My research centers on various aspects of pediatric neurology, primarily epilepsy and surgical management of epilepsy.

Epilepsy is the most common chronic neurological disorder in children and is characterized by recurrent unprovoked seizures due to uncontrolled electrical activity in the brain. Thirty per cent or more of epilepsy cases do not respond to conventional epileptic medications. Other treatments for epilepsy are epilepsy surgery, vagus nerve stimulation, the ketogenic diet and investigational anti-epileptic drugs.

The epilepsy surgery program at BC Children’s Hospital was established in the mid 90s. My research focuses on outcomes following epilepsy surgery of various types and the influence of surgery on seizure control, quality of life, learning and attention. I am also involved in research in video-EEG monitoring, psychogenic non-epileptic seizures, psychiatric comorbidity in epilepsy and adverse reactions to anti-epileptic drugs.


Exome sequencing identified a de novo mutation of PURA gene in a patient with familial Xp22.31 microduplication
European Journal of Medical Genetics
Ying Qiao and Hani Bagheri and Flamingo Tang and Chansonette Badduke and Sally Martell and Suzanne M.E. Lewis and Wendy Robinson and Mary B. Connolly and Laura Arbour and Evica Rajcan-Separovic
DOI: 10.1016/j.ejmg.2018.06.010

CYP2D6 as a treatment decision aid for ER-positive non-metastatic breast cancer patients: a systematic review with accompanying clinical practice guidelines
Breast Cancer Research and Treatment
DOI: 10.1007/s10549-018-5027-0

Care-related quality of life in caregivers of children with drug-resistant epilepsy
Journal of Neurology
DOI: 10.1007/s00415-018-8979-4

Incidence and prevalence of MS in children
DOI: 10.1212/wnl.0000000000006395

Humanized mouse model of Rasmussen’s encephalitis supports the immune-mediated hypothesis
Journal of Clinical Investigation
Hania Kebir and Lionel Carmant and François Fontaine and Kathie Béland and Ciprian M. Bosoi and Nathalie T. Sanon and Jorge I. Alvarez and Sébastien Desgent and Camille L. Pittet and David Hébert and Marie-Josée Langlois and Rose-Marie Rébillard and Dang K. Nguyen and Cécile Cieuta-Walti and Gregory L. Holmes and Howard P. Goodkin and John R. Mytinger and Mary B. Connolly and Alexandre Prat and Elie Haddad
DOI: 10.1172/jci97098

MRI and laboratory features and the performance of international criteria in the diagnosis of multiple sclerosis in children and adolescents: a prospective cohort study
The Lancet Child & Adolescent Health
Giulia Fadda and Robert A Brown and Giulia Longoni and Denise A Castro and Julia O'Mahony and Leonard H Verhey and Helen M Branson and Patrick Waters and Amit Bar-Or and Ruth Ann Marrie and E Ann Yeh and Sridar Narayanan and Douglas L Arnold and Brenda Banwell and Katherine Wambera and Mary B Connolly and Jerome Yager and Jean K Mah and Giullaume Sebire and David Callen and Brandon Meaney and Marie-Emmanuelle Dilenge and Anne Lortie and Daniela Pohl and Asif Doja and Sunita Venkateswaran and Simon Levin and E Athen MacDonald and David Meek and Ellen Wood and David Buckley and Mark Awuku and J Burke Baird and Virender Bhan and Rozie Arnaoutelis and Danusha Nandamalavan
DOI: 10.1016/s2352-4642(18)30026-9

Improvement of Self-Injury With Dopamine and Serotonin Replacement Therapy in a Patient With a Hemizygous PAK3 Mutation: A New Therapeutic Strategy for Neuropsychiatric Features of an Intellectual Disability Syndrome.
Journal of child neurology
Horvath GA and Tarailo-Graovac M and Bartel T and Race S and Van Allen MI and Blydt-Hansen I and Ross CJ and Wasserman WW and Connolly MB and van Karnebeek CDM
DOI: 10.1177/0883073817740443
PubMed: 29246092

Assessing an Interactive Online Tool to Support Parents' Genomic Testing Decisions
Journal of Genetic Counseling
Shelin Adam and Patricia H. Birch and Rachel R. Coe and Nick Bansback and Adrian L. Jones and Mary B. Connolly and Michelle K. Demos and Eric B. Toyota and Matthew J. Farrer and Jan M. Friedman
DOI: 10.1007/s10897-018-0281-1

An Infant With Epilepsy and Recurrent Hemiplegia due to Compound Heterozygous Variants in ATP1A2.
Pediatric neurology
Wilbur C and Buerki SE and Guella I and Toyota EB and Evans DM and McKenzie MB and Datta A and Michoulas A and Adam S and Van Allen MI and Nelson TN and Farrer MJ and Connolly MB and Demos M
DOI: 10.1016/j.pediatrneurol.2017.06.003
PubMed: 28811059

