Laura Sly

Early Marrow Microenvironment Immune Patterns After Hematopoietic Stem Cell Transplant in Pediatric Acute Lymphoblastic Leukemia Are Associated with Later Development of Chronic GvHD and Relapse

International Journal of Molecular Sciences

Catherine M. Njeru and Bernard Ng and Sayeh Abdossamadi and Alima Suleimenova and Carmen Dolores De Luca and Vaishnavi Parthasarathy and Laura M. Sly and Gregor S. D. Reid and Chia Huan Ng and Kirk R. Schultz

03 / 2026

RIPK2 Inhibition Blocks NOD2-Mediated IL-1 Production by Macrophages In Vitro but Exacerbates Crohns Disease-like Ileitis in SHIP"/" Mice

Immuno

Pang, Y.C.F. and Ma, W.J. and Menzies, S.C. and Sly, L.M.

Bespoke plant glycoconjugates for gut microbiota"mediated drug targeting

Science

Ma, W.J. and Wang, C. and Kothandapani, J. and Luzentales-Simpson, M. and Menzies, S.C. and Bescucci, D.M. and Lange, M.E. and Fraser, A.S.C. and Gusse, J.F. and House, K.E. and Moote, P.E. and Xing, X. and Grondin, J.M. and Hui, B.W.-Q. and Clarke, S.T. and Shelton, T.G. and Haskey, N. and Gibson, D.L. and Martens, E.C. and Abbott, D.W. and Inglis, G.D. and Sly, L.M. and Brumer, H.

Alleviation of severe chronic arthritic pain using polyvalent immunoglobulins (KMP01): Two case reports

International Journal of Clinical Pharmacology and Therapeutics

Woodcock, B.G. and Braun, P. and Gasser, M. and Sly, L. and Lissner, R.

Bio-engineering a common probiotic to exploit colonic inflammation promotes reliable efficacy in translational models of colitis

Biorxiv

Verdugo-Meza, A. and Gill, S.K. and Godovannyi, A. and Adur, M.K. and Barnett, J.A. and Estaki, M. and Ye, J. and Haskey, N. and Mehain, H. and Josephson, J.K. and Ishida, R. and Ghesquiere, C. and Sly, L.M. and Gibson, D.L.

Macrophage immunotherapy: overcoming impediments to realize promise

Trends in Immunology

Sly, L.M. and McKay, D.M.

Evidence that oral immunoglobulins (KMP01) suppress pro-tumor inflammation in rectal carcinoma: Case report and treatment concept

International Journal of Clinical Pharmacology and Therapeutics

Oguz, S. and Buia, A. and Albers, B. and Suna, K. and Piroski, V. and Knapp, A. and Sly, L. and Dll, U. and Braun, P. and Woodcock, B.G.

A188 TARGETING RIPK2 TO TREAT INTESTINAL INFLAMMATION CAUSED BY SHIP DEFICIENCY

Journal of the Canadian Association of Gastroenterology

Pang Y and Menzies S and Baksh S and Sly L

03 / 2021

Vedolizumab: Potential Mechanisms of Action for Reducing Pathological Inflammation in Inflammatory Bowel Diseases.

Frontiers in cell and developmental biology

Luzentales-Simpson M and Pang YCF and Zhang A and Sousa JA and Sly LM

02 / 2021

COVID-19: Cytokine storm modulation/blockade with oral polyvalent immunoglobulins (PVIG, KMP01D): A potential and safe therapeutic agent (Primum nil nocere).

International journal of clinical pharmacology and therapeutics

Sly LM and Braun P and Woodcock BG

12 / 2020

A202 DYSREGULATED ENDOPLASMIC RETICULUM STRESS PATHWAYS IN COLON-DERIVED ENTEROIDS FROM INFLAMMATORY BOWEL DISEASE PATIENTS DRIVE DC MATURATION LEADING TO A PRO-INFLAMMATORY PHENOTYPE.

