Overview

As a pediatric electrophysiologist, my research focuses on the rhythm of the heart. Disturbances in the rhythm of the heart, or arrhythmias, can occur in otherwise healthy children or in children with heart disease. My research aims to improve the outcome of children who have arrhythmias.

Many potentially lethal conditions affecting the heart rhythm are inherited and I work on heritable conditions causing arrhythmias. This research involves collaborations with clinician and basic scientists from all over the world to improve our understanding of inherited heart rhythm disorders.

Publications

Polymorphic ventricular tachycardia associated with an episode of reflex syncope: is this the needle in the haystack?
HeartRhythm Case Reports
Matthew A. Tester and Brooke C.D. Hockin and Thuso David and Sonia Franciosi and Kevin Harris and Victoria E. Claydon and Shubhayan Sanatani
DOI: 10.1016/j.hrcr.2018.07.013
08/2018

Predictors of ECG Screening Failure for the Subcutaneous Implantable Cardioverter Defibrillator in Children. A Prospective Multi-Center Study.
Heart rhythm
Campbell M, Moore JP, Sreeram N, von Alvensleben JC, Shah A, Batra A, Law I, Sanatani S, Thomas V, Nik-Ahd F, Williams S, Nosavan N, Maldonado J, Balaji S
DOI: 10.1016/j.hrthm.2018.01.004
PubMed: 29309839
01/2018

The 2017 Seventh World Congress of Pediatric Cardiology & Cardiac Surgery: Week in review: electrophysiology.
Cardiology in the young
Cohen MI, Etheridge S, Sanatani S, Celiker A
DOI: 10.1017/s1047951117002268
PubMed: 29286280
12/2017

Functional characterization of a novel hERG variant in a family with recurrent sudden infant death syndrome: Retracting a genetic diagnosis.
Forensic science international
Sergeev V, Perry F, Roston TM, Sanatani S, Tibbits GF, Claydon TW
DOI: 10.1016/j.forsciint.2017.12.028
PubMed: 29331839
12/2017

The Safety and Effectiveness of Flecainide in Children in the Current Era.
Pediatric cardiology
Cunningham T, Uzun O, Morris R, Franciosi S, Wong A, Jeremiasen I, Sherwin E, Sanatani S
DOI: 10.1007/s00246-017-1707-5
PubMed: 28840327
12/2017

Response Letter to 'Optimising physiology for adolescents with dysautonomia'.
Acta paediatrica (Oslo, Norway : 1992)
Armstrong KR, De Souza AM, Sneddon PL, Potts JE, Claydon VE, Sanatani S
DOI: 10.1111/apa.14058
PubMed: 28906019
12/2017

The accessibility and utilization of genetic testing for inherited heart rhythm disorders: a Canadian cross-sectional survey study.
Journal of community genetics
Roston TM, Dewar L, Franciosi S, Hathaway J, Bartels K, Cunningham T, Gibbs KA, Sheps S, Laksman ZWM, Sanatani S, Krahn AD
DOI: 10.1007/s12687-017-0348-y
PubMed: 29170972
11/2017

Differential calcium sensitivity in NaV 1.5 mixed syndrome mutants.
The Journal of physiology
Abdelsayed M, Baruteau AE, Gibbs K, Sanatani S, Krahn AD, Probst V, Ruben PC
DOI: 10.1113/jp274536
PubMed: 28734073
09/2017

Loss-of-Function KCNE2 Variants: True Monogenic Culprits of Long-QT Syndrome or Proarrhythmic Variants Requiring Secondary Provocation?
Circulation. Arrhythmia and electrophysiology
Roberts JD, Krahn AD, Ackerman MJ, Rohatgi RK, Moss AJ, Nazer B, Tadros R, Gerull B, Sanatani S, Wijeyeratne YD, Baruteau AE, Muir AR, Pang B, Scheinman MM
DOI: 10.1161/circep.117.005282
PubMed: 28794082
08/2017

Investigating the Genetic Causes of Sudden Unexpected Death in Children Through Targeted Next-Generation Sequencing Analysis.
Circulation. Cardiovascular genetics
Dewar LJ, Alcaide M, Fornika D, D'Amato L, Shafaatalab S, Stevens CM, Balachandra T, Phillips SM, Sanatani S, Morin RD, Tibbits GF
DOI: 10.1161/circgenetics.116.001738
PubMed: 28807990
08/2017

The role of the autonomic nervous system in arrhythmias and sudden cardiac death.
Autonomic neuroscience : basic & clinical
Franciosi S, Perry FKG, Roston TM, Armstrong KR, Claydon VE, Sanatani S
DOI: 10.1016/j.autneu.2017.03.005
PubMed: 28392310
07/2017

KCNQ1 p.L353L affects splicing and modifies the phenotype in a founder population with long QT syndrome type 1.
Journal of medical genetics
Kapplinger JD, Erickson A, Asuri S, Tester DJ, McIntosh S, Kerr CR, Morrison J, Tang A, Sanatani S, Arbour L, Ackerman MJ
DOI: 10.1136/jmedgenet-2016-104153
PubMed: 28264985
06/2017

Exercise and the multidisciplinary holistic approach to adolescent dysautonomia.
Acta Paediatrica (Oslo, Norway : 1992)
Armstrong KR, De Souza AM, Sneddon PL, Potts JE, Claydon VE, Sanatani S
DOI: 10.1111/apa.13750
PubMed: 28112424
04/2017

Canadian Cardiovascular Society and Canadian Pediatric Cardiology Association Position Statement on the Approach to Syncope in the Pediatric Patient.
The Canadian Journal of Cardiology
Sanatani S, Chau V, Fournier A, Dixon A, Blondin R, Sheldon RS
DOI: 10.1016/j.cjca.2016.09.006
PubMed: 27838109
02/2017

Catecholaminergic polymorphic ventricular tachycardia: a model for genotype-specific therapy.
Current opinion in cardiology
Roston TM, Van Petegem F, Sanatani S
DOI: 10.1097/hco.0000000000000360
PubMed: 27861184
01/2017