De Novo Mutations in YWHAG Cause Early-Onset Epilepsy.
American journal of human genetics
Guella I and McKenzie MB and Evans DM and Buerki SE and Toyota EB and Van Allen MI and Epilepsy Genomics Study and Suri M and Elmslie F and Farrer MJ
DOI: 10.1016/j.ajhg.2017.07.004
PubMed: 28777935

Clinical Experience With Perampanel for Refractory Pediatric Epilepsy in One Canadian Center.
Journal of child neurology
Datta AN and Xu Q and Sachedina S and Boelman C and Huh L and Connolly MB
DOI: 10.1177/0883073817709195
PubMed: 28511603

Loss-of-Function and Gain-of-Function Mutations in KCNQ5 Cause Intellectual Disability or Epileptic Encephalopathy.
American journal of human genetics
Lehman A and Thouta S and Mancini GMS and Naidu S and van Slegtenhorst M and McWalter K and Person R and Mwenifumbo J and Salvarinova R and CAUSES Study and EPGEN Study and Guella I and Claydon T
DOI: 10.1016/j.ajhg.2017.05.016
PubMed: 28669405

Child- and parent-reported quality of life trajectories in children with epilepsy: A prospective cohort study.
Ferro MA and Avery L and Fayed N and Streiner DL and Cunningham CE and Boyle MH and Lach L and Glidden G and Rosenbaum PL and Ronen GM and QUALITÉ group
DOI: 10.1111/epi.13774
PubMed: 28485850

The relationship between d-beta-hydroxybutyrate blood concentrations and seizure control in children treated with the ketogenic diet for medically intractable epilepsy
Epilepsia Open
Jeffrey R. Buchhalter and Sabrina D'Alfonso and Mary Connolly and Ernest Fung and Aspasia Michoulas and David Sinasac and Rachel Singer and Jacklyn Smith and Narender Singh and Jong M. Rho
DOI: 10.1002/epi4.12058

ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology.
Scheffer IE and Berkovic S and Capovilla G and Connolly MB and French J and Guilhoto L and Hirsch E and Jain S and Mathern GW and Moshé SL and Nordli DR and Perucca E and Tomson T and Zuberi SM
DOI: 10.1111/epi.13709
PubMed: 28276062

Clinical, imaging, and immunohistochemical characteristics of focal cortical dysplasia Type II extratemporal epilepsies in children: analyses of an institutional case series.
Journal of neurosurgery. Pediatrics
Knerlich-Lukoschus F and Connolly MB and Hendson G and Steinbok P and Dunham C
DOI: 10.3171/2016.8.peds1686
PubMed: 27885945

Manifestations of Tuberous Sclerosis Complex: The Experience of a Provincial Clinic.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Wilbur C and Sanguansermsri C and Chable H and Anghelina M and Peinhof S and Anderson K and Steinbok P and Singhal A and Datta A and Connolly MB
DOI: 10.1017/cjn.2016.311
PubMed: 28004629

Secondary Abnormal CSF Neurotransmitter Metabolite Profiles in a Pediatric Tertiary Care Centre
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Clara D.M. van Karnebeek and Mary Dunbar and Csilla Egri and Bryan Sayson and Janetta Milea and Sylvia Stockler-Ipsiroglu and Linda Huh and Mary B. Connolly and Gabriella A. Horvath
DOI: 10.1017/cjn.2017.271

De novo FGF12 mutation in 2 patients with neonatal-onset epilepsy.
Neurology. Genetics
Guella I and Huh L and McKenzie MB and Toyota EB and Bebin EM and Thompson ML and Cooper GM and Evans DM and Buerki SE and Adam S and Van Allen MI and Nelson TN and Connolly MB and Farrer MJ and Demos M
DOI: 10.1212/nxg.0000000000000120
PubMed: 27872899

Dravet Syndrome: Diagnosis and Long-Term Course.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Connolly MB
DOI: 10.1017/cjn.2016.243
PubMed: 27264139

Correlates of health-related quality of life in children with drug resistant epilepsy
Lauryn Conway and Mary Lou Smith and Mark A. Ferro and Kathy N. Speechley and Mary B. Connoly and O. Carter Snead and Elysa Widjaja and the PEPSQOL Study Team
DOI: 10.1111/epi.13441

Exome Sequencing and the Management of Neurometabolic Disorders.
The New England journal of medicine
Tarailo-Graovac M and Shyr C and Ross CJ and Horvath GA and Salvarinova R and Ye XC and Zhang LH and Bhavsar AP and Lee JJ and Drögemöller BI and Abdelsayed M and Alfadhel M and van Karnebeek CD
DOI: 10.1056/nejmoa1515792
PubMed: 27276562

Resective Epilepsy Surgery for Tuberous Sclerosis in Children: Determining Predictors of Seizure Outcomes in a Multicenter Retrospective Cohort Study.
Fallah A and Rodgers SD and Weil AG and Vadera S and Mansouri A and Connolly MB and Major P and Ma T and Devinsky O and Weiner HL and Gonzalez-Martinez JA and Bingaman WE and Najm I and Rutka JT
DOI: 10.1227/neu.0000000000000875
PubMed: 26120800