Journal of the Canadian Association of Gastroenterology

Rees WD and Stahl M and Jacobson K and Bressler B and Sly LM and Vallance B and Steiner T

02 / 2020

A10 TR1 CELL-BASED THERAPY FOR INFLAMMATORY ILEITIS IN SHIP-/- MICE.

Journal of the Canadian Association of Gastroenterology

Lisko D and Menzies S and Sly LM and Steiner T

02 / 2020

Enteroids derived from inflammatory bowel disease patients display dysregulated endoplasmic reticulum stress pathways, leading to differential inflammatory responses and dendritic cell maturation

Journal of Crohn's and Colitis

Rees, W.D. and Stahl, M. and Jacobson, K. and Bressler, B. and Sly, L.M. and Vallance, B.A. and Steiner, T.S.

How do immune and mesenchymal cells influence the intestinal epithelial cell compartment in inflammatory bowel disease? Let's crosstalk about it!

Journal of Leukocyte Biology

Rees, W.D. and Sly, L.M. and Steiner, T.S.

FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity

The Journal of experimental medicine

Hubbard, J.J. and Pyzik, M. and Rath, T. and Kozicky, L.K. and Sand, K.M.K. and Gandhi, A.K. and Grevys, A. and Foss, S. and Menzies, S.C. and Glickman, J.N. and Fiebiger, E. and Roopenian, D.C. and Sandlie, I. and Andersen, J.T. and Sly, L.M. and Baker, K. and Blumberg, R.S.

Gut microbes in pediatric ALL survivorship

Pediatric Hematology and Oncology

Sly, L.M.

Intravenous immunoglobulin (IVIg) or IVIg-treated macrophages reduce DSS-induced colitis by inducing macrophage IL-10 production

European Journal of Immunology

Kozicky, L.K. and Menzies, S.C. and Hotte, N. and Madsen, K.L. and Sly, L.M.

Malt1 deficient mice develop osteoporosis independent of osteoclast-intrinsic effects of Malt1 deficiency

Journal of Leukocyte Biology

Monajemi, M. and Fisk, S. and Pang, Y.C.F. and Leung, J. and Menzies, S.C. and Ben-Othman, R. and Cai, B. and Kollmann, T.R. and Rozmus, J. and Sly, L.M.

Compositional changes to the ileal microbiome precede the onset of spontaneous ileitis in SHIP deficient mice

Gut Microbes

Dobranowski, P.A. and Tang, C. and Sauv, J.P. and Menzies, S.C. and Sly, L.M.

Integrins and ERp57 coordinate to regulate cell surface calreticulin in immunogenic cell death

Frontiers in Oncology

Liu, C.-C. and Leclair, P. and Pedari, F. and Vieira, H. and Monajemi, M. and Sly, L.M. and Reid, G.S. and Lim, C.J.

Phosphatidylinositol 3-kinase p110d drives intestinal fibrosis in SHIP deficiency

Mucosal Immunology

Lo, Y. and Sauve, J.P. and Menzies, S.C. and Steiner, T.S. and Sly, L.M.

A80 MALT1 BLOCKS IL-1-MEDIATED INTESTINAL INFLAMMATION.

Journal of the Canadian Association of Gastroenterology

Monajemi M and Pang Y and Menzies S and Sly LM

02 / 2018

A7 PI3KP110d DRIVES INTESTINAL FIBROSIS IN SHIP DEFICIENT MICE.

Journal of the Canadian Association of Gastroenterology

Lo Y and Sauv J and Menzies S and Sly LM

02 / 2018

A94 SHIP-MICROBIOME INTERACTIONS IN INTESTINAL INFLAMMATION.

Journal of the Canadian Association of Gastroenterology

Dobranowski P and Menzies S and Sly LM

02 / 2018

CD47-ligation induced cell death in T-acute lymphoblastic leukemia article

Cell Death and Disease

Leclair, P. and Liu, C.-C. and Monajemi, M. and Reid, G.S. and Sly, L.M. and Lim, C.J.

SHIP negatively regulates type II immune responses in mast cells and macrophages

Journal of Leukocyte Biology

Dobranowski, P. and Sly, L.M.

