Overview

My research centers on various aspects of pediatric neurology, primarily epilepsy and surgical management of epilepsy.

Epilepsy is the most common chronic neurological disorder in children and is characterized by recurrent unprovoked seizures due to uncontrolled electrical activity in the brain. Thirty per cent or more of epilepsy cases do not respond to conventional epileptic medications. Other treatments for epilepsy are epilepsy surgery, vagus nerve stimulation, the ketogenic diet and investigational anti-epileptic drugs.

The epilepsy surgery program at BC Children’s Hospital was established in the mid 90s. My research focuses on outcomes following epilepsy surgery of various types and the influence of surgery on seizure control, quality of life, learning and attention. I am also involved in research in video-EEG monitoring, psychogenic non-epileptic seizures, psychiatric comorbidity in epilepsy and adverse reactions to anti-epileptic drugs.

Publications

Improvement of Self-Injury With Dopamine and Serotonin Replacement Therapy in a Patient With a Hemizygous PAK3 Mutation: A New Therapeutic Strategy for Neuropsychiatric Features of an Intellectual Disability Syndrome.
Journal of child neurology
Horvath GA, Tarailo-Graovac M, Bartel T, Race S, Van Allen MI, Blydt-Hansen I, Ross CJ, Wasserman WW, Connolly MB, van Karnebeek CDM
DOI: 10.1177/0883073817740443
PubMed: 29246092
01/2018

An Infant With Epilepsy and Recurrent Hemiplegia due to Compound Heterozygous Variants in ATP1A2.
Pediatric neurology
Wilbur C, Buerki SE, Guella I, Toyota EB, Evans DM, McKenzie MB, Datta A, Michoulas A, Adam S, Van Allen MI, Nelson TN, Farrer MJ, Connolly MB, Demos M
DOI: 10.1016/j.pediatrneurol.2017.06.003
PubMed: 28811059
10/2017

De Novo Mutations in YWHAG Cause Early-Onset Epilepsy.
American journal of human genetics
Guella I, McKenzie MB, Evans DM, Buerki SE, Toyota EB, Van Allen MI, Epilepsy Genomics Study, Suri M, Elmslie F, Farrer MJ
DOI: 10.1016/j.ajhg.2017.07.004
PubMed: 28777935
08/2017

Clinical Experience With Perampanel for Refractory Pediatric Epilepsy in One Canadian Center.
Journal of child neurology
Datta AN, Xu Q, Sachedina S, Boelman C, Huh L, Connolly MB
DOI: 10.1177/0883073817709195
PubMed: 28511603
08/2017

Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy.
American journal of human genetics
Lehman A, Thouta S, Mancini GMS, Naidu S, van Slegtenhorst M, McWalter K, Person R, Mwenifumbo J, Salvarinova R, CAUSES Study, EPGEN Study, Guella I, Claydon T
DOI: 10.1016/j.ajhg.2017.05.016
PubMed: 28669405
07/2017

Child- and parent-reported quality of life trajectories in children with epilepsy: A prospective cohort study.
Epilepsia
Ferro MA, Avery L, Fayed N, Streiner DL, Cunningham CE, Boyle MH, Lach L, Glidden G, Rosenbaum PL, Ronen GM, QUALITÉ group
DOI: 10.1111/epi.13774
PubMed: 28485850
07/2017

The relationship between d-beta-hydroxybutyrate blood concentrations and seizure control in children treated with the ketogenic diet for medically intractable epilepsy
Epilepsia Open
Jeffrey R. Buchhalter, Sabrina D'Alfonso, Mary Connolly, Ernest Fung, Aspasia Michoulas, David Sinasac, Rachel Singer, Jacklyn Smith, Narender Singh, Jong M. Rho
DOI: 10.1002/epi4.12058
05/2017

ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology.
Epilepsia
Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L, Hirsch E, Jain S, Mathern GW, Moshé SL, Nordli DR, Perucca E, Tomson T, Zuberi SM
DOI: 10.1111/epi.13709
PubMed: 28276062
04/2017

Clinical, imaging, and immunohistochemical characteristics of focal cortical dysplasia Type II extratemporal epilepsies in children: analyses of an institutional case series.
Journal of neurosurgery. Pediatrics
Knerlich-Lukoschus F, Connolly MB, Hendson G, Steinbok P, Dunham C
DOI: 10.3171/2016.8.peds1686
PubMed: 27885945
02/2017

Manifestations of Tuberous Sclerosis Complex: The Experience of a Provincial Clinic.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Wilbur C, Sanguansermsri C, Chable H, Anghelina M, Peinhof S, Anderson K, Steinbok P, Singhal A, Datta A, Connolly MB
DOI: 10.1017/cjn.2016.311
PubMed: 28004629
01/2017

