Overview

My research centers on various aspects of pediatric neurology, primarily epilepsy and surgical management of epilepsy.

Epilepsy is the most common chronic neurological disorder in children and is characterized by recurrent unprovoked seizures due to uncontrolled electrical activity in the brain. Thirty per cent or more of epilepsy cases do not respond to conventional epileptic medications. Other treatments for epilepsy are epilepsy surgery, vagus nerve stimulation, the ketogenic diet and investigational anti-epileptic drugs.

The epilepsy surgery program at BC Children’s Hospital was established in the mid 90s. My research focuses on outcomes following epilepsy surgery of various types and the influence of surgery on seizure control, quality of life, learning and attention. I am also involved in research in video-EEG monitoring, psychogenic non-epileptic seizures, psychiatric comorbidity in epilepsy and adverse reactions to anti-epileptic drugs.

Publications

Where there is no genetic counselor: An online decision-aid supports the majority of parents’ diagnostic genomic testing choices for their children
Genetics in Medicine
DOI: 10.1016/j.gim.2024.101173
2024

Expanding the genotype-phenotype spectrum in SCN8A-related disorders
BMC Neurology
DOI: 10.1186/s12883-023-03478-y
2024

Seizing the moment: communicating ethics, decisions, and neurotechnological approaches to pediatric drug-resistant epilepsy
Frontiers in Communication
DOI: 10.3389/fcomm.2024.1267065
2024

Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS)
Epilepsia
DOI: 10.1111/epi.17689
2024

Trajectories of parent well-being in children with drug-resistant epilepsy
Epilepsia
DOI: 10.1111/epi.17797
2023

Pre-Operative Predictors of Health-Related Quality of Life Two Years After Pediatric Epilepsy Surgery: A Prospective Cohort Study
Seizure
DOI: 10.1016/j.seizure.2023.08.016
2023

A longitudinal cohort study of mediators of health-related quality of life after pediatric epilepsy surgery or medical treatment
Epilepsia
Smith, M.L. and Puka, K. and Speechley, K.N. and Ferro, M.A. and Connolly, M.B. and Major, P. and Gallagher, A. and Almubarak, S. and Hasal, S. and Ramachandrannair, R. and Andrade, A. and Xu, Q. and Leung, E. and Snead, O.C. and Widjaja, E.
DOI: 10.1111/epi.17660
2023

Trajectory of Health-Related Quality of Life after Pediatric Epilepsy Surgery
JAMA Network Open
Widjaja, E. and Puka, K. and Speechley, K.N. and Ferro, M.A. and Connolly, M.B. and Major, P. and Gallagher, A. and Almubarak, S. and Hasal, S. and Ramachandrannair, R. and Andrade, A. and Xu, Q. and Leung, E. and Snead, O.C. and Smith, M.L.
DOI: 10.1001/jamanetworkopen.2023.4858
2023

Added value of corpus callosotomy following vagus nerve stimulation in children with Lennox–Gastaut syndrome: A multicenter, multinational study
Epilepsia
DOI: 10.1111/epi.17796
2023

ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions
Epilepsia
Hirsch, E. and French, J. and Scheffer, I.E. and Bogacz, A. and Alsaadi, T. and Sperling, M.R. and Abdulla, F. and Zuberi, S.M. and Trinka, E. and Specchio, N. and Somerville, E. and Samia, P. and Riney, K. and Nabbout, R. and Jain, S. and Wilmshurst, J.M. and Auvin, S. and Wiebe, S. and Perucca, E. and Moshé, S. and Tinuper, P. and Wirrell, E.C. and Adikaibe, D.B. and Al Baradi, R. and Andrade, D. and Bast, T. and Beydoun, A. and Bien, C. and Caraballo, R. and Carolina Coan, A. and Connolly, M. and Dunne, J. and Haut, S. and Jansen, F. and Jobst, B. and Kalviainen, R. and Kakooza, A. and Kato, M. and Knupp, K. and Kochen, S. and Lagae, L. and Carlos Mayor, L. and Okujava, N. and Radakishnan, K. and Roulet-Perez, E. and Rios, L. and Sadleir, L. and Juan-Orta, D.S. and Serratosa, J. and Shellhaas, R. and Tsai, M.-H. and Udani, V. and Yue-Hua Zhang,, H. and Zhou., D.
DOI: 10.1111/epi.17236
2022

Understanding Attributes that Influence Physician and Caregiver Decisions About Neurotechnology for Pediatric Drug-Resistant Epilepsy: A Formative Qualitative Study to Support the Development of a Discrete Choice Experiment
Patient
Apantaku, G. and Aguiar, M. and Kaal, K.J. and McDonald, P.J. and Connolly, M.B. and Hrincu, V. and Illes, J. and Harrison, M.
DOI: 10.1007/s40271-021-00544-w
2022

Targeted Whole Exome Sequencing in Children With Early-Onset Epilepsy: Parent Experiences
Journal of Child Neurology
Alam, A. and Parfyonov, M. and Huang, C.Y. and Gill, I. and Connolly, M.B. and Illes, J.
DOI: 10.1177/08830738221113901
2022

Effect of Training on Visual Identification of High Frequency Oscillations—A Delphi-Style Intervention
Frontiers in Neurology
Spring, A.M. and Pittman, D.J. and Rizwan, A. and Aghakhani, Y. and Jirsch, J. and Connolly, M. and Wiebe, S. and Appendino, J.P. and Datta, A. and Steve, T. and Pillay, N. and Javidan, M. and Scantlebury, M. and Hrazdil, C. and Josephson, C.B. and Boelman, C. and Gross, D. and Singh, S. and Bello-Espinosa, L. and Huh, L. and Jetté, N. and Federico, P.
DOI: 10.3389/fneur.2022.794668
2022

Adults with tuberous sclerosis complex: A distinct patient population
Epilepsia
Bachour, K. and House, A.A. and Andrade, D.M. and Connolly, M. and Debicki, D.B. and Desbiens, R. and Fantaneanu, T.A. and Kyriakopoulos, P. and Lattouf, J.-B. and Suller-Marti, A. and Marques, P. and Keezer, M.R.
DOI: 10.1111/epi.17159
2022

Clinician preferences for neurotechnologies in pediatric drug-resistant epilepsy: A discrete choice experiment
Epilepsia
Apantaku, G.O. and McDonald, P.J. and Aguiar, M. and Cabrera, L.Y. and Chiong, W. and Connolly, M.B. and Hrincu, V. and Ibrahim, G.M. and Kaal, K.J. and Lawson, A. and Naftel, R. and Racine, E. and Safari, A. and Harrison, M. and Illes, J.
DOI: 10.1111/epi.17328
2022

Cognitive outcome in children with infantile spasms using a standardized treatment protocol. A five-year longitudinal study
Seizure
Bitton, J.Y. and Desnous, B. and Sauerwein, H.C. and Connolly, M. and Weiss, S.K. and Donner, E.J. and Whiting, S. and Mohamed, I.S. and Wirrell, E.C. and Ronen, G.M. and Lortie, A.
DOI: 10.1016/j.seizure.2021.04.027
2021

Seizure action plans in the pediatric population with epilepsy: Uptake, determinants, and parental interest in a mobile application
Epilepsy and Behavior
Chiu, M. and Peinhof, S. and De Guzman, C. and Borhani, M. and Siu, C. and Kuzeljevic, B. and Schrader, D. and Huh, L. and Connolly, M.B.
DOI: 10.1016/j.yebeh.2021.107860
2021

Choice and Trade-offs: Parent Decision Making for Neurotechnologies for Pediatric Drug-Resistant Epilepsy
Journal of Child Neurology
Hrincu, V. and McDonald, P.J. and Connolly, M.B. and Harrison, M.J. and Ibrahim, G.M. and Naftel, R.P. and Chiong, W. and Alam, A. and Ribary, U. and Illes, J.
DOI: 10.1177/08830738211015010
2021

Rapid Implementation of Virtual Health in a Pediatric Neurology Practice during COVID-19
Canadian Journal of Neurological Sciences
Lee, J. and Schrader, D. and Boelman, C. and Huh, L. and Connolly, M.B.
DOI: 10.1017/cjn.2020.241
2021

SETD1B -associated neurodevelopmental disorder
Journal of Medical Genetics
Roston, A. and Evans, D. and Gill, H. and McKinnon, M. and Isidor, B. and Cogné, B. and Mwenifumbo, J. and Van Karnebeek, C. and An, J. and Jones, S.J.M. and Farrer, M. and Demos, M. and Connolly, M. and Gibson, W.T.
DOI: 10.1136/jmedgenet-2019-106756
2021