Advances in the diagnosis and treatment of catecholaminergic polymorphic ventricular tachycardia.
Cardiology in the young
Roston TM, Cunningham TC, Sanatani S
DOI: 10.1017/s1047951116002237
PubMed: 28084961
01/2017

Morbidities in the ultra-athlete and marathoner.
Cardiology in the young
Cunningham TC, Maghrabi K, Sanatani S
DOI: 10.1017/s1047951116002304
PubMed: 28084966
01/2017

Novel Variant in the ANK2 Membrane-Binding Domain Is Associated With Ankyrin-B Syndrome and Structural Heart Disease in a First Nations Population With a High Rate of Long QT Syndrome.
Circulation. Cardiovascular genetics
Swayne LA, Murphy NP, Asuri S, Chen L, Xu X, McIntosh S, Wang C, Lancione PJ, Roberts JD, Kerr C, Sanatani S, Sherwin E, Kline CF, Zhang M, Mohler PJ, Arbour LT
DOI: 10.1161/circgenetics.116.001537
PubMed: 28196901
01/2017

The clinical and genetic spectrum of catecholaminergic polymorphic ventricular tachycardia: findings from an international multicentre registry.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
Roston TM, Yuchi Z, Kannankeril PJ, Hathaway J, Vinocur JM, Etheridge SP, Potts JE, Maginot KR, Salerno JC, Cohen MI, Hamilton RM, Pflaumer A, Sanatani S
DOI: 10.1093/europace/euw389
PubMed: 28158428
01/2017

Genetic Insurance Discrimination in Sudden Arrhythmia Death Syndromes: Empirical Evidence From a Cross-Sectional Survey in North America.
Circulation. Cardiovascular genetics
Mohammed S, Lim Z, Dean PH, Potts JE, Tang JN, Etheridge SP, Lara A, Husband P, Sherwin ED, Ackerman MJ, Sanatani S
DOI: 10.1161/circgenetics.116.001442
PubMed: 28119333
01/2017

Suppression-of-function mutations in the cardiac ryanodine receptor: Emerging evidence for a novel arrhythmia syndrome?
Heart rhythm
Roston TM, Sanatani S, Chen SR
DOI: 10.1016/j.hrthm.2016.11.004
PubMed: 27818320
01/2017

Beyond the Electrocardiogram: Mutations in Cardiac Ion Channel Genes Underlie Nonarrhythmic Phenotypes.
Clinical Medicine Insights. Cardiology
Roston TM, Cunningham T, Lehman A, Laksman ZW, Krahn AD, Sanatani S
DOI: 10.1177/1179546817698134
PubMed: 28469493
2017

A novel RYR2 loss-of-function mutation (I4855M) is associated with left ventricular non-compaction and atypical catecholaminergic polymorphic ventricular tachycardia.
Journal of electrocardiology
Roston TM, Guo W, Krahn AD, Wang R, Van Petegem F, Sanatani S, Chen SR, Lehman A
DOI: 10.1016/j.jelectrocard.2016.09.006
PubMed: 27646203
2017

The Canadian Arrhythmogenic Right Ventricular Cardiomyopathy Registry: Rationale, Design, and Preliminary Recruitment.
The Canadian Journal of Cardiology
Krahn AD, Healey JS, Gerull B, Angaran P, Chakrabarti S, Sanatani S, Arbour L, Laksman ZW, Carroll SL, Seifer C, Green M, Roberts JD, Talajic M, Gardner M
DOI: 10.1016/j.cjca.2016.04.004
PubMed: 27474350
12/2016

Ischemia-reperfusion destabilizes rhythmicity in immature atrioventricular pacemakers: A predisposing factor for postoperative arrhythmias in neonate rabbits.
Heart rhythm
Chenliu C, Sheng X, Dan P, Qu Y, Claydon VE, Lin E, Hove-Madsen L, Sanatani S, Tibbits GF
DOI: 10.1016/j.hrthm.2016.07.022
PubMed: 27451283
12/2016

Management of Gene-Positive Catecholaminergic Polymorphic Ventricular Tachycardia: Are the Long Term Outcomes on Therapy Really So Poor?
Circulation journal : official journal of the Japanese Circulation Society
Roston TM, Sanatani S
DOI: 10.1253/circj.cj-16-0842
PubMed: 27840378
11/2016

Use of dofetilide in adult patients with atrial arrhythmias and congenital heart disease: A PACES collaborative study.
Heart rhythm
El-Assaad I, Al-Kindi SG, Abraham J, Sanatani S, Bradley DJ, Halsey C, Law IH, Balaji S, Shetty I, Aziz PF
DOI: 10.1016/j.hrthm.2016.07.016
PubMed: 27435587
10/2016

A Clinical Risk Score to Improve the Diagnosis of Tachycardia-Induced Cardiomyopathy in Childhood.
The American journal of cardiology
Moore JP, Wang S, Albers EL, Salerno JC, Stephenson EA, Shah MJ, Pflaumer A, Czosek RJ, Garnreiter JM, Collins K, Papez AL, Sanatani S, Cain NB, Shannon KM
DOI: 10.1016/j.amjcard.2016.07.008
PubMed: 27515893
10/2016

Cardiac Abnormalities in First-Degree Relatives of Unexplained Cardiac Arrest Victims: A Report From the Cardiac Arrest Survivors With Preserved Ejection Fraction Registry.
Circulation. Arrhythmia and electrophysiology
Steinberg C, Padfield GJ, Champagne J, Sanatani S, Angaran P, Andrade JG, Roberts JD, Healey JS, Chauhan VS, Birnie DH, Janzen M, Gerull B, Klein GJ, Krahn AD
DOI: 10.1161/circep.115.004274
PubMed: 27635072
09/2016

Recommendations for genetic testing to reduce the incidence of anthracycline-induced cardiotoxicity.
British journal of clinical pharmacology
Aminkeng F, Ross CJ, Rassekh SR, Hwang S, Rieder MJ, Bhavsar AP, Smith A, Sanatani S, Gelmon KA, Bernstein D, Hayden MR, Amstutz U, Carleton BC, CPNDS Clinical Practice Recommendations Group
DOI: 10.1111/bcp.13008
PubMed: 27197003
09/2016

