Overview

The aim of our research at the Vaccine Evaluation Center (VEC) is to lower the burden of childhood infectious disease through vaccination by building an evidence base for local, national and international vaccine policy. My research program includes laboratory studies to develop new and better vaccines, clinical trials to identify how best to utilize new and approved vaccines, and population-based investigations to identify targets for new vaccines and demonstrate vaccine impact.

Publications

Association between human papillomavirus vaccine status and sexually transmitted infection outcomes among females aged 18-35 with a history of sexual activity in the United States: A population survey-based cross-sectional analysis
Vaccine
Kalysha Closson and Mohammad E. Karim and Manish Sadarangani and Monika Naus and Gina S. Ogilvie and Robine Donken
DOI: 10.1016/j.vaccine.2020.10.033
11/2020

Matrix-assisted laser desorption/ionization time-of-flight MS for the accurate identification of Burkholderia cepacia complex and Burkholderia gladioli in the clinical microbiology laboratory
Journal of Medical Microbiology
Kendrew S. K. Wong and Suk Dhaliwal and Jennifer Bilawka and Jocelyn A. Srigley and Sylvie Champagne and Marc G. Romney and Peter Tilley and Manish Sadarangani and James E. A. Zlosnik and Mark A. Chilvers
DOI: 10.1099/jmm.0.001223
08/2020

Immunogenicity of 2 and 3 Doses of the Quadrivalent Human Papillomavirus Vaccine up to 120 Months Postvaccination: Follow-up of a Randomized Clinical Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Donken R and Dobson SRM and Marty KD and Cook D and Sauvageau C and Gilca V and Dionne M and McNeil S and Krajden M and Money D and Kellner J and Scheifele DW and Kollmann T and Ogilvie GS
DOI: 10.1093/cid/ciz887
PubMed: 31617568
08/2020

Profiling avidity of antibodies elicited by vaccination using enzyme-linked immunosorbent assay-based elution – Insights into a novel experimental and analytical approach
Vaccine
Bahaa Abu-Raya and Michelle L Giles and Tobias R. Kollmann and Manish Sadarangani
DOI: 10.1016/j.vaccine.2020.06.060
07/2020

Challenges in evaluating SARS-CoV-2 vaccines during the COVID-19 pandemic.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
Abu-Raya B and Gantt S and Sadarangani M
DOI: 10.1503/cmaj.201237
PubMed: 32646869
07/2020

Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 From the Mother to the Infant.
JAMA pediatrics
Abu Raya B and Giles ML and Sadarangani M
DOI: 10.1001/jamapediatrics.2020.2150
PubMed: 32687555
07/2020

What is the role of SARS-CoV-2 PCR testing in discontinuation of transmission-based precautions for COVID-19 patients?
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Abu Raya B and Goldfarb DM and Sadarangani M
DOI: 10.1093/cid/ciaa671
PubMed: 32472672
05/2020

Study protocol: NeoCLEAR: Neonatal Champagne Lumbar punctures Every time - An RCT: a multicentre, randomised controlled 2¿×¿2 factorial trial to investigate techniques to increase lumbar puncture success.
BMC pediatrics
Marshall ASJ and Sadarangani M and Scrivens A and Williams R and Yong J and Bowler U and Linsell L and Chiocchia V and Bell JL and Stokes C and Santhanadass P and Adams E and ‘The NeoCLEAR Collaborative Group’
DOI: 10.1186/s12887-020-02050-8
PubMed: 32295554
04/2020

Improving Vaccine-Induced Immunity: Can Baseline Predict Outcome?
Trends in immunology
Tsang JS and Dobaño C and VanDamme P and Moncunill G and Marchant A and Othman RB and Sadarangani M and Koff WC and Kollmann TR
DOI: 10.1016/j.it.2020.04.001
PubMed: 32340868
04/2020

Neuropsychological and psychiatric outcomes in encephalitis: A multi-centre case-control study.
PloS one
Harris L and Griem J and Gummery A and Marsh L and Defres S and Bhojak M and Das K and Easton A and Solomon T and Kopelman M and ENCEPH UK study group
DOI: 10.1371/journal.pone.0230436
PubMed: 32210460
03/2020

Estimated susceptibility of Canadian meningococcal B isolates to a meningococcal serogroup B vaccine (MenB-FHbp)
Vaccine
Julie A. Bettinger and Paul Liberator and Scott A. Halperin and Wendy Vaudry and Manish Sadarangani and Li Hao and Nathaniel Lambert and Kathrin U. Jansen and Annaliesa S. Anderson and Raymond Tsang
DOI: 10.1016/j.vaccine.2019.12.051
02/2020

Cervical Intraepithelial Neoplasia Rates in British Columbia Women: A Population-Level Data Linkage Evaluation of the School-Based HPV Immunization Program.
The Journal of infectious diseases
Racey CS and Albert A and Donken R and Smith L and Spinelli JJ and Pedersen H and de Bruin P and Masaro C and Mitchell-Foster S and Sadarangani M and Dawar M and Krajden M and Naus M and Ogilvie G
DOI: 10.1093/infdis/jiz422
PubMed: 31504649
01/2020

Outcomes beyond hospital discharge in infants and children with viral meningitis: A systematic review
Reviews in Medical Virology
Hudson, J.A. and Broad, J. and Martin, N.G. and Sadarangani, M. and Galal, U. and Kelly, D.F. and Pollard, A.J. and Kadambari, S.
DOI: 10.1002/rmv.2083
2020

Burden of Children Hospitalized With Pertussis in Canada in the Acellular Pertussis Vaccine Era, 1999-2015
Journal of the Pediatric Infectious Diseases Society
Abu-Raya, B. and Bettinger, J.A. and Vanderkooi, O.G. and Vaudry, W. and Halperin, S.A. and Sadarangani, M.
DOI: 10.1093/jpids/piy128
2020

