Overview

The aim of our research at the Vaccine Evaluation Center (VEC) is to lower the burden of childhood infectious disease through vaccination by building an evidence base for local, national and international vaccine policy. My research program includes laboratory studies to develop new and better vaccines, clinical trials to identify how best to utilize new and approved vaccines, and population-based investigations to identify targets for new vaccines and demonstrate vaccine impact.

Publications

Prevalence and decay of maternal pneumococcal and meningococcal antibodies: A meta-analysis of type-specific decay rates
Vaccine
Merryn Voysey, Andrew J. Pollard, Manish Sadarangani, Thomas R. Fanshawe
DOI: 10.1016/j.vaccine.2017.09.002
10/2017

Persistence of immunity after vaccination with a capsular group B meningococcal vaccine in 3 different toddler schedules
Canadian Medical Association Journal
Manish Sadarangani, Tim Sell, Mildred A. Iro, Matthew D. Snape, Merryn Voysey, Adam Finn, Paul T. Heath, Gianni Bona, Susanna Esposito, Javier Diez-Domingo, Roman Prymula, Adefowope Odueyungbo, Daniela Toneatto, Andrew J. Pollard
DOI: 10.1503/cmaj.161288
10/2017

Maternal immunisation: collaborating with mother nature
The Lancet Infectious Diseases
Arnaud Marchant, Manish Sadarangani, Mathieu Garand, Nicolas Dauby, Valerie Verhasselt, Lenore Pereira, Gordean Bjornson, Christine E Jones, Scott A Halperin, Kathryn M Edwards, Paul Heath, Peter J Openshaw, David W Scheifele, Tobias R Kollmann
DOI: 10.1016/s1473-3099(17)30229-3
07/2017

Group B streptococcus and respiratory syncytial virus immunisation during pregnancy: a landscape analysis
The Lancet Infectious Diseases
Paul T Heath, Fiona J Culley, Christine E Jones, Beate Kampmann, Kirsty Le Doare, Marta C Nunes, Manish Sadarangani, Zain Chaudhry, Carol J Baker, Peter J M Openshaw
DOI: 10.1016/s1473-3099(17)30232-3
07/2017

The Influence of Maternally Derived Antibody and Infant Age at Vaccination on Infant Vaccine Responses An Individual Participant Meta-analysis
JAMA Pediatrics
Merryn Voysey, Dominic F. Kelly, Thomas R. Fanshawe, Manish Sadarangani, Katherine L. O’Brien, Rafael Perera, Andrew J. Pollard
DOI: 10.1001/jamapediatrics.2017.0638
07/2017

Whither vaccines?
Journal of Infection
Charlene M.C. Rodrigues, Marta V. Pinto, Manish Sadarangani, Stanley A. Plotkin
DOI: 10.1016/s0163-4453(17)30184-6
06/2017

30-year trends in admission rates for encephalitis in children in England and effect of improved diagnostics and measles-mumps-rubella vaccination: a population-based observational study
The Lancet Infectious Diseases
Mildred A Iro, Manish Sadarangani, Raphael Goldacre, Alecia Nickless, Andrew J Pollard, Michael J Goldacre
DOI: 10.1016/s1473-3099(17)30114-7
04/2017

Four Component Meningococcal Capsular Group B Vaccine in Preterm Infants
Journal of the Pediatric Infectious Diseases Society
Manish Sadarangani, Sheula Barlow, Mark Anthony, Andrew J Pollard
DOI: 10.1093/jpids/pix013
03/2017

Age-specific trends in antibiotic resistance in Escherichia coli infections in Oxford, United Kingdom 2013–2014
Journal of Infection
Rebecca C. Robey, Simon B. Drysdale, Dominic F. Kelly, Ian CJW. Bowler, Manish Sadarangani
DOI: 10.1016/j.jinf.2016.10.006
02/2017

Immunizing Patients with Adverse Events Following Immunization in the Canadian Special Immunization Clinic Network (2015–2017)
Open Forum Infectious Diseases
Karina A Top, Francois D Boucher, Athena McConnell, Jeffrey Pernica, Anne Pham-Huy, Wendy Vaudry, Shelley L Deeks, Francisco Noya, Bruce Tapiero, Caroline Quach, Dat Tran, Shaun K Morris, Simon Dobson, Manish Sadarangani, Shelly A McNeil, Donna MacKinnon-Cameron, Lingyun Ye, Scott A Halperin, Gaston De Serres
DOI: 10.1093/ofid/ofx163.1339
2017