Recovery From Central Nervous System Acute Demyelination in Children.
O'Mahony J and Marrie RA and Laporte A and Yeh EA and Bar-Or A and Phan C and Buckley D and Callen D and Connolly MB and Pohl D and Dilenge ME and Bernard G and Lortie A and Lowry N and Banwell B
DOI: 10.1542/peds.2015-0028
PubMed: 26034241

Tick paralysis: Presentation as a pure cerebellar syndrome
Journal of Pediatric Neurology
Raed Alroughani and Jonathan Guilfoyle and Mary Connolly
DOI: 10.1055/s-0035-1557486

Does treatment have an impact on incidence and risk factors for autism spectrum disorders in children with infantile spasms?
Bitton JY and Demos M and Elkouby K and Connolly M and Weiss SK and Donner EJ and Whiting S and Ronen GM and Bello-Espinosa L and Wirrell EC and Mohamed IS and Dooley JM and Carmant L
DOI: 10.1111/epi.12997
PubMed: 25944453

The "vagal ansa": a source of complication in vagus nerve stimulation.
Journal of neurosurgery. Pediatrics
Gopalakrishnan CV and Kestle JR and Connolly MB
DOI: 10.3171/2014.10.peds14259
PubMed: 25700120

Children's perspective of quality of life in epilepsy
N. Fayed and A. M. Davis and D. L. Streiner and P. L. Rosenbaum and C. E. Cunningham and L. M. Lach and M. H. Boyle and G. M. Ronen and On behalf of the QUALITE Study Group
DOI: 10.1212/wnl.0000000000001536

The importance of cerebral magnetic resonance imaging in evaluation of neonatal seizures.
Developmental medicine and child neurology
Buerki SE and Connolly MB
DOI: 10.1111/dmcn.12640
PubMed: 25407829

Diagnostic value of a multidisciplinary clinic for intellectual disability.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
van Karnebeek C and Murphy T and Giannasi W and Thomas M and Connolly M and Stockler-Ipsiroglu S
PubMed: 24718818

Clinical and magnetic resonance imaging (MRI) distinctions between tumefactive demyelination and brain tumors in children.
Journal of child neurology
Yiu EM and Laughlin S and Verhey LH and Banwell BL and Canadian Pediatric Demyelinating Disease Network
DOI: 10.1177/0883073813500713
PubMed: 24092896

Recommendations for HLA-B*15:02 and HLA-A*31:01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity reactions.
Amstutz U and Shear NH and Rieder MJ and Hwang S and Fung V and Nakamura H and Connolly MB and Ito S and Carleton BC and CPNDS clinical recommendation group
DOI: 10.1111/epi.12564
PubMed: 24597466

Pyridoxine responsiveness in novel mutations of the PNPO gene.
Plecko B and Paul K and Mills P and Clayton P and Paschke E and Maier O and Hasselmann O and Schmiedel G and Kanz S and Connolly M and Wolf N and Struys E and Stockler S and Abela L and Hofer D
DOI: 10.1212/wnl.0000000000000344
PubMed: 24658933

Classifying Epileptic Seizures and the Epilepsies
Valeria M. Muro and Mary B. Connolly
DOI: 10.1002/9781118456989.ch2

Outcomes trajectories in children with epilepsy: hypotheses and methodology of a Canadian longitudinal observational study.
Pediatric neurology
Ronen GM and Streiner DL and Boyle MH and Cunningham CE and Lach L and Verhey LH and Fayed N and Chen K and Rosenbaum PL and QUALITÉ Group and Connolly M and Bello-Espinosa LE and Carmant L
DOI: 10.1016/j.pediatrneurol.2013.08.024
PubMed: 24370172

MRI findings in infants with infantile spasms after neonatal hypoxic-ischemic encephalopathy.
Pediatric neurology
Gano D and Sargent MA and Miller SP and Connolly MB and Wong P and Glass HC and Poskitt KJ and Chau V
DOI: 10.1016/j.pediatrneurol.2013.08.007
PubMed: 24095571

Hippocampal Malrotation and Temporal Lobe Epilepsy: What is the Relationship?
The Canadian Journal of Neurological Sciences
Mary B. Connolly
DOI: 10.1017/s0317167100014839

A case report of obsessive-compulsive disorder following acute disseminated encephalomyelitis.
Muir KE and McKenney KS and Connolly MB and Stewart SE
DOI: 10.1542/peds.2012-2876
PubMed: 23918895

Hippocampal malrotation and temporal lobe epilepsy: what is the relationship?
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Connolly MB
PubMed: 23968933

Status epilepticus amauroticus and posterior reversible encephalopathy syndrome in children.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
Muro VL and Yip S and Huh L and Connolly MB
DOI: 10.1097/wnp.0b013e31829de004
PubMed: 23912571

Masquerades of acquired demyelination in children: experiences of a national demyelinating disease program.
Journal of child neurology
O'Mahony J and Bar-Or A and Arnold DL and Sadovnick AD and Marrie RA and Banwell B and Canadian Pediatric Demyelinating Disease Network
DOI: 10.1177/0883073812443006
PubMed: 22573735