Is there a difference in the immune response, efficacy, effectiveness and safety of seasonal influenza vaccine in males and females? – A systematic review
Vaccine
Tadount, F. and Doyon-Plourde, P. and Rafferty, E. and MacDonald, S. and Sadarangani, M. and Quach, C.
DOI: 10.1016/j.vaccine.2019.10.091
2020

Fifteen-minute consultation: Prevention and treatment of chickenpox in newborns
Archives of Disease in Childhood: Education and Practice Edition
Holland, C. and Sadarangani, M.
DOI: 10.1136/archdischild-2018-316715
2020

The prevalence and clinical characteristics of pertussis-associated pneumonia among infants in Botswana.
BMC pediatrics
Abu-Raya B and Goldfarb DM and Smieja M and Luinstra K and Richard-Greenblatt M and Steenhoff AP and Feemster KA and Arscott-Mills T and Cunningham CK and Shah SS and Patel MZ and Sadarangani M
DOI: 10.1186/s12887-019-1820-0
PubMed: 31733643
11/2019

The Effect of Timing of Tetanus-Diphtheria-Acellular Pertussis Vaccine Administration in Pregnancy on the Avidity of Pertussis Antibodies.
Frontiers in immunology
Abu-Raya B and Giles ML and Kollmann TR and Sadarangani M
DOI: 10.3389/fimmu.2019.02423
PubMed: 31681310
10/2019

Comparative transcriptomics between species attributes reactogenicity pathways induced by the capsular group B meningococcal vaccine, 4CMenB, to the membrane-bound endotoxin of its outer membrane vesicle component.
Scientific reports
Sheerin D and O'Connor D and Dold C and Clutterbuck E and Attar M and Rollier CS and Sadarangani M and Pollard AJ
DOI: 10.1038/s41598-019-50310-0
PubMed: 31551511
09/2019

Understanding parental perspectives on outcomes following paediatric encephalitis: A qualitative study.
PloS one
Lemon J and Cooper J and Defres S and Easton A and Sadarangani M and Griffiths MJ and Pollard AJ and Solomon T and Kneen R
DOI: 10.1371/journal.pone.0220042
PubMed: 31525232
09/2019

Recurrent immune thrombocytopenia following different vaccines.
BMJ case reports
Morin E and Sadarangani M
DOI: 10.1136/bcr-2019-231260
PubMed: 31540926
09/2019

Meningitis vaccines in children: what have we achieved and where next?
Current opinion in infectious diseases
McAlpine A and Sadarangani M
DOI: 10.1097/qco.0000000000000580
PubMed: 31335439
07/2019

A Population-based Observational Study of Childhood Encephalitis in Children Admitted to Pediatric Intensive Care Units in England and Wales.
The Pediatric infectious disease journal
Iro MA and Sadarangani M and Nickless A and Kelly DF and Pollard AJ
DOI: 10.1097/inf.0000000000002280
PubMed: 30640197
07/2019

Targeted metagenomic sequencing enhances the identification of pathogens associated with acute infection
Goh C and Golubchik T and Ansari MA and de Cesare M and Trebes A and Elliott I and Bonsall D and Piazza P and Brown A and Slawinski H and Martin N and Defres S and Griffiths MJ and Bowden R
DOI: 10.1101/716902
07/2019

Dilemmas With Rotavirus Vaccine: The Neonate and Immunocompromised.
The Pediatric infectious disease journal
Chiu M and Bao C and Sadarangani M
DOI: 10.1097/inf.0000000000002322
PubMed: 31205244
06/2019

To LP or not to LP? Identifying the Etiology of Pediatric Meningitis.
The Pediatric infectious disease journal
Mijovic H and Sadarangani M
DOI: 10.1097/inf.0000000000002313
PubMed: 31205243
06/2019

42 A risk factor approach is highly effective at selecting 29-34w gestation infants at risk for first season RSV-related admissions – a population study.
Paediatrics & Child Health
Sidi S and Claydon J and Solimano A and Taylor R and Lavoie P and Christopherson C and Kuzeljevic B and Gantt S and Sadarangani M and Burns G and Bayzand L
05/2019

41 Lessons learned during the practice of a no-conflict of-interest panel-of-three adjudication process in the RSV program.
Paediatrics & Child Health
Sidi S and Claydon J and Christopherson C and Taylor R and Gantt S and Sadarangani M and Lavoie P and Solimano A
05/2019

From mother to baby: antenatal exposure to monoclonal antibody biologics.
Expert review of clinical immunology
Pham-Huy A and Sadarangani M and Huang V and Ostensen M and Castillo E and Troster SM and Vaudry W and Nguyen GC and Top KA
DOI: 10.1080/1744666x.2019.1561282
PubMed: 30570400
01/2019

From mother to baby: antenatal exposure to monoclonal antibody biologics
Expert Review of Clinical Immunology
Pham-Huy, A. and Sadarangani, M. and Huang, V. and Ostensen, M. and Castillo, E. and Troster, S.M. and Vaudry, W. and Nguyen, G.C. and Top, K.A.
DOI: 10.1080/1744666X.2019.1561282
2019

To LP or not to LP? Identifying the Etiology of Pediatric Meningitis
Pediatric Infectious Disease Journal
Mijovic, H. and Sadarangani, M. and Sadarangani, M.
DOI: 10.1097/INF.0000000000002313
2019

Separating myths from reality for vaccines causing adverse events following immunization: An interview with Manish Sadarangani
Future Microbiology
Sadarangani, M.
DOI: 10.2217/fmb-2019-0187
2019

Meningitis vaccines in children: What have we achieved and where next?
Current Opinion in Infectious Diseases
McAlpine, A. and Sadarangani, M.
DOI: 10.1097/QCO.0000000000000580
2019

Strategies to improve detection and management of human parechovirus infection in young infants
The Lancet Infectious Diseases
Kadambari, S. and Harvala, H. and Simmonds, P. and Pollard, A.J. and Sadarangani, M.
DOI: 10.1016/S1473-3099(18)30288-3
2019