Meningococcal Vaccines
Pediatric Vaccines and Vaccinations
Andrew J. Pollard and Matthew D. Snape and Manish Sadarangani
DOI: 10.1007/978-3-319-59952-6_22
2017

Pneumocystis jirovecii Pneumonia in Pediatric Inflammatory Bowel Disease: A Case Report and Literature Review
Frontiers in Pediatrics
DOI: 10.3389/fped.2017.00161
2017

Hospital admissions for viral meningitis in children in England over five decades: a population-based observational study
The Lancet Infectious Diseases
Natalie G Martin, Mildred A Iro, Manish Sadarangani, Raphael Goldacre, Andrew J Pollard, Michael J Goldacre
DOI: 10.1016/s1473-3099(16)30201-8
11/2016

Symptomatic stroke complicating central skull base osteomyelitis following otitis media in a 2-year old boy: Case report and review of the literature
International Journal of Pediatric Otorhinolaryngology
Eliz Kilich, Reena Dwivedi, Shelley Segal, Sandeep Jayawant, Manish Sadarangani
DOI: 10.1016/j.ijporl.2016.08.003
10/2016

Strengthening the Reporting of Observational Studies in Epidemiology for Newborn Infection (STROBE-NI): an extension of the STROBE statement for neonatal infection research
The Lancet Infectious Diseases
Elizabeth J A Fitchett, Anna C Seale, Stefania Vergnano, Michael Sharland, Paul T Heath, Samir K Saha, Ramesh Agarwal, Adejumoke I Ayede, Zulfiqar A Bhutta, Robert Black, Kalifa Bojang, Harry Campbell, Simon Cousens, Gary L Darmstadt, Shabir A Madhi, Ajoke Sobanjo-ter Meulen, Neena Modi, Janna Patterson, Shamim Qazi, Stephanie J Schrag, Barbara J Stoll, Stephen N Wall, Robinson D Wammanda, Joy E Lawn
DOI: 10.1016/s1473-3099(16)30082-2
10/2016

Gene expression profiles are different in venous and capillary blood: Implications for vaccine studies
Vaccine
D.F. Stein, D. O’Connor, C.J. Blohmke, M. Sadarangani, A.J. Pollard
DOI: 10.1016/j.vaccine.2016.09.007
10/2016

Use of rotavirus vaccines in preterm babies on the neonatal unit
Expert Review of Vaccines
Eliz Kilich, Manish Sadarangani
DOI: 10.1080/14760584.2016.1216318
08/2016

The impact of administration of conjugate vaccines containing cross reacting material on Haemophilus influenzae type b antibody responses in infants: A systematic review and meta-analysis of randomised controlled trials
Vaccine
Merryn Voysey, Manish Sadarangani, Elizabeth Clutterbuck, Barbara Bolgiano, Andrew J. Pollard
DOI: 10.1016/j.vaccine.2016.06.038
07/2016

Unusual case of lymphangitis in a 2-year-old boy
BMJ Case Reports
Rhian Morgan and James Teh and Janet Craze and Manish Sadarangani
DOI: 10.1136/bcr-2016-215058
05/2016

Characterisation of the Immunomodulatory Effects of Meningococcal Opa Proteins on Human Peripheral Blood Mononuclear Cells and CD4+ T Cells
PLOS ONE
Claire Jones, Manish Sadarangani, Susan Lewis, Isabelle Payne, Muhammad Saleem, Jeremy P. Derrick, Andrew J. Pollard
DOI: 10.1371/journal.pone.0154153
04/2016

A humanized microbiota mouse model of ovalbumin-induced lung inflammation
Gut Microbes
Marie-Claire Arrieta, Manish Sadarangani, Eric M. Brown, Shannon L. Russell, Michael Nimmo, John Dean, Stuart E. Turvey, Edmond S. Chan, B. Brett Finlay
DOI: 10.1080/19490976.2016.1182293
04/2016