Comparison of the real-world effectiveness of vertical versus lateral functional hemispherotomy techniques for pediatric drug-resistant epilepsy: A post hoc analysis of the HOPS study
Epilepsia
Fallah, A. and Lewis, E. and Ibrahim, G.M. and Kola, O. and Tseng, C.-H. and Harris, W.B. and Chen, J.-S. and Lin, K.-M. and Cai, L.-X. and Liu, Q.-Z. and Lin, J.-L. and Zhou, W.-J. and Mathern, G.W. and Smyth, M.D. and O'Neill, B.R. and Dudley, R.W.R. and Ragheb, J. and Bhatia, S. and Delev, D. and Ramantani, G. and Zentner, J. and Wang, A.C. and Dorfer, C. and Feucht, M. and Czech, T. and Bollo, R.J. and Issabekov, G. and Zhu, H. and Connolly, M. and Steinbok, P. and Zhang, J.-G. and Zhang, K. and Hidalgo, E.T. and Weiner, H.L. and Wong-Kisiel, L. and Lapalme-Remis, S. and Tripathi, M. and Sarat Chandra, P. and Hader, W. and Wang, F.-P. and Yao, Y. and Champagne, P.-O. and Brunette-Clément, T. and Guo, Q. and Li, S.-C. and Budke, M. and Pérez-Jiménez, M.A. and Raftopoulos, C. and Finet, P. and Michel, P. and Schaller, K. and Stienen, M.N. and Baro, V. and Cantillano Malone, C. and Pociecha, J. and Chamorro, N. and Muro, V.L. and von Lehe, M. and Vieker, S. and Oluigbo, C. and Gaillard, W.D. and Al-Khateeb, M. and Al Otaibi, F. and Krayenbühl, N. and Bolton, J. and Pearl, P.L. and Weil, A.G.
DOI: 10.1111/epi.17021
2021

Longitudinal changes in emotional functioning following pediatric resective epilepsy surgery: 2-Year follow-up.
Epilepsy & behavior : E&B
Phillips NL and Widjaja E and Speechley K and Ferro M and Connolly M and Major P and Gallagher A and Ramachandrannair R and Almubarak S and Hasal S and Andrade A and Xu Q and Leung E and Smith ML
DOI: 10.1016/j.yebeh.2020.107585
PubMed: 33272893
11/2020

Novel Neurotechnological Interventions for Pediatric Drug-Resistant Epilepsy: Physician Perspectives.
Journal of child neurology
McDonald PJ and Hrincu V and Connolly MB and Harrison MJ and Ibrahim GM and Naftel RP and Chiong W and Udwadia F and Illes J
DOI: 10.1177/0883073820966935
PubMed: 33111593
10/2020

Youth Weigh In: Views on Advanced Neurotechnology for Drug-Resistant Epilepsy.
Journal of child neurology
Udwadia FR and McDonald PJ and Connolly MB and Hrincu V and Illes J
DOI: 10.1177/0883073820957810
PubMed: 32942941
09/2020

Ethically Problematic Medical Device Representation.
The American journal of bioethics : AJOB
Illes J and McDonald PJ and Lau C and Hrincu VM and Connolly MB
DOI: 10.1080/15265161.2020.1782643
PubMed: 32757913
08/2020

Erratum: Pathophysiology of and therapeutic options for a GABRA1 variant linked to epileptic encephalopathy (Molecular Brain (2019) 12 (92) DOI: 10.1186/s13041-019-0513-9)
Molecular Brain
Bai, Y.-F. and Chiu, M. and Chan, E.S. and Axerio-Cilies, P. and Lu, J. and Huh, L. and Connolly, M.B. and Guella, I. and Farrer, M.J. and Xu, Z.-Q.D. and Liu, L. and Demos, M. and Wang, Y.T.
DOI: 10.1186/s13041-020-00593-6
2020

Seizure freedom improves health-related quality of life after epilepsy surgery in children
Developmental Medicine and Child Neurology
Jain, P. and Smith, M.L. and Speechley, K. and Ferro, M. and Connolly, M. and Ramachandrannair, R. and Almubarak, S. and Andrade, A. and Widjaja, E.
DOI: 10.1111/dmcn.14390
2020

Assessing an Interactive Online Tool to Support Parents' Genomic Testing Decisions
Journal of Genetic Counseling
Adam, S. and Birch, P.H. and Coe, R.R. and Bansback, N. and Jones, A.L. and Connolly, M.B. and Demos, M.K. and Toyota, E.B. and Farrer, M.J. and Friedman, J.M.
DOI: 10.1007/s10897-018-0281-1
2019

Exome sequencing identified a de novo mutation of PURA gene in a patient with familial Xp22.31 microduplication
European Journal of Medical Genetics
Qiao, Y. and Bagheri, H. and Tang, F. and Badduke, C. and Martell, S. and Lewis, S.M.E. and Robinson, W. and Connolly, M.B. and Arbour, L. and Rajcan-Separovic, E.
DOI: 10.1016/j.ejmg.2018.06.010
2019

mTOR Inhibitors as a New Therapeutic Strategy in Treatment Resistant Epilepsy in Hemimegalencephaly: A Case Report
Journal of Child Neurology
Xu, Q. and Uliel-Sibony, S. and Dunham, C. and Sarnat, H. and Flores-Sarnat, L. and Brunga, L. and Davidson, S. and Lo, W. and Shlien, A. and Connolly, M. and Boelman, C. and Datta, A.
DOI: 10.1177/0883073818813238
2019

CYP2D6 as a treatment decision aid for ER-positive non-metastatic breast cancer patients: a systematic review with accompanying clinical practice guidelines
Breast Cancer Research and Treatment
Drögemöller, B.I. and Wright, G.E.B. and Shih, J. and Monzon, J.G. and Gelmon, K.A. and Ross, C.J.D. and Amstutz, U. and Carleton, B.C. and Chang, W.C. and Connolly, M.B. and Dionne, F. and Groeneweg, G. and Loucks, C.M. and MacLeod, S.M. and Pritchard, S. and Rassekh, S.R. and Sanatani, S. and Tanoshima, R. and Virani, S.A. and Monzon, J.G. and Bhavsar, A.P. and Rieder, M.J. and Shear, N.H. and Liu, G. and Khayat, P. and Bernstein, D. and Lesko, L.J. and Aminkeng, F.
DOI: 10.1007/s10549-018-5027-0
2019

Atypical cerebral palsy: genomics analysis enables precision medicine
Genetics in Medicine
Matthews, A.M. and Blydt-Hansen, I. and Al-Jabri, B. and Andersen, J. and Tarailo-Graovac, M. and Price, M. and Selby, K. and Demos, M. and Connolly, M. and Drögemoller, B. and Shyr, C. and Mwenifumbo, J. and Elliott, A.M. and Lee, J. and Ghani, A. and Stöckler, S. and Salvarinova, R. and Vallance, H. and Sinclair, G. and Ross, C.J. and Wasserman, W.W. and McKinnon, M.L. and Horvath, G.A. and Goez, H. and van Karnebeek, C.D.
DOI: 10.1038/s41436-018-0376-y
2019

Position Statement on the Use of Medical Cannabis for the Treatment of Epilepsy in Canada,Énoncé de position quant à l'utilisation du cannabis médical dans le traitement de l'épilepsie
Canadian Journal of Neurological Sciences
Appendino, J.P. and Boelman, C. and Brna, P.M. and Burneo, J.G. and Claassen, C.S. and Connolly, M.B. and De Guzman, M.V.T. and Federico, P. and Floyd, D. and Huntsman, R.J. and Javidan, M. and Jette, N. and Jurasek, L.L. and Keezer, M.R. and Lau, J.C. and McCoy, B. and McLachlan, R.S. and Ng, M.C. and Nguyen, D.K. and Reid, A.Y. and Rho, J.M. and Snead, O.C. and Téllez-Zenteno, J.F. and Wang, L. and Zak, M.M.
DOI: 10.1017/cjn.2019.282
2019

Pathophysiology of and therapeutic options for a GABRA1 variant linked to epileptic encephalopathy
Molecular Brain
Bai, Y.-F. and Chiu, M. and Chan, E.S. and Axerio-Cilies, P. and Lu, J. and Huh, L. and Connolly, M.B. and Guella, I. and Farrer, M.J. and Xu, Z.-Q.D. and Liu, L. and Demos, M. and Wang, Y.T.
DOI: 10.1186/s13041-019-0513-9
2019

Care-related quality of life in caregivers of children with drug-resistant epilepsy
Journal of Neurology
Jain, P. and Subendran, J. and Smith, M.L. and Widjaja, E. and Carter Snead, O. and Go, C. and Connolly, M. and Ramachandrannair, R. and Carmant, L. and Speechley, K. and Andrade, A. and Ferro, M. and Bello-Espinosa, L. and Xu, Q. and Leung, E. and Almubarak, S. and Brna, P.
DOI: 10.1007/s00415-018-8979-4
2018

