Overview

The focus of the neonatal neurology research group is to better understand brain development and injury in the newborn. Using advanced magnetic resonance (MR) techniques and bedside brain monitoring we study how white matter injury and systemic illness affects brain development in critically ill newborns. A better understanding of the factors that impact brain development and injury will allow us to directly improve the neurodevelopmental outcome of high-risk newborns.

Neurodevelopmental impairments are common in newborns delivered prior to term age and in newborns with heart birth defects, and result in a large burden of long-term disability. White matter injury, abnormal brain development and systemic illness are interrelated abnormalities that commonly follow preterm birth or heart birth defects, with focal non-cystic white matter injury being the characteristic pattern of brain injury. Though focal non-cystic white matter injury is associated with diffuse abnormalities of motor and cognitive function, how this happens is unknown. Systemic illness (e.g. infection) and therapy (e.g. steroids) may also be associated with diffuse abnormalities of motor and cognitive function.

Publications

The association between cardiac physiology, acquired brain injury, and postnatal brain growth in critical congenital heart disease.
The Journal of thoracic and cardiovascular surgery
Peyvandi S, Kim H, Lau J, Barkovich AJ, Campbell A, Miller S, Xu D, McQuillen P
DOI: 10.1016/j.jtcvs.2017.08.019
PubMed: 28918207
01/2018

Imaging the neonatal brain in the 21st century: why, when and how?
Archives of disease in childhood. Fetal and neonatal edition
Cheong JLY, Miller SP
DOI: 10.1136/archdischild-2017-313572
PubMed: 29074721
01/2018

Early procedural pain is associated with regionally-specific alterations in thalamic development in preterm neonates.
The Journal of Neuroscience
Duerden EG, Grunau RE, Guo T, Foong J, Pearson A, Au-Young S, Lavoie R, Chakravarty MM, Chau V, Synnes A, Miller SP
DOI: 10.1523/jneurosci.0867-17.2017
PubMed: 29255007
12/2017

PROCEDURAL PAIN AND ORAL GLUCOSE IN PRETERM NEONATES: BRAIN DEVELOPMENT AND SEX-SPECIFIC EFFECTS.
Pain
Schneider J, Duerden EG, Guo T, Ng K, Hagmann P, Graz MB, Grunau RE, Chakravarty MM, Hüppi PS, Truttmann AC, Miller SP
DOI: 10.1097/j.pain.0000000000001123
PubMed: 29200180
12/2017

COL4A1 and fetal vascular origins of schizencephaly.
Neurology
Khalid R, Krishnan P, Andres K, Blaser S, Miller S, Moharir M, Dlamini N
DOI: 10.1212/wnl.0000000000004890
PubMed: 29282339
12/2017

Severe retinopathy of prematurity predicts delayed white matter maturation and poorer neurodevelopment.
Archives of disease in childhood. Fetal and neonatal edition
Glass TJA, Chau V, Gardiner J, Foong J, Vinall J, Zwicker JG, Grunau RE, Synnes A, Poskitt KJ, Miller SP
DOI: 10.1136/archdischild-2016-312533
PubMed: 28536205
11/2017

Postnatal polyunsaturated fatty acids associated with larger preterm brain tissue volumes and better outcomes.
Pediatric research
Kamino D, Studholme C, Liu M, Chau V, Miller SP, Synnes A, Rogers EE, Barkovich AJ, Ferriero DM, Brant R, Tam EWY
DOI: 10.1038/pr.2017.230
PubMed: 28915231
10/2017

Complementary cortical gray and white matter developmental patterns in healthy, preterm neonates.
Human brain mapping
Rajagopalan V, Scott JA, Liu M, Poskitt K, Chau V, Miller S, Studholme C
DOI: 10.1002/hbm.23618
PubMed: 28608653
09/2017

Neonatal stroke and haematuria: Questions.
Pediatric nephrology (Berlin, Germany)
Kellett S, Lemaire M, Miller SP, Licht C, Yoon G, Dlamini N, Noone D
DOI: 10.1007/s00467-017-3745-x
PubMed: 28717936
07/2017

Neonatal stroke and haematuria: Answers.
Pediatric nephrology (Berlin, Germany)
Kellett S, Lemaire M, Miller SP, Licht C, Yoon G, Dlamini N, Noone D
DOI: 10.1007/s00467-017-3747-8
PubMed: 28717939
07/2017

GSK-3ß inhibitor TDZD-8 reduces neonatal hypoxic-ischemic brain injury in mice.
CNS neuroscience & therapeutics
Huang S, Wang H, Turlova E, Abussaud A, Ji X, Britto LR, Miller SP, Martinez A, Sun HS, Feng ZP
DOI: 10.1111/cns.12683
PubMed: 28256059
05/2017

Initiation of passive cooling at referring centre is most predictive of achieving early therapeutic hypothermia in asphyxiated newborns
Paediatrics & Child Health
Brigitte Lemyre, Linh Ly, Vann Chau, Anil Chacko, Nicholas Barrowman, Hilary Whyte, Steven P. Miller
DOI: 10.1093/pch/pxx062
05/2017

Harnessing Neuroimaging Capability in Pediatric Stroke: Proceedings of the Stroke Imaging Laboratory for Children Workshop.
Pediatric neurology
Dlamini N, Wintermark M, Fullerton H, Strother S, Lee W, Bjornson B, Guilliams KP, Miller S, Kirton A, Filippi CG, Linds A, Askalan R, deVeber G
DOI: 10.1016/j.pediatrneurol.2017.01.006
PubMed: 28259513
04/2017

Association between corpus callosum development on magnetic resonance imaging and diffusion tensor imaging, and neurodevelopmental outcome in neonates born very preterm.
Developmental medicine and child neurology
Malavolti AM, Chau V, Brown-Lum M, Poskitt KJ, Brant R, Synnes A, Grunau RE, Miller SP
DOI: 10.1111/dmcn.13364
PubMed: 27976377
04/2017

Clinical Risk Factors for Punctate White Matter Lesions on Early Magnetic Resonance Imaging in Preterm Newborns.
The Journal of pediatrics
Wagenaar N, Chau V, Groenendaal F, Kersbergen KJ, Poskitt KJ, Grunau RE, Synnes A, Duerden EG, de Vries LS, Miller SP, Benders MJNL
DOI: 10.1016/j.jpeds.2016.11.073
PubMed: 28063691
03/2017

Quantitative assessment of white matter injury in preterm neonates: Association with outcomes.
Neurology
Guo T, Duerden EG, Adams E, Chau V, Branson HM, Chakravarty MM, Poskitt KJ, Synnes A, Grunau RE, Miller SP
DOI: 10.1212/wnl.0000000000003606
PubMed: 28100727
02/2017

BrainNetCNN: Convolutional neural networks for brain networks; towards predicting neurodevelopment.
NeuroImage
Kawahara J, Brown CJ, Miller SP, Booth BG, Chau V, Grunau RE, Zwicker JG, Hamarneh G
DOI: 10.1016/j.neuroimage.2016.09.046
PubMed: 27693612
02/2017

Antenatal exposure to antidepressants is associated with altered brain development in very preterm-born neonates.
Neuroscience
Podrebarac SK, Duerden EG, Chau V, Grunau RE, Synnes A, Oberlander TF, Miller SP
DOI: 10.1016/j.neuroscience.2016.11.025
PubMed: 27890829
02/2017

The 'ouR-HOPE' approach for ethics and communication about neonatal neurological injury.
Developmental medicine and child neurology
Racine E, Bell E, Farlow B, Miller S, Payot A, Rasmussen LA, Shevell MI, Thomson D, Wintermark P
DOI: 10.1111/dmcn.13343
PubMed: 27915463
02/2017