De novo FGF12 mutation in 2 patients with neonatal-onset epilepsy.
Neurology. Genetics
Guella I, Huh L, McKenzie MB, Toyota EB, Bebin EM, Thompson ML, Cooper GM, Evans DM, Buerki SE, Adam S, Van Allen MI, Nelson TN, Connolly MB, Farrer MJ, Demos M
DOI: 10.1212/nxg.0000000000000120
PubMed: 27872899
12/2016

Correlates of health-related quality of life in children with drug resistant epilepsy
Epilepsia
Lauryn Conway, Mary Lou Smith, Mark A. Ferro, Kathy N. Speechley, Mary B. Connoly, O. Carter Snead, Elysa Widjaja, the PEPSQOL Study Team
DOI: 10.1111/epi.13441
06/2016

Dravet Syndrome: Diagnosis and Long-Term Course.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Connolly MB
DOI: 10.1017/cjn.2016.243
PubMed: 27264139
06/2016

Exome Sequencing and the Management of Neurometabolic Disorders.
The New England journal of medicine
Tarailo-Graovac M, Shyr C, Ross CJ, Horvath GA, Salvarinova R, Ye XC, Zhang LH, Bhavsar AP, Lee JJ, Drögemöller BI, Abdelsayed M, Alfadhel M, van Karnebeek CD
DOI: 10.1056/nejmoa1515792
PubMed: 27276562
06/2016

Resective Epilepsy Surgery for Tuberous Sclerosis in Children: Determining Predictors of Seizure Outcomes in a Multicenter Retrospective Cohort Study.
Neurosurgery
Fallah A, Rodgers SD, Weil AG, Vadera S, Mansouri A, Connolly MB, Major P, Ma T, Devinsky O, Weiner HL, Gonzalez-Martinez JA, Bingaman WE, Najm I, Rutka JT
DOI: 10.1227/neu.0000000000000875
PubMed: 26120800
10/2015

Tick paralysis: Presentation as a pure cerebellar syndrome
Journal of Pediatric Neurology
Raed Alroughani, Jonathan Guilfoyle, Mary Connolly
DOI: 10.1055/s-0035-1557486
07/2015

Recovery From Central Nervous System Acute Demyelination in Children.
Pediatrics
O'Mahony J, Marrie RA, Laporte A, Yeh EA, Bar-Or A, Phan C, Buckley D, Callen D, Connolly MB, Pohl D, Dilenge ME, Bernard G, Lortie A, Lowry N, Banwell B
DOI: 10.1542/peds.2015-0028
PubMed: 26034241
07/2015

Does treatment have an impact on incidence and risk factors for autism spectrum disorders in children with infantile spasms?
Epilepsia
Bitton JY, Demos M, Elkouby K, Connolly M, Weiss SK, Donner EJ, Whiting S, Ronen GM, Bello-Espinosa L, Wirrell EC, Mohamed IS, Dooley JM, Carmant L
DOI: 10.1111/epi.12997
PubMed: 25944453
06/2015

The "vagal ansa": a source of complication in vagus nerve stimulation.
Journal of neurosurgery. Pediatrics
Gopalakrishnan CV, Kestle JR, Connolly MB
DOI: 10.3171/2014.10.peds14259
PubMed: 25700120
05/2015

Children's perspective of quality of life in epilepsy
Neurology
N. Fayed, A. M. Davis, D. L. Streiner, P. L. Rosenbaum, C. E. Cunningham, L. M. Lach, M. H. Boyle, G. M. Ronen, On behalf of the QUALITE Study Group
DOI: 10.1212/wnl.0000000000001536
04/2015

The importance of cerebral magnetic resonance imaging in evaluation of neonatal seizures.
Developmental medicine and child neurology
Buerki SE, Connolly MB
DOI: 10.1111/dmcn.12640
PubMed: 25407829
03/2015

Clinical and magnetic resonance imaging (MRI) distinctions between tumefactive demyelination and brain tumors in children.
Journal of child neurology
Yiu EM, Laughlin S, Verhey LH, Banwell BL, Canadian Pediatric Demyelinating Disease Network
DOI: 10.1177/0883073813500713
PubMed: 24092896
05/2014

Diagnostic value of a multidisciplinary clinic for intellectual disability.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
van Karnebeek C, Murphy T, Giannasi W, Thomas M, Connolly M, Stockler-Ipsiroglu S
PubMed: 24718818
05/2014

Pyridoxine responsiveness in novel mutations of the PNPO gene.
Neurology
Plecko B, Paul K, Mills P, Clayton P, Paschke E, Maier O, Hasselmann O, Schmiedel G, Kanz S, Connolly M, Wolf N, Struys E, Stockler S, Abela L, Hofer D
DOI: 10.1212/wnl.0000000000000344
PubMed: 24658933
04/2014

