Overview

As a pediatric electrophysiologist, my research focuses on the rhythm of the heart. Disturbances in the rhythm of the heart, or arrhythmias, can occur in otherwise healthy children or in children with heart disease. My research aims to improve the outcome of children who have arrhythmias.

Many potentially lethal conditions affecting the heart rhythm are inherited and I work on heritable conditions causing arrhythmias. This research involves collaborations with clinician and basic scientists from all over the world to improve our understanding of inherited heart rhythm disorders.

Publications

Beyond the exercise stress test: Does the cardiac ryanodine receptor affect intellectual function?
Heart Rhythm
Thomas M. Roston and Shubhayan Sanatani
DOI: 10.1016/j.hrthm.2018.09.003
09/2018

Polymorphic ventricular tachycardia associated with an episode of reflex syncope: is this the needle in the haystack?
HeartRhythm Case Reports
Matthew A. Tester and Brooke C.D. Hockin and Thuso David and Sonia Franciosi and Kevin Harris and Victoria E. Claydon and Shubhayan Sanatani
DOI: 10.1016/j.hrcr.2018.07.013
08/2018

Predictors of ECG Screening Failure for the Subcutaneous Implantable Cardioverter Defibrillator in Children. A Prospective Multi-Center Study.
Heart rhythm
Campbell M and Moore JP and Sreeram N and von Alvensleben JC and Shah A and Batra A and Law I and Sanatani S and Thomas V and Nik-Ahd F and Williams S and Nosavan N and Maldonado J and Balaji S
DOI: 10.1016/j.hrthm.2018.01.004
PubMed: 29309839
01/2018

Functional characterization of a novel hERG variant in a family with recurrent sudden infant death syndrome: Retracting a genetic diagnosis.
Forensic science international
Sergeev V and Perry F and Roston TM and Sanatani S and Tibbits GF and Claydon TW
DOI: 10.1016/j.forsciint.2017.12.028
PubMed: 29331839
12/2017

The Safety and Effectiveness of Flecainide in Children in the Current Era.
Pediatric cardiology
Cunningham T and Uzun O and Morris R and Franciosi S and Wong A and Jeremiasen I and Sherwin E and Sanatani S
DOI: 10.1007/s00246-017-1707-5
PubMed: 28840327
12/2017

Response Letter to 'Optimising physiology for adolescents with dysautonomia'.
Acta paediatrica (Oslo, Norway : 1992)
Armstrong KR and De Souza AM and Sneddon PL and Potts JE and Claydon VE and Sanatani S
DOI: 10.1111/apa.14058
PubMed: 28906019
12/2017

The 2017 Seventh World Congress of Pediatric Cardiology & Cardiac Surgery: Week in review: electrophysiology.
Cardiology in the young
Cohen MI and Etheridge S and Sanatani S and Celiker A
DOI: 10.1017/s1047951117002268
PubMed: 29286280
12/2017

The accessibility and utilization of genetic testing for inherited heart rhythm disorders: a Canadian cross-sectional survey study.
Journal of community genetics
Roston TM and Dewar L and Franciosi S and Hathaway J and Bartels K and Cunningham T and Gibbs KA and Sheps S and Laksman ZWM and Sanatani S and Krahn AD
DOI: 10.1007/s12687-017-0348-y
PubMed: 29170972
11/2017

Differential calcium sensitivity in NaV 1.5 mixed syndrome mutants.
The Journal of physiology
Abdelsayed M and Baruteau AE and Gibbs K and Sanatani S and Krahn AD and Probst V and Ruben PC
DOI: 10.1113/jp274536
PubMed: 28734073
09/2017

Investigating the Genetic Causes of Sudden Unexpected Death in Children Through Targeted Next-Generation Sequencing Analysis.
Circulation. Cardiovascular genetics
Dewar LJ and Alcaide M and Fornika D and D'Amato L and Shafaatalab S and Stevens CM and Balachandra T and Phillips SM and Sanatani S and Morin RD and Tibbits GF
DOI: 10.1161/circgenetics.116.001738
PubMed: 28807990
08/2017

Loss-of-Function KCNE2 Variants: True Monogenic Culprits of Long-QT Syndrome or Proarrhythmic Variants Requiring Secondary Provocation?
Circulation. Arrhythmia and electrophysiology
Roberts JD and Krahn AD and Ackerman MJ and Rohatgi RK and Moss AJ and Nazer B and Tadros R and Gerull B and Sanatani S and Wijeyeratne YD and Baruteau AE and Muir AR and Pang B and Scheinman MM
DOI: 10.1161/circep.117.005282
PubMed: 28794082
08/2017

The role of the autonomic nervous system in arrhythmias and sudden cardiac death.
Autonomic neuroscience : basic & clinical
Franciosi S and Perry FKG and Roston TM and Armstrong KR and Claydon VE and Sanatani S
DOI: 10.1016/j.autneu.2017.03.005
PubMed: 28392310
07/2017

KCNQ1 p.L353L affects splicing and modifies the phenotype in a founder population with long QT syndrome type 1.
Journal of medical genetics
Kapplinger JD and Erickson A and Asuri S and Tester DJ and McIntosh S and Kerr CR and Morrison J and Tang A and Sanatani S and Arbour L and Ackerman MJ
DOI: 10.1136/jmedgenet-2016-104153
PubMed: 28264985
06/2017

Exercise and the multidisciplinary holistic approach to adolescent dysautonomia.
Acta Paediatrica (Oslo, Norway : 1992)
Armstrong KR and De Souza AM and Sneddon PL and Potts JE and Claydon VE and Sanatani S
DOI: 10.1111/apa.13750
PubMed: 28112424
04/2017