Narcotics and Sedative Use in Preterm Neonates.
The Journal of pediatrics
Borenstein-Levin L, Synnes A, Grunau RE, Miller SP, Yoon EW, Shah PS, Canadian Neonatal Network Investigators
DOI: 10.1016/j.jpeds.2016.08.031
PubMed: 27614931
01/2017

Pathophysiology of Neonatal White Matter Injury
Fetal and Neonatal Physiology
Steven P. Miller, Stephen A. Back
DOI: 10.1016/b978-0-323-35214-7.00169-4
2017

Hypoxic-Ischemic Brain Injury in the Term Newborn
Swaiman's Pediatric Neurology
Vann Chau and Donna M. Ferriero and Steven P. Miller
DOI: 10.1016/b978-0-323-37101-8.00019-9
2017

Increased subcortical oligodendroglia-like cells in pharmacoresistant focal epilepsy in children correlate with extensive epileptogenic zones.
Epilepsia
Sakuma S, Halliday WC, Nomura R, Baba S, Sato Y, Okanari K, Nakajima M, Widjaja E, Boelman C, Ochi A, Snead OC, Rutka JT, Drake J, Miller S, Otsubo H
DOI: 10.1111/epi.13590
PubMed: 27859041
12/2016

Cerebral oxygen delivery is reduced in newborns with congenital heart disease.
The Journal of thoracic and cardiovascular surgery
Lim JM, Kingdom T, Saini B, Chau V, Post M, Blaser S, Macgowan C, Miller SP, Seed M
DOI: 10.1016/j.jtcvs.2016.05.027
PubMed: 27349283
10/2016

Fellowship Training in the Emerging Fields of Fetal-Neonatal Neurology and Neonatal Neurocritical Care.
Pediatric neurology
Smyser CD, Tam EWY, Chang T, Soul JS, Miller SP, Glass HC
DOI: 10.1016/j.pediatrneurol.2016.06.006
PubMed: 27473650
10/2016

Interplay of brain structure and function in neonatal congenital heart disease.
Annals of clinical and translational neurology
Birca A, Vakorin VA, Porayette P, Madathil S, Chau V, Seed M, Doesburg SM, Blaser S, Nita DA, Sharma R, Duerden EG, Hickey EJ, Miller SP, Hahn CD
DOI: 10.1002/acn3.336
PubMed: 27648460
09/2016

Low plasma magnesium is associated with impaired brain metabolism in neonates with hypoxic-ischaemic encephalopathy.
Acta paediatrica (Oslo, Norway : 1992)
Chakkarapani E, Chau V, Poskitt KJ, Synnes A, Kwan E, Roland E, Miller SP
DOI: 10.1111/apa.13505
PubMed: 27336238
09/2016

Brain in Congenital Heart Disease Across the Lifespan: The Cumulative Burden of Injury.
Circulation
Marelli A, Miller SP, Marino BS, Jefferson AL, Newburger JW
DOI: 10.1161/circulationaha.115.019881
PubMed: 27185022
05/2016

Early postnatal docosahexaenoic acid levels and improved preterm brain development.
Pediatric research
Tam EW, Chau V, Barkovich AJ, Ferriero DM, Miller SP, Rogers EE, Grunau RE, Synnes AR, Xu D, Foong J, Brant R, Innis SM
DOI: 10.1038/pr.2016.11
PubMed: 26761122
05/2016

Smaller Cerebellar Growth and Poorer Neurodevelopmental Outcomes in Very Preterm Infants Exposed to Neonatal Morphine.
The Journal of pediatrics
Zwicker JG, Miller SP, Grunau RE, Chau V, Brant R, Studholme C, Liu M, Synnes A, Poskitt KJ, Stiver ML, Tam EW
DOI: 10.1016/j.jpeds.2015.12.024
PubMed: 26763312
05/2016

Association of Prenatal Diagnosis of Critical Congenital Heart Disease With Postnatal Brain Development and the Risk of Brain Injury.
JAMA pediatrics
Peyvandi S, De Santiago V, Chakkarapani E, Chau V, Campbell A, Poskitt KJ, Xu D, Barkovich AJ, Miller S, McQuillen P
DOI: 10.1001/jamapediatrics.2015.4450
PubMed: 26902528
04/2016

Midazolam dose correlates with abnormal hippocampal growth and neurodevelopmental outcome in preterm infants.
Annals of neurology
Duerden EG, Guo T, Dodbiba L, Chakravarty MM, Chau V, Poskitt KJ, Synnes A, Grunau RE, Miller SP
DOI: 10.1002/ana.24601
PubMed: 26754148
04/2016

Reliability of Early Magnetic Resonance Imaging (MRI) and Necessity of Repeating MRI in Noncooled and Cooled Infants With Neonatal Encephalopathy.
Journal of child neurology
Chakkarapani E, Poskitt KJ, Miller SP, Zwicker JG, Xu Q, Wong DS, Roland EH, Hill A, Chau V
DOI: 10.1177/0883073815600865
PubMed: 26323498
04/2016

MRI reveals hemodynamic changes with acute maternal hyperoxygenation in human fetuses with and without congenital heart disease.
Prenatal diagnosis
Porayette P, Madathil S, Sun L, Jaeggi E, Grosse-Wortmann L, Yoo SJ, Hickey E, Miller SP, Macgowan CK, Seed M
DOI: 10.1002/pd.4762
PubMed: 26701792
03/2016

Patch-based augmentation of Expectation-Maximization for brain MRI tissue segmentation at arbitrary age after premature birth.
NeuroImage
Liu M, Kitsch A, Miller S, Chau V, Poskitt K, Rousseau F, Shaw D, Studholme C
DOI: 10.1016/j.neuroimage.2015.12.009
PubMed: 26702777
02/2016

Response to Letter Regarding Article, "Reduced Fetal Cerebral Oxygen Consumption Is Associated With Smaller Brain Size in Fetuses With Congenital Heart Disease".
Circulation
Sun L, Macgowan CK, Sled JG, Yoo SJ, Manlhiot C, Porayette P, Grosse-Wortmann L, Jaeggi E, McCrindle B, Kingdom J, Hickey E, Miller S, Seed M
DOI: 10.1161/circulationaha.115.018748
PubMed: 26719396
01/2016

STEAM - Statistical Template Estimation for Abnormality Mapping: A personalized DTI analysis technique with applications to the screening of preterm infants.
NeuroImage
Booth BG, Miller SP, Brown CJ, Poskitt KJ, Chau V, Grunau RE, Synnes AR, Hamarneh G
DOI: 10.1016/j.neuroimage.2015.08.079
PubMed: 26515903
01/2016

Serial prenatal and post-natal brain MRI demonstrates impact of congenital heart disease and cardiac surgery on brain growth and maturity.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
Porayette P, Lim JM, Saini BS, Madathil S, Zhu MY, Jaeggi E, Grosse-Wortmann L, Yoo S, Macgowan C, Miller S, Seed M
2016

Rodent Hypoxia-Ischemia Models for Cerebral Palsy Research: A Systematic Review.
Frontiers in neurology
Rumajogee P, Bregman T, Miller SP, Yager JY, Fehlings MG
DOI: 10.3389/fneur.2016.00057
PubMed: 27199883
2016

Manual-Protocol Inspired Technique for Improving Automated MR Image Segmentation during Label Fusion.
Frontiers in neuroscience
Bhagwat N, Pipitone J, Winterburn JL, Guo T, Duerden EG, Voineskos AN, Lepage M, Miller SP, Pruessner JC, Chakravarty MM
DOI: 10.3389/fnins.2016.00325
PubMed: 27486386
2016

Sensory Processing Patterns in Children Born Very Preterm.
The American journal of occupational therapy : official publication of the American Occupational Therapy Association
Crozier SC, Goodson JZ, Mackay ML, Synnes AR, Grunau RE, Miller SP, Zwicker JG
DOI: 10.5014/ajot.2016.018747
PubMed: 26709425
2016