Recommendations for HLA-B*15:02 and HLA-A*31:01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity reactions.
Epilepsia
Amstutz U, Shear NH, Rieder MJ, Hwang S, Fung V, Nakamura H, Connolly MB, Ito S, Carleton BC, CPNDS clinical recommendation group
DOI: 10.1111/epi.12564
PubMed: 24597466
04/2014

Classifying Epileptic Seizures and the Epilepsies
Epilepsy
Valeria M. Muro and Mary B. Connolly
DOI: 10.1002/9781118456989.ch2
01/2014

Outcomes trajectories in children with epilepsy: hypotheses and methodology of a Canadian longitudinal observational study.
Pediatric neurology
Ronen GM, Streiner DL, Boyle MH, Cunningham CE, Lach L, Verhey LH, Fayed N, Chen K, Rosenbaum PL, QUALITÉ Group, Connolly M, Bello-Espinosa LE, Carmant L
DOI: 10.1016/j.pediatrneurol.2013.08.024
PubMed: 24370172
01/2014

MRI findings in infants with infantile spasms after neonatal hypoxic-ischemic encephalopathy.
Pediatric neurology
Gano D, Sargent MA, Miller SP, Connolly MB, Wong P, Glass HC, Poskitt KJ, Chau V
DOI: 10.1016/j.pediatrneurol.2013.08.007
PubMed: 24095571
12/2013

Hippocampal Malrotation and Temporal Lobe Epilepsy: What is the Relationship?
The Canadian Journal of Neurological Sciences
Mary B. Connolly
DOI: 10.1017/s0317167100014839
09/2013

A case report of obsessive-compulsive disorder following acute disseminated encephalomyelitis.
Pediatrics
Muir KE, McKenney KS, Connolly MB, Stewart SE
DOI: 10.1542/peds.2012-2876
PubMed: 23918895
09/2013

Hippocampal malrotation and temporal lobe epilepsy: what is the relationship?
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Connolly MB
PubMed: 23968933
09/2013

Status epilepticus amauroticus and posterior reversible encephalopathy syndrome in children.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
Muro VL, Yip S, Huh L, Connolly MB
DOI: 10.1097/wnp.0b013e31829de004
PubMed: 23912571
08/2013

Masquerades of acquired demyelination in children: experiences of a national demyelinating disease program.
Journal of child neurology
O'Mahony J, Bar-Or A, Arnold DL, Sadovnick AD, Marrie RA, Banwell B, Canadian Pediatric Demyelinating Disease Network
DOI: 10.1177/0883073812443006
PubMed: 22573735
02/2013

A condensed performance-validation strategy for multiplex detection kits used in studies of human clinical samples
Journal of Immunological Methods
Chahrazed Belabani, Sathyanath Rajasekharan, Viviane Poupon, Trina Johnson, Amit Bar-Or
DOI: 10.1016/j.jim.2012.08.002
01/2013

Epilepsy Surgery in Childhood
The Canadian Journal of Neurological Sciences
Valeria L. Muro, Mary B. Connolly
DOI: 10.1017/s0317167100018163
11/2012

Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials.
Molecular genetics and metabolism
van Karnebeek CD, Hartmann H, Jaggumantri S, Bok LA, Cheng B, Connolly M, Coughlin CR, Das AM, Gospe SM, Jakobs C, van der Lee JH, Stockler S
DOI: 10.1016/j.ymgme.2012.09.006
PubMed: 23022070
11/2012

Discontinuation of antiepileptic drugs after successful epilepsy surgery. a Canadian survey.
Epilepsy research
Téllez-Zenteno JF, Ronquillo LH, Jette N, Burneo JG, Nguyen DK, Donner EJ, Sadler M, Javidan M M, Gross DW, Wiebe S, Canadian Epilepsy Surgery Study Group
DOI: 10.1016/j.eplepsyres.2012.04.018
PubMed: 22595484
11/2012

Benign myoclonic epilepsy of infancy
Pediatric Epilepsy
08/2012

2010 McDonald criteria for diagnosing pediatric multiple sclerosis
Annals of Neurology
Yair Sadaka, Leonard H. Verhey, Manohar M. Shroff, Helen M. Branson, Douglas L. Arnold, Sridar Narayanan, John G. Sled, Amit Bar-Or, A. Dessa Sadovnick, Melissa McGowan, Ruth Ann Marrie, Brenda Banwell, on behalf of the Canadian Pediatric Demyelinating Disease Network
DOI: 10.1002/ana.23575
08/2012