Canadian Cardiovascular Society and Canadian Pediatric Cardiology Association Position Statement on the Approach to Syncope in the Pediatric Patient.
The Canadian Journal of Cardiology
Sanatani S and Chau V and Fournier A and Dixon A and Blondin R and Sheldon RS
DOI: 10.1016/j.cjca.2016.09.006
PubMed: 27838109
02/2017

The clinical and genetic spectrum of catecholaminergic polymorphic ventricular tachycardia: findings from an international multicentre registry.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology
Roston TM and Yuchi Z and Kannankeril PJ and Hathaway J and Vinocur JM and Etheridge SP and Potts JE and Maginot KR and Salerno JC and Cohen MI and Hamilton RM and Pflaumer A and Sanatani S
DOI: 10.1093/europace/euw389
PubMed: 28158428
01/2017

Suppression-of-function mutations in the cardiac ryanodine receptor: Emerging evidence for a novel arrhythmia syndrome?
Heart rhythm
Roston TM and Sanatani S and Chen SR
DOI: 10.1016/j.hrthm.2016.11.004
PubMed: 27818320
01/2017

Advances in the diagnosis and treatment of catecholaminergic polymorphic ventricular tachycardia.
Cardiology in the young
Roston TM and Cunningham TC and Sanatani S
DOI: 10.1017/s1047951116002237
PubMed: 28084961
01/2017

Novel Variant in the ANK2 Membrane-Binding Domain Is Associated With Ankyrin-B Syndrome and Structural Heart Disease in a First Nations Population With a High Rate of Long QT Syndrome.
Circulation. Cardiovascular genetics
Swayne LA and Murphy NP and Asuri S and Chen L and Xu X and McIntosh S and Wang C and Lancione PJ and Roberts JD and Kerr C and Sanatani S and Sherwin E and Kline CF and Zhang M and Mohler PJ and Arbour LT
DOI: 10.1161/circgenetics.116.001537
PubMed: 28196901
01/2017

Genetic Insurance Discrimination in Sudden Arrhythmia Death Syndromes: Empirical Evidence From a Cross-Sectional Survey in North America.
Circulation. Cardiovascular genetics
Mohammed S and Lim Z and Dean PH and Potts JE and Tang JN and Etheridge SP and Lara A and Husband P and Sherwin ED and Ackerman MJ and Sanatani S
DOI: 10.1161/circgenetics.116.001442
PubMed: 28119333
01/2017

Morbidities in the ultra-athlete and marathoner.
Cardiology in the young
Cunningham TC and Maghrabi K and Sanatani S
DOI: 10.1017/s1047951116002304
PubMed: 28084966
01/2017

Catecholaminergic polymorphic ventricular tachycardia: a model for genotype-specific therapy.
Current opinion in cardiology
Roston TM and Van Petegem F and Sanatani S
DOI: 10.1097/hco.0000000000000360
PubMed: 27861184
01/2017

Beyond the Electrocardiogram: Mutations in Cardiac Ion Channel Genes Underlie Nonarrhythmic Phenotypes.
Clinical Medicine Insights. Cardiology
Roston TM and Cunningham T and Lehman A and Laksman ZW and Krahn AD and Sanatani S
DOI: 10.1177/1179546817698134
PubMed: 28469493
2017

A novel RYR2 loss-of-function mutation (I4855M) is associated with left ventricular non-compaction and atypical catecholaminergic polymorphic ventricular tachycardia.
Journal of electrocardiology
Roston TM and Guo W and Krahn AD and Wang R and Van Petegem F and Sanatani S and Chen SR and Lehman A
DOI: 10.1016/j.jelectrocard.2016.09.006
PubMed: 27646203
2017

The Canadian Arrhythmogenic Right Ventricular Cardiomyopathy Registry: Rationale, Design, and Preliminary Recruitment.
The Canadian Journal of Cardiology
Krahn AD and Healey JS and Gerull B and Angaran P and Chakrabarti S and Sanatani S and Arbour L and Laksman ZW and Carroll SL and Seifer C and Green M and Roberts JD and Talajic M and Gardner M
DOI: 10.1016/j.cjca.2016.04.004
PubMed: 27474350
12/2016

Ischemia-reperfusion destabilizes rhythmicity in immature atrioventricular pacemakers: A predisposing factor for postoperative arrhythmias in neonate rabbits.
Heart rhythm
Chenliu C and Sheng X and Dan P and Qu Y and Claydon VE and Lin E and Hove-Madsen L and Sanatani S and Tibbits GF
DOI: 10.1016/j.hrthm.2016.07.022
PubMed: 27451283
12/2016

Management of Gene-Positive Catecholaminergic Polymorphic Ventricular Tachycardia: Are the Long Term Outcomes on Therapy Really So Poor?
Circulation journal : official journal of the Japanese Circulation Society
Roston TM and Sanatani S
DOI: 10.1253/circj.cj-16-0842
PubMed: 27840378
11/2016

Use of dofetilide in adult patients with atrial arrhythmias and congenital heart disease: A PACES collaborative study.
Heart rhythm
El-Assaad I and Al-Kindi SG and Abraham J and Sanatani S and Bradley DJ and Halsey C and Law IH and Balaji S and Shetty I and Aziz PF
DOI: 10.1016/j.hrthm.2016.07.016
PubMed: 27435587
10/2016

A Clinical Risk Score to Improve the Diagnosis of Tachycardia-Induced Cardiomyopathy in Childhood.
The American journal of cardiology
Moore JP and Wang S and Albers EL and Salerno JC and Stephenson EA and Shah MJ and Pflaumer A and Czosek RJ and Garnreiter JM and Collins K and Papez AL and Sanatani S and Cain NB and Shannon KM
DOI: 10.1016/j.amjcard.2016.07.008
PubMed: 27515893
10/2016