Tract-Based Spatial Statistics in Preterm-Born Neonates Predicts Cognitive and Motor Outcomes at 18 Months.
AJNR. American journal of neuroradiology
Duerden EG, Foong J, Chau V, Branson H, Poskitt KJ, Grunau RE, Synnes A, Zwicker JG, Miller SP
DOI: 10.3174/ajnr.a4312
PubMed: 25929880
08/2015

Neonatal Pain and Infection Relate to Smaller Cerebellum in Very Preterm Children at School Age.
The Journal of pediatrics
Ranger M, Zwicker JG, Chau CM, Park MT, Chakravarthy MM, Poskitt K, Miller SP, Bjornson BH, Tam EW, Chau V, Synnes AR, Grunau RE
DOI: 10.1016/j.jpeds.2015.04.055
PubMed: 25987534
08/2015

Neonatal seizures and brain imaging
Journal of Pediatric Neurology
Steven Miller, Sonia Bonifacio
DOI: 10.3233/jpn-2009-0269
07/2015

Neurodevelopmental outcomes after cardiac surgery in infancy.
Pediatrics
Gaynor JW, Stopp C, Wypij D, Andropoulos DB, Atallah J, Atz AM, Beca J, Donofrio MT, Duncan K, Ghanayem NS, Goldberg CS, Hövels-Gürich H, Ichida F, International Cardiac Collaborative on Neurodevelopment (ICCON) Investigators
DOI: 10.1542/peds.2014-3825
PubMed: 25917996
05/2015

Reduced fetal cerebral oxygen consumption is associated with smaller brain size in fetuses with congenital heart disease.
Circulation
Sun L, Macgowan CK, Sled JG, Yoo SJ, Manlhiot C, Porayette P, Grosse-Wortmann L, Jaeggi E, McCrindle BW, Kingdom J, Hickey E, Miller S, Seed M
DOI: 10.1161/circulationaha.114.013051
PubMed: 25762062
04/2015

Oxygen therapy for preterm neonates: the elusive optimal target.
JAMA pediatrics
Synnes A, Miller SP
DOI: 10.1001/jamapediatrics.2014.3664
PubMed: 25664537
04/2015

Magnetic resonance imaging (MRI) and prognostication in neonatal hypoxic-ischemic injury: a vignette-based study of Canadian specialty physicians.
Journal of child neurology
Bell E, Rasmussen LA, Mazer B, Shevell M, Miller SP, Synnes A, Yager JY, Majnemer A, Muhajarine N, Chouinard I, Racine E
DOI: 10.1177/0883073814531821
PubMed: 24789518
02/2015

Cerebral oxygen delivery in newborns with congenital heart disease by phase contrast MRI.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
Lim JM, Kingdom T, Saini B, Blaser S, Grosse-Wortmann L, Yoo S, Hickey EJ, Macgowan C, Miller S, Seed M
DOI: 10.1186/1532-429x-17-s1-m9
2015

MRI reveals increased superior vena caval blood flow in human fetuses with congenital heart disease, abnormal placental pathology and neonatal brain white matter changes.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
Madathil S, Sun L, Saini BS, Yoo S, Jaeggi E, Grosse-Wortmann L, Kingdom J, Hickey EJ, Miller S, Macgowan C, Seed M
DOI: 10.1186/1532-429x-17-s1-o92
2015

Assessment of MRI parameters for studying brain development in newborns with congenital heart disease.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
Saini BS, Muthusami P, Madathil S, Lim JM, Macgowan C, Miller S, Seed M
2015

Early neonatal pain exposure and brain microstructure interact to predict neurodevelopmental outcomes at 18 months corrected age in children born very preterm
International Journal of Developmental Neuroscience
Jillian Vinall, Jill G. Zwicker, Ruth E. Grunau, Vann Chau, Kenneth J. Poskitt, Rollin Brant, Anne R. Synnes, Steven P. Miller
DOI: 10.1016/j.ijdevneu.2015.04.132
2015

Reduced fetal cerebral oxygen consumption is associated with abnormal white matter in newborns with congenital heart disease.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
Muthusami P, Madathil S, Blaser S, Jaeggi E, Grosse-Wortmann L, Yoo S, Kingdom J, Hickey EJ, Sled JG, Macgowan C, Miller S, Seed M
2015

Fetal haemodynamic assessment in a case of late-onset intrauterine growth restriction by phase contrast MRI and T2 mapping.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
Zhu MY, Madathil S, Miller S, Windrim R, Macgowan C, Kingdom J, Seed M
DOI: 10.1186/1532-429x-17-s1-p27
2015

Stochastic process for white matter injury detection in preterm neonates.
NeuroImage. Clinical
Cheng I, Miller SP, Duerden EG, Sun K, Chau V, Adams E, Poskitt KJ, Branson HM, Basu A
DOI: 10.1016/j.nicl.2015.02.015
PubMed: 25844316
2015

Automatic segmentation of the hippocampus for preterm neonates from early-in-life to term-equivalent age.
NeuroImage. Clinical
Guo T, Winterburn JL, Pipitone J, Duerden EG, Park MT, Chau V, Poskitt KJ, Grunau RE, Synnes A, Miller SP, Mallar Chakravarty M
DOI: 10.1016/j.nicl.2015.07.019
PubMed: 26740912
2015

MRI reveals hemodynamic changes with acute maternal hyperoxygenation in human fetuses with and without congenital heart disease.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
Porayette P, Sun L, Jaeggi E, Grosse-Wortmann L, Yoo S, Hickey EJ, Miller S, Macgowan C, Seed M
DOI: 10.1186/1532-429x-17-s1-o55
2015

Society for Pediatric Research 2014 Presidential Address: The test of our progress.
Pediatric research
Miller SP
DOI: 10.1038/pr.2014.149
PubMed: 25397370
12/2014

Minimizing the risk of preoperative brain injury in neonates with aortic arch obstruction.
The Journal of pediatrics
Algra SO, Haas F, Poskitt KJ, Groenendaal F, Schouten AN, Jansen NJ, Azakie A, Gandhi S, Campbell A, Miller SP, McQuillen PS, de Vries LS
DOI: 10.1016/j.jpeds.2014.08.066
PubMed: 25306190
12/2014

Structural network analysis of brain development in young preterm neonates.
NeuroImage
Brown CJ, Miller SP, Booth BG, Andrews S, Chau V, Poskitt KJ, Hamarneh G
DOI: 10.1016/j.neuroimage.2014.07.030
PubMed: 25076107
11/2014

Further evidence for botulinum toxin A in cerebral palsy.
The Journal of pediatrics
Chau V, Fehlings D, Miller SP
DOI: 10.1016/j.jpeds.2014.03.041
PubMed: 24787538
07/2014

Preferential cephalic redistribution of left ventricular cardiac output during therapeutic hypothermia for perinatal hypoxic-ischemic encephalopathy.
The Journal of pediatrics
Hochwald O, Jabr M, Osiovich H, Miller SP, McNamara PJ, Lavoie PM
DOI: 10.1016/j.jpeds.2014.01.028
PubMed: 24582011
05/2014

Brain injury in premature neonates: A primary cerebral dysmaturation disorder?
Annals of neurology
Back SA, Miller SP
DOI: 10.1002/ana.24132
PubMed: 24615937
04/2014

Invasive procedures in preterm children: brain and cognitive development at school age.
Pediatrics
Vinall J, Miller SP, Bjornson BH, Fitzpatrick KP, Poskitt KJ, Brant R, Synnes AR, Cepeda IL, Grunau RE
DOI: 10.1542/peds.2013-1863
PubMed: 24534406
03/2014

Chorioamnionitis in the pathogenesis of brain injury in preterm infants.
Clinics in perinatology
Chau V, McFadden DE, Poskitt KJ, Miller SP
DOI: 10.1016/j.clp.2013.10.009
PubMed: 24524448
03/2014