Profound neonatal hypoglycemia and lactic acidosis caused by pyridoxine-dependent epilepsy.
Pediatrics
Mercimek-Mahmutoglu S, Horvath GA, Coulter-Mackie M, Nelson T, Waters PJ, Sargent M, Struys E, Jakobs C, Stockler-Ipsiroglu S, Connolly MB
DOI: 10.1542/peds.2011-0123
PubMed: 22529283
05/2012

Systematic review and case series of neuropsychological functioning after epilepsy surgery in children with dysembryoplastic neuroepithelial tumors (DNET)
Epilepsy & Behavior
Taryn B. Fay-McClymont, Marianne Hrabok, Elisabeth M.S. Sherman, Walter J. Hader, Mary B. Connolly, Sare Akdag, Ismail S. Mohamed, Samuel Wiebe
DOI: 10.1016/j.yebeh.2011.12.011
04/2012

Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study.
The Lancet. Neurology
Banwell B, Bar-Or A, Arnold DL, Sadovnick D, Narayanan S, McGowan M, O'Mahony J, Magalhaes S, Hanwell H, Vieth R, Tellier R, Vincent T, Disanto G, Marrie RA
DOI: 10.1016/s1474-4422(11)70045-x
PubMed: 21459044
05/2011

HLA-DRB1 confers increased risk of pediatric-onset MS in children with acquired demyelination.
Neurology
Disanto G, Magalhaes S, Handel AE, Morrison KM, Sadovnick AD, Ebers GC, Banwell B, Bar-Or A, Canadian Pediatric Demyelinating Disease Network
DOI: 10.1212/wnl.0b013e31820ee1cd
PubMed: 21288988
03/2011

Mitochondrial DNA haplogroups and mutations in children with acquired central demyelination.
Neurology
Venkateswaran S, Zheng K, Sacchetti M, Gagne D, Arnold DL, Sadovnick AD, Scherer SW, Banwell B, Bar-Or A, Simon DK, Canadian Pediatric Demyelinating Disease Network
DOI: 10.1212/wnl.0b013e31820ee1bb
PubMed: 21288980
03/2011

Cerebral sinus thrombosis following IV immunoglobulin therapy of immune thrombocytopenia purpura
Pediatric Blood & Cancer
Arwa Z. Al-Riyami, James Lee, Mary Connolly, Evan Shereck
DOI: 10.1002/pbc.22968
03/2011

Cerebrovasculopathy in NF1 associated with ocular and scalp defects.
American journal of medical genetics. Part A
Smith M, Heran MK, Connolly MB, Heran HK, Friedman JM, Jett K, Lyons CJ, Steinbok P, Armstrong L
DOI: 10.1002/ajmg.a.33788
PubMed: 21271658
02/2011

Electroclinical features of absence seizures in sleep
Epilepsy Research
Lynette G. Sadleir, Kevin Farrell, Sherry Smith, Mary B. Connolly, Ingrid E. Scheffer
DOI: 10.1016/j.eplepsyres.2010.12.009
02/2011

Landau-Kleffner syndrome: a rare auditory processing disorder series of cases and review of the literature.
International journal of pediatric otorhinolaryngology
Fandiño M, Connolly M, Usher L, Palm S, Kozak FK
DOI: 10.1016/j.ijporl.2010.10.001
PubMed: 21074868
01/2011

Epilepsy with occipital features in children: factors predicting seizure outcome and neuroimaging abnormalities.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
Schrader D, Shukla R, Gatrill R, Farrell K, Connolly M
DOI: 10.1016/j.ejpn.2010.08.005
PubMed: 20829080
01/2011

Approach to a child with a first afebrile seizure
BC Medical Journal
2011

Pyridoxine dependent epilepsy and antiquitin deficiency: clinical and molecular characteristics and recommendations for diagnosis, treatment and follow-up.
Molecular genetics and metabolism
Stockler S, Plecko B, Gospe SM, Coulter-Mackie M, Connolly M, van Karnebeek C, Mercimek-Mahmutoglu S, Hartmann H, Scharer G, Struijs E, Tein I, Van Hove JL
DOI: 10.1016/j.ymgme.2011.05.014
PubMed: 21704546
2011

Treatment of intractable epilepsy in a female with SLC6A8 deficiency.
Molecular genetics and metabolism
Mercimek-Mahmutoglu S, Connolly MB, Poskitt KJ, Horvath GA, Lowry N, Salomons GS, Casey B, Sinclair G, Davis C, Jakobs C, Stockler-Ipsiroglu S
DOI: 10.1016/j.ymgme.2010.08.016
PubMed: 20846889
12/2010