Recommendations for genetic testing to reduce the incidence of anthracycline-induced cardiotoxicity.
British journal of clinical pharmacology
Aminkeng F and Ross CJ and Rassekh SR and Hwang S and Rieder MJ and Bhavsar AP and Smith A and Sanatani S and Gelmon KA and Bernstein D and Hayden MR and Amstutz U and Carleton BC and CPNDS Clinical Practice Recommendations Group
DOI: 10.1111/bcp.13008
PubMed: 27197003
09/2016

Cardiac Abnormalities in First-Degree Relatives of Unexplained Cardiac Arrest Victims: A Report From the Cardiac Arrest Survivors With Preserved Ejection Fraction Registry.
Circulation. Arrhythmia and electrophysiology
Steinberg C and Padfield GJ and Champagne J and Sanatani S and Angaran P and Andrade JG and Roberts JD and Healey JS and Chauhan VS and Birnie DH and Janzen M and Gerull B and Klein GJ and Krahn AD
DOI: 10.1161/circep.115.004274
PubMed: 27635072
09/2016

Pediatric & Congenital Electrophysiology Society: building an international paediatric electrophysiology organisation.
Cardiology in the young
Cohen M and Sanatani S and Stephenson E and Skinner J and Drago F and Davis A and Janousek J and Rosenthal E and Collins KK and Triedman J
DOI: 10.1017/s1047951115002553
PubMed: 27075202
08/2016

Congenital heart disease confounding the diagnosis of arrhythmogenic right ventricular cardiomyopathy.
HeartRhythm case reports
Kiamanesh O and Farhan M and Sanatani S and Grosse-Wortmann L and Duncan W and Hamilton RM
DOI: 10.1016/j.hrcr.2016.01.007
PubMed: 28491693
07/2016

Pediatric & Congenital Electrophysiology Society: building an international paediatric electrophysiology organisation.
Heart rhythm
Cohen M and Sanatani S and Stephenson E and Skinner J and Drago F and Davis A and Janousek J and Rosenthal E and Collins KK and Triedman J
DOI: 10.1016/j.hrthm.2016.01.013
PubMed: 27090729
05/2016

Response to Letter Regarding Article, "Outcome of Apparently Unexplained Cardiac Arrest: Results From Investigation and Follow-Up of the Prospective Cardiac Arrest Survivors With Preserved Ejection Fraction Registry".
Circulation. Arrhythmia and electrophysiology
Herman AR and Cheung C and Gerull B and Simpson CS and Birnie DH and Klein GJ and Champagne J and Healey JS and Gibbs K and Talajic M and Gardner M and Bennett MT and Steinberg C and Krahn AD
DOI: 10.1161/circep.116.004012
PubMed: 27069091
04/2016

Exercise and Inherited Arrhythmias.
The Canadian journal of cardiology
Cheung CC and Laksman ZW and Mellor G and Sanatani S and Krahn AD
DOI: 10.1016/j.cjca.2016.01.007
PubMed: 26927864
04/2016

Evaluation and management of bradycardia in neonates and children.
European journal of pediatrics
Baruteau AE and Perry JC and Sanatani S and Horie M and Dubin AM
DOI: 10.1007/s00431-015-2689-z
PubMed: 26780751
02/2016

Flecainide monotherapy is an option for selected patients with catecholaminergic polymorphic ventricular tachycardia intolerant of ß-blockade.
Heart rhythm
Padfield GJ and AlAhmari L and Lieve KV and AlAhmari T and Roston TM and Wilde AA and Krahn AD and Sanatani S
DOI: 10.1016/j.hrthm.2015.09.027
PubMed: 26416620
02/2016

Characterization of Myocardial Repolarization Reserve in Adolescent Females With Anorexia Nervosa.
Circulation
Padfield GJ and Escudero CA and DeSouza AM and Steinberg C and Gibbs K and Puyat JH and Lam PY and Sanatani S and Sherwin E and Potts JE and Sandor G and Krahn AD
DOI: 10.1161/circulationaha.115.016697
PubMed: 26769740
02/2016

Changes in QTc associated with a rapid bolus dose of dexmedetomidine in patients receiving TIVA: a retrospective study.
Paediatric anaesthesia
Görges M and Whyte SD and Sanatani S and Dawes J and Montgomery CJ and Ansermino JM
DOI: 10.1111/pan.12780
PubMed: 26507917
12/2015

Choking-induced cardiac arrest unmasks a diagnosis of catecholaminergic polymorphic ventricular tachycardia.
HeartRhythm case reports
Roston TM and AlAhmari L and Krahn AD and Sherwin E and Sanatani S
DOI: 10.1016/j.hrcr.2015.08.007
PubMed: 28491614
11/2015

Catecholaminergic polymorphic ventricular tachycardia in children: analysis of therapeutic strategies and outcomes from an international multicenter registry.
Circulation. Arrhythmia and electrophysiology
Roston TM and Vinocur JM and Maginot KR and Mohammed S and Salerno JC and Etheridge SP and Cohen M and Hamilton RM and Pflaumer A and Kanter RJ and Potts JE and LaPage MJ and Sanatani S
DOI: 10.1161/circep.114.002217
PubMed: 25713214
06/2015

Paediatric patient family engagement with clinical research at a tertiary care paediatric hospital.
Paediatrics & Child Health
Gill C and Ansermino MJ and Sanatani S and Mulpuri K and Doan Q
PubMed: 25587233
12/2014

Should early extubation be the goal for children after congenital cardiac surgery?
The Journal of thoracic and cardiovascular surgery
Harris KC and Holowachuk S and Pitfield S and Sanatani S and Froese N and Potts JE and Gandhi SK
DOI: 10.1016/j.jtcvs.2014.06.093
PubMed: 25156467
12/2014