Magnetic resonance imaging in the encephalopathic term newborn.
Current pediatric reviews
Chau V, Poskitt KJ, Dunham CP, Hendson G, Miller SP
DOI: 10.2174/157339631001140408120336
PubMed: 25055861
2014

Abnormal brain maturation in preterm neonates associated with adverse developmental outcomes.
Neurology
Chau V, Synnes A, Grunau RE, Poskitt KJ, Brant R, Miller SP
DOI: 10.1212/01.wnl.0000437298.43688.b9
PubMed: 24212394
12/2013

MRI findings in infants with infantile spasms after neonatal hypoxic-ischemic encephalopathy.
Pediatric neurology
Gano D, Sargent MA, Miller SP, Connolly MB, Wong P, Glass HC, Poskitt KJ, Chau V
DOI: 10.1016/j.pediatrneurol.2013.08.007
PubMed: 24095571
12/2013

Neonatal pain-related stress, functional cortical activity and visual-perceptual abilities in school-age children born at extremely low gestational age.
Pain
Doesburg SM, Chau CM, Cheung TP, Moiseev A, Ribary U, Herdman AT, Miller SP, Cepeda IL, Synnes A, Grunau RE
DOI: 10.1016/j.pain.2013.04.009
PubMed: 23711638
10/2013

Resuscitation intensity at birth is associated with changes in brain metabolic development in preterm neonates.
Neuroradiology
Duerden EG, Brown-Lum M, Chau V, Poskitt KJ, Grunau RE, Synnes A, Miller SP
DOI: 10.1007/s00234-013-1243-9
PubMed: 23921419
09/2013

Parent behaviors moderate the relationship between neonatal pain and internalizing behaviors at 18 months corrected age in children born very prematurely.
Pain
Vinall J, Miller SP, Synnes AR, Grunau RE
DOI: 10.1016/j.pain.2013.05.050
PubMed: 23748079
09/2013

Visual function in preterm infants: visualizing the brain to improve prognosis.
Documenta ophthalmologica. Advances in ophthalmology
Chau V, Taylor MJ, Miller SP
DOI: 10.1007/s10633-013-9397-7
PubMed: 23761036
08/2013

Prenatal and postnatal inflammation in relation to cortisol levels in preterm infants at 18 months corrected age.
Journal of perinatology : official journal of the California Perinatal Association
Gover A, Chau V, Miller SP, Brant R, McFadden DE, Poskitt KJ, Synnes A, Weinberg J, Grunau RE
DOI: 10.1038/jp.2013.24
PubMed: 23558431
08/2013

Evolution of pattern of injury and quantitative MRI on days 1 and 3 in term newborns with hypoxic-ischemic encephalopathy.
Pediatric research
Gano D, Chau V, Poskitt KJ, Hill A, Roland E, Brant R, Chalmers M, Miller SP
DOI: 10.1038/pr.2013.69
PubMed: 23618911
07/2013

Brain injury patterns in hypoglycemia in neonatal encephalopathy.
AJNR. American journal of neuroradiology
Wong DS, Poskitt KJ, Chau V, Miller SP, Roland E, Hill A, Tam EW
DOI: 10.3174/ajnr.a3423
PubMed: 23436054
07/2013

Brain injury and development in newborns with critical congenital heart disease.
Neurology
Dimitropoulos A, McQuillen PS, Sethi V, Moosa A, Chau V, Xu D, Brant R, Azakie A, Campbell A, Barkovich AJ, Poskitt KJ, Miller SP
DOI: 10.1212/wnl.0b013e31829bfdcf
PubMed: 23771484
07/2013

Brain development in infants born preterm: looking beyond injury.
Seminars in pediatric neurology
Duerden EG, Taylor MJ, Miller SP
DOI: 10.1016/j.spen.2013.06.007
PubMed: 23948681
06/2013

Single-ventricle anatomy predicts delayed microstructural brain development.
Pediatric research
Sethi V, Tabbutt S, Dimitropoulos A, Harris KC, Chau V, Poskitt K, Campbell A, Azakie A, Xu D, Barkovich AJ, Miller SP, McQuillen PS
DOI: 10.1038/pr.2013.29
PubMed: 23407116
05/2013

Score for neonatal acute physiology-II and neonatal pain predict corticospinal tract development in premature newborns.
Pediatric neurology
Zwicker JG, Grunau RE, Adams E, Chau V, Brant R, Poskitt KJ, Synnes A, Miller SP
DOI: 10.1016/j.pediatrneurol.2012.10.016
PubMed: 23337005
02/2013

Slower postnatal growth is associated with delayed cerebral cortical maturation in preterm newborns.
Science translational medicine
Vinall J, Grunau RE, Brant R, Chau V, Poskitt KJ, Synnes AR, Miller SP
DOI: 10.1126/scitranslmed.3004666
PubMed: 23325801
01/2013

Paediatric neurology: improved care of the developing brain.
The Lancet. Neurology
Miller SP, Ferriero DM
DOI: 10.1016/s1474-4422(12)70292-2
PubMed: 23237895
01/2013

Neonatal pain-related stress predicts cortical thickness at age 7 years in children born very preterm.
PloS one
Ranger M, Chau CM, Garg A, Woodward TS, Beg MF, Bjornson B, Poskitt K, Fitzpatrick K, Synnes AR, Miller SP, Grunau RE
DOI: 10.1371/journal.pone.0076702
PubMed: 24204657
2013

Magnetic resonance imaging in hypoxic-ischemic encephalopathy: still a cool test.
Archives of pediatrics & adolescent medicine
Chau V, Poskitt KJ, Miller SP
DOI: 10.1001/archpediatrics.2012.579
PubMed: 22751888
07/2012

Neonatal pain in relation to postnatal growth in infants born very preterm.
Pain
Vinall J, Miller SP, Chau V, Brummelte S, Synnes AR, Grunau RE
DOI: 10.1016/j.pain.2012.02.007
PubMed: 22704600
07/2012

Single course of antenatal steroids did not alter cortisol in preterm infants up to 18 months.
Acta paediatrica (Oslo, Norway : 1992)
Gover A, Brummelte S, Synnes AR, Miller SP, Brant R, Weinberg J, Grunau RE
DOI: 10.1111/j.1651-2227.2012.02629.x
PubMed: 22313364
06/2012

Procedural pain and brain development in premature newborns.
Annals of neurology
Brummelte S, Grunau RE, Chau V, Poskitt KJ, Brant R, Vinall J, Gover A, Synnes AR, Miller SP
DOI: 10.1002/ana.22267
PubMed: 22374882
03/2012

Postnatal infection is associated with widespread abnormalities of brain development in premature newborns.
Pediatric research
Chau V, Brant R, Poskitt KJ, Tam EW, Synnes A, Miller SP
DOI: 10.1038/pr.2011.40
PubMed: 22278180
03/2012

Arrested preoligodendrocyte maturation contributes to myelination failure in premature infants.
Annals of neurology
Buser JR, Maire J, Riddle A, Gong X, Nguyen T, Nelson K, Luo NL, Ren J, Struve J, Sherman LS, Miller SP, Chau V, Hendson G, Ballabh P, Grafe MR, Back SA
DOI: 10.1002/ana.22627
PubMed: 22275256
01/2012

Hypoxic-Ischemic Brain Injury in the Term Newborn
Swaiman's Pediatric Neurology
Steven P. Miller, Donna M. Ferriero
DOI: 10.1016/b978-1-4377-0435-8.00017-2
2012

Clinical Approach to Term Encephalopathy
Acquired Brain Injury in the Fetus and Newborn
2012

Brain Injury in Newborn Infants with Congenital Heart Disease
Acquired Brain Injury in the Fetus and Newborn
2012