Pediatric & Congenital Electrophysiology Society: building an international paediatric electrophysiology organisation.
Cardiology in the young
Cohen M, Sanatani S, Stephenson E, Skinner J, Drago F, Davis A, Janousek J, Rosenthal E, Collins KK, Triedman J
DOI: 10.1017/s1047951115002553
PubMed: 27075202
08/2016

Congenital heart disease confounding the diagnosis of arrhythmogenic right ventricular cardiomyopathy.
HeartRhythm case reports
Kiamanesh O, Farhan M, Sanatani S, Grosse-Wortmann L, Duncan W, Hamilton RM
DOI: 10.1016/j.hrcr.2016.01.007
PubMed: 28491693
07/2016

Pediatric & Congenital Electrophysiology Society: building an international paediatric electrophysiology organisation.
Heart rhythm
Cohen M, Sanatani S, Stephenson E, Skinner J, Drago F, Davis A, Janousek J, Rosenthal E, Collins KK, Triedman J
DOI: 10.1016/j.hrthm.2016.01.013
PubMed: 27090729
05/2016

Response to Letter Regarding Article, "Outcome of Apparently Unexplained Cardiac Arrest: Results From Investigation and Follow-Up of the Prospective Cardiac Arrest Survivors With Preserved Ejection Fraction Registry".
Circulation. Arrhythmia and electrophysiology
Herman AR, Cheung C, Gerull B, Simpson CS, Birnie DH, Klein GJ, Champagne J, Healey JS, Gibbs K, Talajic M, Gardner M, Bennett MT, Steinberg C, Krahn AD
DOI: 10.1161/circep.116.004012
PubMed: 27069091
04/2016

Exercise and Inherited Arrhythmias.
The Canadian journal of cardiology
Cheung CC, Laksman ZW, Mellor G, Sanatani S, Krahn AD
DOI: 10.1016/j.cjca.2016.01.007
PubMed: 26927864
04/2016

Characterization of Myocardial Repolarization Reserve in Adolescent Females With Anorexia Nervosa.
Circulation
Padfield GJ, Escudero CA, DeSouza AM, Steinberg C, Gibbs K, Puyat JH, Lam PY, Sanatani S, Sherwin E, Potts JE, Sandor G, Krahn AD
DOI: 10.1161/circulationaha.115.016697
PubMed: 26769740
02/2016

Evaluation and management of bradycardia in neonates and children.
European journal of pediatrics
Baruteau AE, Perry JC, Sanatani S, Horie M, Dubin AM
DOI: 10.1007/s00431-015-2689-z
PubMed: 26780751
02/2016

Flecainide monotherapy is an option for selected patients with catecholaminergic polymorphic ventricular tachycardia intolerant of ß-blockade.
Heart rhythm
Padfield GJ, AlAhmari L, Lieve KV, AlAhmari T, Roston TM, Wilde AA, Krahn AD, Sanatani S
DOI: 10.1016/j.hrthm.2015.09.027
PubMed: 26416620
02/2016

Changes in QTc associated with a rapid bolus dose of dexmedetomidine in patients receiving TIVA: a retrospective study.
Paediatric anaesthesia
Görges M, Whyte SD, Sanatani S, Dawes J, Montgomery CJ, Ansermino JM
DOI: 10.1111/pan.12780
PubMed: 26507917
12/2015

Choking-induced cardiac arrest unmasks a diagnosis of catecholaminergic polymorphic ventricular tachycardia.
HeartRhythm case reports
Roston TM, AlAhmari L, Krahn AD, Sherwin E, Sanatani S
DOI: 10.1016/j.hrcr.2015.08.007
PubMed: 28491614
11/2015

Catecholaminergic polymorphic ventricular tachycardia in children: analysis of therapeutic strategies and outcomes from an international multicenter registry.
Circulation. Arrhythmia and electrophysiology
Roston TM, Vinocur JM, Maginot KR, Mohammed S, Salerno JC, Etheridge SP, Cohen M, Hamilton RM, Pflaumer A, Kanter RJ, Potts JE, LaPage MJ, Sanatani S
DOI: 10.1161/circep.114.002217
PubMed: 25713214
06/2015

Should early extubation be the goal for children after congenital cardiac surgery?
The Journal of thoracic and cardiovascular surgery
Harris KC, Holowachuk S, Pitfield S, Sanatani S, Froese N, Potts JE, Gandhi SK
DOI: 10.1016/j.jtcvs.2014.06.093
PubMed: 25156467
12/2014

Paediatric patient family engagement with clinical research at a tertiary care paediatric hospital.
Paediatrics & Child Health
Gill C, Ansermino MJ, Sanatani S, Mulpuri K, Doan Q
PubMed: 25587233
12/2014

Evaluation of genes encoding for the transient outward current (Ito) identifies the KCND2 gene as a cause of J-wave syndrome associated with sudden cardiac death.
Circulation. Cardiovascular genetics
Perrin MJ, Adler A, Green S, Al-Zoughool F, Doroshenko P, Orr N, Uppal S, Healey JS, Birnie D, Sanatani S, Gardner M, Champagne J, Simpson C, Gollob MH
DOI: 10.1161/circgenetics.114.000623
PubMed: 25214526
12/2014

The safety of modern anesthesia for children with long QT syndrome.
Anesthesia and analgesia
Whyte SD, Nathan A, Myers D, Watkins SC, Kannankeril PJ, Etheridge SP, Andrade J, Collins KK, Law IH, Hayes J, Sanatani S
DOI: 10.1213/ane.0000000000000389
PubMed: 25076102
10/2014

Current management of focal atrial tachycardia in children: a multicenter experience.
Circulation. Arrhythmia and electrophysiology
Kang KT, Etheridge SP, Kantoch MJ, Tisma-Dupanovic S, Bradley DJ, Balaji S, Hamilton RM, Singh AK, Cannon BC, Schaffer MS, Potts JE, Sanatani S
DOI: 10.1161/circep.113.001423
PubMed: 25015944
08/2014