Evaluation of genes encoding for the transient outward current (Ito) identifies the KCND2 gene as a cause of J-wave syndrome associated with sudden cardiac death.
Circulation. Cardiovascular genetics
Perrin MJ and Adler A and Green S and Al-Zoughool F and Doroshenko P and Orr N and Uppal S and Healey JS and Birnie D and Sanatani S and Gardner M and Champagne J and Simpson C and Gollob MH
DOI: 10.1161/circgenetics.114.000623
PubMed: 25214526
12/2014

The safety of modern anesthesia for children with long QT syndrome.
Anesthesia and analgesia
Whyte SD and Nathan A and Myers D and Watkins SC and Kannankeril PJ and Etheridge SP and Andrade J and Collins KK and Law IH and Hayes J and Sanatani S
DOI: 10.1213/ane.0000000000000389
PubMed: 25076102
10/2014

Current management of focal atrial tachycardia in children: a multicenter experience.
Circulation. Arrhythmia and electrophysiology
Kang KT and Etheridge SP and Kantoch MJ and Tisma-Dupanovic S and Bradley DJ and Balaji S and Hamilton RM and Singh AK and Cannon BC and Schaffer MS and Potts JE and Sanatani S
DOI: 10.1161/circep.113.001423
PubMed: 25015944
08/2014

An international multicenter study comparing arrhythmia prevalence between the intracardiac lateral tunnel and the extracardiac conduit type of Fontan operations.
The Journal of thoracic and cardiovascular surgery
Balaji S and Daga A and Bradley DJ and Etheridge SP and Law IH and Batra AS and Sanatani S and Singh AK and Gajewski KK and Tsao S and Singh HR and Tisma-Dupanovic S and Tateno S and Shah M
DOI: 10.1016/j.jtcvs.2013.08.070
PubMed: 24172692
08/2014

Permanent junctional reciprocating tachycardia in children: a multicenter experience.
Heart rhythm
Kang KT and Potts JE and Radbill AE and La Page MJ and Papagiannis J and Garnreiter JM and Kubus P and Kantoch MJ and Von Bergen NH and Fournier A and Côté JM and Paul T and Sanatani S
DOI: 10.1016/j.hrthm.2014.04.033
PubMed: 24769425
08/2014

Nonuniform and variable arrangements of ryanodine receptors within mammalian ventricular couplons.
Circulation research
Asghari P and Scriven DR and Sanatani S and Gandhi SK and Campbell AI and Moore ED
DOI: 10.1161/circresaha.115.303897
PubMed: 24786399
07/2014

Predictors of myocardial recovery in pediatric tachycardia-induced cardiomyopathy.
Heart rhythm
Moore JP and Patel PA and Shannon KM and Albers EL and Salerno JC and Stein MA and Stephenson EA and Mohan S and Shah MJ and Asakai H and Pflaumer A and Czosek RJ and Everitt MD and Balaji S
DOI: 10.1016/j.hrthm.2014.04.023
PubMed: 24751393
07/2014

Procainamide infusion in the evaluation of unexplained cardiac arrest: from the Cardiac Arrest Survivors with Preserved Ejection Fraction Registry (CASPER).
Heart rhythm
Somani R and Krahn AD and Healey JS and Chauhan VS and Birnie DH and Champagne J and Sanatani S and Angaran P and Gow RM and Chakrabarti S and Gerull B and Yee R and Skanes AC and Gula LJ and Simpson CS
DOI: 10.1016/j.hrthm.2014.03.022
PubMed: 24657429
06/2014

Electrocardiogram interpretation by Canadian general paediatricians: Examining practice, accuracy and confidence.
Paediatrics & Child Health
Escudero CA and Sanatani S and Wong KK and Templeton CG
DOI: 10.1093/pch/19.2.77
PubMed: 24596480
02/2014

Evolution of clinical diagnosis in patients presenting with unexplained cardiac arrest or syncope due to polymorphic ventricular tachycardia.
Heart rhythm
Vittoria Matassini M and Krahn AD and Gardner M and Champagne J and Sanatani S and Birnie DH and Gollob MH and Chauhan V and Simpson CS and Hamilton RM and Talajic M and Ahmad K and Healey JS
DOI: 10.1016/j.hrthm.2013.11.008
PubMed: 24239842
02/2014

Reply to letter from Nair et al.--anatomical considerations for cardiac resynchronization therapy in transposition of the great arteries.
The Canadian journal of cardiology
Escudero C and Khairy P and Sanatani S
DOI: 10.1016/j.cjca.2013.09.027
PubMed: 24290863
02/2014

TMEM43 mutations associated with arrhythmogenic right ventricular cardiomyopathy in non-Newfoundland populations.
Human genetics
Baskin B and Skinner JR and Sanatani S and Terespolsky D and Krahn AD and Ray PN and Scherer SW and Hamilton RM
DOI: 10.1007/s00439-013-1323-2
PubMed: 23812740
11/2013

Lone atrial fibrillation in the pediatric population.
The Canadian Journal of Cardiology
Mills LC and Gow RM and Myers K and Kantoch MJ and Gross GJ and Fournier A and Sanatani S
DOI: 10.1016/j.cjca.2013.06.014
PubMed: 24074972
10/2013

Physical activity recommendations for patients with electrophysiologic and structural congenital heart disease: a survey of Canadian health care providers.
Pediatric cardiology
Roston TM and De Souza AM and Sandor GG and Sanatani S and Potts JE
DOI: 10.1007/s00246-013-0654-z
PubMed: 23435716
08/2013

Electrophysiologic considerations in congenital heart disease and their relationship to heart failure.
The Canadian Journal of Cardiology
Escudero C and Khairy P and Sanatani S
DOI: 10.1016/j.cjca.2013.02.016
PubMed: 23642334
07/2013