Early inflammation in the absence of overt infection in preterm neonates exposed to intensive care.
Cytokine
Chang BA, Huang Q, Quan J, Chau V, Ladd M, Kwan E, McFadden DE, Lacaze-Masmonteil T, Miller SP, Lavoie PM
DOI: 10.1016/j.cyto.2011.08.028
PubMed: 21940177
12/2011

Preterm cerebellar growth impairment after postnatal exposure to glucocorticoids.
Science translational medicine
Tam EW, Chau V, Ferriero DM, Barkovich AJ, Poskitt KJ, Studholme C, Fok ED, Grunau RE, Glidden DV, Miller SP
DOI: 10.1126/scitranslmed.3002884
PubMed: 22013125
10/2011

Infection and white matter injury in infants with congenital cardiac disease.
Cardiology in the young
Glass HC, Bowman C, Chau V, Moosa A, Hersh AL, Campbell A, Poskitt K, Azakie A, Barkovich AJ, Miller SP, McQuillen PS
DOI: 10.1017/s1047951111000473
PubMed: 21554828
10/2011

Magnetoencephalography reveals slowing of resting peak oscillatory frequency in children born very preterm.
Pediatric research
Doesburg SM, Ribary U, Herdman AT, Moiseev A, Cheung T, Miller SP, Poskitt KJ, Weinberg H, Whitfield MF, Synnes A, Grunau RE
DOI: 10.1203/pdr.0b013e3182225a9e
PubMed: 21544009
08/2011

Correspondence on ''clinical seizures in neonatal hypoxic-ischemic encephalopathy have no independent impact on neurodevelopmental outcome: secondary analyses of data from the neonatal research network hypothermia trial''.
Journal of child neurology
Glass HC, Ferriero DM, Miller SP
DOI: 10.1177/0883073811399801
PubMed: 21493809
04/2011

The role of hypoxia-ischemia in term newborns with arterial stroke.
Pediatric neurology
Michoulas A, Basheer SN, Roland EH, Poskitt K, Miller S, Hill A
DOI: 10.1016/j.pediatrneurol.2010.10.013
PubMed: 21397165
04/2011

Sildenafil citrate therapy for severe early-onset intrauterine growth restriction.
BJOG : an international journal of obstetrics and gynaecology
von Dadelszen P, Dwinnell S, Magee LA, Carleton BC, Gruslin A, Lee B, Lim KI, Liston RM, Miller SP, Rurak D, Sherlock RL, Skoll MA, Wareing MM, Research into Advanced Fetal Diagnosis and Therapy (RAFT) Group
DOI: 10.1111/j.1471-0528.2010.02879.x
PubMed: 21392225
04/2011

The Cerebral Palsy Demonstration Project: a multidimensional research approach to cerebral palsy.
Seminars in pediatric neurology
Shevell M, Miller SP, Scherer SW, Yager JY, Fehlings MG
DOI: 10.1016/j.spen.2011.02.004
PubMed: 21575839
03/2011

Differential effects of intraventricular hemorrhage and white matter injury on preterm cerebellar growth.
The Journal of pediatrics
Tam EW, Miller SP, Studholme C, Chau V, Glidden D, Poskitt KJ, Ferriero DM, Barkovich AJ
DOI: 10.1016/j.jpeds.2010.09.005
PubMed: 20961562
03/2011

Altered long-range alpha-band synchronization during visual short-term memory retention in children born very preterm.
NeuroImage
Doesburg SM, Ribary U, Herdman AT, Miller SP, Poskitt KJ, Moiseev A, Whitfield MF, Synnes A, Grunau RE
DOI: 10.1016/j.neuroimage.2010.10.044
PubMed: 20974268
02/2011

Extreme premature birth is not associated with impaired development of brain microstructure.
The Journal of pediatrics
Bonifacio SL, Glass HC, Chau V, Berman JI, Xu D, Brant R, Barkovich AJ, Poskitt KJ, Miller SP, Ferriero DM
DOI: 10.1016/j.jpeds.2010.05.026
PubMed: 20598316
11/2010

Imaging selective vulnerability in the developing nervous system.
Journal of anatomy
Ferriero DM, Miller SP
DOI: 10.1111/j.1469-7580.2010.01226.x
PubMed: 20408904
10/2010

Clinically silent preoperative brain injuries do not worsen with surgery in neonates with congenital heart disease.
The Journal of thoracic and cardiovascular surgery
Block AJ, McQuillen PS, Chau V, Glass H, Poskitt KJ, Barkovich AJ, Esch M, Soulikias W, Azakie A, Campbell A, Miller SP
DOI: 10.1016/j.jtcvs.2010.03.035
PubMed: 20434174
09/2010

Tractography-based quantitation of corticospinal tract development in premature newborns.
The Journal of pediatrics
Adams E, Chau V, Poskitt KJ, Grunau RE, Synnes A, Miller SP
DOI: 10.1016/j.jpeds.2009.12.030
PubMed: 20227731
06/2010

Congenital heart disease and brain development.
Annals of the New York Academy of Sciences
McQuillen PS, Miller SP
DOI: 10.1111/j.1749-6632.2009.05116.x
PubMed: 20146691
01/2010

The spectrum of abnormal neurologic outcomes subsequent to term intrapartum asphyxia.
Pediatric neurology
Al-Macki N, Miller SP, Hall N, Shevell M
DOI: 10.1016/j.pediatrneurol.2009.06.001
PubMed: 19931160
12/2009

From selective vulnerability to connectivity: insights from newborn brain imaging.
Trends in neurosciences
Miller SP, Ferriero DM
DOI: 10.1016/j.tins.2009.05.010
PubMed: 19712981
09/2009

Clinical Neonatal Seizures are Independently Associated with Outcome in Infants at Risk for Hypoxic-Ischemic Brain Injury.
The Journal of pediatrics
Glass HC, Glidden D, Jeremy RJ, Barkovich AJ, Ferriero DM, Miller SP
DOI: 10.1016/j.jpeds.2009.03.040
PubMed: 19540512
09/2009

Effect of chorioamnionitis on brain development and injury in premature newborns.
Annals of neurology
Chau V, Poskitt KJ, McFadden DE, Bowen-Roberts T, Synnes A, Brant R, Sargent MA, Soulikias W, Miller SP
DOI: 10.1002/ana.21713
PubMed: 19743455
08/2009

Delayed recognition of initial stroke in children: need for increased awareness.
Pediatrics
Srinivasan J, Miller SP, Phan TG, Mackay MT
DOI: 10.1542/peds.2008-3544
PubMed: 19620205
08/2009

Cerebellar development in the preterm neonate: effect of supratentorial brain injury.
Pediatric research
Tam EW, Ferriero DM, Xu D, Berman JI, Vigneron DB, Barkovich AJ, Miller SP
DOI: 10.1203/pdr.0b013e3181a1fb3d
PubMed: 19287350
07/2009

Advanced neuroimaging techniques for the term newborn with encephalopathy.
Pediatric neurology
Chau V, Poskitt KJ, Miller SP
DOI: 10.1016/j.pediatrneurol.2008.09.012
PubMed: 19218031
03/2009

Neonatal watershed brain injury on magnetic resonance imaging correlates with verbal IQ at 4 years.
Pediatrics
Steinman KJ, Gorno-Tempini ML, Glidden DV, Kramer JH, Miller SP, Barkovich AJ, Ferriero DM
DOI: 10.1542/peds.2008-1203
PubMed: 19255035
03/2009

Systematic review of biomarkers of brain injury in term neonatal encephalopathy.
Pediatric neurology
Ramaswamy V, Horton J, Vandermeer B, Buscemi N, Miller S, Yager J
DOI: 10.1016/j.pediatrneurol.2008.09.026
PubMed: 19218035
03/2009