Inflammatory bowel disease and immunonutrition: novel therapeutic approaches through modulation of diet and the gut microbiome

Immunology

Celiberto, L.S. and Graef, F.A. and Healey, G.R. and Bosman, E.S. and Jacobson, K. and Sly, L.M. and Vallance, B.A.

Malt1 blocks IL-1production by macrophages in vitro and limits dextran sodium sulfate-induced intestinal inflammation in vivo

Journal of Leukocyte Biology

Monajemi, M. and Pang, Y.C.F. and Bjornson, S. and Menzies, S.C. and van Rooijen, N. and Sly, L.M.

IVIg and LPS co-stimulation induces IL-10 production by human monocytes, which is compromised by an FcRIIA disease-associated gene variant

Frontiers in Immunology

Kozicky, L.K. and Menzies, S.C. and Zhao, Z.Y. and Vira, T. and Harnden, K. and Safari, K. and Del Bel, K.L. and Turvey, S.E. and Sly, L.M.

IFN- directly inhibits murine B-cell precursor leukemia-initiating cell proliferation early in life

European Journal of Immunology

Fidanza, M. and Seif, A.E. and Jo, S. and Kariminia, A. and Rolf, N. and Sly, L.M. and Grupp, S.A. and Reid, G.S.D.

Assessment of antibody-based drugs effects on murine bone marrow and peritoneal macrophage activation

Journal of Visualized Experiments

Kozicky, L. and Sly, L.M.

Endosomal pH modulation by peptide-gold nanoparticle hybrids enables potent anti-inflammatory activity in phagocytic immune cells

Biomaterials

Yang, H. and Kozicky, L. and Saferali, A. and Fung, S.-Y. and Afacan, N. and Cai, B. and Falsafi, R. and Gill, E. and Liu, M. and Kollmann, T.R. and Hancock, R.E.W. and Sly, L.M. and Turvey, S.E.

a-Integrin expression and function modulates presentation of cell surface calreticulin

Cell Death and Disease

Liu, C.-C. and Leclair, P. and Monajemi, M. and Sly, L.M. and Reid, G.S. and Lim, C.J.

Activity of SHIP, Which Prevents Expression of Interleukin 1, Is Reduced in Patients with Crohn's Disease

Gastroenterology

Ngoh, E.N. and Weisser, S.B. and Lo, Y. and Kozicky, L.K. and Jen, R. and Brugger, H.K. and Menzies, S.C. and McLarren, K.W. and Nackiewicz, D. and Van Rooijen, N. and Jacobson, K. and Ehses, J.A. and Turvey, S.E. and Sly, L.M.

The Crohn's disease-associated polymorphism in ATG16L1 (rs2241880) reduces SHIP gene expression and activity in human subjects

Genes and Immunity

Ngoh, E.N. and Brugger, H.K. and Monajemi, M. and Menzies, S.C. and Hirschfeld, A.F. and Del Bel, K.L. and Jacobson, K. and Lavoie, P.M. and Turvey, S.E. and Sly, L.M.

Phosphatase regulation of macrophage activation

Seminars in Immunology

Kozicky, L.K. and Sly, L.M.

Impaired NLRP3 inflammasome activity during fetal development regulates IL-1 production in human monocytes

European Journal of Immunology

Sharma, A.A. and Jen, R. and Kan, B. and Sharma, A. and Marchant, E. and Tang, A. and Gadawski, I. and Senger, C. and Skoll, A. and Turvey, S.E. and Sly, L.M. and Ct, H.C.F. and Lavoie, P.M.

Intravenous immunoglobulin skews macrophages to an anti-inflammatory, IL-10-producing activation state

Journal of Leukocyte Biology

Kozicky, L.K. and Zhao, Z.Y. and Menzies, S.C. and Fidanza, M. and Reid, G.S.D. and Wilhelmsen, K. and Hellman, J. and Hotte, N. and Madsen, K.L. and Sly, L.M.