Humanized mouse model of Rasmussen's encephalitis supports the immune-mediated hypothesis
Journal of Clinical Investigation
Kebir, H. and Carmant, L. and Fontaine, F. and Béland, K. and Bosoi, C.M. and Sanon, N.T. and Alvarez, J.I. and Desgent, S. and Pittet, C.L. and Hébert, D. and Langlois, M.-J. and Rébillard, R.-M. and Nguyen, D.K. and Cieuta-Walti, C. and Holmes, G.L. and Goodkin, H.P. and Mytinger, J.R. and Connolly, M.B. and Prat, A. and Haddad, E.
DOI: 10.1172/JCI97098
2018

MRI and laboratory features and the performance of international criteria in the diagnosis of multiple sclerosis in children and adolescents: a prospective cohort study
The Lancet Child and Adolescent Health
Fadda, G. and Brown, R.A. and Longoni, G. and Castro, D.A. and O'Mahony, J. and Verhey, L.H. and Branson, H.M. and Waters, P. and Bar-Or, A. and Marrie, R.A. and Yeh, E.A. and Narayanan, S. and Arnold, D.L. and Banwell, B. and Wambera, K. and Connolly, M.B. and Yager, J. and Mah, J.K. and Sebire, G. and Callen, D. and Meaney, B. and Dilenge, M.-E. and Lortie, A. and Pohl, D. and Doja, A. and Venkateswaran, S. and Levin, S. and MacDonald, E.A. and Meek, D. and Wood, E. and Buckley, D. and Awuku, M. and Baird, J.B. and Bhan, V. and Arnaoutelis, R. and Nandamalavan, D.
DOI: 10.1016/S2352-4642(18)30026-9
2018

Improvement of Self-Injury With Dopamine and Serotonin Replacement Therapy in a Patient With a Hemizygous PAK3 Mutation: A New Therapeutic Strategy for Neuropsychiatric Features of an Intellectual Disability Syndrome
Journal of Child Neurology
Horvath, G.A. and Tarailo-Graovac, M. and Bartel, T. and Race, S. and Van Allen, M.I. and Blydt-Hansen, I. and Ross, C.J. and Wasserman, W.W. and Connolly, M.B. and van Karnebeek, C.D.M.
DOI: 10.1177/0883073817740443
2018

Secondary Abnormal CSF Neurotransmitter Metabolite Profiles in a Pediatric Tertiary Care Centre
Canadian Journal of Neurological Sciences
Van Karnebeek, C.D.M. and Dunbar, M. and Egri, C. and Sayson, B. and Milea, J. and Stockler-Ipsiroglu, S. and Huh, L. and Connolly, M.B. and Horvath, G.A.
DOI: 10.1017/cjn.2017.271
2018

ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology,ILAE-Klassifikation der Epilepsien: Positionspapier der ILAE-Kommission für Klassifikation und Terminologie
Zeitschrift fur Epileptologie
Scheffer, I.E. and Berkovic, S. and Capovilla, G. and Connolly, M.B. and French, J. and Guilhoto, L. and Hirsch, E. and Jain, S. and Mathern, G.W. and Moshé, S.L. and Nordli, D.R. and Perucca, E. and Tomson, T. and Wiebe, S. and Zhang, Y.-H. and Zuberi, S.M.
DOI: 10.1007/s10309-018-0218-6
2018

An Infant With Epilepsy and Recurrent Hemiplegia due to Compound Heterozygous Variants in ATP1A2
Pediatric Neurology
Wilbur, C. and Buerki, S.E. and Guella, I. and Toyota, E.B. and Evans, D.M. and McKenzie, M.B. and Datta, A. and Michoulas, A. and Adam, S. and Van Allen, M.I. and Nelson, T.N. and Farrer, M.J. and Connolly, M.B. and Demos, M.
DOI: 10.1016/j.pediatrneurol.2017.06.003
2017

De Novo Mutations in YWHAG Cause Early-Onset Epilepsy
American Journal of Human Genetics
Guella, I. and McKenzie, M.B. and Evans, D.M. and Buerki, S.E. and Toyota, E.B. and Van Allen, M.I. and Adam, S. and Boelman, C. and Bolbocean, C. and Candido, T. and Eydoux, P. and Horvath, G. and Huh, L. and Nelson, T.N. and Sinclair, G. and van Karnebeek, C. and Vercauteren, S. and Suri, M. and Elmslie, F. and Simon, M.E.H. and van Gassen, K.L.I. and Héron, D. and Keren, B. and Nava, C. and Connolly, M.B. and Demos, M. and Farrer, M.J.
DOI: 10.1016/j.ajhg.2017.07.004
2017

Manifestations of Tuberous Sclerosis Complex: The Experience of a Provincial Clinic
Canadian Journal of Neurological Sciences
Wilbur, C. and Sanguansermsri, C. and Chable, H. and Anghelina, M. and Peinhof, S. and Anderson, K. and Steinbok, P. and Singhal, A. and Datta, A. and Connolly, M.B.
DOI: 10.1017/cjn.2016.311
2017

The relationship between d-beta-hydroxybutyrate blood concentrations and seizure control in children treated with the ketogenic diet for medically intractable epilepsy
Epilepsia Open
Buchhalter, J.R. and D'Alfonso, S. and Connolly, M. and Fung, E. and Michoulas, A. and Sinasac, D. and Singer, R. and Smith, J. and Singh, N. and Rho, J.M.
DOI: 10.1002/epi4.12058
2017

ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology
Epilepsia
Scheffer, I.E. and Berkovic, S. and Capovilla, G. and Connolly, M.B. and French, J. and Guilhoto, L. and Hirsch, E. and Jain, S. and Mathern, G.W. and Moshé, S.L. and Nordli, D.R. and Perucca, E. and Tomson, T. and Wiebe, S. and Zhang, Y.-H. and Zuberi, S.M.
DOI: 10.1111/epi.13709
2017

Child- and parent-reported quality of life trajectories in children with epilepsy: A prospective cohort study
Epilepsia
Ferro, M.A. and Avery, L. and Fayed, N. and Streiner, D.L. and Cunningham, C.E. and Boyle, M.H. and Lach, L. and Glidden, G. and Rosenbaum, P.L. and Ronen, G.M. and Connolly, M. and Bello-Espinosa, L. and Rafay, M.F. and Appendino, J.P. and Shevell, M. and Carmant, L.
DOI: 10.1111/epi.13774
2017

Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy
American Journal of Human Genetics
Lehman, A. and Thouta, S. and Mancini, G.M.S. and Naidu, S. and van Slegtenhorst, M. and McWalter, K. and Person, R. and Mwenifumbo, J. and Salvarinova, R. and Adam, S. and du Souich, C. and Elliott, A.M. and Nelson, T.N. and van Karnebeek, C. and Friedman, J.M. and Boelman, C. and Bolbocean, C. and Buerki, S.E. and Candido, T. and Eydoux, P. and Evans, D.M. and Gibson, W. and Horvath, G. and Huh, L. and Sinclair, G. and Tarling, T. and Toyota, E.B. and Townsend, K.N. and Van Allen, M.I. and Vercauteren, S. and Guella, I. and McKenzie, M.B. and Datta, A. and Connolly, M.B. and Kalkhoran, S.M. and Poburko, D. and Farrer, M.J. and Demos, M. and Desai, S. and Claydon, T.
DOI: 10.1016/j.ajhg.2017.05.016
2017

Clinical, imaging, and immunohistochemical characteristics of focal cortical dysplasia Type II extratemporal epilepsies in children: Analyses of an institutional case series
Journal of Neurosurgery: Pediatrics
Knerlich-Lukoschus, F. and Connolly, M.B. and Hendson, G. and Steinbok, P. and Dunham, C.
DOI: 10.3171/2016.8.PEDS1686
2017

Clinical Experience with Perampanel for Refractory Pediatric Epilepsy in One Canadian Center
Journal of Child Neurology
Datta, A.N. and Xu, Q. and Sachedina, S. and Boelman, C. and Huh, L. and Connolly, M.B.
DOI: 10.1177/0883073817709195
2017

Correlates of health-related quality of life in children with drug resistant epilepsy
Epilepsia
Lauryn Conway and Mary Lou Smith and Mark A. Ferro and Kathy N. Speechley and Mary B. Connoly and O. Carter Snead and Elysa Widjaja and the PEPSQOL Study Team
DOI: 10.1111/epi.13441
06/2016