Quantitative fiber tracking analysis of the optic radiation correlated with visual performance in premature newborns.
AJNR. American journal of neuroradiology
Berman JI, Glass HC, Miller SP, Mukherjee P, Ferriero DM, Barkovich AJ, Vigneron DB, Henry RG
DOI: 10.3174/ajnr.a1304
PubMed: 18832665
01/2009

Preventing brain injury in newborns with congenital heart disease: brain imaging and innovative trial designs.
Stroke
Sherlock RL, McQuillen PS, Miller SP, aCCENT
DOI: 10.1161/strokeaha.108.522664
PubMed: 18988911
01/2009

Comparison of computer tomography and magnetic resonance imaging scans on the third day of life in term newborns with neonatal encephalopathy.
Pediatrics
Chau V, Poskitt KJ, Sargent MA, Lupton BA, Hill A, Roland E, Miller SP
DOI: 10.1542/peds.2008-0283
PubMed: 19117898
01/2009

White matter injury in term newborns with neonatal encephalopathy.
Pediatric research
Li AM, Chau V, Poskitt KJ, Sargent MA, Lupton BA, Hill A, Roland E, Miller SP
DOI: 10.1203/pdr.0b013e31818912d2
PubMed: 18787422
01/2009

Recurrent postnatal infections are associated with progressive white matter injury in premature infants.
Pediatrics
Glass HC, Bonifacio SL, Chau V, Glidden D, Poskitt K, Barkovich AJ, Ferriero DM, Miller SP
DOI: 10.1542/peds.2007-2184
PubMed: 18676547
08/2008

Brain metabolite levels assessed by lactate-edited MR spectroscopy in premature neonates with and without pentobarbital sedation.
AJNR. American journal of neuroradiology
Wang ZJ, Vigneron DB, Miller SP, Mukherjee P, Charlton NN, Lu Y, Barkovich AJ
DOI: 10.3174/ajnr.a0912
PubMed: 18184837
04/2008

White-matter injury is associated with impaired gaze in premature infants.
Pediatric neurology
Glass HC, Fujimoto S, Ceppi-Cozzio C, Bartha AI, Vigneron DB, Barkovich AJ, Glidden DV, Ferriero DM, Miller SP
DOI: 10.1016/j.pediatrneurol.2007.08.019
PubMed: 18054686
01/2008

Abnormal brain development in newborns with congenital heart disease.
The New England journal of medicine
Miller SP, McQuillen PS, Hamrick S, Xu D, Glidden DV, Charlton N, Karl T, Azakie A, Ferriero DM, Barkovich AJ, Vigneron DB
DOI: 10.1056/nejmoa067393
PubMed: 17989385
11/2007

Neurology of congenital heart disease: insight from brain imaging.
Archives of disease in childhood. Fetal and neonatal edition
Miller SP, McQuillen PS
DOI: 10.1136/adc.2006.108845
PubMed: 17848505
11/2007

Brainstem involvement in neonatal herpes simplex virus type 2 encephalitis.
Pediatrics
Pelligra G, Lynch N, Miller SP, Sargent MA, Osiovich H
DOI: 10.1542/peds.2006-3757
PubMed: 17671049
08/2007

Newborn brain injury: looking back to the fetus.
Annals of neurology
Miller SP
DOI: 10.1002/ana.21124
PubMed: 17444513
04/2007

Regional and central venous oxygen saturation monitoring following pediatric cardiac surgery: concordance and association with clinical variables.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
McQuillen PS, Nishimoto MS, Bottrell CL, Fineman LD, Hamrick SE, Glidden DV, Azakie A, Adatia I, Miller SP
DOI: 10.1097/01.pcc.0000257101.37171.be
PubMed: 17273125
03/2007

Temporal and anatomic risk profile of brain injury with neonatal repair of congenital heart defects.
Stroke
McQuillen PS, Barkovich AJ, Hamrick SE, Perez M, Ward P, Glidden DV, Azakie A, Karl T, Miller SP
DOI: 10.1161/01.str.0000247941.41234.90
PubMed: 17261728
02/2007

Neonatal Brain Injuries
Neurobiology of Disease
Steven P. Miller and Donna M. Ferriero
DOI: 10.1016/b978-012088592-3/50056-6
2007

The normal neonatal brain: MR imaging, diffusion tensor imaging, and 3D MR spectroscopy in healthy term neonates.
AJNR. American journal of neuroradiology
Bartha AI, Yap KR, Miller SP, Jeremy RJ, Nishimoto M, Vigneron DB, Barkovich AJ, Ferriero DM
DOI: 10.3174/ajnr.a0521
PubMed: 17569948
2007

Candidate gene polymorphisms do not differ between newborns with stroke and normal controls.
Stroke
Miller SP, Wu YW, Lee J, Lammer EJ, Iovannisci DM, Glidden DV, Bonifacio SL, Collins A, Shaw GM, Barkovich AJ, Ferriero DM
DOI: 10.1161/01.str.0000244810.91105.c9
PubMed: 17008620
11/2006

Does perinatal asphyxia impair cognitive function without cerebral palsy?
Archives of disease in childhood. Fetal and neonatal edition
Gonzalez FF, Miller SP
DOI: 10.1136/adc.2005.092445
PubMed: 17056843
11/2006

Prolonged indomethacin exposure is associated with decreased white matter injury detected with magnetic resonance imaging in premature newborns at 24 to 28 weeks' gestation at birth.
Pediatrics
Miller SP, Mayer EE, Clyman RI, Glidden DV, Hamrick SE, Barkovich AJ
DOI: 10.1542/peds.2005-1767
PubMed: 16651316
05/2006

Pyramidal tract maturation after brain injury in newborns with heart disease.
Annals of neurology
Partridge SC, Vigneron DB, Charlton NN, Berman JI, Henry RG, Mukherjee P, McQuillen PS, Karl TR, Barkovich AJ, Miller SP
DOI: 10.1002/ana.20772
PubMed: 16450369
04/2006

MR imaging, MR spectroscopy, and diffusion tensor imaging of sequential studies in neonates with encephalopathy.
AJNR. American journal of neuroradiology
Barkovich AJ, Miller SP, Bartha A, Newton N, Hamrick SE, Mukherjee P, Glenn OA, Xu D, Partridge JC, Ferriero DM, Vigneron DB
PubMed: 16551990
03/2006

Balloon atrial septostomy is associated with preoperative stroke in neonates with transposition of the great arteries.
Circulation
McQuillen PS, Hamrick SE, Perez MJ, Barkovich AJ, Glidden DV, Karl TR, Teitel D, Miller SP
DOI: 10.1161/circulationaha.105.566752
PubMed: 16401771
01/2006

Neonatal Encephalopathy
Current Therapy in Neurologic Disease
Steven P. Miller
DOI: 10.1016/b978-0-323-03432-6.50026-x
2006

Early brain injury in premature newborns detected with magnetic resonance imaging is associated with adverse early neurodevelopmental outcome.
The Journal of pediatrics
Miller SP, Ferriero DM, Leonard C, Piecuch R, Glidden DV, Partridge JC, Perez M, Mukherjee P, Vigneron DB, Barkovich AJ
DOI: 10.1016/j.jpeds.2005.06.033
PubMed: 16291350
11/2005

Quantitative diffusion tensor MRI fiber tractography of sensorimotor white matter development in premature infants.
NeuroImage
Berman JI, Mukherjee P, Partridge SC, Miller SP, Ferriero DM, Barkovich AJ, Vigneron DB, Henry RG
DOI: 10.1016/j.neuroimage.2005.05.018
PubMed: 15978841
10/2005

Tractography-based quantitation of diffusion tensor imaging parameters in white matter tracts of preterm newborns.
Journal of magnetic resonance imaging : JMRI
Partridge SC, Mukherjee P, Berman JI, Henry RG, Miller SP, Lu Y, Glenn OA, Ferriero DM, Barkovich AJ, Vigneron DB
DOI: 10.1002/jmri.20410
PubMed: 16161075
10/2005