Anti-N-Methyl-D-Aspartate Receptor Encephalitis In A Young Child With Histological Evidence On Brain Biopsy Of Coexistent Herpes Simplex Virus Type 1 Infection
The Pediatric Infectious Disease Journal
Mark A. Ellul, Michael J. Griffiths, Anand Iyer, Shivaram Avula, Sylviane Defres, Atik Baborie, Angela Vincent, Natalie G. Martin, Manish Sadarangani, Andrew J. Pollard, Tom Solomon, Rachel Kneen
DOI: 10.1097/inf.0000000000001011
03/2016

Impact of Reducing Complement Inhibitor Binding on the Immunogenicity of Native Neisseria meningitidis Outer Membrane Vesicles
PLOS ONE
Helene Daniels-Treffandier, Karlijn de Nie, Leanne Marsay, Christina Dold, Manish Sadarangani, Arturo Reyes-Sandoval, Paul R. Langford, David Wyllie, Fergal Hill, Andrew J. Pollard, Christine S. Rollier
DOI: 10.1371/journal.pone.0148840
02/2016

Phase variation of Opa proteins of Neisseria meningitidis and the effects of bacterial transformation
Journal of Biosciences
Manish Sadarangani, J Claire Hoe, Katherine Makepeace, Peter van der Ley, Andrew J Pollard
DOI: 10.1007/s12038-016-9588-y
01/2016

Clinical aspects of meningococcal disease
Handbook of Meningococcal Disease Management
Stephen Pelton, Manish Sadarangani, Linda Glennie, Michael Levin
DOI: 10.1007/978-3-319-28119-3_5
2016

Can we control all-cause meningococcal disease in Europe?
Clinical Microbiology and Infection
M. Sadarangani, A.J. Pollard
DOI: 10.1016/j.cmi.2016.03.006
2016

ImmunoglobuliN in the Treatment of Encephalitis (IgNiTE): protocol for a multicentre randomised controlled trial
BMJ Open
Iro, M A and Sadarangani, M and Absoud, M and Chong, W K and Clark, C A and Easton, A and Gray, V and Kneen, R and Lim, M and Pike, M and Solomon, T and Vincent, A and Willis, L and Yu, L-M and Pollard, A J
DOI: 10.1136/bmjopen-2016-012356
2016

Handbook of Meningococcal Disease Management
DOI: 10.1007/978-3-319-28119-3
2016

Meningitis
Manual of Childhood Infections (4th edition)
2016

Response to Hepatitis B virus vaccine in young adults with perinatally acquired HIV infection
Journal of Infection
Manish Sadarangani, Herman Tam, Susan McDonald, Sarah Fidler, Caroline Foster
DOI: 10.1016/j.jinf.2015.06.003
10/2015

A novel meningococcal outer membrane vesicle vaccine with constitutive expression of FetA: A phase I clinical trial
Journal of Infection
L. Marsay, C. Dold, C.A. Green, C.S. Rollier, G. Norheim, M. Sadarangani, M. Shanyinde, C. Brehony, A.J. Thompson, H. Sanders, H. Chan, K. Haworth, J.P. Derrick, I.M. Feavers, M.C. Maiden, A.J. Pollard
DOI: 10.1016/j.jinf.2015.05.006
09/2015

Brain Abscesses Due to Aspergillus nidulans Infection During Induction Chemotherapy for Acute Lymphoblastic Leukemia
Journal of Pediatric Hematology/Oncology
Manish Sadarangani, Melissa Harvey, Allison McDonald, David P. Speert, David Dix
DOI: 10.1097/mph.0000000000000351
08/2015

Subacute Osteomyelitis of the Femur Due to Fusobacterium nucleatum in a 7-year-old Boy
The Pediatric Infectious Disease Journal
Emily Budd, David S. Johnson, Eva Thomas, Manish Sadarangani
DOI: 10.1097/inf.0000000000000558
03/2015

Outcomes of Invasive Meningococcal Disease in Adults and Children in Canada Between 2002 and 2011: A Prospective Cohort Study
Clinical Infectious Diseases
M. Sadarangani, D. W. Scheifele, S. A. Halperin, W. Vaudry, N. Le Saux, R. Tsang, J. A. Bettinger, investigators of the Canadian Immunization, N. Bridger, R. Morris, S. Halperin, K. Top, P. Dery, D. Moore, M. Lebel, N. Le Saux, D. Tran, L. Ford-Jones, J. Embree, B. Law, R. Tsang, B. Tan, W. Vaudry, T. Jadavji, O. G. Vanderkooi, D. Scheifele, L. Sauve, J. Bettinger, investigators of the Canadian Immunization
DOI: 10.1093/cid/civ028
01/2015