An international multicenter study comparing arrhythmia prevalence between the intracardiac lateral tunnel and the extracardiac conduit type of Fontan operations.
The Journal of thoracic and cardiovascular surgery
Balaji S, Daga A, Bradley DJ, Etheridge SP, Law IH, Batra AS, Sanatani S, Singh AK, Gajewski KK, Tsao S, Singh HR, Tisma-Dupanovic S, Tateno S, Shah M
DOI: 10.1016/j.jtcvs.2013.08.070
PubMed: 24172692
08/2014

Permanent junctional reciprocating tachycardia in children: a multicenter experience.
Heart rhythm
Kang KT, Potts JE, Radbill AE, La Page MJ, Papagiannis J, Garnreiter JM, Kubus P, Kantoch MJ, Von Bergen NH, Fournier A, Côté JM, Paul T, Sanatani S
DOI: 10.1016/j.hrthm.2014.04.033
PubMed: 24769425
08/2014

Nonuniform and variable arrangements of ryanodine receptors within mammalian ventricular couplons.
Circulation research
Asghari P, Scriven DR, Sanatani S, Gandhi SK, Campbell AI, Moore ED
DOI: 10.1161/circresaha.115.303897
PubMed: 24786399
07/2014

Predictors of myocardial recovery in pediatric tachycardia-induced cardiomyopathy.
Heart rhythm
Moore JP, Patel PA, Shannon KM, Albers EL, Salerno JC, Stein MA, Stephenson EA, Mohan S, Shah MJ, Asakai H, Pflaumer A, Czosek RJ, Everitt MD, Balaji S
DOI: 10.1016/j.hrthm.2014.04.023
PubMed: 24751393
07/2014

Procainamide infusion in the evaluation of unexplained cardiac arrest: from the Cardiac Arrest Survivors with Preserved Ejection Fraction Registry (CASPER).
Heart rhythm
Somani R, Krahn AD, Healey JS, Chauhan VS, Birnie DH, Champagne J, Sanatani S, Angaran P, Gow RM, Chakrabarti S, Gerull B, Yee R, Skanes AC, Gula LJ, Simpson CS
DOI: 10.1016/j.hrthm.2014.03.022
PubMed: 24657429
06/2014

Evolution of clinical diagnosis in patients presenting with unexplained cardiac arrest or syncope due to polymorphic ventricular tachycardia.
Heart rhythm
Vittoria Matassini M, Krahn AD, Gardner M, Champagne J, Sanatani S, Birnie DH, Gollob MH, Chauhan V, Simpson CS, Hamilton RM, Talajic M, Ahmad K, Healey JS
DOI: 10.1016/j.hrthm.2013.11.008
PubMed: 24239842
02/2014

Electrocardiogram interpretation by Canadian general paediatricians: Examining practice, accuracy and confidence.
Paediatrics & Child Health
Escudero CA, Sanatani S, Wong KK, Templeton CG
DOI: 10.1093/pch/19.2.77
PubMed: 24596480
02/2014

Reply to letter from Nair et al.--anatomical considerations for cardiac resynchronization therapy in transposition of the great arteries.
The Canadian journal of cardiology
Escudero C, Khairy P, Sanatani S
DOI: 10.1016/j.cjca.2013.09.027
PubMed: 24290863
02/2014

TMEM43 mutations associated with arrhythmogenic right ventricular cardiomyopathy in non-Newfoundland populations.
Human genetics
Baskin B, Skinner JR, Sanatani S, Terespolsky D, Krahn AD, Ray PN, Scherer SW, Hamilton RM
DOI: 10.1007/s00439-013-1323-2
PubMed: 23812740
11/2013

Lone atrial fibrillation in the pediatric population.
The Canadian Journal of Cardiology
Mills LC, Gow RM, Myers K, Kantoch MJ, Gross GJ, Fournier A, Sanatani S
DOI: 10.1016/j.cjca.2013.06.014
PubMed: 24074972
10/2013

Physical activity recommendations for patients with electrophysiologic and structural congenital heart disease: a survey of Canadian health care providers.
Pediatric cardiology
Roston TM, De Souza AM, Sandor GG, Sanatani S, Potts JE
DOI: 10.1007/s00246-013-0654-z
PubMed: 23435716
08/2013

Electrophysiologic considerations in congenital heart disease and their relationship to heart failure.
The Canadian Journal of Cardiology
Escudero C, Khairy P, Sanatani S
DOI: 10.1016/j.cjca.2013.02.016
PubMed: 23642334
07/2013

Fascicular and nonfascicular left ventricular tachycardias in the young: an international multicenter study.
Journal of cardiovascular electrophysiology
Collins KK, Schaffer MS, Liberman L, Saarel E, Knecht M, Tanel RE, Bradley D, Dubin AM, Paul T, Salerno J, Bar-Cohen Y, Sreeram N, Sanatani S, Pediatric and Congenital Electrophysiology Society
DOI: 10.1111/jce.12105
PubMed: 23437865
06/2013

Failure rate of the Riata lead under advisory: a report from the CHRS Device Committee.
Heart rhythm
Parkash R, Exner D, Champagne J, Mangat I, Thibault B, Healey JS, Tung S, Crystal E, Simpson C, Nery PB, Sterns L, Connors S, Cameron D, Verma A, Krahn A
DOI: 10.1016/j.hrthm.2013.01.018
PubMed: 23333722
05/2013

Inherited heart rhythm disease: negotiating the minefield for the practicing cardiologist.
The Canadian Journal of Cardiology
Krahn AD, Sanatani S, Gardner MJ, Arbour L
DOI: 10.1016/j.cjca.2012.11.009
PubMed: 23261322
01/2013

Assessment of genetic causes of cardiac arrest.
The Canadian Journal of Cardiology
Bennett MT, Sanatani S, Chakrabarti S, Deyell MW, Krahn AD
DOI: 10.1016/j.cjca.2012.07.002
PubMed: 23200097
01/2013

Postnatal outcome in patients with fetal tachycardia.
Pediatric cardiology
Moodley S, Sanatani S, Potts JE, Sandor GG
DOI: 10.1007/s00246-012-0392-7
PubMed: 22639009
01/2013