Combined immunodeficiency associated with homozygous MALT1 mutations

Journal of Allergy and Clinical Immunology

McKinnon, M.L. and Rozmus, J. and Fung, S.-Y. and Hirschfeld, A.F. and Del Bel, K.L. and Thomas, L. and Marr, N. and Martin, S.D. and Marwaha, A.K. and Priatel, J.J. and Tan, R. and Senger, C. and Tsang, A. and Prendiville, J. and Junker, A.K. and Seear, M. and Schultz, K.R. and Sly, L.M. and Holt, R.A. and Patel, M.S. and Friedman, J.M. and Turvey, S.E.

Arginase activity in alternatively activated macrophages protects PI3Kp110d deficient mice from dextran sodium sulfate induced intestinal inflammation

European Journal of Immunology

Weisser, S.B. and Kozicky, L.K. and Brugger, H.K. and Ngoh, E.N. and Cheung, B. and Jen, R. and Menzies, S.C. and Samarakoon, A. and Murray, P.J. and Lim, C.J. and Johnson, P. and Boucher, J.-L. and van Rooijen, N. and Sly, L.M.

Generation and characterization of murine alternatively activated macrophages

Methods in Molecular Biology

Weisser, S.B. and McLarren, K.W. and Kuroda, E. and Sly, L.M.

Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML

Blood

Chaturvedi, A. and Araujo Cruz, M.M. and Jyotsana, N. and Sharma, A. and Yun, H. and Grlich, K. and Wichmann, M. and Schwarzer, A. and Preller, M. and Thol, F. and Meyer, J. and Haemmerle, R. and Struys, E.A. and Jansen, E.E. and Modlich, U. and Li, Z. and Sly, L.M. and Geffers, R. and Lindner, R. and Manstein, D.J. and Lehmann, U. and Krauter, J. and Ganser, A. and Heuser, M.

Generation and characterization of murine alternatively activated macrophages.

Weisser SB and McLarren KW and Kuroda E and Sly LM

Depletion and reconstitution of macrophages in mice

Journal of Visualized Experiments

Weisser, S.B. and van Rooijen, N. and Sly, L.M.

Alternative activation of macrophages by IL-4 requires SHIP degradation

European Journal of Immunology

Weisser, S.B. and Mclarren, K.W. and Voglmaier, N. and van Netten-Thomas, C.J. and Antov, A. and Flavell, R.A. and Sly, L.M.

A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation

Cancer Research

Ho, V.W. and Leung, K. and Hsu, A. and Luk, B. and Lai, J. and Shen, S.Y. and Minchinton, A.I. and Waterhouse, D. and Bally, M.B. and Lin, W. and Nelson, B.H. and Sly, L.M. and Krystal, G.

SHIP-deficient, alternatively activated macrophages protect mice during DSS-induced colitis

Journal of Leukocyte Biology

Weisser, S.B. and Brugger, H.K. and Voglmaier, N.S. and McLarren, K.W. and van Rooijen, N. and Sly, L.M.

SHIP represses Th2 skewing by inhibiting IL-4 production from basophils

Journal of Immunology

Kuroda, E. and Antignano, F. and Ho, V.W. and Hughes, M.R. and Ruschmann, J. and Lam, V. and Kawakami, T. and Kerr, W.G. and McNagny, K.M. and Sly, L.M. and Krystal, G.

SHIP-deficient mice develop spontaneous intestinal inflammation and arginase-dependent fibrosis

American Journal of Pathology

McLarren, K.W. and Cole, A.E. and Weisser, S.B. and Voglmaier, N.S. and Conlin, V.S. and Jacobson, K. and Popescu, O. and Boucher, J.-L. and Sly, L.M.

Tyrosine phosphorylation of SHIP promotes its proteasomal degradation

Experimental Hematology

Ruschmann, J. and Ho, V. and Antignano, F. and Kuroda, E. and Lam, V. and Ibaraki, M. and Snyder, K. and Kim, C. and Flavell, R.A. and Kawakami, T. and Sly, L. and Turhan, A.G. and Krystal, G.