Meningococcus
Nelson Textbook of Pediatrics (20th edition)
2015

Childhood meningitis in the conjugate vaccine era: a prospective cohort study
Archives of Disease in Childhood
Manish Sadarangani, Louise Willis, Seilesh Kadambari, Stuart Gormley, Zoe Young, Rebecca Beckley, Katherine Gantlett, Katharine Orf, Sarah Blakey, Natalie G Martin, Dominic F Kelly, Paul T Heath, Simon Nadel, Andrew J Pollard
DOI: 10.1136/archdischild-2014-306813
09/2014

Hospital admission rates for meningitis and septicaemia caused by Haemophilus influenzae, Neisseria meningitidis, and Streptococcus pneumoniae in children in England over five decades: a population-based observational study
The Lancet Infectious Diseases
Natalie G Martin, Manish Sadarangani, Andrew J Pollard, Michael J Goldacre
DOI: 10.1016/s1473-3099(14)70027-1
05/2014

Association between population prevalence of smoking and incidence of meningococcal disease in Norway, Sweden, Denmark and the Netherlands between 1975 and 2009: a population-based time series analysis
BMJ Open
Gunnstein Norheim, Manish Sadarangani, Omar Omar, Ly-Mee Yu, Kåre Mølbak, Michael Howitz, Per Olcén, Margaretha Haglund, Arie van der Ende, Andrew J Pollard
DOI: 10.1136/bmjopen-2013-003312
02/2014

The capsular group B meningococcal vaccine, 4CMenB: clinical experience and potential efficacy
Expert Opinion on Biological Therapy
Christine S Rollier, Christina Dold, Leanne Marsay, Manish Sadarangani, Andrew J Pollard
DOI: 10.1517/14712598.2015.983897
2014

Long-Term Survival and Outcome in Children Admitted to Kilifi District Hospital with Convulsive Status Epilepticus
Epilepsy Research and Treatment
Agnes Prins, Eddie Chengo, Victor Mung'ala Odera, Manish Sadarangani, Claire Seaton, Penny Holding, Greg Fegan, Charles R. Newton
DOI: 10.1155/2014/643747
2014

Adjuvant Effects Elicited by Novel Oligosaccharide Variants of Detoxified Meningococcal Lipopolysaccharides on Neisseria meningitidis Recombinant PorA Protein: A Comparison in Mice
PLoS ONE
Ojas H. Mehta, Gunnstein Norheim, J . Claire Hoe, Christine S. Rollier, Jerry C. Nagaputra, Katherine Makepeace, Muhammad Saleem, Hannah Chan, David J. P. Ferguson, Claire Jones, Manish Sadarangani, Derek W. Hood, Ian Feavers, Jeremy P. Derrick, Andrew J. Pollard, E . Richard Moxon
DOI: 10.1371/journal.pone.0115713
2014

The Impact of the Meningococcal Serogroup C Conjugate Vaccine in Canada Between 2002 and 2012
Clinical Infectious Diseases
Sadarangani, Manish and , and Scheifele, David W. and , and Halperin, Scott A. and , and Vaudry, Wendy and , and Le Saux, Nicole and , and Tsang, Raymond and , and Bettinger, Julie A. and , and Bridger, N. and , and Morris, R. and , and Halperin, S. and , and Top, K. and , and Déry, P. and , and Moore, D. and , and Lebel, M. and , and Le Saux, N. and , and Tran, D. and , and Ford-Jones, L. and , and Embree, J. and , and Law, B. and , and Tsang, R. and , and Tan, B. and , and Vaudry, W. and , and Jadavji, T. and , and Vanderkooi, O. G. and , and Scheifele, D. and , and Sauvé, L. and , and Bettinger, J. and ,
DOI: 10.1093/cid/ciu597
2014

The role of the immune system in governing host-microbe interactions in the intestine
Nature Immunology
Eric M Brown, Manish Sadarangani, B Brett Finlay
DOI: 10.1038/ni.2611
06/2013