Comparing microstructural and macrostructural development of the cerebral cortex in premature newborns: Diffusion tensor imaging versus cortical gyration
NeuroImage
Amy R. deIpolyi, Pratik Mukherjee, Kanwar Gill, Roland G. Henry, Savannah C. Partridge, Srivathsa Veeraraghavan, Hua Jin, Ying Lu, Steven P. Miller, Donna M. Ferriero, Daniel B. Vigneron, A. James Barkovich
DOI: 10.1016/j.neuroimage.2005.04.027
09/2005

Cerebral oxygen balance is impaired during repair of aortic coarctation in infants and children.
The Journal of thoracic and cardiovascular surgery
Azakie A, Muse J, Gardner M, Skidmore KL, Miller SP, Karl TR, McQuillen PS
DOI: 10.1016/j.jtcvs.2005.04.015
PubMed: 16153936
09/2005

Patterns of brain injury in term neonatal encephalopathy.
The Journal of pediatrics
Miller SP, Ramaswamy V, Michelson D, Barkovich AJ, Holshouser B, Wycliffe N, Glidden DV, Deming D, Partridge JC, Wu YW, Ashwal S, Ferriero DM
DOI: 10.1016/j.jpeds.2004.12.026
PubMed: 15812446
04/2005

Infant botulism, type F, presenting at 54 hours of life.
Pediatric neurology
Keet CA, Fox CK, Margeta M, Marco E, Shane AL, Dearmond SJ, Strober JB, Miller SP
DOI: 10.1016/j.pediatrneurol.2004.09.003
PubMed: 15730901
03/2005

Type I spinal muscular atrophy can mimic sensory-motor axonal neuropathy.
Journal of child neurology
Anagnostou E, Miller SP, Guiot MC, Karpati G, Simard L, Dilenge ME, Shevell MI
DOI: 10.1177/08830738050200022101
PubMed: 15794183
02/2005

Neonatal encephalopathy: association of cytokines with MR spectroscopy and outcome.
Pediatric research
Bartha AI, Foster-Barber A, Miller SP, Vigneron DB, Glidden DV, Barkovich AJ, Ferriero DM
DOI: 10.1203/01.pdr.0000144819.45689.bb
PubMed: 15496611
12/2004

Trends in severe brain injury and neurodevelopmental outcome in premature newborn infants: the role of cystic periventricular leukomalacia.
The Journal of pediatrics
Hamrick SE, Miller SP, Leonard C, Glidden DV, Goldstein R, Ramaswamy V, Piecuch R, Ferriero DM
DOI: 10.1016/j.jpeds.2004.05.042
PubMed: 15520756
11/2004

Single-shot fast spin-echo diffusion tensor imaging of the brain and spine with head and phased array coils at 1.5 T and 3.0 T.
Magnetic resonance imaging
Xu D, Henry RG, Mukherjee P, Carvajal L, Miller SP, Barkovich AJ, Vigneron DB
DOI: 10.1016/j.mri.2004.01.075
PubMed: 15234443
07/2004

Diffusion tensor imaging: serial quantitation of white matter tract maturity in premature newborns.
NeuroImage
Partridge SC, Mukherjee P, Henry RG, Miller SP, Berman JI, Jin H, Lu Y, Glenn OA, Ferriero DM, Barkovich AJ, Vigneron DB
DOI: 10.1016/j.neuroimage.2004.02.038
PubMed: 15219602
07/2004

Early laminar organization of the human cerebrum demonstrated with diffusion tensor imaging in extremely premature infants.
NeuroImage
Maas LC, Mukherjee P, Carballido-Gamio J, Veeraraghavan S, Miller SP, Partridge SC, Henry RG, Barkovich AJ, Vigneron DB
DOI: 10.1016/j.neuroimage.2004.02.035
PubMed: 15219585
07/2004

Perinatal stroke in term infants with neonatal encephalopathy.
Neurology
Ramaswamy V, Miller SP, Barkovich AJ, Partridge JC, Ferriero DM
DOI: 10.1212/01.wnl.0000129909.77753.c4
PubMed: 15184620
06/2004

Preoperative brain injury in newborns with transposition of the great arteries.
The Annals of thoracic surgery
Miller SP, McQuillen PS, Vigneron DB, Glidden DV, Barkovich AJ, Ferriero DM, Hamrick SE, Azakie A, Karl TR
DOI: 10.1016/j.athoracsur.2003.10.084
PubMed: 15111170
05/2004

Clinical signs predict 30-month neurodevelopmental outcome after neonatal encephalopathy.
American journal of obstetrics and gynecology
Miller SP, Latal B, Clark H, Barnwell A, Glidden D, Barkovich AJ, Ferriero DM, Partridge JC
DOI: 10.1016/s0002-9378(03)00908-6
PubMed: 14749642
01/2004

DTI-based three-dimensional tractography detects differences in the pyramidal tracts of infants and children with congenital hemiparesis.
Journal of magnetic resonance imaging : JMRI
Glenn OA, Henry RG, Berman JI, Chang PC, Miller SP, Vigneron DB, Barkovich AJ
DOI: 10.1002/jmri.10420
PubMed: 14635148
12/2003

Nucleated red blood cell counts: not associated with brain injury or outcome.
Pediatric neurology
Hamrick SE, Miller SP, Newton NR, Parer JT, Ferriero DM, Barkovich AJ, Partridge JC
DOI: 10.1016/s0887-8994(03)00266-2
PubMed: 14643387
10/2003

Comparing the diagnosis of white matter injury in premature newborns with serial MR imaging and transfontanel ultrasonography findings.
AJNR. American journal of neuroradiology
Miller SP, Cozzio CC, Goldstein RB, Ferriero DM, Partridge JC, Vigneron DB, Barkovich AJ
PubMed: 13679289
09/2003

Intraventricular hemorrhage in term neonates caused by sinovenous thrombosis.
Annals of neurology
Wu YW, Hamrick SE, Miller SP, Haward MF, Lai MC, Callen PW, Barkovich AJ, Ferriero DM
DOI: 10.1002/ana.10619
PubMed: 12838529
07/2003

Encephalopathy as a predictor of magnetic resonance imaging abnormalities in asphyxiated newborns.
Pediatric neurology
Kaufman SA, Miller SP, Ferriero DM, Glidden DH, Barkovich AJ, Partridge JC
DOI: 10.1016/s0887-8994(03)00015-8
PubMed: 12878294
05/2003

Serial quantitative diffusion tensor MRI of the premature brain: development in newborns with and without injury.
Journal of magnetic resonance imaging : JMRI
Miller SP, Vigneron DB, Henry RG, Bohland MA, Ceppi-Cozzio C, Hoffman C, Newton N, Partridge JC, Ferriero DM, Barkovich AJ
DOI: 10.1002/jmri.10205
PubMed: 12451575
12/2002

Multiple risk factors in neonatal sinovenous thrombosis.
Neurology
Wu YW, Miller SP, Chin K, Collins AE, Lomeli SC, Chuang NA, Barkovich AJ, Ferriero DM
DOI: 10.1212/wnl.59.3.438
PubMed: 12177381
08/2002

Predictors of 30-month outcome after perinatal depression: role of proton MRS and socioeconomic factors.
Pediatric research
Miller SP, Newton N, Ferriero DM, Partridge JC, Glidden DV, Barnwell A, Chuang NA, Vigneron DB, Barkovich AJ
DOI: 10.1203/00006450-200207000-00014
PubMed: 12084850
07/2002

Seizure-associated brain injury in term newborns with perinatal asphyxia.
Neurology
Miller SP, Weiss J, Barnwell A, Ferriero DM, Latal-Hajnal B, Ferrer-Rogers A, Newton N, Partridge JC, Glidden DV, Vigneron DB, Barkovich AJ
DOI: 10.1212/wnl.58.4.542
PubMed: 11865130
02/2002