Fascicular and nonfascicular left ventricular tachycardias in the young: an international multicenter study.
Journal of cardiovascular electrophysiology
Collins KK and Schaffer MS and Liberman L and Saarel E and Knecht M and Tanel RE and Bradley D and Dubin AM and Paul T and Salerno J and Bar-Cohen Y and Sreeram N and Sanatani S and Pediatric and Congenital Electrophysiology Society
DOI: 10.1111/jce.12105
PubMed: 23437865
06/2013

Failure rate of the Riata lead under advisory: a report from the CHRS Device Committee.
Heart rhythm
Parkash R and Exner D and Champagne J and Mangat I and Thibault B and Healey JS and Tung S and Crystal E and Simpson C and Nery PB and Sterns L and Connors S and Cameron D and Verma A and Krahn A
DOI: 10.1016/j.hrthm.2013.01.018
PubMed: 23333722
05/2013

Inherited heart rhythm disease: negotiating the minefield for the practicing cardiologist.
The Canadian Journal of Cardiology
Krahn AD and Sanatani S and Gardner MJ and Arbour L
DOI: 10.1016/j.cjca.2012.11.009
PubMed: 23261322
01/2013

Postnatal outcome in patients with fetal tachycardia.
Pediatric cardiology
Moodley S and Sanatani S and Potts JE and Sandor GG
DOI: 10.1007/s00246-012-0392-7
PubMed: 22639009
01/2013

Assessment of genetic causes of cardiac arrest.
The Canadian Journal of Cardiology
Bennett MT and Sanatani S and Chakrabarti S and Deyell MW and Krahn AD
DOI: 10.1016/j.cjca.2012.07.002
PubMed: 23200097
01/2013

The medical management of pediatric arrhythmias.
Current treatment options in cardiovascular medicine
Escudero C and Carr R and Sanatani S
DOI: 10.1007/s11936-012-0194-5
PubMed: 22907424
10/2012

Epinephrine infusion in the evaluation of unexplained cardiac arrest and familial sudden death: from the cardiac arrest survivors with preserved Ejection Fraction Registry.
Circulation. Arrhythmia and electrophysiology
Krahn AD and Healey JS and Chauhan VS and Birnie DH and Champagne J and Sanatani S and Ahmad K and Ballantyne E and Gerull B and Yee R and Skanes AC and Gula LJ and Leong-Sit P and Gardner M
DOI: 10.1161/circep.112.973230
PubMed: 22944906
10/2012

The study of antiarrhythmic medications in infancy (SAMIS): a multicenter, randomized controlled trial comparing the efficacy and safety of digoxin versus propranolol for prophylaxis of supraventricular tachycardia in infants.
Circulation. Arrhythmia and electrophysiology
Sanatani S and Potts JE and Reed JH and Saul JP and Stephenson EA and Gibbs KA and Anderson CC and Mackie AS and Ro PS and Tisma-Dupanovic S and Kanter RJ and Batra AS and Fournier A and Etheridge SP
DOI: 10.1161/circep.112.972620
PubMed: 22962431
10/2012

Biophysical properties of the aorta and left ventricle and exercise capacity in obese children.
The American journal of cardiology
Harris KC and Al Saloos HA and De Souza AM and Sanatani S and Hinchliffe M and Potts JE and Sandor GG
DOI: 10.1016/j.amjcard.2012.05.019
PubMed: 22728002
09/2012

Neuroblastoma masquerading as supraventricular tachycardia: a case of super sinus tachycardia.
Archives of disease in childhood
Harris KC and Retallack JE and Sanatani S
DOI: 10.1136/archdischild-2011-301327
PubMed: 22267393
06/2012

Congenital long QT 3 in the pediatric population.
The American journal of cardiology
Blaufox AD and Tristani-Firouzi M and Seslar S and Sanatani S and Trivedi B and Fischbach P and Paul T and Young ML and Tisma-Dupanovic S and Silva J and Cuneo B and Fournier A and Etheridge SP
DOI: 10.1016/j.amjcard.2012.01.361
PubMed: 22360817
05/2012

Normal Tp-e values in children.
Anesthesia and analgesia
Sanatani S and Whyte S
DOI: 10.1213/ane.0b013e31823554ac
PubMed: 22184612
01/2012

Recurrent congestive heart failure in a child due to probable myocarditis.
Pediatric cardiology
Lee AF and Chiasson DA and Smythe JF and Sanatani S
DOI: 10.1007/s00246-011-0109-3
PubMed: 21910020
01/2012

Sentinel symptoms in patients with unexplained cardiac arrest: from the cardiac arrest survivors with preserved ejection fraction registry (CASPER).
Journal of cardiovascular electrophysiology
Krahn AD and Healey JS and Simpson CS and Chauhan VS and Birnie DH and Champagne J and Gardner M and Sanatani S and Chakrabarti S and Yee R and Skanes AC and Leong-Sit P and Ahmad K and Sheldon RS
DOI: 10.1111/j.1540-8167.2011.02185.x
PubMed: 21955300
01/2012

Assessing the knowledge of sudden unexpected death in the young among Canadian medical students and recent graduates: a cross-sectional study.
BMJ open
Huisma FF and Potts JE and Gibbs KA and Sanatani S
DOI: 10.1136/bmjopen-2012-001798
PubMed: 23242483
2012

Postexertional supraventricular tachycardia in children with catecholaminergic polymorphic ventricular tachycardia.
Case reports in cardiology
Else SD and Potts JE and Sanatani S
DOI: 10.1155/2012/329097
PubMed: 24826246
2012

Isolation and characterization of atrioventricular nodal cells from neonate rabbit heart.
Circulation. Arrhythmia and electrophysiology
Ye Sheng X and Qu Y and Dan P and Lin E and Korthout L and Bradford A and Hove-Madsen L and Sanatani S and Tibbits GF
DOI: 10.1161/circep.111.964056
PubMed: 22002995
12/2011