Parents report more ADHD symptoms than do teachers in children with epilepsy
Epilepsy & Behavior
Elisabeth M.S. Sherman, Brian L. Brooks, Sare Akdag, Mary B. Connolly, Samuel Wiebe
DOI: 10.1016/j.yebeh.2010.08.015
11/2010

Electrocorticography and seizure outcomes in children with lesional epilepsy
Child's Nervous System
Jennifer N. Gelinas, Andrew W. Battison, Sherry Smith, Mary B. Connolly, Paul Steinbok
DOI: 10.1007/s00381-010-1279-7
09/2010

Red reflex mimicking lens subluxation in a child undergoing orthokeratology.
Eye
Wiwatwongwana A, Connolly MB, Lyons CJ
DOI: 10.1038/eye.2009.46
PubMed: 19300465
01/2010

Cingulate lesions presenting with epileptic spasms.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
Schrader D, Langill L, Singhal A, Steinbok P, Connolly MB
DOI: 10.1097/wnp.0b013e3181baaacf
PubMed: 19752743
10/2009

Epilepsy and memory dysfunction.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Connolly MB
PubMed: 19760900
08/2009

EEG features of absence seizures in idiopathic generalized epilepsy: impact of syndrome, age, and state.
Epilepsia
Sadleir LG, Scheffer IE, Smith S, Carstensen B, Farrell K, Connolly MB
DOI: 10.1111/j.1528-1167.2008.02001.x
PubMed: 19243419
06/2009

Automatisms in Absence Seizures in Children With Idiopathic Generalized Epilepsy
Archives of Neurology
Lynette G. Sadleir, Ingrid E. Scheffer, Sherry Smith, Mary B. Connolly, Kevin Farrell
DOI: 10.1001/archneurol.2009.108
06/2009

Epilepsy surgery in the first 3 years of life: a Canadian survey.
Epilepsia
Steinbok P, Gan PY, Connolly MB, Carmant L, Barry Sinclair D, Rutka J, Griebel R, Aronyk K, Hader W, Ventureyra E, Atkinson J
DOI: 10.1111/j.1528-1167.2008.01992.x
PubMed: 19175388
06/2009

Incidence of acquired demyelination of the CNS in Canadian children.
Neurology
Banwell B, Kennedy J, Sadovnick D, Arnold DL, Magalhaes S, Wambera K, Connolly MB, Yager J, Mah JK, Shah N, Sebire G, Meaney B, Dilenge ME, Lortie A, Bar-Or A
DOI: 10.1212/01.wnl.0000339482.84392.bd
PubMed: 19153370
01/2009

Urgent, resective surgery for medically refractory, convulsive status epilepticus.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
Schrader DV, Steinbok P, Connolly M
DOI: 10.1016/j.ejpn.2008.01.011
PubMed: 18460420
01/2009

Factors influencing clinical features of absence seizures.
Epilepsia
Sadleir LG, Scheffer IE, Smith S, Carstensen B, Carlin J, Connolly MB, Farrell K
DOI: 10.1111/j.1528-1167.2008.01708.x
PubMed: 18616552
12/2008

Cranial Neuropathy, Polyneuropathy and Thrombocytopenia with Epstein-Barr Virus Infection
Developmental Medicine & Child Neurology
Mary Connolly, Anne K. Junker, Ka Wah Chan, Kevin Farrell
DOI: 10.1111/j.1469-8749.1994.tb11797.x
11/2008

Quality of life and seizure outcome after vagus nerve stimulation in children with intractable epilepsy.
Journal of child neurology
Sherman EM, Connolly MB, Slick DJ, Eyrl KL, Steinbok P, Farrell K
DOI: 10.1177/0883073808315417
PubMed: 18474931
09/2008

Autosomal recessive GTP cyclohydrolase I deficiency without hyperphenylalaninemia: evidence of a phenotypic continuum between dominant and recessive forms.
Molecular genetics and metabolism
Horvath GA, Stockler-Ipsiroglu SG, Salvarinova-Zivkovic R, Lillquist YP, Connolly M, Hyland K, Blau N, Rupar T, Waters PJ
DOI: 10.1016/j.ymgme.2008.01.003
PubMed: 18276179
05/2008

Sociodemographic correlates of health-related quality of life in pediatric epilepsy
Epilepsy & Behavior
Elisabeth M.S. Sherman, Stephanie Y. Griffiths, Sare Akdag, Mary B. Connolly, Daniel J. Slick, Samuel Wiebe
DOI: 10.1016/j.yebeh.2007.07.009
01/2008

Surgical outcome in tuberous sclerosis complex: a multicenter survey.
Epilepsia
Madhavan D, Schaffer S, Yankovsky A, Arzimanoglou A, Renaldo F, Zaroff CM, LaJoie J, Weiner HL, Andermann E, Franz DN, Leonard J, Connolly M, Devinsky O
DOI: 10.1111/j.1528-1167.2007.01112.x
PubMed: 17484758
08/2007