A Population-based Observational Study of Childhood Encephalitis in Children Admitted to Pediatric Intensive Care Units in England and Wales
The Pediatric infectious disease journal
Iro, M.A. and Sadarangani, M. and Nickless, A. and Kelly, D.F. and Pollard, A.J.
DOI: 10.1097/INF.0000000000002280
2019

Dilemmas With Rotavirus Vaccine: The Neonate and Immunocompromised
The Pediatric infectious disease journal
Chiu, M. and Bao, C. and Sadarangani, M.
DOI: 10.1097/INF.0000000000002322
2019

2466. Evaluation of Immunization on the Neonatal Intensive Care Unit at British Columbia Women’s Hospital.
Open forum infectious diseases
Chiu M and Bao C and Vahedi Y and Paquette V and Osiovich H and Sadarangani M
DOI: 10.1093/ofid/ofy210.2119
11/2018

Protection Against Invasive Infections in Children Caused by Encapsulated Bacteria.
Frontiers in immunology
Sadarangani M
DOI: 10.3389/fimmu.2018.02674
PubMed: 30515161
11/2018

153. The Effect of Timing of Tetanus–Diphtheria and Pertussis Vaccine Administration in Pregnancy on The Avidity of Pertussis Antibodies.
Open forum infectious diseases
Raya BA and Giles M and Kollmann T and Sadarangani M
DOI: 10.1093/ofid/ofy209.023
11/2018

Strategies to improve detection and management of human parechovirus infection in young infants.
The Lancet. Infectious diseases
Kadambari S and Harvala H and Simmonds P and Pollard AJ and Sadarangani M
DOI: 10.1016/s1473-3099(18)30288-3
PubMed: 30322791
10/2018

Computing threshold antibody levels of protection in vaccine clinical trials: An assessment of methodological bias.
PloS one
Voysey M and Sadarangani M and Pollard AJ and Fanshawe TR
DOI: 10.1371/journal.pone.0202517
PubMed: 30192787
09/2018

Effect of human papillomavirus vaccination on sexual behaviour among young females.
Canadian family physician Medecin de famille canadien
Donken R and Ogilvie GS and Bettinger JA and Sadarangani M and Goldman RD
PubMed: 30002026
07/2018

Immunization in Pregnancy: The Future for Neonatal Protection.
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
Castillo E and Sadarangani M
DOI: 10.1016/j.jogc.2018.02.006
PubMed: 29680069
04/2018

L'immunisation pendant la grossesse : l'avenir de la protection néonatale.
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC
DOI: 10.1016/j.jogc.2018.02.015
PubMed: 29680070
04/2018

Meningococcal vaccination in pregnancy.
Human vaccines & immunotherapeutics
Abu Raya B and Sadarangani M
DOI: 10.1080/21645515.2018.1445447
PubMed: 29485347
03/2018

Management of suspected paediatric meningitis: a multicentre prospective cohort study.
Archives of disease in childhood
Ramasamy R and Willis L and Kadambari S and Kelly DF and Heath PT and Nadel S and Pollard AJ and Sadarangani M
DOI: 10.1136/archdischild-2017-313913
PubMed: 29436406
02/2018

Effect of human papillomavirus vaccination on sexual behaviour among young females
Canadian Family Physician
Donken, R. and Ogilvie, G.S. and Bettinger, J.A. and Sadarangani, M. and Goldman, R.D.
2018

Persistence of immunity after vaccination with a capsular group B meningococcal vaccine in 3 different toddler schedules
Canadian Medical Association Journal
Manish Sadarangani and Tim Sell and Mildred A. Iro and Matthew D. Snape and Merryn Voysey and Adam Finn and Paul T. Heath and Gianni Bona and Susanna Esposito and Javier Diez-Domingo and Roman Prymula and Adefowope Odueyungbo and Daniela Toneatto and Andrew J. Pollard
DOI: 10.1503/cmaj.161288
10/2017

Prevalence and decay of maternal pneumococcal and meningococcal antibodies: A meta-analysis of type-specific decay rates
Vaccine
Merryn Voysey and Andrew J. Pollard and Manish Sadarangani and Thomas R. Fanshawe
DOI: 10.1016/j.vaccine.2017.09.002
10/2017

Care beyond the hospital ward: understanding the socio-medical trajectory of herpes simplex virus encephalitis.
BMC health services research
Cooper J and Kierans C and Defres S and Easton A and Kneen R and Solomon T and ENCEPH-UK study group
DOI: 10.1186/s12913-017-2608-2
PubMed: 28899392
09/2017

Maternal immunisation: collaborating with mother nature
The Lancet Infectious Diseases
Arnaud Marchant and Manish Sadarangani and Mathieu Garand and Nicolas Dauby and Valerie Verhasselt and Lenore Pereira and Gordean Bjornson and Christine E Jones and Scott A Halperin and Kathryn M Edwards and Paul Heath and Peter J Openshaw and David W Scheifele and Tobias R Kollmann
DOI: 10.1016/s1473-3099(17)30229-3
07/2017

Group B streptococcus and respiratory syncytial virus immunisation during pregnancy: a landscape analysis
The Lancet Infectious Diseases
Paul T Heath and Fiona J Culley and Christine E Jones and Beate Kampmann and Kirsty Le Doare and Marta C Nunes and Manish Sadarangani and Zain Chaudhry and Carol J Baker and Peter J M Openshaw
DOI: 10.1016/s1473-3099(17)30232-3
07/2017

The Influence of Maternally Derived Antibody and Infant Age at Vaccination on Infant Vaccine Responses
JAMA Pediatrics
Merryn Voysey and Dominic F. Kelly and Thomas R. Fanshawe and Manish Sadarangani and Katherine L. O’Brien and Rafael Perera and Andrew J. Pollard
DOI: 10.1001/jamapediatrics.2017.0638
07/2017

Whither vaccines?
Journal of Infection
Charlene M.C. Rodrigues and Marta V. Pinto and Manish Sadarangani and Stanley A. Plotkin
DOI: 10.1016/s0163-4453(17)30184-6
06/2017