Prevalence and characteristics of early repolarization in the CASPER registry: cardiac arrest survivors with preserved ejection fraction registry.
Journal of the American College of Cardiology
Derval N and Simpson CS and Birnie DH and Healey JS and Chauhan V and Champagne J and Gardner M and Sanatani S and Yee R and Skanes AC and Gula LJ and Leong-Sit P and Ahmad K and Krahn AD
DOI: 10.1016/j.jacc.2011.04.022
PubMed: 21816308
08/2011

Long QT syndrome.
CMAJ : Canadian Medical Association Journal
Jackson H and Huisman LA and Sanatani S and Arbour LT
DOI: 10.1503/cmaj.100138
PubMed: 21482651
08/2011

A novel mechanism for LQT3 with 2:1 block: a pore-lining mutation in Nav1.5 significantly affects voltage-dependence of activation.
Heart rhythm
Horne AJ and Eldstrom J and Sanatani S and Fedida D
DOI: 10.1016/j.hrthm.2010.12.041
PubMed: 21193062
05/2011

Severe amiodarone-induced hypothyroidism in an infant.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Trudel K and Sanatani S and Panagiotopoulos C
DOI: 10.1097/pcc.0b013e3181e2a388
PubMed: 20453707
01/2011

Short- and long-term outcomes in children undergoing radiofrequency catheter ablation before their second birthday.
The Canadian Journal of Cardiology
Kantoch MJ and Gulamhusein SS and Sanatani S
DOI: 10.1016/j.cjca.2010.12.043
PubMed: 21621374
2011

Recommendations for the use of genetic testing in the clinical evaluation of inherited cardiac arrhythmias associated with sudden cardiac death: Canadian Cardiovascular Society/Canadian Heart Rhythm Society joint position paper.
The Canadian Journal of Cardiology
Gollob MH and Blier L and Brugada R and Champagne J and Chauhan V and Connors S and Gardner M and Green MS and Gow R and Hamilton R and Harris L and Healey JS and Hodgkinson K and Woo A
DOI: 10.1016/j.cjca.2010.12.078
PubMed: 21459272
2011

Echocardiographic tools for pacemaker optimization of ventricular function in an infant following surgical repair for double outlet right ventricle.
The Canadian Journal of Cardiology
Jeewa A and Potts MT and Sanatani S and Duncan WJ
DOI: 10.1016/s0828-282x(10)70472-4
PubMed: 21165368
12/2010

The effects of droperidol and ondansetron on dispersion of myocardial repolarization in children.
Paediatric anaesthesia
Mehta D and Sanatani S and Whyte SD
DOI: 10.1111/j.1460-9592.2010.03408.x
PubMed: 20849495
10/2010

Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of IKs.
The Journal of General Physiology
Eldstrom J and Xu H and Werry D and Kang C and Loewen ME and Degenhardt A and Sanatani S and Tibbits GF and Sanders C and Fedida D
DOI: 10.1085/jgp.200910351
PubMed: 20421371
05/2010

Benign cardiac tumours, malignant arrhythmias.
The Canadian Journal of Cardiology
Myers KA and Wong KK and Tipple M and Sanatani S
DOI: 10.1016/s0828-282x(10)70009-x
PubMed: 20151061
02/2010

Does biventricular pacing improve hemodynamics in children undergoing routine congenital heart surgery?
Pediatric cardiology
Jeewa A and Pitfield AF and Potts JE and Soulikias W and DeSouza ES and Hollinger AJ and Sandor GG and LeBlanc JG and Campbell AM and Sanatani S
DOI: 10.1007/s00246-009-9581-4
PubMed: 19936587
02/2010

A review of sudden unexpected death in the young in British Columbia.
The Canadian Journal of Cardiology
Lim Z and Gibbs K and Potts JE and Sanatani S
DOI: 10.1016/s0828-282x(10)70329-9
PubMed: 20101353
01/2010

Pacemaker therapy of postoperative arrhythmias after pediatric cardiac surgery.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Skippen P and Sanatani S and Froese N and Gow RM
DOI: 10.1097/pcc.0b013e3181ae5b8a
PubMed: 19581822
01/2010

L’évaluation du risque cardiaque avant l’utilisation de stimulants chez les enfants et les adolescents.
Paediatrics & Child Health
Bélanger S and Warren A and Hamilton R and Gray C and Gow R and Sanatani S and Côté J and Lougheed J and LeBlanc J and Martin S and Miles B and Mitchell C and Gorman D and Weiss M and Schachar R
DOI: 10.1093/pch/14.9.586
11/2009

Cardiac risk assessment before the use of stimulant medications in children and youth.
Paediatrics & Child Health
Bélanger SA and Warren AE and Hamilton RM and Gray C and Gow RM and Sanatani S and Côté JM and Frcpc JL and Leblanc J and Martin S and Miles B and Mitchell C and Gorman DA and Weiss M and Schachar R
DOI: 10.1093/pch/14.9.579
PubMed: 21037835
11/2009

Cardiac risk assessment before the use of stimulant medications in children and youth: A joint position statement by the Canadian Paediatric Society, the Canadian Cardiovascular Society, and the Canadian Academy of Child and Adolescent Psychiatry.
The Canadian Journal of Cardiology
Warren AE and Hamilton RM and Bélanger SA and Gray C and Gow RM and Sanatani S and Côté JM and Lougheed J and LeBlanc J and Martin S and Miles B and Mitchell C and Gorman DA and Weiss M and Schachar R
DOI: 10.1016/s0828-282x(09)70157-6
PubMed: 19898693
11/2009

Are implantable loop recorders useful in detecting arrhythmias in children with unexplained syncope?
Pacing and clinical electrophysiology : PACE
Al Dhahri KN and Potts JE and Chiu CC and Hamilton RM and Sanatani S
DOI: 10.1111/j.1540-8159.2009.02486.x
PubMed: 19694968
11/2009