Exome sequencing and the management of neurometabolic disorders
New England Journal of Medicine
Tarailo-Graovac, M. and Shyr, C. and Ross, C.J. and Horvath, G.A. and Salvarinova, R. and Ye, X.C. and Zhang, L.-H. and Bhavsar, A.P. and Lee, J.J.Y. and Drögemöller, B.I. and Abdelsayed, M. and Alfadhel, M. and Armstrong, L. and Baumgartner, M.R. and Burda, P. and Connolly, M.B. and Cameron, J. and Demos, M. and Dewan, T. and Dionne, J. and Evans, A.M. and Friedman, J.M. and Garber, I. and Lewis, S. and Ling, J. and Mandal, R. and Mattman, A. and McKinnon, M. and Michoulas, A. and Metzger, D. and Ogunbayo, O.A. and Rakic, B. and Rozmus, J. and Ruben, P. and Sayson, B. and Santra, S. and Schultz, K.R. and Selby, K. and Shekel, P. and Sirrs, S. and Skrypnyk, C. and Superti-Furga, A. and Turvey, S.E. and Van Allen, M.I. and Wishart, D. and Wu, J. and Wu, J. and Zafeiriou, D. and Kluijtmans, L. and Wevers, R.A. and Eydoux, P. and Lehman, A.M. and Vallance, H. and Stockler-Ipsiroglu, S. and Sinclair, G. and Wasserman, W.W. and Van Karnebeek, C.D.
DOI: 10.1056/NEJMoa1515792
2016

De novo FGF12 mutation in 2 patients with neonatal-onset epilepsy
Neurology: Genetics
Guella, I. and Huh, L. and McKenzie, M.B. and Toyota, E.B. and Martina Bebin, E. and Thompson, M.L. and Cooper, G.M. and Evans, D.M. and Buerki, S.E. and Adam, S. and Van Allen, M.I. and Nelson, T.N. and Connolly, M.B. and Farrer, M.J. and Demos, M.
DOI: 10.1212/NXG.0000000000000120
2016

Dravet Syndrome: Diagnosis and Long-Term Course
Canadian Journal of Neurological Sciences
Connolly, M.B.
DOI: 10.1017/cjn.2016.243
2016

Children's perspective of quality of life in epilepsy
Neurology
N. Fayed and A. M. Davis and D. L. Streiner and P. L. Rosenbaum and C. E. Cunningham and L. M. Lach and M. H. Boyle and G. M. Ronen and On behalf of the QUALITE Study Group
DOI: 10.1212/wnl.0000000000001536
04/2015

Recovery from central nervous system acute demyelination in children
Pediatrics
O'Mahony, J. and Marrie, R.A. and Laporte, A. and Yeh, E.A. and Bar-Or, A. and Phan, C. and Buckley, D. and Callen, D. and Connolly, M.B. and Pohl, D. and Dilenge, M.-E. and Bernard, G. and Lortie, A. and Lowry, N. and MacDonald, E.A. and Meek, D. and Sébire, G. and Venkateswaran, S. and Wood, E. and Yager, J. and Banwell, B.
DOI: 10.1542/peds.2015-0028
2015

Resective Epilepsy Surgery for Tuberous Sclerosis in Children: Determining Predictors of Seizure Outcomes in a Multicenter Retrospective Cohort Study
Neurosurgery
Fallah, A. and Rodgers, S.D. and Weil, A.G. and Vadera, S. and Mansouri, A. and Connolly, M.B. and Major, P. and Ma, T. and Devinsky, O. and Weiner, H.L. and Gonzalez-Martinez, J.A. and Bingaman, W.E. and Najm, I. and Gupta, A. and Ragheb, J. and Bhatia, S. and Steinbok, P. and Witiw, C.D. and Widjaja, E. and Snead, O.C. and Rutka, J.T.
DOI: 10.1227/NEU.0000000000000875
2015

The importance of cerebral magnetic resonance imaging in evaluation of neonatal seizures
Developmental Medicine and Child Neurology
Buerki, S.E. and Connolly, M.B.
DOI: 10.1111/dmcn.12640
2015

The "vagal ansa": A source of complication in vagus nerve stimulation
Journal of Neurosurgery: Pediatrics
Gopalakrishnan, C.V. and Kestle, J.R.W. and Connolly, M.B.
DOI: 10.3171/2014.10.PEDS14259
2015

Does treatment have an impact on incidence and risk factors for autism spectrum disorders in children with infantile spasms?
Epilepsia
Bitton, J.Y. and Demos, M. and Elkouby, K. and Connolly, M. and Weiss, S.K. and Donner, E.J. and Whiting, S. and Ronen, G.M. and Bello-Espinosa, L. and Wirrell, E.C. and Mohamed, I.S. and Dooley, J.M. and Carmant, L.
DOI: 10.1111/epi.12997
2015

Clinical and magnetic resonance imaging (MRI) distinctions between tumefactive demyelination and brain tumors in children.
Journal of child neurology
Yiu EM and Laughlin S and Verhey LH and Banwell BL and Canadian Pediatric Demyelinating Disease Network
DOI: 10.1177/0883073813500713
PubMed: 24092896
05/2014

Diagnostic value of a multidisciplinary clinic for intellectual disability.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
van Karnebeek C and Murphy T and Giannasi W and Thomas M and Connolly M and Stockler-Ipsiroglu S
PubMed: 24718818
05/2014

Outcomes trajectories in children with epilepsy: hypotheses and methodology of a Canadian longitudinal observational study.
Pediatric neurology
Ronen GM and Streiner DL and Boyle MH and Cunningham CE and Lach L and Verhey LH and Fayed N and Chen K and Rosenbaum PL and QUALITÉ Group and Connolly M and Bello-Espinosa LE and Carmant L
DOI: 10.1016/j.pediatrneurol.2013.08.024
PubMed: 24370172
01/2014

Diagnostic Value of a Multidisciplinary Clinic for Intellectual Disability
Canadian Journal of Neurological Sciences
Van Karnebeek, C. and Murphy, T. and Giannasi, W. and Thomas, M. and Connolly, M. and Stockler-Ipsiroglu, S.
DOI: 10.1017/S0317167100017273
2014

Pyridoxine responsiveness in novel mutations of the PNPO gene
Neurology
Plecko, B. and Paul, K. and Mills, P. and Clayton, P. and Paschke, E. and Maier, O. and Hasselmann, O. and Schmiedel, G. and Kanz, S. and Connolly, M. and Wolf, N. and Struys, E. and Stockler, S. and Abela, L. and Hofer, D.
DOI: 10.1212/WNL.0000000000000344
2014

Acute flaccid paralysis in a child infected with enterovirus D68: A case report
British Columbia Medical Journal
Sherwood, M.D. and Gantt, S. and Connolly, M. and Dobson, S.
2014

Recommendations for HLA-B15:02 and HLA-A31:01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity reactions
Epilepsia
Amstutz, U. and Shear, N.H. and Rieder, M.J. and Hwang, S. and Fung, V. and Nakamura, H. and Connolly, M.B. and Ito, S. and Carleton, B.C.
DOI: 10.1111/epi.12564
2014

Classifying Epileptic Seizures and the Epilepsies
Epilepsy
DOI: 10.1002/9781118456989.ch2
2014

Masquerades of acquired demyelination in children: experiences of a national demyelinating disease program.
Journal of child neurology
O'Mahony J and Bar-Or A and Arnold DL and Sadovnick AD and Marrie RA and Banwell B and Canadian Pediatric Demyelinating Disease Network
DOI: 10.1177/0883073812443006
PubMed: 22573735
02/2013

A condensed performance-validation strategy for multiplex detection kits used in studies of human clinical samples
Journal of Immunological Methods
Chahrazed Belabani and Sathyanath Rajasekharan and Viviane Poupon and Trina Johnson and Amit Bar-Or
DOI: 10.1016/j.jim.2012.08.002
01/2013

Hippocampal malrotation and temporal lobe epilepsy: What is the relationship?
Canadian Journal of Neurological Sciences
Connolly, M.B.
DOI: 10.1017/S0317167100014839
PubMed: 23968933
2013

A case report of obsessive-compulsive disorder following acute disseminated encephalomyelitis
Pediatrics
Muir, K.E. and McKenney, K.S. and Connolly, M.B. and Evelyn Stewart, S.
DOI: 10.1542/peds.2012-2876
2013

MRI findings in infants with infantile spasms after neonatal hypoxic-ischemic encephalopathy
Pediatric Neurology
Gano, D. and Sargent, M.A. and Miller, S.P. and Connolly, M.B. and Wong, P. and Glass, H.C. and Poskitt, K.J. and Chau, V.
DOI: 10.1016/j.pediatrneurol.2013.08.007
2013

Status epilepticus amauroticus and posterior reversible encephalopathy syndrome in children
Journal of Clinical Neurophysiology
Muro, V.L. and Yip, S. and Huh, L. and Connolly, M.B.
DOI: 10.1097/WNP.0b013e31829de004
2013