A condensed performance-validation strategy for multiplex detection kits used in studies of human clinical samples
Journal of Immunological Methods
Chahrazed Belabani and Sathyanath Rajasekharan and Viviane Poupon and Trina Johnson and Amit Bar-Or
DOI: 10.1016/j.jim.2012.08.002

Epilepsy Surgery in Childhood
The Canadian Journal of Neurological Sciences
Valeria L. Muro and Mary B. Connolly
DOI: 10.1017/s0317167100018163

Discontinuation of antiepileptic drugs after successful epilepsy surgery. a Canadian survey.
Epilepsy research
Téllez-Zenteno JF and Ronquillo LH and Jette N and Burneo JG and Nguyen DK and Donner EJ and Sadler M and Javidan M M and Gross DW and Wiebe S and Canadian Epilepsy Surgery Study Group
DOI: 10.1016/j.eplepsyres.2012.04.018
PubMed: 22595484

Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials.
Molecular genetics and metabolism
van Karnebeek CD and Hartmann H and Jaggumantri S and Bok LA and Cheng B and Connolly M and Coughlin CR and Das AM and Gospe SM and Jakobs C and van der Lee JH and Stockler S
DOI: 10.1016/j.ymgme.2012.09.006
PubMed: 23022070

2010 McDonald criteria for diagnosing pediatric multiple sclerosis
Annals of Neurology
Yair Sadaka and Leonard H. Verhey and Manohar M. Shroff and Helen M. Branson and Douglas L. Arnold and Sridar Narayanan and John G. Sled and Amit Bar-Or and A. Dessa Sadovnick and Melissa McGowan and Ruth Ann Marrie and Brenda Banwell and on behalf of the Canadian Pediatric Demyelinating Disease Network
DOI: 10.1002/ana.23575

Benign myoclonic epilepsy of infancy
Pediatric Epilepsy

Profound neonatal hypoglycemia and lactic acidosis caused by pyridoxine-dependent epilepsy.
Mercimek-Mahmutoglu S and Horvath GA and Coulter-Mackie M and Nelson T and Waters PJ and Sargent M and Struys E and Jakobs C and Stockler-Ipsiroglu S and Connolly MB
DOI: 10.1542/peds.2011-0123
PubMed: 22529283

Systematic review and case series of neuropsychological functioning after epilepsy surgery in children with dysembryoplastic neuroepithelial tumors (DNET)
Epilepsy & Behavior
Taryn B. Fay-McClymont and Marianne Hrabok and Elisabeth M.S. Sherman and Walter J. Hader and Mary B. Connolly and Sare Akdag and Ismail S. Mohamed and Samuel Wiebe
DOI: 10.1016/j.yebeh.2011.12.011

Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study.
The Lancet. Neurology
Banwell B and Bar-Or A and Arnold DL and Sadovnick D and Narayanan S and McGowan M and O'Mahony J and Magalhaes S and Hanwell H and Vieth R and Tellier R and Vincent T and Disanto G and Marrie RA
DOI: 10.1016/s1474-4422(11)70045-x
PubMed: 21459044

HLA-DRB1 confers increased risk of pediatric-onset MS in children with acquired demyelination.
Disanto G and Magalhaes S and Handel AE and Morrison KM and Sadovnick AD and Ebers GC and Banwell B and Bar-Or A and Canadian Pediatric Demyelinating Disease Network
DOI: 10.1212/wnl.0b013e31820ee1cd
PubMed: 21288988

Cerebral sinus thrombosis following IV immunoglobulin therapy of immune thrombocytopenia purpura
Pediatric Blood & Cancer
Arwa Z. Al-Riyami and James Lee and Mary Connolly and Evan Shereck
DOI: 10.1002/pbc.22968

Mitochondrial DNA haplogroups and mutations in children with acquired central demyelination.
Venkateswaran S and Zheng K and Sacchetti M and Gagne D and Arnold DL and Sadovnick AD and Scherer SW and Banwell B and Bar-Or A and Simon DK and Canadian Pediatric Demyelinating Disease Network
DOI: 10.1212/wnl.0b013e31820ee1bb
PubMed: 21288980

Electroclinical features of absence seizures in sleep
Epilepsy Research
Lynette G. Sadleir and Kevin Farrell and Sherry Smith and Mary B. Connolly and Ingrid E. Scheffer
DOI: 10.1016/j.eplepsyres.2010.12.009

Cerebrovasculopathy in NF1 associated with ocular and scalp defects.
American journal of medical genetics. Part A
Smith M and Heran MK and Connolly MB and Heran HK and Friedman JM and Jett K and Lyons CJ and Steinbok P and Armstrong L
DOI: 10.1002/ajmg.a.33788
PubMed: 21271658

Landau-Kleffner syndrome: a rare auditory processing disorder series of cases and review of the literature.
International journal of pediatric otorhinolaryngology
Fandiño M and Connolly M and Usher L and Palm S and Kozak FK
DOI: 10.1016/j.ijporl.2010.10.001
PubMed: 21074868