30-year trends in admission rates for encephalitis in children in England and effect of improved diagnostics and measles-mumps-rubella vaccination: a population-based observational study
The Lancet Infectious Diseases
Mildred A Iro and Manish Sadarangani and Raphael Goldacre and Alecia Nickless and Andrew J Pollard and Michael J Goldacre
DOI: 10.1016/s1473-3099(17)30114-7
04/2017

Four Component Meningococcal Capsular Group B Vaccine in Preterm Infants
Journal of the Pediatric Infectious Diseases Society
Manish Sadarangani and Sheula Barlow and Mark Anthony and Andrew J Pollard
DOI: 10.1093/jpids/pix013
03/2017

Age-specific trends in antibiotic resistance in Escherichia coli infections in Oxford, United Kingdom 2013–2014
Journal of Infection
Rebecca C. Robey and Simon B. Drysdale and Dominic F. Kelly and Ian CJW. Bowler and Manish Sadarangani
DOI: 10.1016/j.jinf.2016.10.006
02/2017

A Feasibility Study of Quantifying Longitudinal Brain Changes in Herpes Simplex Virus (HSV) Encephalitis Using Magnetic Resonance Imaging (MRI) and Stereology.
PloS one
DOI: 10.1371/journal.pone.0170215
PubMed: 28125598
01/2017

Immunizing Patients with Adverse Events Following Immunization in the Canadian Special Immunization Clinic Network (2015–2017)
Open Forum Infectious Diseases
Karina A Top and Francois D Boucher and Athena McConnell and Jeffrey Pernica and Anne Pham-Huy and Wendy Vaudry and Shelley L Deeks and Francisco Noya and Bruce Tapiero and Caroline Quach and Dat Tran and Shaun K Morris and Simon Dobson and Manish Sadarangani and Shelly A McNeil and Donna MacKinnon-Cameron and Lingyun Ye and Scott A Halperin and Gaston De Serres
DOI: 10.1093/ofid/ofx163.1339
2017

30-year trends in admission rates for encephalitis in children in England and effect of improved diagnostics and measles-mumps-rubella vaccination: a population-based observational study
The Lancet Infectious Diseases
Iro, M.A. and Sadarangani, M. and Goldacre, R. and Nickless, A. and Pollard, A.J. and Goldacre, M.J.
DOI: 10.1016/S1473-3099(17)30114-7
2017

Pneumocystis jirovecii pneumonia in pediatric inflammatory bowel disease: A case report and literature review
Frontiers in Pediatrics
Lawrence, S.J. and Sadarangani, M. and Jacobson, K.
DOI: 10.3389/fped.2017.00161
2017

Maternal immunisation: collaborating with mother nature
The Lancet Infectious Diseases
Marchant, A. and Sadarangani, M. and Garand, M. and Dauby, N. and Verhasselt, V. and Pereira, L. and Bjornson, G. and Jones, C.E. and Halperin, S.A. and Edwards, K.M. and Heath, P. and Openshaw, P.J. and Scheifele, D.W. and Kollmann, T.R.
DOI: 10.1016/S1473-3099(17)30229-3
2017

Whither vaccines?
Journal of Infection
Rodrigues, C.M.C. and Pinto, M.V. and Sadarangani, M. and Plotkin, S.A.
DOI: 10.1016/S0163-4453(17)30184-6
2017

Group B streptococcus and respiratory syncytial virus immunisation during pregnancy: a landscape analysis
The Lancet Infectious Diseases
Heath, P.T. and Culley, F.J. and Jones, C.E. and Kampmann, B. and Le Doare, K. and Nunes, M.C. and Sadarangani, M. and Chaudhry, Z. and Baker, C.J. and Openshaw, P.J.M.
DOI: 10.1016/S1473-3099(17)30232-3
2017

Meningococcal Vaccines
Pediatric Vaccines and Vaccinations
DOI: 10.1007/978-3-319-59952-6_22
2017

Hospital admissions for viral meningitis in children in England over five decades: a population-based observational study
The Lancet Infectious Diseases
Natalie G Martin and Mildred A Iro and Manish Sadarangani and Raphael Goldacre and Andrew J Pollard and Michael J Goldacre
DOI: 10.1016/s1473-3099(16)30201-8
11/2016

Symptomatic stroke complicating central skull base osteomyelitis following otitis media in a 2-year old boy: Case report and review of the literature
International Journal of Pediatric Otorhinolaryngology
Eliz Kilich and Reena Dwivedi and Shelley Segal and Sandeep Jayawant and Manish Sadarangani
DOI: 10.1016/j.ijporl.2016.08.003
10/2016

Gene expression profiles are different in venous and capillary blood: Implications for vaccine studies
Vaccine
D.F. Stein and D. O’Connor and C.J. Blohmke and M. Sadarangani and A.J. Pollard
DOI: 10.1016/j.vaccine.2016.09.007
10/2016

Strengthening the Reporting of Observational Studies in Epidemiology for Newborn Infection (STROBE-NI): an extension of the STROBE statement for neonatal infection research.
The Lancet. Infectious Diseases
Fitchett EJA and Seale AC and Vergnano S and Sharland M and Heath PT and Saha SK and Agarwal R and Ayede AI and Bhutta ZA and Black R and Bojang K and Campbell H and Cousens S and SPRING (Strengthening Publications Reporting Infection in Newborns Globally) Group
DOI: 10.1016/s1473-3099(16)30082-2
PubMed: 27633910
09/2016

Use of rotavirus vaccines in preterm babies on the neonatal unit
Expert Review of Vaccines
Eliz Kilich and Manish Sadarangani
DOI: 10.1080/14760584.2016.1216318
08/2016

The impact of administration of conjugate vaccines containing cross reacting material on Haemophilus influenzae type b antibody responses in infants: A systematic review and meta-analysis of randomised controlled trials
Vaccine
Merryn Voysey and Manish Sadarangani and Elizabeth Clutterbuck and Barbara Bolgiano and Andrew J. Pollard
DOI: 10.1016/j.vaccine.2016.06.038
07/2016