Epilepsy associated with a cerebellar arachnoid cyst: seizure control following fenestration of the cyst
Child's Nervous System
Yee Chiung Gan, Mary B. C. Connolly, Paul Steinbok
DOI: 10.1007/s00381-007-0439-x
08/2007

ADHD, neurological correlates and health-related quality of life in severe pediatric epilepsy.
Epilepsia
Sherman EM, Slick DJ, Connolly MB, Eyrl KL
DOI: 10.1111/j.1528-1167.2007.01028.x
PubMed: 17381442
06/2007

Postsurgical health-related quality of life (HRQOL) in children following hemispherectomy for intractable epilepsy.
Epilepsia
Griffiths SY, Sherman EM, Slick DJ, Eyrl K, Connolly MB, Steinbok P
DOI: 10.1111/j.1528-1167.2006.00966.x
PubMed: 17284297
03/2007

The spectrum of SCN1A-related infantile epileptic encephalopathies.
Brain : a journal of neurology
Harkin LA, McMahon JM, Iona X, Dibbens L, Pelekanos JT, Zuberi SM, Sadleir LG, Andermann E, Gill D, Farrell K, Connolly M, Stanley T, Harbord M, Scheffer IE
DOI: 10.1093/brain/awm002
PubMed: 17347258
03/2007

Hemispheric surgery in children with refractory epilepsy: seizure outcome, complications, and adaptive function.
Epilepsia
Basheer SN, Connolly MB, Lautzenhiser A, Sherman EM, Hendson G, Steinbok P
DOI: 10.1111/j.1528-1167.2006.00909.x
PubMed: 17241220
01/2007

Pharmacological management of a youth with ADHD and a seizure disorder.
Journal of the American Academy of Child and Adolescent Psychiatry
Gonzalez-Heydrich J, Weiss M, Connolly M, Wambera K, Jan JE, Plioplys S, Dunn DW, Kratochvil CJ
DOI: 10.1097/01.chi.0000240836.71361.39
PubMed: 17135999
12/2006

Electroclinical features of absence seizures in childhood absence epilepsy.
Neurology
Sadleir LG, Farrell K, Smith S, Connolly MB, Scheffer IE
DOI: 10.1212/01.wnl.0000228257.60184.82
PubMed: 16894100
08/2006

Tuberous sclerosis complex: a review of the management of epilepsy with emphasis on surgical aspects
Child's Nervous System
Mary B. Connolly, Glenda Hendson, Paul Steinbok
DOI: 10.1007/s00381-006-0130-7
06/2006

6-pyruvoyl-tetrahydropterin synthase deficiency with mild hyperphenylalaninemia.
Annals of neurology
Demos MK, Waters PJ, Vallance HD, Lillquist Y, Makhseed N, Hyland K, Blau N, Connolly MB
DOI: 10.1002/ana.20532
PubMed: 15984017
07/2005

Preserved episodic memory in subcortical band heterotopia.
Epilepsia
Janzen L, Sherman E, Langfitt J, Berg M, Connolly M
DOI: 10.1111/j.0013-9580.2004.53203.x
PubMed: 15101838
05/2004

Neurophysiological investigations
Epilepsy in Children, 2E
Mary Connolly and Peter Wong
DOI: 10.1201/b13560-42
02/2004

Rasmussen syndrome
Epilepsy in Children, 2E
Mary Connolly
DOI: 10.1201/b13560-30
02/2004

Spasms in children with definite and probable mitochondrial disease.
European journal of neurology
Sadleir LG, Connolly MB, Applegarth D, Hendson G, Clarke L, Rakshi C, Farrell K
DOI: 10.1046/j.1351-5101.2003.00724.x
PubMed: 14748770
02/2004

Reexamining the effects of epilepsy surgery on IQ in children: use of regression-based change scores.
Journal of the International Neuropsychological Society : JINS
Sherman E, Slick DJ, Connolly MB, Steinbok P, Martin R, Strauss E, Chelune GJ, Farrell K
PubMed: 14632247
09/2003

Melatonin does not trigger convulsions
Pediatrics and Child Health
2003

Electrical fields and recording techniques
Current Practice of Clinical Electroencephalography, 3rd Edition
2003

Hyperventilation-induced high-amplitude rhythmic slowing with altered awareness: a video-EEG comparison with absence seizures.
Epilepsia
Lum LM, Connolly MB, Farrell K, Wong PK
DOI: 10.1046/j.1528-1157.2002.35101.x
PubMed: 12423387
11/2002