The medical management of pediatric arrhythmias.
Current treatment options in cardiovascular medicine
Escudero C, Carr R, Sanatani S
DOI: 10.1007/s11936-012-0194-5
PubMed: 22907424
10/2012

The study of antiarrhythmic medications in infancy (SAMIS): a multicenter, randomized controlled trial comparing the efficacy and safety of digoxin versus propranolol for prophylaxis of supraventricular tachycardia in infants.
Circulation. Arrhythmia and electrophysiology
Sanatani S, Potts JE, Reed JH, Saul JP, Stephenson EA, Gibbs KA, Anderson CC, Mackie AS, Ro PS, Tisma-Dupanovic S, Kanter RJ, Batra AS, Fournier A, Etheridge SP
DOI: 10.1161/circep.112.972620
PubMed: 22962431
10/2012

Epinephrine infusion in the evaluation of unexplained cardiac arrest and familial sudden death: from the cardiac arrest survivors with preserved Ejection Fraction Registry.
Circulation. Arrhythmia and electrophysiology
Krahn AD, Healey JS, Chauhan VS, Birnie DH, Champagne J, Sanatani S, Ahmad K, Ballantyne E, Gerull B, Yee R, Skanes AC, Gula LJ, Leong-Sit P, Gardner M
DOI: 10.1161/circep.112.973230
PubMed: 22944906
10/2012

Biophysical properties of the aorta and left ventricle and exercise capacity in obese children.
The American journal of cardiology
Harris KC, Al Saloos HA, De Souza AM, Sanatani S, Hinchliffe M, Potts JE, Sandor GG
DOI: 10.1016/j.amjcard.2012.05.019
PubMed: 22728002
09/2012

Neuroblastoma masquerading as supraventricular tachycardia: a case of super sinus tachycardia.
Archives of disease in childhood
Harris KC, Retallack JE, Sanatani S
DOI: 10.1136/archdischild-2011-301327
PubMed: 22267393
06/2012

Congenital long QT 3 in the pediatric population.
The American journal of cardiology
Blaufox AD, Tristani-Firouzi M, Seslar S, Sanatani S, Trivedi B, Fischbach P, Paul T, Young ML, Tisma-Dupanovic S, Silva J, Cuneo B, Fournier A, Etheridge SP
DOI: 10.1016/j.amjcard.2012.01.361
PubMed: 22360817
05/2012

Sentinel symptoms in patients with unexplained cardiac arrest: from the cardiac arrest survivors with preserved ejection fraction registry (CASPER).
Journal of cardiovascular electrophysiology
Krahn AD, Healey JS, Simpson CS, Chauhan VS, Birnie DH, Champagne J, Gardner M, Sanatani S, Chakrabarti S, Yee R, Skanes AC, Leong-Sit P, Ahmad K, Sheldon RS
DOI: 10.1111/j.1540-8167.2011.02185.x
PubMed: 21955300
01/2012

Recurrent congestive heart failure in a child due to probable myocarditis.
Pediatric cardiology
Lee AF, Chiasson DA, Smythe JF, Sanatani S
DOI: 10.1007/s00246-011-0109-3
PubMed: 21910020
01/2012

Normal Tp-e values in children.
Anesthesia and analgesia
Sanatani S, Whyte S
DOI: 10.1213/ane.0b013e31823554ac
PubMed: 22184612
01/2012

Postexertional supraventricular tachycardia in children with catecholaminergic polymorphic ventricular tachycardia.
Case reports in cardiology
Else SD, Potts JE, Sanatani S
DOI: 10.1155/2012/329097
PubMed: 24826246
2012

Assessing the knowledge of sudden unexpected death in the young among Canadian medical students and recent graduates: a cross-sectional study.
BMJ open
Huisma FF, Potts JE, Gibbs KA, Sanatani S
DOI: 10.1136/bmjopen-2012-001798
PubMed: 23242483
2012

Isolation and characterization of atrioventricular nodal cells from neonate rabbit heart.
Circulation. Arrhythmia and electrophysiology
Ye Sheng X, Qu Y, Dan P, Lin E, Korthout L, Bradford A, Hove-Madsen L, Sanatani S, Tibbits GF
DOI: 10.1161/circep.111.964056
PubMed: 22002995
12/2011

Prevalence and characteristics of early repolarization in the CASPER registry: cardiac arrest survivors with preserved ejection fraction registry.
Journal of the American College of Cardiology
Derval N, Simpson CS, Birnie DH, Healey JS, Chauhan V, Champagne J, Gardner M, Sanatani S, Yee R, Skanes AC, Gula LJ, Leong-Sit P, Ahmad K, Krahn AD
DOI: 10.1016/j.jacc.2011.04.022
PubMed: 21816308
08/2011

Long QT syndrome.
CMAJ : Canadian Medical Association Journal
Jackson H, Huisman LA, Sanatani S, Arbour LT
DOI: 10.1503/cmaj.100138
PubMed: 21482651
08/2011

A novel mechanism for LQT3 with 2:1 block: a pore-lining mutation in Nav1.5 significantly affects voltage-dependence of activation.
Heart rhythm
Horne AJ, Eldstrom J, Sanatani S, Fedida D
DOI: 10.1016/j.hrthm.2010.12.041
PubMed: 21193062
05/2011

Severe amiodarone-induced hypothyroidism in an infant.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Trudel K, Sanatani S, Panagiotopoulos C
DOI: 10.1097/pcc.0b013e3181e2a388
PubMed: 20453707
01/2011

Recommendations for the use of genetic testing in the clinical evaluation of inherited cardiac arrhythmias associated with sudden cardiac death: Canadian Cardiovascular Society/Canadian Heart Rhythm Society joint position paper.
The Canadian Journal of Cardiology
Gollob MH, Blier L, Brugada R, Champagne J, Chauhan V, Connors S, Gardner M, Green MS, Gow R, Hamilton R, Harris L, Healey JS, Hodgkinson K, Woo A
DOI: 10.1016/j.cjca.2010.12.078
PubMed: 21459272
2011