Discontinuation of antiepileptic drugs after successful epilepsy surgery. a Canadian survey.
Epilepsy research
Téllez-Zenteno JF and Ronquillo LH and Jette N and Burneo JG and Nguyen DK and Donner EJ and Sadler M and Javidan M M and Gross DW and Wiebe S and Canadian Epilepsy Surgery Study Group
DOI: 10.1016/j.eplepsyres.2012.04.018
PubMed: 22595484
11/2012

Benign myoclonic epilepsy of infancy
Pediatric Epilepsy
08/2012

2010 McDonald criteria for diagnosing pediatric multiple sclerosis
Annals of Neurology
Yair Sadaka and Leonard H. Verhey and Manohar M. Shroff and Helen M. Branson and Douglas L. Arnold and Sridar Narayanan and John G. Sled and Amit Bar-Or and A. Dessa Sadovnick and Melissa McGowan and Ruth Ann Marrie and Brenda Banwell and on behalf of the Canadian Pediatric Demyelinating Disease Network
DOI: 10.1002/ana.23575
08/2012

Epilepsy surgery in childhood
Canadian Journal of Neurological Sciences
Muro, V.L. and Connolly, M.B.
DOI: 10.1017/s0317167100018163
2012

Lysine restricted diet for pyridoxine-dependent epilepsy: First evidence and future trials
Molecular Genetics and Metabolism
van Karnebeek, C.D.M. and Hartmann, H. and Jaggumantri, S. and Bok, L.A. and Cheng, B. and Connolly, M. and Coughlin, C.R. and Das, A.M. and Gospe, S.M. and Jakobs, C. and van der Lee, J.H. and Mercimek-Mahmutoglu, S. and Meyer, U. and Struys, E. and Sinclair, G. and Van Hove, J. and Collet, J.-P. and Plecko, B.R. and Stockler, S.
DOI: 10.1016/j.ymgme.2012.09.006
2012

Profound neonatal hypoglycemia and lactic acidosis caused by pyridoxine-dependent epilepsy
Pediatrics
Mercimek-Mahmutoglu, S. and Horvath, G.A. and Coulter-Mackie, M. and Nelson, T. and Waters, P.J. and Sargent, M. and Struys, E. and Jakobs, C. and Stockler-Ipsiroglu, S. and Connolly, M.B.
DOI: 10.1542/peds.2011-0123
2012

Systematic review and case series of neuropsychological functioning after epilepsy surgery in children with dysembryoplastic neuroepithelial tumors (DNET)
Epilepsy and Behavior
Fay-McClymont, T.B. and Hrabok, M. and Sherman, E.M.S. and Hader, W.J. and Connolly, M.B. and Akdag, S. and Mohamed, I.S. and Wiebe, S.
DOI: 10.1016/j.yebeh.2011.12.011
2012

Mitochondrial DNA haplogroups and mutations in children with acquired central demyelination.
Neurology
Venkateswaran S and Zheng K and Sacchetti M and Gagne D and Arnold DL and Sadovnick AD and Scherer SW and Banwell B and Bar-Or A and Simon DK and Canadian Pediatric Demyelinating Disease Network
DOI: 10.1212/wnl.0b013e31820ee1bb
PubMed: 21288980
03/2011

HLA-DRB1 confers increased risk of pediatric-onset MS in children with acquired demyelination.
Neurology
Disanto G and Magalhaes S and Handel AE and Morrison KM and Sadovnick AD and Ebers GC and Banwell B and Bar-Or A and Canadian Pediatric Demyelinating Disease Network
DOI: 10.1212/wnl.0b013e31820ee1cd
PubMed: 21288988
03/2011

Approach to a child with a first afebrile seizure
British Columbia Medical Journal
Michoulas, A. and Farrell, K. and Connolly, M.
2011

Electroclinical features of absence seizures in sleep
Epilepsy Research
Sadleir, L.G. and Farrell, K. and Smith, S. and Connolly, M.B. and Scheffer, I.E.
DOI: 10.1016/j.eplepsyres.2010.12.009
2011

Landau-Kleffner syndrome: A rare Auditory Processing Disorder. Series of cases and review of the literature
International Journal of Pediatric Otorhinolaryngology
Fandiño, M. and Connolly, M. and Usher, L. and Palm, S. and Kozak, F.K.
DOI: 10.1016/j.ijporl.2010.10.001
2011

Improving the management of epilepsy in children
British Columbia Medical Journal
Farrell Dr., K. and Connolly Dr., M.
2011

Cerebral sinus thrombosis following IV immunoglobulin therapy of immune thrombocytopenia purpura
Pediatric Blood and Cancer
Al-Riyami, A.Z. and Lee, J. and Connolly, M. and Shereck, E.
DOI: 10.1002/pbc.22968
2011

Cerebrovasculopathy in NF1 associated with ocular and scalp defects
American Journal of Medical Genetics, Part A
Smith, M. and Heran, M.K. and Connolly, M.B. and Heran, H.K. and Friedman, J.M. and Jett, K. and Lyons, C.J. and Steinbok, P. and Armstrong, L.
DOI: 10.1002/ajmg.a.33788
2011

Epilepsy with occipital features in children: Factors predicting seizure outcome and neuroimaging abnormalities
European Journal of Paediatric Neurology
Schrader, D. and Shukla, R. and Gatrill, R. and Farrell, K. and Connolly, M.
DOI: 10.1016/j.ejpn.2010.08.005
2011

Electrocorticography and seizure outcomes in children with lesional epilepsy
Child's Nervous System
Gelinas, J.N. and Battison, A.W. and Smith, S. and Connolly, M.B. and Steinbok, P.
DOI: 10.1007/s00381-010-1279-7
2011

Pyridoxine dependent epilepsy and antiquitin deficiency. Clinical and molecular characteristics and recommendations for diagnosis, treatment and follow-up
Molecular Genetics and Metabolism
Stockler, S. and Plecko, B. and Gospe, S.M. and Coulter-Mackie, M. and Connolly, M. and van Karnebeek, C. and Mercimek-Mahmutoglu, S. and Hartmann, H. and Scharer, G. and Struijs, E. and Tein, I. and Jakobs, C. and Clayton, P. and Van Hove, J.L.K.
DOI: 10.1016/j.ymgme.2011.05.014
2011

Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: A prospective national cohort study
The Lancet Neurology
Banwell, B. and Bar-Or, A. and Arnold, D.L. and Sadovnick, D. and Narayanan, S. and McGowan, M. and O'Mahony, J. and Magalhaes, S. and Hanwell, H. and Vieth, R. and Tellier, R. and Vincent, T. and Disanto, G. and Ebers, G. and Wambera, K. and Connolly, M.B. and Yager, J. and Mah, J.K. and Booth, F. and Sebire, G. and Callen, D. and Meaney, B. and Dilenge, M.-E. and Lortie, A. and Pohl, D. and Doja, A. and Venketaswaran, S. and Levin, S. and MacDonald, E.A. and Meek, D. and Wood, E. and Lowry, N. and Buckley, D. and Yim, C. and Awuku, M. and Cooper, P. and Grand'Maison, F. and Baird, J.B. and Bhan, V. and Marrie, R.A.
DOI: 10.1016/S1474-4422(11)70045-X
2011

Parents report more ADHD symptoms than do teachers in children with epilepsy
Epilepsy and Behavior
Sherman, E.M.S. and Brooks, B.L. and Akdag, S. and Connolly, M.B. and Wiebe, S.
DOI: 10.1016/j.yebeh.2010.08.015
2010

Treatment of intractable epilepsy in a female with SLC6A8 deficiency
Molecular Genetics and Metabolism
Mercimek-Mahmutoglu, S. and Connolly, M.B. and Poskitt, K.J. and Horvath, G.A. and Lowry, N. and Salomons, G.S. and Casey, B. and Sinclair, G. and Davis, C. and Jakobs, C. and Stockler-Ipsiroglu, S.
DOI: 10.1016/j.ymgme.2010.08.016
2010

Red reflex mimicking lens subluxation in a child undergoing orthokeratology
Eye
Wiwatwongwana, A. and Connolly, M.B. and Lyons, C.J.
DOI: 10.1038/eye.2009.46
2010

Epilepsy and memory dysfunction.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Connolly MB
PubMed: 19760900
08/2009

Epilepsy surgery in the first 3 years of life: A Canadian survey
Epilepsia
Steinbok, P. and Gan, P.Y.C. and Connolly, M.B. and Carmant, L. and Barry Sinclair, D. and Rutka, J. and Griebel, R. and Aronyk, K. and Hader, W. and Ventureyra, E. and Atkinson, J.
DOI: 10.1111/j.1528-1167.2008.01992.x
2009

Automatisms in absence seizures in children with idiopathic generalized epilepsy
Archives of Neurology
Sadleir, L.G. and Scheffer, I.E. and Smith, S. and Connolly, M.B. and Farrell, K.
DOI: 10.1001/archneurol.2009.108
2009