Adolescents need a booster of serogroup C meningococcal vaccine to protect them and maintain population control of the disease
Archives of Disease in Childhood
A. J. Pollard, C. Green, M. Sadarangani, M. D. Snape
DOI: 10.1136/archdischild-2012-303103
03/2013

Neisseria meningitidis Native Outer Membrane Vesicles Containing Different Lipopolysaccharide Glycoforms as Adjuvants for Meningococcal and Nonmeningococcal Antigens
Clinical and Vaccine Immunology
Jerry C. Nagaputra, Christine S. Rollier, Manish Sadarangani, J. Claire Hoe, Ojas Hrakesh Mehta, Gunnstein Norheim, Muhammad Saleem, Hannah Chan, Jeremy P. Derrick, Ian Feavers, Andrew J. Pollard, E. Richard Moxon
DOI: 10.1128/cvi.00561-13
2013

How best to describe the risk of meningococcal B infection?
Paediatrics & Child Health
Manish Sadarangani, Julie A Bettinger, David W Scheifele
DOI: 10.1093/pch/18.10.543
2013

Neonatal Sepsis due to Coagulase-Negative Staphylococci
Clinical and Developmental Immunology
Elizabeth A. Marchant, Guilaine K. Boyce, Manish Sadarangani, Pascal M. Lavoie
DOI: 10.1155/2013/586076
2013

Construction of Opa-Positive and Opa-Negative Strains of Neisseria meningitidis to Evaluate a Novel Meningococcal Vaccine
PLoS ONE
Manish Sadarangani, J. Claire Hoe, Martin J. Callaghan, Claire Jones, Hannah Chan, Katherine Makepeace, Hélène Daniels-Treffandier, Mary E. Deadman, Christopher Bayliss, Ian Feavers, Peter van der Ley, Andrew J. Pollard
DOI: 10.1371/journal.pone.0051045
2012

Bacterial Meningitis in Childhood
Hot Topics in Infection and Immunity in Children VIII
Manish Sadarangani, Andrew J. Pollard
DOI: 10.1007/978-1-4614-0204-6_16
09/2011

Opa proteins and CEACAMs: pathways of immune engagement for pathogenicNeisseria
FEMS Microbiology Reviews
Manish Sadarangani, Andrew J. Pollard, Scott D. Gray-Owen
DOI: 10.1111/j.1574-6976.2010.00260.x
05/2011

Potential of Recombinant Opa Proteins as Vaccine Candidates against Hyperinvasive Meningococci
Infection and Immunity
M. J. Callaghan, S. Lewis, M. Sadarangani, S. E. S. Bailey, H. Chan, D. J. P. Ferguson, J. P. Derrick, I. Feavers, M. C. Maiden, A. J. Pollard
DOI: 10.1128/iai.01338-10
04/2011

Acute seizures attributable to falciparum malaria in an endemic area on the Kenyan coast
Brain
Symon M. Kariuki, Michelle Ikumi, John Ojal, Manish Sadarangani, Richard Idro, Ally Olotu, Philip Bejon, James A. Berkley, Kevin Marsh, Charles R. J. C. Newton
DOI: 10.1093/brain/awr051
04/2011

Meningitis
Manual of Childhood Infections (3rd edition)
2011

Serogroup B meningococcal vaccines—an unfinished story
The Lancet Infectious Diseases
Manish Sadarangani, Andrew J Pollard
DOI: 10.1016/s1473-3099(09)70324-x
02/2010

An observational study of children with sickle cell disease in Kilifi, Kenya
British Journal of Haematology
Manish Sadarangani, Julie Makani, Albert N. Komba, Tolu Ajala-Agbo, Charles R. Newton, Kevin Marsh, Thomas N. Williams
DOI: 10.1111/j.1365-2141.2009.07771.x
09/2009

Malaria as a Cause of Morbidity and Mortality in Children with Homozygous Sickle Cell Disease on the Coast of Kenya
Clinical Infectious Diseases
Albert N. Komba, Julie Makani, Manish Sadarangani, Tolu Ajala-Agbo, James A. Berkley, Charles R. J. C. Newton, Kevin Marsh, Thomas N. Williams
DOI: 10.1086/599834
07/2009