Short- and long-term outcomes in children undergoing radiofrequency catheter ablation before their second birthday.
The Canadian Journal of Cardiology
Kantoch MJ, Gulamhusein SS, Sanatani S
DOI: 10.1016/j.cjca.2010.12.043
PubMed: 21621374
2011

Echocardiographic tools for pacemaker optimization of ventricular function in an infant following surgical repair for double outlet right ventricle.
The Canadian Journal of Cardiology
Jeewa A, Potts MT, Sanatani S, Duncan WJ
DOI: 10.1016/s0828-282x(10)70472-4
PubMed: 21165368
12/2010

The effects of droperidol and ondansetron on dispersion of myocardial repolarization in children.
Paediatric anaesthesia
Mehta D, Sanatani S, Whyte SD
DOI: 10.1111/j.1460-9592.2010.03408.x
PubMed: 20849495
10/2010

Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of IKs.
The Journal of General Physiology
Eldstrom J, Xu H, Werry D, Kang C, Loewen ME, Degenhardt A, Sanatani S, Tibbits GF, Sanders C, Fedida D
DOI: 10.1085/jgp.200910351
PubMed: 20421371
05/2010

Benign cardiac tumours, malignant arrhythmias.
The Canadian Journal of Cardiology
Myers KA, Wong KK, Tipple M, Sanatani S
DOI: 10.1016/s0828-282x(10)70009-x
PubMed: 20151061
02/2010

Does biventricular pacing improve hemodynamics in children undergoing routine congenital heart surgery?
Pediatric cardiology
Jeewa A, Pitfield AF, Potts JE, Soulikias W, DeSouza ES, Hollinger AJ, Sandor GG, LeBlanc JG, Campbell AM, Sanatani S
DOI: 10.1007/s00246-009-9581-4
PubMed: 19936587
02/2010

A review of sudden unexpected death in the young in British Columbia.
The Canadian Journal of Cardiology
Lim Z, Gibbs K, Potts JE, Sanatani S
DOI: 10.1016/s0828-282x(10)70329-9
PubMed: 20101353
01/2010

Pacemaker therapy of postoperative arrhythmias after pediatric cardiac surgery.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Skippen P, Sanatani S, Froese N, Gow RM
DOI: 10.1097/pcc.0b013e3181ae5b8a
PubMed: 19581822
01/2010

Cardiac risk assessment before the use of stimulant medications in children and youth.
Paediatrics & Child Health
Bélanger SA, Warren AE, Hamilton RM, Gray C, Gow RM, Sanatani S, Côté JM, Frcpc JL, Leblanc J, Martin S, Miles B, Mitchell C, Gorman DA, Weiss M, Schachar R
DOI: 10.1093/pch/14.9.579
PubMed: 21037835
11/2009

L’évaluation du risque cardiaque avant l’utilisation de stimulants chez les enfants et les adolescents.
Paediatrics & Child Health
Bélanger S, Warren A, Hamilton R, Gray C, Gow R, Sanatani S, Côté J, Lougheed J, LeBlanc J, Martin S, Miles B, Mitchell C, Gorman D, Weiss M, Schachar R
DOI: 10.1093/pch/14.9.586
11/2009

Cardiac risk assessment before the use of stimulant medications in children and youth: A joint position statement by the Canadian Paediatric Society, the Canadian Cardiovascular Society, and the Canadian Academy of Child and Adolescent Psychiatry.
The Canadian Journal of Cardiology
Warren AE, Hamilton RM, Bélanger SA, Gray C, Gow RM, Sanatani S, Côté JM, Lougheed J, LeBlanc J, Martin S, Miles B, Mitchell C, Gorman DA, Weiss M, Schachar R
DOI: 10.1016/s0828-282x(09)70157-6
PubMed: 19898693
11/2009

Are implantable loop recorders useful in detecting arrhythmias in children with unexplained syncope?
Pacing and clinical electrophysiology : PACE
Al Dhahri KN, Potts JE, Chiu CC, Hamilton RM, Sanatani S
DOI: 10.1111/j.1540-8159.2009.02486.x
PubMed: 19694968
11/2009

Diagnosis of postoperative arrhythmias following paediatric cardiac surgery.
Anaesthesia and intensive care
Skippen PW, Sanatani S, Gow RM, Froese N
PubMed: 19775033
09/2009

Systematic assessment of patients with unexplained cardiac arrest: Cardiac Arrest Survivors With Preserved Ejection Fraction Registry (CASPER).
Circulation
Krahn AD, Healey JS, Chauhan V, Birnie DH, Simpson CS, Champagne J, Gardner M, Sanatani S, Exner DV, Klein GJ, Yee R, Skanes AC, Gula LJ, Gollob MH
DOI: 10.1161/circulationaha.109.853143
PubMed: 19597050
07/2009

Formation of a national network for rapid response to device and lead advisories: The Canadian Heart Rhythm Society Device Advisory Committee.
The Canadian Journal of Cardiology
Krahn AD, Simpson CS, Parkash R, Yee R, Champagne J, Healey JS, Cameron D, Thibault B, Mangat I, Tung S, Sterns L, Birnie DH, Exner DV, Gardner M
DOI: 10.1016/s0828-282x(09)70502-1
PubMed: 19584969
07/2009

Utilization of a national network for rapid response to the Medtronic Fidelis lead advisory: the Canadian Heart Rhythm Society Device Advisory Committee.
Heart rhythm
Krahn AD, Simpson CS, Parkash R, Yee R, Champagne J, Healey JS, Cameron D, Thibault B, Mangat I, Tung S, Sterns L, Birnie DH, Exner DV, Essebag V
DOI: 10.1016/j.hrthm.2009.01.012
PubMed: 19324305
04/2009

Pediatric nonpost-operative junctional ectopic tachycardia medical management and interventional therapies.
Journal of the American College of Cardiology
Collins KK, Van Hare GF, Kertesz NJ, Law IH, Bar-Cohen Y, Dubin AM, Etheridge SP, Berul CI, Avari JN, Tuzcu V, Sreeram N, Schaffer MS, Fournier A, Tanel RE
DOI: 10.1016/j.jacc.2008.11.019
PubMed: 19232902
02/2009