Diagnosis of postoperative arrhythmias following paediatric cardiac surgery.
Anaesthesia and intensive care
Skippen PW and Sanatani S and Gow RM and Froese N
PubMed: 19775033
09/2009

Formation of a national network for rapid response to device and lead advisories: The Canadian Heart Rhythm Society Device Advisory Committee.
The Canadian Journal of Cardiology
Krahn AD and Simpson CS and Parkash R and Yee R and Champagne J and Healey JS and Cameron D and Thibault B and Mangat I and Tung S and Sterns L and Birnie DH and Exner DV and Gardner M
DOI: 10.1016/s0828-282x(09)70502-1
PubMed: 19584969
07/2009

Systematic assessment of patients with unexplained cardiac arrest: Cardiac Arrest Survivors With Preserved Ejection Fraction Registry (CASPER).
Circulation
Krahn AD and Healey JS and Chauhan V and Birnie DH and Simpson CS and Champagne J and Gardner M and Sanatani S and Exner DV and Klein GJ and Yee R and Skanes AC and Gula LJ and Gollob MH
DOI: 10.1161/circulationaha.109.853143
PubMed: 19597050
07/2009

Utilization of a national network for rapid response to the Medtronic Fidelis lead advisory: the Canadian Heart Rhythm Society Device Advisory Committee.
Heart rhythm
Krahn AD and Simpson CS and Parkash R and Yee R and Champagne J and Healey JS and Cameron D and Thibault B and Mangat I and Tung S and Sterns L and Birnie DH and Exner DV and Essebag V
DOI: 10.1016/j.hrthm.2009.01.012
PubMed: 19324305
04/2009

Pediatric nonpost-operative junctional ectopic tachycardia medical management and interventional therapies.
Journal of the American College of Cardiology
Collins KK and Van Hare GF and Kertesz NJ and Law IH and Bar-Cohen Y and Dubin AM and Etheridge SP and Berul CI and Avari JN and Tuzcu V and Sreeram N and Schaffer MS and Fournier A and Tanel RE
DOI: 10.1016/j.jacc.2008.11.019
PubMed: 19232902
02/2009

Bovine aortic arch in association with double inlet left ventricle and pulmonary atresia: a novel association.
Congenital heart disease
Alghamdi MH and Sanatani S
DOI: 10.1111/j.1747-0803.2009.00265.x
PubMed: 19664036
2009

The effect of propofol concentration on dispersion of myocardial repolarization in children.
Anesthesia and analgesia
Hume-Smith HV and Sanatani S and Lim J and Chau A and Whyte SD
DOI: 10.1213/ane.0b013e3181815ce3
PubMed: 18713888
09/2008

A KCNQ1 V205M missense mutation causes a high rate of long QT syndrome in a First Nations community of northern British Columbia: a community-based approach to understanding the impact.
Genetics in medicine : official journal of the American College of Medical Genetics
Arbour L and Rezazadeh S and Eldstrom J and Weget-Simms G and Rupps R and Dyer Z and Tibbits G and Accili E and Casey B and Kmetic A and Sanatani S and Fedida D
DOI: 10.1097/gim.0b013e31817c6b19
PubMed: 18580685
07/2008

The challenge of diagnosing arrhythmogenic right ventricular cardiomyopathy in the young.
Pediatric cardiology
Sanatani S and Duncan W and Chan S
DOI: 10.1007/s00246-008-9238-8
PubMed: 18427879
07/2008

Congenital long QT syndrome in children identified by family screening.
The American journal of cardiology
Petko C and Bradley DJ and Tristani-Firouzi M and Cohen MI and Sanatani S and Saarel EV and Albaro CA and Etheridge SP
DOI: 10.1016/j.amjcard.2008.02.068
PubMed: 18549854
06/2008

Invasive measurements of atrioventricular conduction parameters prior to and following ventricular septal defect closure with the amplatzer device.
The Journal of invasive cardiology
Kramoh EK and Dahdah N and Fournier A and Sanatani S and Hosking M and Miró J
PubMed: 18460702
05/2008

Long QT syndrome in children in the era of implantable defibrillators.
Journal of the American College of Cardiology
Etheridge SP and Sanatani S and Cohen MI and Albaro CA and Saarel EV and Bradley DJ
DOI: 10.1016/j.jacc.2007.05.042
PubMed: 17903632
10/2007

A comparison of the effect on dispersion of repolarization of age-adjusted MAC values of sevoflurane in children.
Anesthesia and analgesia
Whyte SD and Sanatani S and Lim J and Booker PD
DOI: 10.1213/01.ane.0000252417.23986.6e
PubMed: 17242080
02/2007

Right ventricular outflow tract tachycardia in children.
The Journal of pediatrics
Harris KC and Potts JE and Fournier A and Gross GJ and Kantoch MJ and Cote JM and Sanatani S
DOI: 10.1016/j.jpeds.2006.08.076
PubMed: 17137900
12/2006

Minimally invasive approach to the child with palpitations.
Expert review of cardiovascular therapy
Rajagopalan K and Potts JE and Sanatani S
DOI: 10.1586/14779072.4.5.681
PubMed: 17081090
09/2006

Sudden unexpected death in children with heart disease.
Congenital heart disease
Sanatani S and Wilson G and Smith CR and Hamilton RM and Williams WG and Adatia I
DOI: 10.1111/j.1747-0803.2006.00014.x
PubMed: 18377551
05/2006

An alternate technique to pacing in complex congenital heart disease: assessment of the left thoracotomy approach.
The Canadian Journal of Cardiology
Roberts AD and Sett S and Leblanc J and Sanatani S
DOI: 10.1016/s0828-282x(06)70264-1
PubMed: 16685311
05/2006

Medications used to manage supraventricular tachycardia in the infant a North American survey.
Pediatric cardiology
Wong KK and Potts JE and Etheridge SP and Sanatani S
DOI: 10.1007/s00246-005-1126-x
PubMed: 16391988
2006