Epilepsy with occipital features in children: factors predicting seizure outcome and neuroimaging abnormalities.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
Schrader D and Shukla R and Gatrill R and Farrell K and Connolly M
DOI: 10.1016/j.ejpn.2010.08.005
PubMed: 20829080

Pyridoxine dependent epilepsy and antiquitin deficiency: clinical and molecular characteristics and recommendations for diagnosis, treatment and follow-up.
Molecular genetics and metabolism
Stockler S and Plecko B and Gospe SM and Coulter-Mackie M and Connolly M and van Karnebeek C and Mercimek-Mahmutoglu S and Hartmann H and Scharer G and Struijs E and Tein I and Van Hove JL
DOI: 10.1016/j.ymgme.2011.05.014
PubMed: 21704546

Approach to a child with a first afebrile seizure
BC Medical Journal

Treatment of intractable epilepsy in a female with SLC6A8 deficiency.
Molecular genetics and metabolism
Mercimek-Mahmutoglu S and Connolly MB and Poskitt KJ and Horvath GA and Lowry N and Salomons GS and Casey B and Sinclair G and Davis C and Jakobs C and Stockler-Ipsiroglu S
DOI: 10.1016/j.ymgme.2010.08.016
PubMed: 20846889

Parents report more ADHD symptoms than do teachers in children with epilepsy
Epilepsy & Behavior
Elisabeth M.S. Sherman and Brian L. Brooks and Sare Akdag and Mary B. Connolly and Samuel Wiebe
DOI: 10.1016/j.yebeh.2010.08.015

Electrocorticography and seizure outcomes in children with lesional epilepsy
Child's Nervous System
Jennifer N. Gelinas and Andrew W. Battison and Sherry Smith and Mary B. Connolly and Paul Steinbok
DOI: 10.1007/s00381-010-1279-7

Red reflex mimicking lens subluxation in a child undergoing orthokeratology.
Wiwatwongwana A and Connolly MB and Lyons CJ
DOI: 10.1038/eye.2009.46
PubMed: 19300465

Cingulate lesions presenting with epileptic spasms.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
Schrader D and Langill L and Singhal A and Steinbok P and Connolly MB
DOI: 10.1097/wnp.0b013e3181baaacf
PubMed: 19752743

Epilepsy and memory dysfunction.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
Connolly MB
PubMed: 19760900

Automatisms in Absence Seizures in Children With Idiopathic Generalized Epilepsy
Archives of Neurology
Lynette G. Sadleir and Ingrid E. Scheffer and Sherry Smith and Mary B. Connolly and Kevin Farrell
DOI: 10.1001/archneurol.2009.108

Epilepsy surgery in the first 3 years of life: a Canadian survey.
Steinbok P and Gan PY and Connolly MB and Carmant L and Barry Sinclair D and Rutka J and Griebel R and Aronyk K and Hader W and Ventureyra E and Atkinson J
DOI: 10.1111/j.1528-1167.2008.01992.x
PubMed: 19175388

EEG features of absence seizures in idiopathic generalized epilepsy: impact of syndrome, age, and state.
Sadleir LG and Scheffer IE and Smith S and Carstensen B and Farrell K and Connolly MB
DOI: 10.1111/j.1528-1167.2008.02001.x
PubMed: 19243419

Incidence of acquired demyelination of the CNS in Canadian children.
Banwell B and Kennedy J and Sadovnick D and Arnold DL and Magalhaes S and Wambera K and Connolly MB and Yager J and Mah JK and Shah N and Sebire G and Meaney B and Dilenge ME and Lortie A and Bar-Or A
DOI: 10.1212/01.wnl.0000339482.84392.bd
PubMed: 19153370

Urgent, resective surgery for medically refractory, convulsive status epilepticus.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
Schrader DV and Steinbok P and Connolly M
DOI: 10.1016/j.ejpn.2008.01.011
PubMed: 18460420

Factors influencing clinical features of absence seizures.
Sadleir LG and Scheffer IE and Smith S and Carstensen B and Carlin J and Connolly MB and Farrell K
DOI: 10.1111/j.1528-1167.2008.01708.x
PubMed: 18616552

Cranial Neuropathy, Polyneuropathy and Thrombocytopenia with Epstein-Barr Virus Infection
Developmental Medicine & Child Neurology
Mary Connolly and Anne K. Junker and Ka Wah Chan and Kevin Farrell
DOI: 10.1111/j.1469-8749.1994.tb11797.x

Quality of life and seizure outcome after vagus nerve stimulation in children with intractable epilepsy.
Journal of child neurology
Sherman EM and Connolly MB and Slick DJ and Eyrl KL and Steinbok P and Farrell K
DOI: 10.1177/0883073808315417
PubMed: 18474931

