Care Pediatric Setting: A 28-Year Review.
Journal of the Pediatric Infectious Diseases Society
PubMed: 26952095
03/2016

Respiratory Presentation of Pediatric Patients in the 2014 Enterovirus D68 Outbreak.
Canadian Respiratory Journal : Journal of the Canadian Thoracic Society
Martin G and Li R and Cook VE and Carwana M and Tilley P and Sauve L and Tang P and Kapur A and Yang CL
DOI: 10.1155/2016/8302179
PubMed: 27610028
2016

8th IAS Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015).
Journal of the International AIDS Society
DOI: 10.7448/ias.18.5.20479
PubMed: 26205488
07/2015

Outcomes of invasive meningococcal disease in adults and children in Canada between 2002 and 2011: a prospective cohort study.
Sadarangani M and Scheifele DW and Halperin SA and Vaudry W and Le Saux N and Tsang R and Bettinger JA and investigators of the Canadian Immunization Monitoring Program and ACTive (IMPACT)
PubMed: 25605282
04/2015

Outcomes of invasive meningococcal disease in adults and children in Canada between 2002 and 2011: a prospective cohort study.
Clinical Infectious Diseases
PubMed: 25605282
04/2015

Canadian Paediatric Society 92nd Annual Conference: Abstracts.
2015

Canadian Paediatric Society 92nd Annual Conference: Abstracts.
Paediatrics & Child Health
2015

24(th) Annual Canadian Conference on HIV/AIDS Research/24(e) Congres Annuel Canadien de Recherche sur le VIH/sida CAHR Committees / Comites de l'ACRV.
The Canadian Journal of Infectious Diseases & Medical Microbiology
PubMed: 26015799
2015

Development and validation of weight, height and age bands to guide the prescription of fixed-dose dispersible tablet formulations.
Journal of Pediatric Pharmacology and Therapeutics
PubMed: 25859167
2015

Development and validation of weight, height and age bands to guide the prescription of fixed-dose dispersible tablet formulations.
Larson CP and Sauvé L and Senkungu JK and Arifeen SE and Brant R
PubMed: 25859167
2015

24(th) Annual Canadian Conference on HIV/AIDS Research/24(e) Congres Annuel Canadien de Recherche sur le VIH/sida CAHR Committees / Comites de l'ACRV.
PubMed: 26015799
2015

1614High Rates of Preterm Birth and Small for Gestational Age in a Cohort of HIV Infected Women in Canada: Role of Ritonavir Boosted Regimens?
Open forum infectious diseases
Kakkar F and Boucoiran I and Lee T and Singer J and Sauve LJ and Samson LM and Money D
12/2014

The impact of the meningococcal serogroup C conjugate vaccine in Canada between 2002 and 2012.
Sadarangani M and Scheifele DW and Halperin SA and Vaudry W and Le Saux N and Tsang R and Bettinger JA and investigators of the Canadian Immunization Monitoring Program and ACTive (IMPACT)
PubMed: 25069868
11/2014

The impact of the meningococcal serogroup C conjugate vaccine in Canada between 2002 and 2012.
Clinical Infectious Diseases
PubMed: 25069868
11/2014

Prevention of vertical HIV transmission and management of the HIV-exposed infant in Canada in 2014.
The Canadian Journal of Infectious Diseases & Medical Microbiology
Bitnun A and Brophy J and Samson L and Alimenti A and Kakkar F and Lamarre V and Moore D and Karatzios C and Seigel S and Sauve L and Vaudry W and Yudin MH and Money D
DOI: 10.1155/2014/526019
PubMed: 24855474
03/2014

Prevention of vertical HIV transmission and management of the HIV-exposed infant in Canada in 2014
Canadian Journal of Infectious Diseases and Medical Microbiology
2014

Burden of seasonal influenza in children with neurodevelopmental conditions
Pediatric Infectious Disease Journal
DOI: 10.1097/INF.0000000000000272
2014

Diversity of Canadian meningococcal serogroup B isolates and estimated coverage by an investigational meningococcal serogroup B vaccine (4CMenB).
Bettinger JA and Scheifele DW and Halperin SA and Vaudry W and Findlow J and Borrow R and Medini D and Tsang R and members of the Canadian Immunization Monitoring Program and Active (IMPACT)
PubMed: 23588089
12/2013