Incidence of acquired demyelination of the CNS in Canadian children
Neurology
Banwell, B. and Kennedy, J. and Sadovnick, D. and Arnold, D.L. and Magalhaes, S. and Wambera, K. and Connolly, M.B. and Yager, J. and Mah, J.K. and Shah, N. and Sebire, G. and Meaney, B. and Dilenge, M.-E. and Lortie, A. and Whiting, S. and Doja, A. and Levin, S. and Macdonald, E.A. and Meek, D. and Wood, E. and Lowry, N. and Buckley, D. and Yim, C. and Awuku, M. and Guimond, C. and Cooper, P. and Grand'maison, F. and Baird, J.B. and Bhan, V. and Bar-Or, A.
DOI: 10.1212/01.wnl.0000339482.84392.bd
2009

Cingulate lesions presenting with epileptic spasms
Journal of Clinical Neurophysiology
Schrader, D. and Langill, L. and Singhal, A. and Steinbok, P. and Connolly, M.B.
DOI: 10.1097/WNP.0b013e3181baaacf
2009

Epilepsy and memory dysfunction
Canadian Journal of Neurological Sciences
2009

Urgent, resective surgery for medically refractory, convulsive status epilepticus
European Journal of Paediatric Neurology
Schrader, D.V. and Steinbok, P. and Connolly, M.
DOI: 10.1016/j.ejpn.2008.01.011
2009

EEG features of absence seizures in idiopathic generalized epilepsy: Impact of syndrome, age, and state
Epilepsia
Sadleir, L.G. and Scheffer, I.E. and Smith, S. and Carstensen, B. and Farrell, K. and Connolly, M.B.
DOI: 10.1111/j.1528-1167.2008.02001.x
2009

Factors influencing clinical features of absence seizures
Epilepsia
Sadleir, L.G. and Scheffer, I.E. and Smith, S. and Carstensen, B. and Carlin, J. and Connolly, M.B. and Farrell, K.
DOI: 10.1111/j.1528-1167.2008.01708.x
2008

Epilepsy associated with a cerebellar arachnoid cyst: Seizure control following fenestration of the cyst
Child's Nervous System
Gan, Y.C. and Connolly, M.B.C. and Steinbok, P.
DOI: 10.1007/s00381-007-0439-x
2008

Autosomal recessive GTP cyclohydrolase I deficiency without hyperphenylalaninemia: Evidence of a phenotypic continuum between dominant and recessive forms
Molecular Genetics and Metabolism
Horvath, G.A. and Stockler-Ipsiroglu, S.G. and Salvarinova-Zivkovic, R. and Lillquist, Y.P. and Connolly, M. and Hyland, K. and Blau, N. and Rupar, T. and Waters, P.J.
DOI: 10.1016/j.ymgme.2008.01.003
2008

Sociodemographic correlates of health-related quality of life in pediatric epilepsy
Epilepsy and Behavior
Sherman, E.M.S. and Griffiths, S.Y. and Akdag, S. and Connolly, M.B. and Slick, D.J. and Wiebe, S.
DOI: 10.1016/j.yebeh.2007.07.009
2008

Quality of life and seizure outcome after vagus nerve stimulation in children with intractable epilepsy
Journal of Child Neurology
Sherman, E.M.S. and Connolly, M.B. and Slick, D.J. and Eyrl, K.L. and Steinbok, P. and Farrell, K.
DOI: 10.1177/0883073808315417
2008

Tick paralysis: Presentation as a pure cerebellar syndrome
Journal of Pediatric Neurology
Alroughani, R. and Guilfoyle, J. and Connolly, M.B.
DOI: 10.1055/s-0035-1557486
2008

The spectrum of SCN1A-related infantile epileptic encephalopathies
Brain
Harkin, L.A. and McMahon, J.M. and Iona, X. and Dibbens, L. and Pelekanos, J.T. and Zuberi, S.M. and Sadleir, L.G. and Andermann, E. and Gill, D. and Farrell, K. and Connolly, M. and Stanley, T. and Harbord, M. and Andermann, F. and Wang, J. and Batish, S.D. and Jones, J.G. and Seltzer, W.K. and Gardner, A. and Sutherland, G. and Berkovic, S.F. and Mulley, J.C. and Scheffer, I.E. and Abbott, K. and Andrews, I. and Appleton, B. and Bleasel, A. and Buchanan, N. and Burke, C. and Bye, A. and Camfield, C. and Camfield, P. and Chow, G. and Collins, K. and Cook, M. and Cross, J.H. and Crow, Y. and D'Agostino, M.D. and Delatycki, M. and Dunkley, C. and Fawke, J. and Ferrie, C. and Geraghty, M. and Graham, G. and Grattan-Smith, P. and Hallam, E. and Hamiwka, L. and Harding, A. and Harvey, S. and Hayman, M. and Hufton, I. and Humphries, P. and Jacob, P. and Jacquemard, R. and Jamison, D. and Jardine, P. and Jones, S. and Keene, D. and Kelley, K. and Ketteridge, D. and Kim, A. and Kivity, S. and Kneebone, C. and Kornberg, A. and Lamb, C. and Lander, C. and Lerman-Sagie, T. and Lev, D. and Leventer, R. and Mackay, M. and Malone, S. and Manson, J. and McLellan, A. and Moore, P. and Nagarajan, L. and Nash, M. and Nikanorova, M. and Nordli, D. and O'Regan, M. and Ouvrier, R. and Patel, J. and Pridmore, C. and Ramesh, V. and Reutens, D. and Rowe, P. and Shield, L. and Shillito, P. and Smith, L. and Spooner, C. and Wallace, G. and Watemberg, N. and Whitehouse, W. and Wirrell, E.
DOI: 10.1093/brain/awm002
2007

Postsurgical health-related quality of life (HRQOL) in children following hemispherectomy for intractable epilepsy
Epilepsia
Griffiths, S.Y. and Sherman, E.M.S. and Slick, D.J. and Eyrl, K. and Connolly, M.B. and Steinbok, P.
DOI: 10.1111/j.1528-1167.2006.00966.x
2007

Surgical outcome in tuberous sclerosis complex: A multicenter survey
Epilepsia
Madhavan, D. and Schaffer, S. and Yankovsky, A. and Arzimanoglou, A. and Renaldo, F. and Zaroff, C.M. and LaJoie, J. and Weiner, H.L. and Andermann, E. and Franz, D.N. and Leonard, J. and Connolly, M. and Cascino, G.D. and Devinsky, O.
DOI: 10.1111/j.1528-1167.2007.01112.x
2007

ADHD, neurological correlates and health-related quality of life in severe pediatric epilepsy
Epilepsia
Sherman, E.M.S. and Slick, D.J. and Connolly, M.B. and Eyrl, K.L.
DOI: 10.1111/j.1528-1167.2007.01028.x
2007

Hemispheric surgery in children with refractory epilepsy: Seizure outcome, complications, and adaptive function
Epilepsia
Basheer, S.N. and Connolly, M.B. and Lautzenhiser, A. and Sherman, E.M.S. and Hendson, G. and Steinbok, P.
DOI: 10.1111/j.1528-1167.2006.00909.x
2007

Tuberous sclerosis complex: A review of the management of epilepsy with emphasis on surgical aspects
Child's Nervous System
Connolly, M.B. and Hendson, G. and Steinbok, P.
DOI: 10.1007/s00381-006-0130-7
2006

Electroclinical features of absence seizures in childhood absence epilepsy
Neurology
Sadleir, L.G. and Farrell, K. and Smith, S. and Connolly, M.B. and Scheffer, I.E.
DOI: 10.1212/01.wnl.0000228257.60184.82
2006

Pharmacological management of a youth with ADHD and a seizure disorder
Journal of the American Academy of Child and Adolescent Psychiatry
Gonzalez-Heydrich, J. and Weiss, M. and Connolly, M. and Wambera, K. and Jan, J.E. and Plioplys, S. and Dunn, D.W. and Kratochvil, C.J.
DOI: 10.1097/01.chi.0000240836.71361.39
2006

Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patienst with bipolar disorder: Consensus and controversies
Bipolar Disorders, Supplement
Yatham, L.N. and Kennedy, S.H. and O'Donovan, C. and Parikh, S. and MacQueen, G. and McIntyre, R. and Sharma, V. and Silverstone, P. and Alda, M. and Baruch, P. and Beaullieu, S. and Daigneault, A. and Milev, R. and Young, L.T. and Ravindran, A. and Schaffer, A. and Connolly, M. and Gorman, C.P.
2005