Autosomal recessive GTP cyclohydrolase I deficiency without hyperphenylalaninemia: evidence of a phenotypic continuum between dominant and recessive forms.
Molecular genetics and metabolism
Horvath GA and Stockler-Ipsiroglu SG and Salvarinova-Zivkovic R and Lillquist YP and Connolly M and Hyland K and Blau N and Rupar T and Waters PJ
DOI: 10.1016/j.ymgme.2008.01.003
PubMed: 18276179

Sociodemographic correlates of health-related quality of life in pediatric epilepsy
Epilepsy & Behavior
Elisabeth M.S. Sherman and Stephanie Y. Griffiths and Sare Akdag and Mary B. Connolly and Daniel J. Slick and Samuel Wiebe
DOI: 10.1016/j.yebeh.2007.07.009

Epilepsy associated with a cerebellar arachnoid cyst: seizure control following fenestration of the cyst
Child's Nervous System
Yee Chiung Gan and Mary B. C. Connolly and Paul Steinbok
DOI: 10.1007/s00381-007-0439-x

Surgical outcome in tuberous sclerosis complex: a multicenter survey.
Madhavan D and Schaffer S and Yankovsky A and Arzimanoglou A and Renaldo F and Zaroff CM and LaJoie J and Weiner HL and Andermann E and Franz DN and Leonard J and Connolly M and Devinsky O
DOI: 10.1111/j.1528-1167.2007.01112.x
PubMed: 17484758

ADHD, neurological correlates and health-related quality of life in severe pediatric epilepsy.
Sherman EM and Slick DJ and Connolly MB and Eyrl KL
DOI: 10.1111/j.1528-1167.2007.01028.x
PubMed: 17381442

The spectrum of SCN1A-related infantile epileptic encephalopathies.
Brain : a journal of neurology
Harkin LA and McMahon JM and Iona X and Dibbens L and Pelekanos JT and Zuberi SM and Sadleir LG and Andermann E and Gill D and Farrell K and Connolly M and Stanley T and Harbord M and Scheffer IE
DOI: 10.1093/brain/awm002
PubMed: 17347258

Postsurgical health-related quality of life (HRQOL) in children following hemispherectomy for intractable epilepsy.
Griffiths SY and Sherman EM and Slick DJ and Eyrl K and Connolly MB and Steinbok P
DOI: 10.1111/j.1528-1167.2006.00966.x
PubMed: 17284297

Hemispheric surgery in children with refractory epilepsy: seizure outcome, complications, and adaptive function.
Basheer SN and Connolly MB and Lautzenhiser A and Sherman EM and Hendson G and Steinbok P
DOI: 10.1111/j.1528-1167.2006.00909.x
PubMed: 17241220

Pharmacological management of a youth with ADHD and a seizure disorder.
Journal of the American Academy of Child and Adolescent Psychiatry
Gonzalez-Heydrich J and Weiss M and Connolly M and Wambera K and Jan JE and Plioplys S and Dunn DW and Kratochvil CJ
DOI: 10.1097/01.chi.0000240836.71361.39
PubMed: 17135999

Electroclinical features of absence seizures in childhood absence epilepsy.
Sadleir LG and Farrell K and Smith S and Connolly MB and Scheffer IE
DOI: 10.1212/01.wnl.0000228257.60184.82
PubMed: 16894100

Tuberous sclerosis complex: a review of the management of epilepsy with emphasis on surgical aspects
Child's Nervous System
Mary B. Connolly and Glenda Hendson and Paul Steinbok
DOI: 10.1007/s00381-006-0130-7

6-pyruvoyl-tetrahydropterin synthase deficiency with mild hyperphenylalaninemia.
Annals of neurology
Demos MK and Waters PJ and Vallance HD and Lillquist Y and Makhseed N and Hyland K and Blau N and Connolly MB
DOI: 10.1002/ana.20532
PubMed: 15984017

Preserved episodic memory in subcortical band heterotopia.
Janzen L and Sherman E and Langfitt J and Berg M and Connolly M
DOI: 10.1111/j.0013-9580.2004.53203.x
PubMed: 15101838

Neurophysiological investigations
Epilepsy in Children, 2E
Mary Connolly and Peter Wong
DOI: 10.1201/b13560-42

Spasms in children with definite and probable mitochondrial disease.
European journal of neurology
Sadleir LG and Connolly MB and Applegarth D and Hendson G and Clarke L and Rakshi C and Farrell K
DOI: 10.1046/j.1351-5101.2003.00724.x
PubMed: 14748770

Rasmussen syndrome
Epilepsy in Children, 2E
DOI: 10.1201/b13560-30

Reexamining the effects of epilepsy surgery on IQ in children: use of regression-based change scores.
Journal of the International Neuropsychological Society : JINS
Sherman E and Slick DJ and Connolly MB and Steinbok P and Martin R and Strauss E and Chelune GJ and Farrell K
PubMed: 14632247

Electrical fields and recording techniques
Current Practice of Clinical Electroencephalography, 3rd Edition

Melatonin does not trigger convulsions
Pediatrics and Child Health

New antiepileptic drug therapies.
Neurologic clinics
Bergin AM and Connolly M
DOI: 10.1016/s0733-8619(02)00017-8
PubMed: 12616686