The p110a and p110 isoforms of class i phosphatidylinositol 3-kinase are involved in toll-like receptor 5 signaling in epithelial cells

Mediators of Inflammation

Ivison, S.M. and Khan, M.A.S. and Graham, N.R. and Shobab, L.A. and Yao, Y. and Kifayet, A. and Sly, L.M. and Steiner, T.S.

Derivation and characterization of murine alternatively activated (m2) macrophages

Methods in Molecular Biology

Ho, V.W.H. and Sly, L.M.

SHIP prevents lipopolysaccharide from triggering an antiviral response in mice

Blood

Sly, L.M. and Hamilton, M.J. and Kuroda, E. and Ho, V.W. and Antignano, F.L. and Omeis, S.L. and Van Netten-Thomas, C.J. and Wong, D. and Brugger, H.K. and Williams, O. and Feldman, M.E. and Houseman, B.T. and Fiedler, D. and Shokat, K.M. and Krystal, G.

Modeling the functional heterogeneity of leukemia stem cells: Role of STAT5 in leukemia stem cell self-renewal

Blood

Heuser, M. and Sly, L.M. and Argiropoulos, B. and Kuchenbauer, F. and Lai, C. and Weng, A. and Leung, M. and Lin, G. and Brookes, C. and Fung, S. and Valk, P.J. and Delwel, R. and Lwenberg, B. and Krystal, G. and Humphries, R.K.

The Src Homology 2 Containing Inositol 5' Phosphatases

Handbook of Cell Signaling, Second Edition

Antignano, F. and Ruschmann, J. and Hamilton, M. and Ho, V. and Lam, V. and Kuroda, E. and Sly, L.M. and Krystal, G.

SHIP represses the generation of IL-3-induced M2 macrophages by inhibiting IL-4 production from basophils

Journal of Immunology

Kuroda, E. and Ho, V. and Ruschmann, J. and Antignano, F. and Hamilton, M. and Rauh, M.J. and Antov, A. and Flavell, R.A. and Sly, L.M. and Krystal, G.

SHIP regulates the reciprocal development of T regulatory and Th17 cells

Journal of Immunology

Locke, N.R. and Patterson, S.J. and Hamilton, M.J. and Sly, L.M. and Krystal, G. and Levings, M.K.

Linkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3

Experimental Hematology

Argiropoulos, B. and Palmqvist, L. and Yung, E. and Kuchenbauer, F. and Heuser, M. and Sly, L.M. and Wan, A. and Krystal, G. and Humphries, R.K.

The inositol phosphatase SHIP controls Salmonella enterica serovar typhimurium infection in vivo

Infection and Immunity

Bishop, J.L. and Sly, L.M. and Krystal, G. and Finlay, B.B.

IgE-induced mast cell survival requires the prolonged generation of reactive oxygen species

Journal of Immunology

Sly, L.M. and Kalesnikoff, J. and Lam, V. and Wong, D. and Song, C. and Omeis, S. and Chan, K. and Lee, C.W.K. and Siraganian, R.P. and Rivera, J. and Krystal, G.

Re: The terminology issue for myeloid-derived suppressor cells

Cancer Research

Krystal, G. and Sly, L. and Antignano, F. and Ho, V. and Ruschmann, J. and Hamilton, M.

Monocyte p110a phosphatidylinositol 3-kinase regulates phagocytosis, the phagocyte oxidase, and cytokine production

Journal of Leukocyte Biology

Lee, J.S. and Nauseef, W.M. and Moeenrezakhanlou, A. and Sly, L.M. and Noubir, S. and Leidal, K.G. and Schlomann, J.M. and Krystal, G. and Reiner, N.E.

The role of SHIP in macrophages

Frontiers in Bioscience

Sly, L.M. and Ho, V. and Antignano, F. and Ruschmann, J. and Hamilton, M. and Lam, V. and Rauh, M.J. and Krystal, G.

The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia

Blood

Palmqvist, L. and Argiropoulos, B. and Pineault, N. and Abramovich, C. and Sly, L.M. and Krystal, G. and Wan, A. and Humphries, R.K.