The Newborn Brain: Neuroscience and Clinical Applications
Archives of Pediatric Adolescence Medicine
2002

Building Canada's health research capacity within the framework of the Canadian Institutes of Health Research.
Paediatrics & child health
Benzies KM, Barnes D, Clifford T, Bouayad A, Hardy D, Korneluk Y, Marrache AM, McCusker C, Miller S, Ring T, Walker M, Waterhouse C
DOI: 10.1093/pch/6.8.517
PubMed: 20084120
10/2001

Diagnostic profile of neonatal hypotonia: an 11-year study.
Pediatric neurology
Richer LP, Shevell MI, Miller SP
DOI: 10.1016/s0887-8994(01)00277-6
PubMed: 11483393
07/2001

Neuromotor spectrum of periventricular leukomalacia in children born at term.
Pediatric neurology
Miller SP, Shevell MI, Patenaude Y, O'Gorman AM
DOI: 10.1016/s0887-8994(00)00172-7
PubMed: 11020641
08/2000

Recurrent artery of Heubner infarction in infancy.
Developmental medicine and child neurology
Miller SP, O'Gorman AM, Shevell MI
DOI: 10.1017/s0012162200000608
PubMed: 10855656
05/2000

Neuronal dysfunction in children with newly diagnosed temporal lobe epilepsy.
Pediatric neurology
Miller SP, Li LM, Cendes F, Caramanos Z, Rosenblatt B, Shevell MI, Andermann F, Arnold DL
DOI: 10.1016/s0887-8994(99)00159-9
PubMed: 10788744
04/2000

Septo-optic dysplasia plus: a spectrum of malformations of cortical development.
Neurology
Miller SP, Shevell MI, Patenaude Y, Poulin C, O'Gorman AM
DOI: 10.1212/wnl.54.8.1701
PubMed: 10762523
04/2000

Medial temporal lobe neuronal damage in temporal and extratemporal lesional epilepsy.
Neurology
Miller SP, Li LM, Cendes F, Tasch E, Andermann F, Dubeau F, Arnold DL
DOI: 10.1212/wnl.54.7.1465
PubMed: 10751259
04/2000

Treatment of acute disseminated encephalomyelitis with intravenous immunoglobulin.
Neurology
Sahlas DJ, Miller SP, Guerin M, Veilleux M, Francis G
DOI: 10.1212/wnl.54.6.1370
PubMed: 10746613
03/2000

Neonatal neurologic prognostication: the asphyxiated term newborn.
Pediatric neurology
Shevell MI, Majnemer A, Miller SP
DOI: 10.1016/s0887-8994(99)00102-2
PubMed: 10593666
11/1999

Neonatal seizures: unusual causes.
Seminars in pediatric neurology
Miller SP, Shevell MI
DOI: 10.1016/s1071-9091(99)80002-3
PubMed: 10522328
09/1999

The neonatal presentation of Prader-Willi syndrome revisited.
The Journal of pediatrics
Miller SP, Riley P, Shevell MI
DOI: 10.1016/s0022-3476(99)70420-8
PubMed: 9931534
02/1999

Tuberous sclerosis complex and neonatal seizures.
Journal of child neurology
Miller SP, Tasch T, Sylvain M, Farmer JP, O'Gorman AM, Shevell MI
DOI: 10.1177/088307389801301205
PubMed: 9881532
12/1998

Spastic paraplegia, optic atrophy, microcephaly with normal intelligence, and XY sex reversal: a new autosomal recessive syndrome?
Journal of Medical Genetics
A S Teebi, S Miller, H Ostrer, P Eydoux, C Colomb-Brockmann, K Oudjhane, G Watters
DOI: 10.1136/jmg.35.9.759
09/1998

Infantile epileptic encephalopathy (Ohtahara syndrome) and migrational disorder.
Pediatric neurology
Miller SP, Dilenge ME, Meagher-Villemure K, O'Gorman AM, Shevell MI
DOI: 10.1016/s0887-8994(98)00009-5
PubMed: 9682886
07/1998

Congenital bilateral perisylvian polymicrogyria presenting as congenital hemiplegia.
Neurology
Miller SP, Shevell M, Rosenblatt B, Silver K, O'Gorman A, Andermann F
DOI: 10.1212/wnl.50.6.1866
PubMed: 9633745
06/1998

The diagnostic yield of the nerve–muscle skin biopsy in paediatric neurology practice
Pediatric Rehabilitation
S. Miller, M. Shevell, K. Silver, M. Kramer
DOI: 10.3109/17518429809068161
01/1998

Aberrant Internal Carotid Artery Presenting in the Midline Retropharyngeal Space: Case Report
Canadian Association of Radiologists Journal
PubMed: 9030067
1997

Research

Current Projects
Advances in magnetic resonance (MR) technology allow for brain development and injury to be studied safely in critically ill newborns. MR imaging (MRI) is a sensitive tool to measure brain structure and injury. In particular, deformation morphometry, diffusion tensor imaging, and MR spectroscopic imaging, can be used to quantify brain structure, microstructure and metabolism. Using advanced magnetic resonance (MR) techniques, as well as bedside brain monitoring, such as amplitude integrated EEG and near infra-red spectroscopy, we study brain development and injury in vulnerable populations of newborns.

Abnormal brain development and injury in premature newborns

In 2003 in British Columbia, more than 5% of all newborns were born prematurely and/or at low birth weight. These children are at very high risk for developmental delays: 5-10% of low birth-weight children exhibit major motor deficits and 25-50% exhibit significant developmental and visual deficits. The most important brain pathology associated with these deficits is injury to the white matter. Our study is characterizing the consequences of abnormal brain development and white matter injury in the premature newborn, including how delayed brain development results in impaired motor and cognitive function. This study builds on our earlier observations that: 1) brain injury in premature newborns is safely detected with MRI before term-equivalent age; 2) focal non-cystic white matter injury is the characteristic pattern of injury in the premature newborn; 3) early brain injury is associated with adverse early neurodevelopmental outcome; and 4) brain injury in the immature brain impairs subsequent brain development.

Brain Injury in Newborns with Congenital Heart Disease

Developmental deficits in children with congenital heart disease are a serious problem and may be seen in more than one third of affected newborns. However, the reasons for these developmental deficits remain unknown and may occur prior to, during or following their cardiac surgery. In this study we are investigating the timing and severity of brain injury in newborns with congenital heart disease using advanced MR imaging techniques in utero, shortly before open-heart surgery and again soon after surgery. As newborns with congenital heart disease, like premature newborns, are also specifically vulnerable to white matter injury, studying these two populations allows us to explore shared mechanisms of white matter injury. Knowing the mechanisms and timing of brain injury in newborns with heart disease will be important for the rational design of studies to evaluate emerging strategies to protect the developing brain from injury.

Many physicians consider brain injury to be the major remaining challenge in caring for critically ill newborns. The ability of advanced MR brain imaging techniques to detect which newborns have abnormalities of the brain will help parents and physicians better care for these critically ill infants. The longer-term goal of my research program will be to test new strategies to prevent brain injury in the human newborn. The advanced MR techniques I am applying in this research program provide us with powerful surrogate markers of brain injury that will allow us to monitor the effect of novel strategies to protect the brain from injury.

Grants

CIHR Operating Grant – Project: "Analgesia and sedation in the preterm neonate: brain development and outcome" (2014-2020)

Honours & Awards

Tier 2 Canada Research Chair in Neonatal Neuroscience - 2010-2015

President Elect, Society for Pediatric Research 2012

Bloorview Children's Hospital Foundation Chair in Paediatric Neuroscience 2012

Research Group Members

Emily Gardiner
Anton R Miller, Investigator, BC Children's Hospital
Jane Shen