Hyperventilation-induced high-amplitude rhythmic slowing with altered awareness: a video-EEG comparison with absence seizures.
Lum LM and Connolly MB and Farrell K and Wong PK
DOI: 10.1046/j.1528-1157.2002.35101.x
PubMed: 12423387

Validity of three measures of health-related quality of life in children with intractable epilepsy.
Sherman EM and Slick DJ and Connolly MB and Steinbok P and Camfield C and Eyrl KL and Massey C and Farrell K
DOI: 10.1046/j.1528-1157.2002.03602.x
PubMed: 12366740

Surgical Resection for Intractable Epilepsy in “Double Cortex” Syndrome Yields Inadequate Results
A. Bernasconi and V. Martinez and P. Rosa-Neto and D. D'Agostino and N. Bernasconi and S. Berkovic and M. MacKay and A. Simon Harvey and A. Palmini and J. Costa Da Costa and Eliseu Paglioli and H.I. Kim and M. Connolly and A. Olivier and F. Dubeau and E. Andermann and R. Guerrini and W. Whisler and L. De Toledo-Morrell and F. Morrell and F. Andermann
DOI: 10.1046/j.1528-1157.2001.39900.x

Temporal Lobectomy in Early Childhood: The Need for Long-Term Follow-Up
Journal of Child Neurology
Márcio A. Sotero de Menezes and Mary Connolly and Addison Bolanos and Joseph Madsen and Peter McL. Black and James J. Riviello
DOI: 10.1177/088307380101600809

Postvaricella angiopathy: report of a case with pathologic correlation.
Pediatric neurology
Hayman M and Hendson G and Poskitt KJ and Connolly MB
DOI: 10.1016/s0887-8994(01)00272-7
PubMed: 11516617

Cortical visual impairment in children with infantile spasms
Journal of AAPOS
Giovanni Castano and Christopher J. Lyons and James E. Jan and Mary Connolly
DOI: 10.1067/mpa.2000.104483

Editorial Comment
Child's Nervous System
P. Steinbok and M. Connolly
DOI: 10.1007/s003810050515

Factors associated with behavioral and cognitive abnormalities in children receiving topiramate.
Pediatric neurology
Gerber PE and Hamiwka L and Connolly MB and Farrell K
DOI: 10.1016/s0887-8994(99)00151-4
PubMed: 10734250

Pediatric Peri-Insular Hemispherotomy
Pediatric Neurosurgery
J. Kestle and M. Connolly and D. Cochrane
DOI: 10.1159/000028896

Psychological assessment and treatment of psychogenic symptoms in children and adolescents
Non-epileptic Seizures, 2nd Edition

Editorial Comment
Child's Nervous System
M. Connolly and P. Steinbok and G. Hendson
DOI: 10.1007/s003810050424

Melatonin treatment of non-epileptic myoclonus in children.
Developmental medicine and child neurology
Jan JE and Connolly MB and Hamilton D and Freeman RD and Laudon M
DOI: 10.1017/s0012162299000535
PubMed: 10355809

Acquired brachial-plexus neuropathy in the neonate: a rare presentation of late-onset group-B streptococcal osteomyelitis.
Developmental medicine and child neurology
Sadleir LG and Connolly MB
PubMed: 9698064

Encephalopathy complicating Henoch-Schönlein purpura: reversible MRI changes.
Pediatric neurology
Woolfenden AR and Hukin J and Poskitt KJ and Connolly MB
DOI: 10.1016/s0887-8994(98)00027-7
PubMed: 9682892

Prospective, open-label, add-on study of lamotrigine in 56 children with intractable generalized epilepsy
Pediatric Neurology
Kevin Farrell and Mary B Connolly and Robert Munn and Shumin Peng and Laurie M MacWilliam
DOI: 10.1016/s0887-8994(97)00010-6

Seizures involving the supplementary sensorimotor area in children: a video-EEG analysis.
Connolly MB and Langill L and Wong PK and Farrell K
DOI: 10.1111/j.1528-1157.1995.tb00962.x
PubMed: 7555953

Alternating paroxysmal dystonia and hemiplegia in childhood as a symptom of basal ganglia disease.
Journal of Neurology, Neurosurgery & Psychiatry
Y M Hart and D Tampieri and E Andermann and F Andermann and M Connolly and K Farrell
DOI: 10.1136/jnnp.59.4.453

Rapid cycling in severely multidisabled children: a form of bipolar affective disorder?
Pediatric neurology
Jan JE and Abroms IF and Freeman RD and Brown GM and Espezel H and Connolly MB
DOI: 10.1016/0887-8994(94)90064-7
PubMed: 8198670

Biological bases of brain function and disease
Journal of Epilepsy
Mary Connolly
DOI: 10.1016/0896-6974(94)90039-6

Outpatient video-EEG monitoring in children.
Connolly MB and Wong PK and Karim Y and Smith S and Farrell K
DOI: 10.1111/j.1528-1157.1994.tb02465.x
PubMed: 8026391