SHIP represses the generation of alternatively activated macrophages

Immunity

Rauh, M.J. and Ho, V. and Pereira, C. and Sham, A. and Sly, L.M. and Lam, V. and Huxham, L. and Minchinton, A.I. and Mui, A. and Krystal, G.

The role of SHIP1 in macrophage programming and activation.

Rauh MJ and Sly LM and Kalesnikoff J and Hughes MR and Cao LP and Lam V and Krystal G

11 / 2004

The role of SHIP1 in macrophage programming and activation

Biochemical Society Transactions

Rauh, M.J. and Sly, L.M. and Kalesnikoff, I. and Hughes, M.R. and Cao, L.-P. and Lam, V. and Krystal, G.

LPS-induced upregulation of SHIP is essential for endotoxin tolerance

Immunity

Sly, L.M. and Rauh, M.J. and Kalesnikoff, J. and Song, C.H. and Krystal, G.

Role of Src homology 2-containing-inositol 5'-phosphatase (SHIP) in mast cells and macrophages.

Rauh MJ and Kalesnikoff J and Hughes M and Sly L and Lam V and Krystal G

02 / 2003

The 19-kDa Mycobacterium tuberculosis protein induces macrophage apoptosis through toll-like receptor-2

Journal of Immunology

Lpez, M. and Sly, L.M. and Luu, Y. and Young, D. and Cooper, H. and Reiner, N.E.

The role of SHIP in cytokine-induced signaling.

Reviews of physiology, biochemistry and pharmacology

Kalesnikoff, J. and Sly, L.M. and Hughes, M.R. and Bchse, T. and Rauh, M.J. and Cao, L.P. and Lam, V. and Mui, A. and Huber, M. and Krystal, G.

Survival of Mycobacterium tuberculosis in host macrophages involves resistance to apoptosis dependent upon induction of antiapoptotic Bcl-2 family member Mcl-1

Journal of Immunology

Sly, L.M. and Hingley-Wilson, S.M. and Reiner, N.E. and McMaster, W.R.

Role of Src homology 2-containing-inositol 5'-phosphatase (SHIP) in mast cells and macrophages

Biochemical Society Transactions

Rauh, M.J. and Kalesnikoff, J. and Hughes, M. and Sly, L. and Lam, V. and Krystal, G.

SHIP, SHIP2, and PTEN activities are regulated in vivo by modulation of their protein levels: SHIP is up-regulated in macrophages and mast cells by lipopolysaccharide

Experimental Hematology

Sly, L.M. and Rauh, M.J. and Kalesnikoff, J. and Bchse, T. and Krystal, G.

Salmonella enterica serovar Typhimurium periplasmic superoxide dismutases SodCI and SodCII are required for protection against the phagocyte oxidative burst

Infection and Immunity

Sly, L.M. and Guiney, D.G. and Reiner, N.E.

1a,25-Dihydroxyvitamin D3-induced Monocyte Antimycobacterial Activity is Regulated by Phosphatidylinositol 3-Kinase and Mediated by the NADPH-dependent Phagocyte Oxidase

Journal of Biological Chemistry

Sly, L.M. and Lopez, M. and Nauseef, W.M. and Reiner, N.E.

1a,25-dihydroxyvitamin D3-induced myeloid cell differentiation is regulated by a vitamin D receptor-phosphatidylinositol 3-kinase signaling complex

Journal of Experimental Medicine

Hmama, Z. and Nandan, D. and Sly, L. and Knutson, K.L. and Herrera-Velit, P. and Reiner, N.E.

Reconstitution of glucose uptake and chemotaxis in Pseudomonas aeruginosa glucose transport defective mutants.

Sly LM and Worobec EA and Perkins RE and Phibbs PV

11 / 1993

Reconstitution of glucose uptake and chemotaxis in Pseudomonas aeruginosa glucose transport defective mutants

Canadian Journal of Microbiology

Sly, L.M. and Worobec, E.A. and Perkins, R.E. and Phibbs Jr., P.V.