New antiepileptic drug therapies.
Neurologic clinics
Bergin AM, Connolly M
DOI: 10.1016/s0733-8619(02)00017-8
PubMed: 12616686
11/2002

Validity of three measures of health-related quality of life in children with intractable epilepsy.
Epilepsia
Sherman EM, Slick DJ, Connolly MB, Steinbok P, Camfield C, Eyrl KL, Massey C, Farrell K
DOI: 10.1046/j.1528-1157.2002.03602.x
PubMed: 12366740
10/2002

Surgical Resection for Intractable Epilepsy in “Double Cortex” Syndrome Yields Inadequate Results
Epilepsia
A. Bernasconi, V. Martinez, P. Rosa-Neto, D. D'Agostino, N. Bernasconi, S. Berkovic, M. MacKay, A. Simon Harvey, A. Palmini, J. Costa Da Costa, Eliseu Paglioli, H.I. Kim, M. Connolly, A. Olivier, F. Dubeau, E. Andermann, R. Guerrini, W. Whisler, L. De Toledo-Morrell, F. Morrell, F. Andermann
DOI: 10.1046/j.1528-1157.2001.39900.x
01/2002

Temporal Lobectomy in Early Childhood: The Need for Long-Term Follow-Up
Journal of Child Neurology
Márcio A. Sotero de Menezes, Mary Connolly, Addison Bolanos, Joseph Madsen, Peter McL. Black, James J. Riviello
DOI: 10.1177/088307380101600809
08/2001

Postvaricella angiopathy: report of a case with pathologic correlation.
Pediatric neurology
Hayman M, Hendson G, Poskitt KJ, Connolly MB
DOI: 10.1016/s0887-8994(01)00272-7
PubMed: 11516617
05/2001

Cortical visual impairment in children with infantile spasms
Journal of AAPOS
Giovanni Castano, Christopher J. Lyons, James E. Jan, Mary Connolly
DOI: 10.1067/mpa.2000.104483
06/2000

Editorial Comment
Child's Nervous System
P. Steinbok, M. Connolly
DOI: 10.1007/s003810050515
05/2000

Factors associated with behavioral and cognitive abnormalities in children receiving topiramate.
Pediatric neurology
Gerber PE, Hamiwka L, Connolly MB, Farrell K
DOI: 10.1016/s0887-8994(99)00151-4
PubMed: 10734250
03/2000

Psychological assessment and treatment of psychogenic symptoms in children and adolescents
Non-epileptic Seizures, 2nd Edition
2000

Pediatric Peri-Insular Hemispherotomy
Pediatric Neurosurgery
J. Kestle, M. Connolly, D. Cochrane
DOI: 10.1159/000028896
2000

Editorial Comment
Child's Nervous System
M. Connolly, P. Steinbok, G. Hendson
DOI: 10.1007/s003810050424
08/1999

Melatonin treatment of non-epileptic myoclonus in children.
Developmental medicine and child neurology
Jan JE, Connolly MB, Hamilton D, Freeman RD, Laudon M
DOI: 10.1017/s0012162299000535
PubMed: 10355809
04/1999

Encephalopathy complicating Henoch-Schönlein purpura: reversible MRI changes.
Pediatric neurology
Woolfenden AR, Hukin J, Poskitt KJ, Connolly MB
DOI: 10.1016/s0887-8994(98)00027-7
PubMed: 9682892
07/1998

Acquired brachial-plexus neuropathy in the neonate: a rare presentation of late-onset group-B streptococcal osteomyelitis.
Developmental medicine and child neurology
Sadleir LG, Connolly MB
PubMed: 9698064
07/1998

Prospective, open-label, add-on study of lamotrigine in 56 children with intractable generalized epilepsy
Pediatric Neurology
Kevin Farrell, Mary B Connolly, Robert Munn, Shumin Peng, Laurie M MacWilliam
DOI: 10.1016/s0887-8994(97)00010-6
04/1997

Alternating paroxysmal dystonia and hemiplegia in childhood as a symptom of basal ganglia disease.
Journal of Neurology, Neurosurgery & Psychiatry
Y M Hart, D Tampieri, E Andermann, F Andermann, M Connolly, K Farrell
DOI: 10.1136/jnnp.59.4.453
10/1995

Seizures involving the supplementary sensorimotor area in children: a video-EEG analysis.
Epilepsia
Connolly MB, Langill L, Wong PK, Farrell K
DOI: 10.1111/j.1528-1157.1995.tb00962.x
PubMed: 7555953
10/1995

Rapid cycling in severely multidisabled children: a form of bipolar affective disorder?
Pediatric neurology
Jan JE, Abroms IF, Freeman RD, Brown GM, Espezel H, Connolly MB
DOI: 10.1016/0887-8994(94)90064-7
PubMed: 8198670
02/1994