6-Pyruvoyl-tetrahydropterin synthase deficiency with mild hyperphenylalaninemia
Annals of Neurology
Demos, M.K. and Waters, P.J. and Vallance, H.D. and Lillquist, Y. and Makhseed, N. and Hyland, K. and Blau, N. and Connolly, M.B.
DOI: 10.1002/ana.20532
2005

Rasmussen syndrome
Epilepsy in Children, 2E
DOI: 10.1201/b13560-30
02/2004

Epileptic syndromes with onset in middle childhood: Rasmussen syndrome
Epilepsy in Children, 2E
Connolly, M.B. and Arrell, K.F.
2004

Spasms in children with definite and probable mitochondrial disease
European Journal of Neurology
Sadleir, L.G. and Connolly, M.B. and Applegarth, D. and Hendson, G. and Clarke, L. and Rakshi, C. and Farrell, K.
DOI: 10.1046/j.1351-5101.2003.00724.x
2004

Preserved Episodic Memory in Subcortical Band Heterotopia
Epilepsia
Janzen, L. and Sherman, E. and Langfitt, J. and Berg, M. and Connolly, M.
DOI: 10.1111/j.0013-9580.2004.53203.x
2004

Neurophysiological investigations
Epilepsy in Children, 2E
2004

Reexamining the effects of epilepsy surgery on IQ in children: use of regression-based change scores.
Journal of the International Neuropsychological Society : JINS
Sherman E and Slick DJ and Connolly MB and Steinbok P and Martin R and Strauss E and Chelune GJ and Farrell K
PubMed: 14632247
09/2003

Electrical fields and recording techniques
Current Practice of Clinical Electroencephalography, 3rd Edition
2003

Erratum: Melatonin does not trigger convulsions (Pediatrics and Child Health (2003)8:7(471))
Paediatrics and Child Health
Connolly, M.
2003

Risperidone in acute and continuation treatment of mania
International Clinical Psychopharmacology
Yatham, L.N. and Binder, C. and Riccardelli, R. and Leblanc, J. and Connolly, M. and Kusumakar, V.
DOI: 10.1097/00004850-200307000-00005
2003

Reexamining the effects of epilepsy surgery on IQ in children: Use of regression-based change scores
Journal of the International Neuropsychological Society
Sherman, E.M.S. and Slick, D.J. and Connolly, M.B. and Steinbok, P. and Martin, R. and Strauss, E. and Chelune, G.J. and Farrell, K.
DOI: 10.1017/S1355617703960085
2003

Melatonin does not trigger convulsions
Pediatrics and Child Health
2003

New antiepileptic drug therapies
Neurologic Clinics
Bergin, A.M. and Connolly, M.
DOI: 10.1016/S0733-8619(02)00017-8
2002

Validity of three measures of health-related quality of life in children with intractable epilepsy
Epilepsia
Sherman, E.M.S. and Slick, D.J. and Connolly, M.B. and Steinbok, P. and Camfield, C. and Eyrl, K.L. and Massey, C. and Farrell, K.
DOI: 10.1046/j.1528-1157.2002.03602.x
2002

Hyperventilation-induced high-amplitude rhythmic slowing with altered awareness: A video-EEG comparison with absence seizures
Epilepsia
Lum, L.M. and Connolly, M.B. and Farrell, K. and Wong, P.K.H.
DOI: 10.1046/j.1528-1157.2002.35101.x
2002

Surgical resection for intractable epilepsy in "double cortex" syndrome yields inadequate results
Epilepsia
Bernasconi, A. and Martinez, V. and Rosa-Neto, P. and D'Agostino, D. and Bernasconi, N. and Berkovic, S. and MacKay, M. and Simon Harvey, A. and Palmini, A. and Costa Da Costa, J. and Paglioli, E. and Kim, H.I. and Connolly, M. and Olivier, A. and Dubeau, F. and Andermann, E. and Guerrini, R. and Whisler, W. and De Toledo-Morrell, L. and Morrell, F. and Andermann, F.
DOI: 10.1046/j.1528-1157.2001.39900.x
2001

Temporal lobectomy in early childhood: The need for long-term follow-up
Journal of Child Neurology
Sotero de Menezes, M.A. and Connolly, M. and Bolanos, A. and Madsen, J. and Black, P.M. and Riviello, J.J.
DOI: 10.1177/088307380101600809
2001

Postvaricella angiopathy: Report of a case with pathologic correlation
Pediatric Neurology
Hayman, M. and Hendson, G. and Poskitt, K.J. and Connolly, M.B.
DOI: 10.1016/S0887-8994(01)00272-7
2001

Cortical visual impairment in children with infantile spasms
Journal of AAPOS
Giovanni Castano and Christopher J. Lyons and James E. Jan and Mary Connolly
DOI: 10.1067/mpa.2000.104483
06/2000

Editorial Comment
Child's Nervous System
P. Steinbok and M. Connolly
DOI: 10.1007/s003810050515
05/2000

Factors associated with behavioral and cognitive abnormalities in children receiving Topiramate
Pediatric Neurology
Gerber, P.E. and Hamiwka, L. and Connolly, M.B. and Farrell, K.
DOI: 10.1016/S0887-8994(99)00151-4
2000

Cortical visual impairment in children with infantile spasms.
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus
Castano, G. and Lyons, C.J. and Jan, J.E. and Connolly, M.
DOI: 10.1016/S1091-8531(00)70009-7
2000

Psychological assessment and treatment of psychogenic symptoms in children and adolescents
Non-epileptic Seizures, 2nd Edition
2000

Pediatric peri-insular hemispherotomy
Pediatric Neurosurgery
Kestle, J. and Connolly, M. and Cochrane, D.
DOI: 10.1159/000028896
2000

Melatonin treatment of non-epileptic myoclonus in children
Developmental Medicine and Child Neurology
Jan, J.E. and Connolly, M.B.C. and Hamilton, D. and Freeman, R.D. and Laudon, M.
DOI: 10.1017/S0012162299000535
1999

High resolution EEG & seizure localization
NeuroImage
Wong, P.K.H. and Bjornson, B. and Connolly, M. and Steinbok, P. and Young, S.A. and Giaschi, D. and Gregory, D. and Smith, S. and Lee, R. and Man, A. and Cochrane, D.
1999

Non-invasive mapping of sensorimotor cortex in a child with a cavernous angioma: FMRI and high-resolution EEG compared with surgical mapping
NeuroImage
Bjornson, B. and Giaschi, D. and Cochrane, D. and Au Young, S. and Rootman, D. and Boden, C. and Connolly, M. and Poskitt, K. and Boyle, C. and Smith, S. and Akagemi, R. and Wong, P.K.H.
1999

Acquired brachial-plexus neuropathy in the neonate: a rare presentation of late-onset group-B streptococcal osteomyelitis.
Developmental medicine and child neurology
Sadleir LG and Connolly MB
PubMed: 9698064
07/1998

Acquired brachial-plexus neuropathy in the neonate: A rare presentation of late-onset group-B streptococcal osteomyelitis
Developmental Medicine and Child Neurology
Sadleir, L.G. and Connolly, M.B.
1998

Encephalopathy complicating henoch schonlein purpura: Reversible MRI changes
Pediatric Neurology
Woolfenden, A.R. and Hukin, J. and Poskitt, K.J. and Connolly, M.B.
DOI: 10.1016/S0887-8994(98)00027-7
1998

Prospective, open-label, add-on study of lamotrigine in 56 children with intractable generalized epilepsy
Pediatric Neurology
Farrell, K. and Connolly, M.B. and Munn, R. and Peng, S. and MacWilliam, L.M.
DOI: 10.1016/S0887-8994(97)00010-6
1997

Reengineering a home health care agency to achieve cost effectiveness
Home Health Care Management and Practice
Connolly, M.L.
DOI: 10.1177/108482239701000106
1997

Home health care and burn care: An educational and economical program
Journal of Burn Care and Rehabilitation
Dattolo, J. and Trout, S. and Connolly, M.L.
DOI: 10.1097/00004630-199603000-00017
1996

Alternating paroxysmal dystonia and hemiplegia in childhood as a symptom of basal ganglia disease
Journal of Neurology, Neurosurgery and Psychiatry
Hart, Y.M. and Tampieri, D. and Andermann, E. and Andermann, F. and Connolly, M. and Farrell, K.
DOI: 10.1136/jnnp.59.4.453
1995

Seizures Involving the Supplementary Sensorimotor Area in Children: A Video-EEG Analysis
Epilepsia
Connolly, M.B. and Langill, L. and Wong, P.K.H. and Farrell, K.
DOI: 10.1111/j.1528-1157.1995.tb00962.x
1995

Home care of the prostate cryosurgery patient.
Today"s OR nurse
Connolly, M.L. and Russell, M. and Reyna, C.
1995

Biological bases of brain function and disease
Journal of Epilepsy
Mary Connolly
DOI: 10.1016/0896-6974(94)90039-6
01/1994