Bovine aortic arch in association with double inlet left ventricle and pulmonary atresia: a novel association.
Congenital heart disease
Alghamdi MH, Sanatani S
DOI: 10.1111/j.1747-0803.2009.00265.x
PubMed: 19664036
2009

The effect of propofol concentration on dispersion of myocardial repolarization in children.
Anesthesia and analgesia
Hume-Smith HV, Sanatani S, Lim J, Chau A, Whyte SD
DOI: 10.1213/ane.0b013e3181815ce3
PubMed: 18713888
09/2008

A KCNQ1 V205M missense mutation causes a high rate of long QT syndrome in a First Nations community of northern British Columbia: a community-based approach to understanding the impact.
Genetics in medicine : official journal of the American College of Medical Genetics
Arbour L, Rezazadeh S, Eldstrom J, Weget-Simms G, Rupps R, Dyer Z, Tibbits G, Accili E, Casey B, Kmetic A, Sanatani S, Fedida D
DOI: 10.1097/gim.0b013e31817c6b19
PubMed: 18580685
07/2008

The challenge of diagnosing arrhythmogenic right ventricular cardiomyopathy in the young.
Pediatric cardiology
Sanatani S, Duncan W, Chan S
DOI: 10.1007/s00246-008-9238-8
PubMed: 18427879
07/2008

Congenital long QT syndrome in children identified by family screening.
The American journal of cardiology
Petko C, Bradley DJ, Tristani-Firouzi M, Cohen MI, Sanatani S, Saarel EV, Albaro CA, Etheridge SP
DOI: 10.1016/j.amjcard.2008.02.068
PubMed: 18549854
06/2008

Invasive measurements of atrioventricular conduction parameters prior to and following ventricular septal defect closure with the amplatzer device.
The Journal of invasive cardiology
Kramoh EK, Dahdah N, Fournier A, Sanatani S, Hosking M, Miró J
PubMed: 18460702
05/2008

Long QT syndrome in children in the era of implantable defibrillators.
Journal of the American College of Cardiology
Etheridge SP, Sanatani S, Cohen MI, Albaro CA, Saarel EV, Bradley DJ
DOI: 10.1016/j.jacc.2007.05.042
PubMed: 17903632
10/2007

A comparison of the effect on dispersion of repolarization of age-adjusted MAC values of sevoflurane in children.
Anesthesia and analgesia
Whyte SD, Sanatani S, Lim J, Booker PD
DOI: 10.1213/01.ane.0000252417.23986.6e
PubMed: 17242080
02/2007

Right ventricular outflow tract tachycardia in children.
The Journal of pediatrics
Harris KC, Potts JE, Fournier A, Gross GJ, Kantoch MJ, Cote JM, Sanatani S
DOI: 10.1016/j.jpeds.2006.08.076
PubMed: 17137900
12/2006

Minimally invasive approach to the child with palpitations.
Expert review of cardiovascular therapy
Rajagopalan K, Potts JE, Sanatani S
DOI: 10.1586/14779072.4.5.681
PubMed: 17081090
09/2006

Sudden unexpected death in children with heart disease.
Congenital heart disease
Sanatani S, Wilson G, Smith CR, Hamilton RM, Williams WG, Adatia I
DOI: 10.1111/j.1747-0803.2006.00014.x
PubMed: 18377551
05/2006

An alternate technique to pacing in complex congenital heart disease: assessment of the left thoracotomy approach.
The Canadian Journal of Cardiology
Roberts AD, Sett S, Leblanc J, Sanatani S
DOI: 10.1016/s0828-282x(06)70264-1
PubMed: 16685311
05/2006

Medications used to manage supraventricular tachycardia in the infant a North American survey.
Pediatric cardiology
Wong KK, Potts JE, Etheridge SP, Sanatani S
DOI: 10.1007/s00246-005-1126-x
PubMed: 16391988
2006

Dilated cardiomyopathy masquerading as long QT syndrome.
Pediatric cardiology
Walls J, Dipchand A, Sanatani S
DOI: 10.1007/s00246-005-1114-1
PubMed: 16391990
2006

Resynchronization therapy in pediatric and congenital heart disease patients: an international multicenter study.
Journal of the American College of Cardiology
Dubin AM, Janousek J, Rhee E, Strieper MJ, Cecchin F, Law IH, Shannon KM, Temple J, Rosenthal E, Zimmerman FJ, Davis A, Karpawich PP, Al Ahmad A, Collins KK
DOI: 10.1016/j.jacc.2005.05.096
PubMed: 16360058
12/2005

Documenting junctional ectopic tachycardia following pediatric open heart surgery.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet
Gengsakul A, Potts JE, Sandhu A, Patterson MW, Sett SS, Taylor G, Sanatani S
PubMed: 16858961
11/2005

Cerebral oxygenation during defibrillator threshold testing of implantable cardioverter defibrillators.
Pacing and clinical electrophysiology : PACE
McNeill E, Gagnon RE, Potts JE, Yeung-Lai-Wah JA, Kerr CR, Sanatani S
DOI: 10.1111/j.1540-8159.2005.09518.x
PubMed: 15955185
06/2005

Anomalous origin of the left coronary artery with diffuse coronary hypoplasia resulting in sudden death.
The Canadian Journal of Cardiology
Ho J, Jevon G, Sanatani S
PubMed: 15917883
05/2005

The protean manifestations of blunt cardiac trauma in children.
Pediatric emergency care
Milligan J, Potts JE, Human DG, Sanatani S
DOI: 10.1097/01.pec.0000159071.62938.5b
PubMed: 15874814
05/2005

The Brugada ECG pattern in a neonate.
Journal of cardiovascular electrophysiology
Sanatani S, Mahkseed N, Vallance H, Brugada R
DOI: 10.1046/j.1540-8167.2005.40607.x
PubMed: 15817096
03/2005

Post-hoc diagnosis of congenital long QT syndrome in patients with tetralogy of Fallot.
Pediatric cardiology
Walls J, Sanatani S, Hamilton R
DOI: 10.1007/s00246-004-0712-7
PubMed: 15793661
2005