Epilepsy in infants and children
Conn's Current Therapy

Intrapartum Asphyxia in Term and Postterm Infants
Obstetrical & Gynecological Survey
DOI: 10.1097/00006254-199306000-00009

MRI in pseudotumour cerebri
Pediatric Neurology Briefs

Magnetic resonance imaging in pseudotumor cerebri.
Developmental medicine and child neurology
Connolly MB and Farrell K and Hill A and Flodmark O
PubMed: 1451939

Clinical features for prediction of survival in neonatal muscle disease.
Pediatric neurology
Connolly MB and Roland EH and Hill A
DOI: 10.1016/0887-8994(92)90367-8
PubMed: 1388418

Letter to the editor: Rapid recovery from cortical visual impairment following correction of prolonged shunt malfunction
Archives of Neurology

Hepatic dysfunction in Alström disease.
American journal of medical genetics
Connolly MB and Jan JE and Couch RM and Wong LT and Dimmick JE and Rigg JM
DOI: 10.1002/ajmg.1320400408
PubMed: 1746604

Rapid recovery from cortical visual impairment following correction of prolonged shunt malfunction in congenital hydrocephalus.
Archives of neurology
Connolly MB and Jan JE and Cochrane DD
DOI: 10.1001/archneur.1991.00530210082028
PubMed: 1953421

Intravenous immunoglobulin and pyridoxine-dependent seizures.
Connolly MB and Jan JE and Junker AK
DOI: 10.1212/wnl.41.9.1524
PubMed: 1891109

An approach to the diagnosis and treatment of seizures in children
Canadian Journal of Pediatrics

Head shaking by visually impaired children: a voluntary neurovisual adaptation which can be confused with spasmus nutans.
Developmental medicine and child neurology
Jan JE and Groenveld M and Connolly MB
PubMed: 2286305

Cost of neonatal intensive and special care
Irish Medical Journal

Diagnostic Yield and Treatment Impact of Targeted Exome Sequencing in Early-onset Epilepsy
Michelle Demos and Ilaria Guella and Marna B. McKenzie and Sarah E. Buerki and Daniel M. Evans and Eric B. Toyota and Cyrus Boelman and Linda L. Huh and Anita Datta and Aspasia Michoulas and Kathryn Selby and Bruce H. Bjornson and Gabriella Horvath and Elena Lopez-Rangel and Clara DM van Karnebeek and Ramona Salvarinova and Erin Slade and Patrice Eydoux and Shelin Adam and Margot. I. Van Allen and Tanya N. Nelson and Corneliu Bolbocean and Mary B. Connolly and Matthew J. Farrer
DOI: 10.1101/139329


Acute psychiatric adverse events associated with Levetiracetam therapy in children with epilepsy
This study analyzes acute psychiatric adverse events (PAEs) in children receiving Levetiracetam, a new anti-epileptic drug. Predisposing factors such a personal or family history of psychiatric illness dosing schedules are reviewed. The aim is to identify risk factors and try to minimize PAEs on Levetiracetam.

Outcome Trajectories in Children with Epilepsy: What Factors are Important?
Our centre is participating in this multicentre study funded by CIHR. A variety of factors, both environmental and organic, influence the life quality outcomes in children with epilepsy. Our hypothesis that changes in children’s outcomes over time will be more strongly related to child and family psychosocial factors than to epilepsy-specific variables. The outcomes examined in this study include biomedical health and functional status (primarily mental health and intellectual abilities), academic achievement and participation. We will also measure the subjective experience of epilepsy with generic and condition-specific self- and proxy-reported ‘quality of life’ (HRQL) instruments.

Outcome following epilepsy surgery
Since the epilepsy surgery program was established, I have personally followed all children who have had surgery longitudinally from a clinical perspective. Neuropsychological and quality of life studies have been performed prior to surgery and on follow-up.

With colleagues in neurosurgery and neuropsychology, I have published several papers on long-term outcomes and quality of life following hemispheric surgery, surgery for tuberous sclerosis and vagus nerve stimulation. We also recently reported the a group of children with refractory status epilepticus who had urgent epilepsy surgery. A recent study of epilepsy surgery in the first 3 years of life across Canada, one of the largest series in young children in the literature, outlines the success in this group.

I am currently studying outcomes in children who had epilepsy surgery in the frontal lobe and assessing factors which may negatively affect the outcome. I am also studying the long-term outcome in children who had temporal lobe surgery and assessing outcomes and the influence of neuropsychiatric disorders such as depression, psychosis and anxiety on outcome.

Honours & Awards

Award of Distinction from Partners in Care - BC Children’s Hospital, 2006

BC Children’s Hospital Education Award - Education Day for Families, 2005

Research Group Members

Elena Mihaela Anghelina, Clinical Research Coordinator
Stephanie Kwok, Research Coordinator
Vesna Popovska, Director, Research, Pediatric Neurology & Neurosurgery, UBC Adult Neurosurgery
Naheeda Rajmohamed, Research Assistant