Diversity of Canadian meningococcal serogroup B isolates and estimated coverage by an investigational meningococcal serogroup B vaccine (4CMenB).
Vaccine
PubMed: 23588089
12/2013

Unusual patterns of IgG avidity in some young children following two doses of the adjuvanted pandemic H1N1 (2009) influenza virus vaccine.
Yam KK and Gupta J and Brewer A and Scheifele DW and Halperin S and Ward BJ and Public Health Agency of Canada/Canadian Institute of Health Research and Influenza Research Network (PCIRN) Rapid Trial Study 3 (RT-03) Investigators
PubMed: 23345582
04/2013

Unusual patterns of IgG avidity in some young children following two doses of the adjuvanted pandemic H1N1 (2009) influenza virus vaccine.
Clinical and Vaccine Immunology
PubMed: 23345582
04/2013

Applicability of the Brighton Collaboration Case Definition for seizure after immunization in active and passive surveillance in Canada
Vaccine
DOI: 10.1016/j.vaccine.2013.09.048
2013

Development and evaluation of global child health educational modules
Pediatrics
DOI: 10.1542/peds.2013-1534
2013

The effect of funded varicella immunization programs on varicella-related hospitalizations in IMPACT centers, Canada, 2000-2008.
Tan B and Bettinger J and McConnell A and Scheifele D and Halperin S and Vaudry W and Law B and Members of the Canadian Immunization Monitoring Program and Active (IMPACT)
PubMed: 22647896
09/2012

The effect of funded varicella immunization programs on varicella-related hospitalizations in IMPACT centers, Canada, 2000-2008.
The Pediatric Infectious Disease Journal
PubMed: 22647896
09/2012

Comparison of children hospitalized with seasonal versus pandemic influenza A, 2004-2009.
Tran D and Vaudry W and Moore DL and Bettinger JA and Halperin SA and Scheifele DW and Aziz S and IMPACT investigators
PubMed: 22931901
09/2012

Molecular characterization of rotavirus isolates from select Canadian pediatric hospitals
BMC Infectious Diseases
DOI: 10.1186/1471-2334-12-306
2012

The responses of Aboriginal Canadians to adjuvanted pandemic (H1N1) 2009 influenza vaccine.
Rubinstein E and Predy G and Sauvé L and Hammond GW and Aoki F and Sikora C and Li Y and Law B and Halperin S and Scheifele D
PubMed: 21788422
09/2011

The responses of Aboriginal Canadians to adjuvanted pandemic (H1N1) 2009 influenza vaccine.
Canadian Medical Association Journal
PubMed: 21788422
09/2011

Drug-resistant Tuberculosis
The Pediatric Infectious Disease Journal
Mona Al-Dabbagh and Keswadee Lapphra and Rumi McGloin and Kelsey Inrig and H. Simon Schaaf and Ben J. Marais and Laura Sauve and Ian Kitai and Tobias R. Kollmann
DOI: 10.1097/inf.0b013e31820b583d
06/2011

Evaluation of adjuvanted pandemic H1N1(2009) influenza vaccine after one and two doses in young children.
Scheifele DW and Ward BJ and Dionne M and Vanderkooi O and Langley JM and Dobson S and Li Y and Law B and Halperin SA and Public Health Agency of Canada/Canadian Institutes of Health Research Influenza Research Network (PCIRN) Rapid Trials Investigators
PubMed: 21178654
05/2011

Evaluation of adjuvanted pandemic H1N1(2009) influenza vaccine after one and two doses in young children.
The Pediatric Infectious Disease Journal
PubMed: 21178654
05/2011

The responses of Aboriginal Canadians to adjuvanted pandemic (H1N1) 2009 influenza vaccine
CMAJ
DOI: 10.1503/cmaj.110196
2011

Drug-resistant tuberculosis: Pediatric guidelines
Pediatric Infectious Disease Journal
DOI: 10.1097/INF.0b013e31820b583d
2011

Pandemic influenza in Canadian children: a summary of hospitalized pediatric cases.
Bettinger JA and Sauvé LJ and Scheifele DW and Moore D and Vaudry W and Tran D and Halperin SA and Pelletier L
PubMed: 20189488
04/2010

Pandemic influenza in Canadian children: a summary of hospitalized pediatric cases.
Vaccine
PubMed: 20189488
04/2010