Unusual cause of lymphangitis in a 2-year-old boy
BMJ Case Reports
Rhian Morgan and James Teh and Janet Craze and Manish Sadarangani
DOI: 10.1136/bcr-2016-215058
05/2016

A humanized microbiota mouse model of ovalbumin-induced lung inflammation
Gut Microbes
Marie-Claire Arrieta and Manish Sadarangani and Eric M. Brown and Shannon L. Russell and Michael Nimmo and John Dean and Stuart E. Turvey and Edmond S. Chan and B. Brett Finlay
DOI: 10.1080/19490976.2016.1182293
04/2016

Characterisation of the Immunomodulatory Effects of Meningococcal Opa Proteins on Human Peripheral Blood Mononuclear Cells and CD4+ T Cells
PLOS ONE
Claire Jones and Manish Sadarangani and Susan Lewis and Isabelle Payne and Muhammad Saleem and Jeremy P. Derrick and Andrew J. Pollard
DOI: 10.1371/journal.pone.0154153
04/2016

Anti-N-Methyl-D-Aspartate Receptor Encephalitis In A Young Child With Histological Evidence On Brain Biopsy Of Coexistent Herpes Simplex Virus Type 1 Infection
The Pediatric Infectious Disease Journal
Mark A. Ellul and Michael J. Griffiths and Anand Iyer and Shivaram Avula and Sylviane Defres and Atik Baborie and Angela Vincent and Natalie G. Martin and Manish Sadarangani and Andrew J. Pollard and Tom Solomon and Rachel Kneen
DOI: 10.1097/inf.0000000000001011
03/2016

Impact of Reducing Complement Inhibitor Binding on the Immunogenicity of Native Neisseria meningitidis Outer Membrane Vesicles
PLOS ONE
Helene Daniels-Treffandier and Karlijn de Nie and Leanne Marsay and Christina Dold and Manish Sadarangani and Arturo Reyes-Sandoval and Paul R. Langford and David Wyllie and Fergal Hill and Andrew J. Pollard and Christine S. Rollier
DOI: 10.1371/journal.pone.0148840
02/2016

Phase variation of Opa proteins of Neisseria meningitidis and the effects of bacterial transformation
Journal of Biosciences
Manish Sadarangani and J Claire Hoe and Katherine Makepeace and Peter van der Ley and Andrew J Pollard
DOI: 10.1007/s12038-016-9588-y
01/2016

Clinical aspects of meningococcal disease
Handbook of Meningococcal Disease Management
Stephen Pelton and Manish Sadarangani and Linda Glennie and Michael Levin
DOI: 10.1007/978-3-319-28119-3_5
2016

Can we control all-cause meningococcal disease in Europe?
Clinical Microbiology and Infection
Sadarangani, M. and Pollard, A.J.
DOI: 10.1016/j.cmi.2016.03.006
2016

Anti-N-methyl-d-aspartate receptor encephalitis in a young child with histological evidence on brain biopsy of coexistent herpes simplex virus type 1 infection
Pediatric Infectious Disease Journal
Ellul, M.A. and Griffiths, M.J. and Iyer, A. and Avula, S. and Defres, S. and Baborie, A. and Vincent, A. and Martin, N.G. and Sadarangani, M. and Pollard, A.J. and Solomon, T. and Kneen, R.
DOI: 10.1097/INF.0000000000001011
2016

Hospital admissions for viral meningitis in children in England over five decades: a population-based observational study
The Lancet Infectious Diseases
Martin, N.G. and Iro, M.A. and Sadarangani, M. and Goldacre, R. and Pollard, A.J. and Goldacre, M.J.
DOI: 10.1016/S1473-3099(16)30201-8
2016

I mmuno g lobuli N i n the T reatment of e ncephalitis (IgNiTE): Protocol for a multicentre randomised controlled trial
BMJ Open
Iro, M.A. and Sadarangani, M. and Absoud, M. and Chong, W.K. and Clark, C.A. and Easton, A. and Gray, V. and Kneen, R. and Lim, M. and Pike, M. and Solomon, T. and Vincent, A. and Willis, L. and Yu, L.-M. and Pollard, A.J.
DOI: 10.1136/bmjopen-2016-012356
2016

Handbook of meningococcal disease management
Handbook of Meningococcal Disease Management
Feavers, I. and Pollard, A.J. and Sadarangani, M.
DOI: 10.1007/978-3-319-28119-3
2016

Meningitis
Manual of Childhood Infections (4th edition)
2016

Response to Hepatitis B virus vaccine in young adults with perinatally acquired HIV infection
Journal of Infection
Manish Sadarangani and Herman Tam and Susan McDonald and Sarah Fidler and Caroline Foster
DOI: 10.1016/j.jinf.2015.06.003
10/2015

A novel meningococcal outer membrane vesicle vaccine with constitutive expression of FetA: A phase I clinical trial
Journal of Infection
L. Marsay and C. Dold and C.A. Green and C.S. Rollier and G. Norheim and M. Sadarangani and M. Shanyinde and C. Brehony and A.J. Thompson and H. Sanders and H. Chan and K. Haworth and J.P. Derrick and I.M. Feavers and M.C. Maiden and A.J. Pollard
DOI: 10.1016/j.jinf.2015.05.006
09/2015

Brain Abscesses Due to Aspergillus nidulans Infection During Induction Chemotherapy for Acute Lymphoblastic Leukemia
Journal of Pediatric Hematology/Oncology
Manish Sadarangani and Melissa Harvey and Allison McDonald and David P. Speert and David Dix
DOI: 10.1097/mph.0000000000000351
08/2015

Subacute Osteomyelitis of the Femur Due to Fusobacterium nucleatum in a 7-year-old Boy
The Pediatric Infectious Disease Journal
Emily Budd and David S. Johnson and Eva Thomas and Manish Sadarangani
DOI: 10.1097/inf.0000000000000558
03/2015