Challenges and progress in the development of a serogroup B meningococcal vaccine
Expert Review of Vaccines
Susan Lewis, Manish Sadarangani, J Claire Hoe, Andrew J Pollard
DOI: 10.1586/erv.09.30
06/2009

Role of Acquired Immunity in Neisseria Infections
Neisseria: Molecular Mechanisms of Pathogenesis
2009

Incidence and outcome of convulsive status epilepticus in Kenyan children: a cohort study
The Lancet Neurology
Manish Sadarangani, Claire Seaton, J Anthony G Scott, Bernhards Ogutu, Tansy Edwards, Agnes Prins, Hellen Gatakaa, Richard Idro, James A Berkley, Norbert Peshu, Brian G Neville, Charles R Newton
DOI: 10.1016/s1474-4422(07)70331-9
02/2008

An analysis of herpes simplex virus gene expression during latency establishment and reactivation.
Journal of General Virology
R H Lachmann, S Efstathiou, M Sadarangani, H R Atkinson
DOI: 10.1099/0022-1317-80-5-1271
05/1999

Research

Proection against infant pertussis through immunization in pregnancy
Infants with pertussis aged

Better protection against penumococcal and meningococcal infections
S. pneumoniae and N. meningitidis are primary causes of septicemia and meningitis. In Canada and other developed countries, case fatality rates for invasive disease caused by S. pneumoniae and N. meningitidis are 5-10%. Long-term disabling sequelae (e.g., deafness, epilepsy, motor impairment, and blindness) occur in one-fifth of bacterial meningitis survivors, most often after pneumococcal meningitis. In BC and across Canada, routine childhood immunization schedules include vaccines against all of these pathogens, yet they still cause a significant burden of serious disease. Vaccine introduction also exerts selection pressure on the target bacteria, modifying the genetic epidemiology and disease transmission. There is therefore a need for ongoing evaluation of existing vaccine schedules to ensure they provide optimal protection, and also to better understand host immune responses and bacterial evolution following vaccine introduction. I am currently undertaking randomized controlled trials to evaluate existing pneumococcal and meningococcal vaccine programs in Canada, as well a study of the molecular epidemiology of S. pneumoniae in children with pneumococcal pneumonia.

Development of a vaccine against Haemophilus influenzae type a
Haemophilus influenzae type a (Hia) causes meningitis and septicemia, with particularly high rates in indigenous populations. In this collaboration with the Northern Ontario School of Medicine, we will be assessing specific risk factors for Hia disease, the burden of invasive disease, mucosal disease (such as otitis media and pneumonia) and asymptomatic carriage of Hia. We will also be carrying out seroeipdemiology studies to assess anti-Hia antibodies in salvia and serum as an indication of exposure. These data will provide the information needed for the implementation of a new immunization policy for a Hia vaccine which is currently in development. Determination of immunological correlates of protection against invasive Hia disease and identification of the target populations groups for immunization will be of particular importance to design future clinical trials of these vaccines.

Grants

2017-2019. Molecular epidemiology of Streptococcus pneumoniae in children with pneumococcal pneumonia in Canada between 1991 and 2016 and implications for future vaccine design. BC Lung Association. 2017-2022. Canadian Immunization Research Network. CIHR 2018-2020. Influenza immunization for all Canadians. Does one size fit all? CIHR 2018-2021 Impact of maternal pertussis immunization on pregnancy outcome and child health. CIHR

2015-2017 Meningitis Research Foundation. Using high-throughput genomic sequencing to determine the aetiology of meningitis in UK children. £83,181

2015-2017 Thrasher Research Fund Early Career Award Program Grant (Mentor). Investigating the effect of Intravenous immunoglobulin treatment on the immunological and inflammatory response in childhood encephalitis. US$26,750

2016 European Society for Paediatric Infectious Diseases. The effect of latent cytomegalovirus infection on response to conjugate vaccines in children. €5999,18

Research Group Members

Michelle Mozel, Database Coordinator
Gordean Bjornson, Research Administrator
Cecilia Jankowski, Clinical Secretary
Karen Simmons, Research Administrator
Giulio Laino, Research Assistant Co-Op Student
Adriana Cabrera, Research Technician at Sadarangani Lab Canadian Burkholderia cepacia Complex Research and Referral Repository (CBCCRRR) technician
Melissa Chiu, Undergraduate Medical Student
Yasmin Vahedi