The effect of routine vaccination on invasive pneumococcal infections in Canadian children, Immunization Monitoring Program, Active 2000-2007.
Bettinger JA and Scheifele DW and Kellner JD and Halperin SA and Vaudry W and Law B and Tyrrell G and Canadian Immunization Monitoring Program and Active (IMPACT)
PubMed: 20044050
02/2010

The effect of routine vaccination on invasive pneumococcal infections in Canadian children, Immunization Monitoring Program, Active 2000-2007.
Vaccine
PubMed: 20044050
02/2010

Postvaccination Thrombocytopenia in Canada
The Pediatric Infectious Disease Journal
Laura J. Sauvé and Julie Bettinger and David Scheifele and Scott Halperin and Wendy Vaudry and Barbara Law
DOI: 10.1097/inf.0b013e3181d2bb45
02/2010

Pandemic influenza in Canadian children: A summary of hospitalized pediatric cases
Vaccine
DOI: 10.1016/j.vaccine.2010.02.044
2010

Postvaccination thrombocytopenia in Canada
Pediatric Infectious Disease Journal
DOI: 10.1097/INF.0b013e3181d2bb45
2010

Increasing fluoroquinolone resistance in Salmonella typhi in Ontario, 2002-2007.
Morris SK and Richardson SE and Sauve LJ and Ford-Jones EL and Jamieson F
PubMed: 19478267
06/2009

Do childhood vaccines cause thrombocytopenia?
Paediatrics & Child Health
Laura J Sauvé and David Scheifele
DOI: 10.1093/pch/14.1.31
01/2009

Do childhood vaccines cause thrombocytopenia?
Paediatrics and Child Health
2009

Short report: Increasing fluoroquinolone resistance in Salmonella typhi in Ontario, 2002-2007
American Journal of Tropical Medicine and Hygiene
2009

Case 2: Fever in a new immigrant
Paediatrics and Child Health
2005

Harmonization of regional health data requirements in the South Pacific.
Souarès Y and Sauve L
PubMed: 10167221
1997

Harmonization of regional health data requirements in the South Pacific.
Clinical Performance and Quality Healthcare
PubMed: 10167221
1997

The Health Interview: Automated Assessment in a Multidisciplinary Outpatient Hypertension Treatment Program
M.D. Computing
1996

Research

Canadian Perinatal HIV Surveillance Program (WHRI)
Dr. Sauvé recently took over as co-chair of the CPHSP, which as done active surveillance for vertical transmission of HIV in 22 sites across Canada since 1990. It is funded by the Public Health Agency of Canada. This surveillance program prospectively collects data on all births to HIV infected women in the 22 participating sites, as well as all vertically HIV infected children in Canada. It provides important epidemiologic data on vertical transmission of HIV in Canada. Data is presented annually at HIV meetings and in 2012, there was a major article in AIDS (completed prior to when Dr Sauvé joined the team).

Flocked swab evaluation
In this study which is in the final manuscript stages, Dr Sauvé and her co-investigators prospectively evaluated two methods of acquiring samples for respiratory virus testing, comparing the BC Children's Hospital standard of nasopharyngeal wash, to a newer technology: flocked nasopharyngeal swabs.

Immunization Monitoring Program, Active
Dr. Sauvé is the BC site investigator for this project which has ongoing surveillance for vaccine preventable diseases and adverse events following immunization; there are 12 sites across the country. She sits on the AEFI and Haemophilous Influenzae working groups. Nurse monitors at each site do active surveillance for the target conditions, finding all hospitalized cases of those target conditions using a variety of methods. Data is entered into the IMPACT databases which are coordinated through the Vaccine Evaluation Center's IMPACT data center (led by CFRI investigators Dr. David Scheifele and Dr. Julie Bettinger). Summarized surveillance data is provided to the Public Health Agency of Canada and published in peer-reviewed publications.

Grants

BC Children's Hospital Foundation Telethon Fund (flocked swab study) $24,000

CPHSP - $39,000 per year (ongoing)

IMPACT / CPS - Approximately $57,000 per year for BC Site (ongoing)

Research Group Members

Natasha Benson, PGY1 Resident
Julie Jesson, Visiting Postdoctoral Fellow
Jessica Li, Research Assistant