Outcomes of Invasive Meningococcal Disease in Adults and Children in Canada Between 2002 and 2011: A Prospective Cohort Study
Clinical Infectious Diseases
M. Sadarangani and D. W. Scheifele and S. A. Halperin and W. Vaudry and N. Le Saux and R. Tsang and J. A. Bettinger and investigators of the Canadian Immunization and N. Bridger and R. Morris and S. Halperin and K. Top and P. Dery and D. Moore and M. Lebel and N. Le Saux and D. Tran and L. Ford-Jones and J. Embree and B. Law and R. Tsang and B. Tan and W. Vaudry and T. Jadavji and O. G. Vanderkooi and D. Scheifele and L. Sauve and J. Bettinger and investigators of the Canadian Immunization
DOI: 10.1093/cid/civ028
01/2015

Meningococcus
Nelson Textbook of Pediatrics (20th edition)
2015

Brain Abscesses Due to Aspergillus nidulans Infection during Induction Chemotherapy for Acute Lymphoblastic Leukemia
Journal of Pediatric Hematology/Oncology
Sadarangani, M. and Harvey, M. and McDonald, A. and Speert, D.P. and Dix, D.
DOI: 10.1097/MPH.0000000000000351
2015

Subacute osteomyelitis of the femur due to Fusobacterium nucleatum in a 7-year-old boy
Pediatric Infectious Disease Journal
Budd, E. and Johnson, D.S. and Thomas, E. and Sadarangani, M.
DOI: 10.1097/INF.0000000000000558
2015

Childhood meningitis in the conjugate vaccine era: A prospective cohort study
Archives of Disease in Childhood
Sadarangani, M. and Willis, L. and Kadambari, S. and Gormley, S. and Young, Z. and Beckley, R. and Gantlett, K. and Orf, K. and Blakey, S. and Martin, N.G. and Kelly, D.F. and Heath, P.T. and Nadel, S. and Pollard, A.J.
DOI: 10.1136/archdischild-2014-306813
2015

The capsular group B meningococcal vaccine, 4CMenB: Clinical experience and potential efficacy
Expert Opinion on Biological Therapy
Rollier, C.S. and Dold, C. and Marsay, L. and Sadarangani, M. and Pollard, A.J.
DOI: 10.1517/14712598.2015.983897
2015

Hospital admission rates for meningitis and septicaemia caused by Haemophilus influenzae, Neisseria meningitidis, and Streptococcus pneumoniae in children in England over five decades: a population-based observational study
The Lancet Infectious Diseases
Natalie G Martin and Manish Sadarangani and Andrew J Pollard and Michael J Goldacre
DOI: 10.1016/s1473-3099(14)70027-1
05/2014

Association between population prevalence of smoking and incidence of meningococcal disease in Norway, Sweden, Denmark and the Netherlands between 1975 and 2009: a population-based time series analysis
BMJ Open
Gunnstein Norheim and Manish Sadarangani and Omar Omar and Ly-Mee Yu and Kåre Mølbak and Michael Howitz and Per Olcén and Margaretha Haglund and Arie van der Ende and Andrew J Pollard
DOI: 10.1136/bmjopen-2013-003312
02/2014

Long-Term Survival and Outcome in Children Admitted to Kilifi District Hospital with Convulsive Status Epilepticus
Epilepsy Research and Treatment
Agnes Prins and Eddie Chengo and Victor Mung'ala Odera and Manish Sadarangani and Claire Seaton and Penny Holding and Greg Fegan and Charles R. Newton
DOI: 10.1155/2014/643747
2014

Erratum: The role of the immune system in governing host-microbe interactions in the intestine (Nature Immunology (2013) 14 (660-667))
Nature Immunology
Brown, E.M. and Sadarangani, M. and Finlay, B.B.
DOI: 10.1038/ni0214-205d
2014

Neisseria meningitidis native outer membrane vesicles containing different lipopolysaccharide glycoforms as adjuvants for meningococcal and nonmeningococcal antigens
Clinical and Vaccine Immunology
Nagaputra, J.C. and Rollier, C.S. and Sadarangani, M. and Hoe, J.C. and Mehta, O.H. and Norheim, G. and Saleem, M. and Chan, H. and Derrick, J.P. and Feavers, I. and Pollard, A.J. and Moxon, E.R.
DOI: 10.1128/CVI.00561-13
2014

The impact of the meningococcal serogroup C conjugate vaccine in Canada between 2002 and 2012
Clinical Infectious Diseases
Sadarangani, M. and Scheifele, D.W. and Halperin, S.A. and Vaudry, W. and Saux, N.L. and Tsang, R. and Bettinger, J.A.
DOI: 10.1093/cid/ciu597
2014

Adjuvant effects elicited by novel oligosaccharide variants of detoxified meningococcal lipopolysaccharides on Neisseria meningitidis recombinant PorA protein: A comparison in mice
PLoS ONE
Mehta, O.H. and Norheim, G. and Hoe, J.C. and Rollier, C.S. and Nagaputra, J.C. and Makepeace, K. and Saleem, M. and Chan, H. and Ferguson, D.J.P. and Jones, C. and Sadarangani, M. and Hood, D.W. and Feavers, I. and Derrick, J.P. and Pollard, A.J. and Moxon, E.R.
DOI: 10.1371/journal.pone.0115713
2014

Hospital admission rates for meningitis and septicaemia caused by Haemophilus influenzae, Neisseria meningitidis, and Streptococcus pneumoniae in children in England over five decades: A population-based observational study
The Lancet Infectious Diseases
Martin, N.G. and Sadarangani, M. and Pollard, A.J. and Goldacre, M.J.
DOI: 10.1016/S1473-3099(14)70027-1
2014