Biological bases of brain function and disease
Journal of Epilepsy
Mary Connolly
DOI: 10.1016/0896-6974(94)90039-6
01/1994

Outpatient video-EEG monitoring in children.
Epilepsia
Connolly MB, Wong PK, Karim Y, Smith S, Farrell K
DOI: 10.1111/j.1528-1157.1994.tb02465.x
PubMed: 8026391
1994

Epilepsy in infants and children
Conn's Current Therapy
1994

Intrapartum Asphyxia in Term and Postterm Infants
Obstetrical & Gynecological Survey
A HALLIGAN, M CONNOLLY, T CLARKE, R P GLEESON, M HOLOHAN, T MATTHEWS, M KING, M R N DARLING
DOI: 10.1097/00006254-199306000-00009
06/1993

MRI in pseudotumour cerebri
Pediatric Neurology Briefs
1993

Magnetic resonance imaging in pseudotumor cerebri.
Developmental medicine and child neurology
Connolly MB, Farrell K, Hill A, Flodmark O
PubMed: 1451939
12/1992

Clinical features for prediction of survival in neonatal muscle disease.
Pediatric neurology
Connolly MB, Roland EH, Hill A
DOI: 10.1016/0887-8994(92)90367-8
PubMed: 1388418
1992

Letter to the editor: Rapid recovery from cortical visual impairment following correction of prolonged shunt malfunction
Archives of Neurology
1992

Intravenous immunoglobulin and pyridoxine-dependent seizures.
Neurology
Connolly MB, Jan JE, Junker AK
DOI: 10.1212/wnl.41.9.1524
PubMed: 1891109
09/1991

Rapid recovery from cortical visual impairment following correction of prolonged shunt malfunction in congenital hydrocephalus.
Archives of neurology
Connolly MB, Jan JE, Cochrane DD
DOI: 10.1001/archneur.1991.00530210082028
PubMed: 1953421
09/1991

Hepatic dysfunction in Alström disease.
American journal of medical genetics
Connolly MB, Jan JE, Couch RM, Wong LT, Dimmick JE, Rigg JM
DOI: 10.1002/ajmg.1320400408
PubMed: 1746604
09/1991

An approach to the diagnosis and treatment of seizures in children
Canadian Journal of Pediatrics
1991

Head shaking by visually impaired children: a voluntary neurovisual adaptation which can be confused with spasmus nutans.
Developmental medicine and child neurology
Jan JE, Groenveld M, Connolly MB
PubMed: 2286305
12/1990

Cost of neonatal intensive and special care
Irish Medical Journal
02/1989

Research

Acute psychiatric adverse events associated with Levetiracetam therapy in children with epilepsy
This study analyzes acute psychiatric adverse events (PAEs) in children receiving Levetiracetam, a new anti-epileptic drug. Predisposing factors such a personal or family history of psychiatric illness dosing schedules are reviewed. The aim is to identify risk factors and try to minimize PAEs on Levetiracetam.

Outcome Trajectories in Children with Epilepsy: What Factors are Important?
Our centre is participating in this multicentre study funded by CIHR. A variety of factors, both environmental and organic, influence the life quality outcomes in children with epilepsy. Our hypothesis that changes in children’s outcomes over time will be more strongly related to child and family psychosocial factors than to epilepsy-specific variables. The outcomes examined in this study include biomedical health and functional status (primarily mental health and intellectual abilities), academic achievement and participation. We will also measure the subjective experience of epilepsy with generic and condition-specific self- and proxy-reported ‘quality of life’ (HRQL) instruments.

Outcome following epilepsy surgery
Since the epilepsy surgery program was established, I have personally followed all children who have had surgery longitudinally from a clinical perspective. Neuropsychological and quality of life studies have been performed prior to surgery and on follow-up.

With colleagues in neurosurgery and neuropsychology, I have published several papers on long-term outcomes and quality of life following hemispheric surgery, surgery for tuberous sclerosis and vagus nerve stimulation. We also recently reported the a group of children with refractory status epilepticus who had urgent epilepsy surgery. A recent study of epilepsy surgery in the first 3 years of life across Canada, one of the largest series in young children in the literature, outlines the success in this group.

I am currently studying outcomes in children who had epilepsy surgery in the frontal lobe and assessing factors which may negatively affect the outcome. I am also studying the long-term outcome in children who had temporal lobe surgery and assessing outcomes and the influence of neuropsychiatric disorders such as depression, psychosis and anxiety on outcome.

Honours & Awards

Award of Distinction from Partners in Care - BC Children’s Hospital, 2006

BC Children’s Hospital Education Award - Education Day for Families, 2005

Research Group Members

Vesna Popovska, Clinical Research Coordinator