Long on QT and low on calcium.
Cardiology in the young
Bradley TJ, Metzger DL, Sanatani S
DOI: 10.1017/s1047951104006134
PubMed: 15680004
12/2004

Coronary vessel involvement by chronic graft-versus-host disease presenting as sudden cardiac death.
Bone marrow transplantation
Prevost D, Taylor G, Sanatani S, Schultz KR
DOI: 10.1038/sj.bmt.1704625
PubMed: 15300232
10/2004

Evolution of heart rate control after transplantation: conduction versus autonomic innervation.
Pediatric cardiology
Sanatani S, Chiu C, Nykanen D, Coles J, West L, Hamilton R
DOI: 10.1007/s00246-003-0387-5
PubMed: 14647999
2004

Use of an implantable loop recorder in the evaluation of children with congenital heart disease.
American heart journal
Sanatani S, Peirone A, Chiu C, Human DG, Gross GJ, Hamilton RM
DOI: 10.1067/mhj.2002.120157
PubMed: 11835044
02/2002

Predictors of refractory tachycardia in infants with supraventricular tachycardia.
Pediatric cardiology
Sanatani S, Hamilton RM, Gross GJ
DOI: 10.1007/s00246-002-1514-4
PubMed: 12189406
2002

Spontaneously terminating apparent ventricular fibrillation during transesophageal electrophysiological testing in infants with Wolff-Parkinson-White syndrome.
Pacing and clinical electrophysiology : PACE
Sanatani S, Saul JP, Walsh EP, Gross GJ
DOI: 10.1046/j.1460-9592.2001.01816.x
PubMed: 11817818
12/2001

Balloon angioplasty of right ventricular outflow tract conduits.
Pediatric cardiology
Sanatani S, Potts JE, Human DG, Sandor GG, Patterson MW, Gordon Culham JA
DOI: 10.1007/s002460010209
PubMed: 11343149
2001

Echocardiography and pulmonary function testing in childhood onset systemic lupus erythematosus.
Lupus
Al-Abbad AJ, Cabral DA, Sanatani S, Sandor GG, Seear M, Petty RE, Malleson PN
DOI: 10.1191/096120301669980721
PubMed: 11243507
2001

Early and intermediate-term complications of self-expanding stents limit its potential application in children with congenital heart disease.
Journal of the American College of Cardiology
Cheung YF, Sanatani S, Leung MP, Human DG, Chau AK, Culham JA
DOI: 10.1016/s0735-1097(99)00644-0
PubMed: 10732902
03/2000

Coil occlusion of the patent ductus arteriosus: lessons learned.
Cardiovascular and interventional radiology
Sanatani S, Potts JE, Ryan A, Sandor GG, Human DG, Culham JA
DOI: 10.1007/s002709910019
PubMed: 10795831
2000

Vascular abnormalities in Adams-Oliver syndrome: cause or effect?
American journal of medical genetics
Swartz EN, Sanatani S, Sandor GG, Schreiber RA
DOI: 10.1002/(sici)1096-8628(19990101)82:13.0.co;2-m
PubMed: 9916843
01/1999

Extracardiac Fontan operation with tube fenestration allowing transcatheter coil occlusion.
The Annals of thoracic surgery
Sanatani S, Sett SS, Human DG, Culham JA, LeBlanc JG
DOI: 10.1016/s0003-4975(98)00560-8
PubMed: 9768957
09/1998

Kawasaki disease in the older child.
Pediatrics
Momenah T, Sanatani S, Potts J, Sandor GG, Human DG, Patterson MW
DOI: 10.1542/peds.102.1.e7
PubMed: 9651459
07/1998

Research

Supraventricular tachycardia (SVT)
Supraventricular tachycardia remains the most common chronic rhythm disturbance. I was the Principal Investigator on a Heart and Stroke funded multi-site study examining two antiarrhythmia medications in infants with this rhythm disturbance. This study was among very few prospective controlled studies in pediatric electrophysiology. This study led to the creation of the International SVT Pediatric SVT Research Interest group, which continues to support pediatric SVT research.

In the realm of SVT, CIHR-funded collaborations with the cardiac basic science group are ongoing, examining mechanisms of post-operative arrhythmias. This group has isolated cells from a neonatal rabbit’s cardiac conduction system. To our knowledge, the isolation of neonatal AV nodal cells had not been done before.

Sudden unexpected death (SUD)
Sudden death affects about 500000 individuals each year in North America. The vast majority of these cases occur in older individuals with coronary artery disease. An important number of cases, however, are due to hidden heart disease, either latent structural disease or primary electrical heart disease. These disorders are typically due to mutations in the genes responsible for the electrical heart beat and corresponding muscle contraction. The abnormalities predispose the individual to potentially lethal cardiac rhythm abnormalities.

I am part of a national research collaboration examining families of SUD victims to identify the cause of SUD in these families. We have many active research collaborations on sudden death in the young. My clinical work in SUD substrates has led to multidisciplinary collaboration with basic scientists, geneticists, genetic counselors and lay personnel. We have described a novel mutation in a Northern British Columbia community predisposing many individuals to SUD. This work has led to further collaboration, grants and ongoing research. We currently lead an international registry on pediatric catecholaminergic polymorphic ventricular tachycardia, a rare, but lethal heart condition.

Working with a group of anesthetists, we examined the effects of anesthetic agents on cardiac repolarization. Abnormalities of repolarization have been linked to sudden death and arrhythmias. This project was one of several projects dealing with cardiac repolarization.

I am a member of the medical advisory for the Sudden Arrhythmia Death Syndromes (SADS) Foundation and serve on the scientific advisory board of the American SADS Foundation. I was the Vice-President of Research for the international Pediatric and Congenital Electrophysiology Society (PACES) prior to serving as president in 2016-17.

Honours & Awards

Resident Research Faculty Mentor of the Year Award, UBC Department of Pediatrics. 2011-2012

Canadian Pacific Has Heart Cardiovascular Award. Heart and Stroke Foundation. Oct 2015

Research Group Members

Jeff Chen
Christopher Li
Sonia Franciosi
Dallas Kallas, Graduate Student