Correction: Construction of Opa-Positive and Opa-Negative Strains of Neisseria meningitidis to Evaluate a Novel Meningococcal Vaccine.
PloS one
Sadarangani M and Hoe JC and Callaghan MJ and Jones C and Chan H and Makepeace K and Daniels-Treffandier H and Deadman ME and Bayliss C and Feavers I and van der Ley P and Pollard AJ
DOI: 10.1371/annotation/900641dd-0b06-4a77-9e2c-b7161dd49e1d
10/2013

The role of the immune system in governing host-microbe interactions in the intestine
Nature Immunology
Eric M Brown and Manish Sadarangani and B Brett Finlay
DOI: 10.1038/ni.2611
06/2013

Adolescents need a booster of serogroup C meningococcal vaccine to protect them and maintain population control of the disease
Archives of Disease in Childhood
A. J. Pollard and C. Green and M. Sadarangani and M. D. Snape
DOI: 10.1136/archdischild-2012-303103
03/2013

Neonatal Sepsis due to Coagulase-Negative Staphylococci
Clinical and Developmental Immunology
Elizabeth A. Marchant and Guilaine K. Boyce and Manish Sadarangani and Pascal M. Lavoie
DOI: 10.1155/2013/586076
2013

How best to describe the risk of meningococcal B infection?
Paediatrics and Child Health (Canada)
Sadarangani, M. and Bettinger, J.A. and Scheifele, D.W.
DOI: 10.1093/pch/18.10.543
2013

Neisseria meningitidis Native Outer Membrane Vesicles Containing Different Lipopolysaccharide Glycoforms as Adjuvants for Meningococcal and Nonmeningococcal Antigens
Clinical and Vaccine Immunology
Jerry C. Nagaputra and Christine S. Rollier and Manish Sadarangani and J. Claire Hoe and Ojas Hrakesh Mehta and Gunnstein Norheim and Muhammad Saleem and Hannah Chan and Jeremy P. Derrick and Ian Feavers and Andrew J. Pollard and E. Richard Moxon
DOI: 10.1128/cvi.00561-13
2013

Construction of Opa-Positive and Opa-Negative Strains of Neisseria meningitidis to Evaluate a Novel Meningococcal Vaccine
PLoS ONE
Manish Sadarangani and J. Claire Hoe and Martin J. Callaghan and Claire Jones and Hannah Chan and Katherine Makepeace and Hélène Daniels-Treffandier and Mary E. Deadman and Christopher Bayliss and Ian Feavers and Peter van der Ley and Andrew J. Pollard
DOI: 10.1371/journal.pone.0051045
2012

Bacterial Meningitis in Childhood
Hot Topics in Infection and Immunity in Children VIII
Manish Sadarangani and Andrew J. Pollard
DOI: 10.1007/978-1-4614-0204-6_16
09/2011

Opa proteins and CEACAMs: pathways of immune engagement for pathogenicNeisseria
FEMS Microbiology Reviews
Manish Sadarangani and Andrew J. Pollard and Scott D. Gray-Owen
DOI: 10.1111/j.1574-6976.2010.00260.x
05/2011

Acute seizures attributable to falciparum malaria in an endemic area on the Kenyan coast
Brain
Symon M. Kariuki and Michelle Ikumi and John Ojal and Manish Sadarangani and Richard Idro and Ally Olotu and Philip Bejon and James A. Berkley and Kevin Marsh and Charles R. J. C. Newton
DOI: 10.1093/brain/awr051
04/2011

Potential of Recombinant Opa Proteins as Vaccine Candidates against Hyperinvasive Meningococci
Infection and Immunity
M. J. Callaghan and S. Lewis and M. Sadarangani and S. E. S. Bailey and H. Chan and D. J. P. Ferguson and J. P. Derrick and I. Feavers and M. C. Maiden and A. J. Pollard
DOI: 10.1128/iai.01338-10
04/2011

Meningitis
Manual of Childhood Infections (3rd edition)
2011

Potential of recombinant opa proteins as vaccine candidates against hyperinvasive meningococci
Infection and Immunity
Callaghan, M.J. and Lewis, S. and Sadarangani, M. and Bailey, S.E.S. and Chan, H. and Ferguson, D.J.P. and Derrick, J.P. and Feavers, I. and Maiden, M.C. and Pollard, A.J.
DOI: 10.1128/IAI.01338-10
2011

Serogroup B meningococcal vaccines—an unfinished story
The Lancet Infectious Diseases
Manish Sadarangani and Andrew J Pollard
DOI: 10.1016/s1473-3099(09)70324-x
02/2010

Serogroup B meningococcal vaccines-an unfinished story
The Lancet Infectious Diseases
Sadarangani, M. and Pollard, A.J.
DOI: 10.1016/S1473-3099(09)70324-X
2010

An observational study of children with sickle cell disease in Kilifi, Kenya
British Journal of Haematology
Manish Sadarangani and Julie Makani and Albert N. Komba and Tolu Ajala-Agbo and Charles R. Newton and Kevin Marsh and Thomas N. Williams
DOI: 10.1111/j.1365-2141.2009.07771.x
09/2009

Malaria as a Cause of Morbidity and Mortality in Children with Homozygous Sickle Cell Disease on the Coast of Kenya
Clinical Infectious Diseases
Albert N. Komba and Julie Makani and Manish Sadarangani and Tolu Ajala-Agbo and James A. Berkley and Charles R. J. C. Newton and Kevin Marsh and Thomas N. Williams
DOI: 10.1086/599834
07/2009

Challenges and progress in the development of a serogroup B meningococcal vaccine
Expert Review of Vaccines
Susan Lewis and Manish Sadarangani and J Claire Hoe and Andrew J Pollard
DOI: 10.1586/erv.09.30
06/2009

Role of Acquired Immunity in Neisseria Infections
Neisseria: Molecular Mechanisms of Pathogenesis
2009