Cranial Neuropathy, Polyneuropathy and Thrombocytopenia with Epstein-Barr Virus Infection
Developmental Medicine & Child Neurology
Connolly, M. and Junker, A.K. and Chan, K.W. and Farrell, K.
DOI: 10.1111/j.1469-8749.1994.tb11797.x
1994

Outpatient Video-EEG Monitoring in Children
Epilepsia
Connolly, M.B. and Wong, P.K.H. and Karim, Y. and Smith, S. and Farrell, K.
DOI: 10.1111/j.1528-1157.1994.tb02465.x
1994

Epilepsy in infants and children
Conn's Current Therapy
1994

Rapid cycling in severely multidisabled children: A form of bipolar affective disorder?
Pediatric Neurology
Jan, J.E. and Abroms, I.F. and Freeman, R.D. and Brown, G.M. and Espezel, H. and Connolly, M.B.
DOI: 10.1016/0887-8994(94)90064-7
1994

Intrapartum Asphyxia in Term and Postterm Infants
Obstetrical & Gynecological Survey
A HALLIGAN and M CONNOLLY and T CLARKE and R P GLEESON and M HOLOHAN and T MATTHEWS and M KING and M R N DARLING
DOI: 10.1097/00006254-199306000-00009
06/1993

Searching for Human Epilepsy Genes: A Progress Report
Brain Pathology
DOI: 10.1111/j.1750-3639.1993.tb00764.x
1993

MRI in pseudotumour cerebri
Pediatric Neurology Briefs
1993

Seizure characteristics in chromosome 20 benign familial neonatal convulsions
Neurology
Ronen, G.M. and Rosales, T.O. and Connolly, M. and Anderson, V.E. and Leppert, M.
1993

Magnetic resonance imaging in pseudotumor cerebri.
Developmental medicine and child neurology
Connolly MB and Farrell K and Hill A and Flodmark O
PubMed: 1451939
12/1992

Letter to the editor: Rapid recovery from cortical visual impairment following correction of prolonged shunt malfunction
Archives of Neurology
1992

MAGNETIC RESONANCE IMAGING IN PSEUDOTUMOR CEREBRI
Developmental Medicine & Child Neurology
Connolly, M.B. and Farrell, K. and Hill, A. and Flodmark, O.
DOI: 10.1111/j.1469-8749.1992.tb11422.x
1992

Clinical features for prediction of survival in neonatal muscle disease
Pediatric Neurology
Connolly, M.B. and Roland, E.H. and Hill, A.
DOI: 10.1016/0887-8994(92)90367-8
1992

Visual evoked potentials and intracranial pressure-reply
Archives of Neurology
Connolly, M.B. and Jan, J.E. and Cochrane, D.D.
DOI: 10.1001/archneur.1992.00530350021011
1992

Rapid Recovery From Cortical Visual Impairment Following Correction of Prolonged Shunt Malfunction in Congenital Hydrocephalus
Archives of Neurology
Connolly, M.B. and Jan, J.E. and Cochrane, D.D.
DOI: 10.1001/archneur.1991.00530210082028
1991

Hepatic dysfunction in Alstrom disease
American Journal of Medical Genetics
Connolly, M.B. and Jan, J.E. and Couch, R.M. and Wong, L.T.K. and Dimmick, J.E. and Rigg, J.M.
DOI: 10.1002/ajmg.1320400408
1991

Intravenous immunoglobulin and pyridoxine–dependent seizures
Neurology
Connolly, M.B. and Jan, J.E. and Junker, A.K.
DOI: 10.1212/WNL.41.9.1524
1991

An approach to the diagnosis and treatment of seizures in children
Canadian Journal of Pediatrics
1991

Head shaking by visually impaired children: a voluntary neurovisual adaptation which can be confused with spasmus nutans.
Developmental medicine and child neurology
Jan JE and Groenveld M and Connolly MB
PubMed: 2286305
12/1990

Head Shaking By Visually Impaired Children: A Voluntary Neurovisual Adaptation Which Can Be Confused With Spasmus Nutans
Developmental Medicine & Child Neurology
Jan, J.E. and Groenveld, M. and Connolly, M.B.
DOI: 10.1111/j.1469-8749.1990.tb08524.x
1990

Cost of neonatal intensive and special care
Irish Medical Journal
02/1989

Organize your workday: For more effective discharge planning
Nursing
Connolly, M.L.
DOI: 10.1097/00152193-198107000-00015
1981

Diagnostic Yield and Treatment Impact of Targeted Exome Sequencing in Early-onset Epilepsy
Michelle Demos and Ilaria Guella and Marna B. McKenzie and Sarah E. Buerki and Daniel M. Evans and Eric B. Toyota and Cyrus Boelman and Linda L. Huh and Anita Datta and Aspasia Michoulas and Kathryn Selby and Bruce H. Bjornson and Gabriella Horvath and Elena Lopez-Rangel and Clara DM van Karnebeek and Ramona Salvarinova and Erin Slade and Patrice Eydoux and Shelin Adam and Margot. I. Van Allen and Tanya N. Nelson and Corneliu Bolbocean and Mary B. Connolly and Matthew J. Farrer
DOI: 10.1101/139329

Research

Acute psychiatric adverse events associated with Levetiracetam therapy in children with epilepsy
This study analyzes acute psychiatric adverse events (PAEs) in children receiving Levetiracetam, a new anti-epileptic drug. Predisposing factors such a personal or family history of psychiatric illness dosing schedules are reviewed. The aim is to identify risk factors and try to minimize PAEs on Levetiracetam.

Outcome Trajectories in Children with Epilepsy: What Factors are Important?
Our centre is participating in this multicentre study funded by CIHR. A variety of factors, both environmental and organic, influence the life quality outcomes in children with epilepsy. Our hypothesis that changes in children’s outcomes over time will be more strongly related to child and family psychosocial factors than to epilepsy-specific variables. The outcomes examined in this study include biomedical health and functional status (primarily mental health and intellectual abilities), academic achievement and participation. We will also measure the subjective experience of epilepsy with generic and condition-specific self- and proxy-reported ‘quality of life’ (HRQL) instruments.

Outcome following epilepsy surgery
Since the epilepsy surgery program was established, I have personally followed all children who have had surgery longitudinally from a clinical perspective. Neuropsychological and quality of life studies have been performed prior to surgery and on follow-up.

With colleagues in neurosurgery and neuropsychology, I have published several papers on long-term outcomes and quality of life following hemispheric surgery, surgery for tuberous sclerosis and vagus nerve stimulation. We also recently reported the a group of children with refractory status epilepticus who had urgent epilepsy surgery. A recent study of epilepsy surgery in the first 3 years of life across Canada, one of the largest series in young children in the literature, outlines the success in this group.

I am currently studying outcomes in children who had epilepsy surgery in the frontal lobe and assessing factors which may negatively affect the outcome. I am also studying the long-term outcome in children who had temporal lobe surgery and assessing outcomes and the influence of neuropsychiatric disorders such as depression, psychosis and anxiety on outcome.

Grants

2014-2022 Impact of Pediatric Epilepsy Surgery on Health-Related Quality of Life

2019 An Open-Label Extension Trial to Assess the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution as an Adjunctive Therapy for Seizures in Patients with Rare Seizure Disorders Such as Epileptic Encephalopathies Including Dravet Syndrome and Lennox- Gastaut Syndrome

2022-2023 An Open-Label n Study of XEN496 in Pediatric Subjects with KCNQ2 Developmental and Epileptic EncephalopathyExtensio

2022-2023 A Phase 3 Study of Adjunctive XEN496 in Pediatric Subjects with KCNQ2 Developmental and Epileptic Encephalopathy

2023-2026 A 20-Week Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of EPX-100 (Clemizole Hydrochloride) as Adjunctive Therapy in Patients with Dravet Syndrome

Canadian Epilepsy Database and Registry (CEDAR)

Honours & Awards

2002 Partners in Care Award – BC Children’s Hospital

2005 First Recipient of the Annual Dr. Parminder Singh Award of Distinction for most valuable subspecialty consultant – BC Pediatric Society

2015 Clinical Practice and Advocacy Award from the Canadian League Against Epilepsy

2021 Clinician Practitioner Excellence in Leadership Award from the Pediatrics Chairs of Canada

Award of Distinction from Partners in Care - BC Children’s Hospital, 2006

BC Children’s Hospital Education Award - Education Day for Families, 2005

Research Group Members

Mihaela Anghelina, Clinical Research Coordinator
Billie Beis-Leech, Research Assistant
Stephanie Kwok, Research Coordinator
Sharon Park, Clinical Research Coordinator
Vesna Popovska, Research Director, Pediatric Neurology & Neurosurgery
Dora Xiong, Clinical Research Coordinator