Incidence and outcome of convulsive status epilepticus in Kenyan children: a cohort study
The Lancet Neurology
Manish Sadarangani and Claire Seaton and J Anthony G Scott and Bernhards Ogutu and Tansy Edwards and Agnes Prins and Hellen Gatakaa and Richard Idro and James A Berkley and Norbert Peshu and Brian G Neville and Charles R Newton
DOI: 10.1016/s1474-4422(07)70331-9
02/2008

Incidence and outcome of convulsive status epilepticus in Kenyan children: a cohort study
The Lancet Neurology
Sadarangani, M. and Seaton, C. and Scott, J.A.G. and Ogutu, B. and Edwards, T. and Prins, A. and Gatakaa, H. and Idro, R. and Berkley, J.A. and Peshu, N. and Neville, B.G. and Newton, C.R.
DOI: 10.1016/S1474-4422(07)70331-9
2008

An analysis of herpes simplex virus gene expression during latency establishment and reactivation.
Journal of General Virology
R H Lachmann and S Efstathiou and M Sadarangani and H R Atkinson
DOI: 10.1099/0022-1317-80-5-1271
05/1999

Research

Proection against infant pertussis through immunization in pregnancy
Infants with pertussis aged

Better protection against penumococcal and meningococcal infections
S. pneumoniae and N. meningitidis are primary causes of septicemia and meningitis. In Canada and other developed countries, case fatality rates for invasive disease caused by S. pneumoniae and N. meningitidis are 5-10%. Long-term disabling sequelae (e.g., deafness, epilepsy, motor impairment, and blindness) occur in one-fifth of bacterial meningitis survivors, most often after pneumococcal meningitis. In BC and across Canada, routine childhood immunization schedules include vaccines against all of these pathogens, yet they still cause a significant burden of serious disease. Vaccine introduction also exerts selection pressure on the target bacteria, modifying the genetic epidemiology and disease transmission. There is therefore a need for ongoing evaluation of existing vaccine schedules to ensure they provide optimal protection, and also to better understand host immune responses and bacterial evolution following vaccine introduction. I am currently undertaking randomized controlled trials to evaluate existing pneumococcal and meningococcal vaccine programs in Canada, as well a study of the molecular epidemiology of S. pneumoniae in children with pneumococcal pneumonia.

Development of a vaccine against Haemophilus influenzae type a
Haemophilus influenzae type a (Hia) causes meningitis and septicemia, with particularly high rates in indigenous populations. In this collaboration with the Northern Ontario School of Medicine, we will be assessing specific risk factors for Hia disease, the burden of invasive disease, mucosal disease (such as otitis media and pneumonia) and asymptomatic carriage of Hia. We will also be carrying out seroeipdemiology studies to assess anti-Hia antibodies in salvia and serum as an indication of exposure. These data will provide the information needed for the implementation of a new immunization policy for a Hia vaccine which is currently in development. Determination of immunological correlates of protection against invasive Hia disease and identification of the target populations groups for immunization will be of particular importance to design future clinical trials of these vaccines.

Grants

2017-2019. Molecular epidemiology of Streptococcus pneumoniae in children with pneumococcal pneumonia in Canada between 1991 and 2016 and implications for future vaccine design. BC Lung Association. 2017-2022. Canadian Immunization Research Network. CIHR 2018-2020. Influenza immunization for all Canadians. Does one size fit all? CIHR 2018-2021 Impact of maternal pertussis immunization on pregnancy outcome and child health. CIHR

2015-2017 Meningitis Research Foundation. Using high-throughput genomic sequencing to determine the aetiology of meningitis in UK children. £83,181

2015-2017 Thrasher Research Fund Early Career Award Program Grant (Mentor). Investigating the effect of Intravenous immunoglobulin treatment on the immunological and inflammatory response in childhood encephalitis. US$26,750

2016 European Society for Paediatric Infectious Diseases. The effect of latent cytomegalovirus infection on response to conjugate vaccines in children. €5999,18

Research Group Members

Bahaa Abu Raya
Carol Bao, Medical Student
Lizl Bonifacio, Work Learn Student
Adriana Cabrera, Research Technician at Sadarangani Lab Canadian Burkholderia cepacia Complex Research and Referral Repository (CBCCRRR) technician
Yen Chan
Emily Chan, Student
Larry Cheng, Summer student
Melissa Chiu, Undergraduate Medical Student
Rachael Chow, Volunteer
Nasrin Chowdhury, Data Quality Control Specialist
Vivek Gill, Research Assistant
Engy Grove
Tony Harn, Research Technician
Helen He, Research Coordinator
Angela Kalia, Clinical Trainee
Jung-Bahadur Kandola, Co-op student
Wendy Klassen, Data Coordinator Assistant
Giulio Laino, Research Assistant Co-Op Student
Rebecca Lim, Research Assistant
Suzanne Liu, Statistician
Jennifer Mark, Research Coordinator
Florencia Olivo, Research Nurse
Imogen Porter
Anjana Rajendran, Undergraduate Research Assistant
Brittany Seligman, Research Asst/Tech 3
Sonali Sharma, Volunteer
Sarah Silverberg, Clinical Trainee
Kelly Simmons, Research Nurse
Karen Simmons, Research Administrator
Caitlyn Southey, Volunteer Student
Natasha Stekl, Volunteer
Myriam Maude Verly, Clinical Trainee
Theresa Williams, Research Asst/Tech 2
Betty Wong, Research Administrator
Zoe Wong, Volunteer
Kendrew Wong, Coop Student - Medicine
Yanbo Yan, Research Asst/Tech 2
Yi Zhou, Research Asst/Tech 1
James Zlosnik, Research Associate - Chronic Bacterial Infections in Cystic Fibrosis. Primary Scientist and Manager - Canadian Burkholderia Cepacia Complex research Referral Repository. Project Manager - Centre for Understanding and Preventing Infection in Children. , Research Associate - Chronic Bacterial Infections in Cystic Fibrosis. Primary Scientist and Manager - Canadian Burkholderia Cepacia Complex research Referral Repository. Project Manager - Centre for Understanding and Preventing Infection in Children.
Anna de Waal, Volunteer Student