Dilated cardiomyopathy masquerading as long QT syndrome.
Pediatric cardiology
Walls J and Dipchand A and Sanatani S
DOI: 10.1007/s00246-005-1114-1
PubMed: 16391990
2006

Resynchronization therapy in pediatric and congenital heart disease patients: an international multicenter study.
Journal of the American College of Cardiology
Dubin AM and Janousek J and Rhee E and Strieper MJ and Cecchin F and Law IH and Shannon KM and Temple J and Rosenthal E and Zimmerman FJ and Davis A and Karpawich PP and Al Ahmad A and Collins KK
DOI: 10.1016/j.jacc.2005.05.096
PubMed: 16360058
12/2005

Documenting junctional ectopic tachycardia following pediatric open heart surgery.
Journal of the Medical Association of Thailand = Chotmaihet thangphaet
Gengsakul A and Potts JE and Sandhu A and Patterson MW and Sett SS and Taylor G and Sanatani S
PubMed: 16858961
11/2005

Cerebral oxygenation during defibrillator threshold testing of implantable cardioverter defibrillators.
Pacing and clinical electrophysiology : PACE
McNeill E and Gagnon RE and Potts JE and Yeung-Lai-Wah JA and Kerr CR and Sanatani S
DOI: 10.1111/j.1540-8159.2005.09518.x
PubMed: 15955185
06/2005

Anomalous origin of the left coronary artery with diffuse coronary hypoplasia resulting in sudden death.
The Canadian Journal of Cardiology
Ho J and Jevon G and Sanatani S
PubMed: 15917883
05/2005

The protean manifestations of blunt cardiac trauma in children.
Pediatric emergency care
Milligan J and Potts JE and Human DG and Sanatani S
DOI: 10.1097/01.pec.0000159071.62938.5b
PubMed: 15874814
05/2005

The Brugada ECG pattern in a neonate.
Journal of cardiovascular electrophysiology
Sanatani S and Mahkseed N and Vallance H and Brugada R
DOI: 10.1046/j.1540-8167.2005.40607.x
PubMed: 15817096
03/2005

Post-hoc diagnosis of congenital long QT syndrome in patients with tetralogy of Fallot.
Pediatric cardiology
Walls J and Sanatani S and Hamilton R
DOI: 10.1007/s00246-004-0712-7
PubMed: 15793661
2005

Long on QT and low on calcium.
Cardiology in the young
Bradley TJ and Metzger DL and Sanatani S
DOI: 10.1017/s1047951104006134
PubMed: 15680004
12/2004

Coronary vessel involvement by chronic graft-versus-host disease presenting as sudden cardiac death.
Bone marrow transplantation
Prevost D and Taylor G and Sanatani S and Schultz KR
DOI: 10.1038/sj.bmt.1704625
PubMed: 15300232
10/2004

Evolution of heart rate control after transplantation: conduction versus autonomic innervation.
Pediatric cardiology
Sanatani S and Chiu C and Nykanen D and Coles J and West L and Hamilton R
DOI: 10.1007/s00246-003-0387-5
PubMed: 14647999
2004

Use of an implantable loop recorder in the evaluation of children with congenital heart disease.
American heart journal
Sanatani S and Peirone A and Chiu C and Human DG and Gross GJ and Hamilton RM
DOI: 10.1067/mhj.2002.120157
PubMed: 11835044
02/2002

Predictors of refractory tachycardia in infants with supraventricular tachycardia.
Pediatric cardiology
Sanatani S and Hamilton RM and Gross GJ
DOI: 10.1007/s00246-002-1514-4
PubMed: 12189406
2002

Spontaneously terminating apparent ventricular fibrillation during transesophageal electrophysiological testing in infants with Wolff-Parkinson-White syndrome.
Pacing and clinical electrophysiology : PACE
Sanatani S and Saul JP and Walsh EP and Gross GJ
DOI: 10.1046/j.1460-9592.2001.01816.x
PubMed: 11817818
12/2001

Balloon angioplasty of right ventricular outflow tract conduits.
Pediatric cardiology
Sanatani S and Potts JE and Human DG and Sandor GG and Patterson MW and Gordon Culham JA
DOI: 10.1007/s002460010209
PubMed: 11343149
2001

Echocardiography and pulmonary function testing in childhood onset systemic lupus erythematosus.
Lupus
Al-Abbad AJ and Cabral DA and Sanatani S and Sandor GG and Seear M and Petty RE and Malleson PN
DOI: 10.1191/096120301669980721
PubMed: 11243507
2001

Early and intermediate-term complications of self-expanding stents limit its potential application in children with congenital heart disease.
Journal of the American College of Cardiology
Cheung YF and Sanatani S and Leung MP and Human DG and Chau AK and Culham JA
DOI: 10.1016/s0735-1097(99)00644-0
PubMed: 10732902
03/2000

Coil occlusion of the patent ductus arteriosus: lessons learned.
Cardiovascular and interventional radiology
Sanatani S and Potts JE and Ryan A and Sandor GG and Human DG and Culham JA
DOI: 10.1007/s002709910019
PubMed: 10795831
2000

Vascular abnormalities in Adams-Oliver syndrome: cause or effect?
American journal of medical genetics
Swartz EN and Sanatani S and Sandor GG and Schreiber RA
DOI: 10.1002/(sici)1096-8628(19990101)82:13.0.co;2-m
PubMed: 9916843
01/1999

Extracardiac Fontan operation with tube fenestration allowing transcatheter coil occlusion.
The Annals of thoracic surgery
Sanatani S and Sett SS and Human DG and Culham JA and LeBlanc JG
DOI: 10.1016/s0003-4975(98)00560-8
PubMed: 9768957
09/1998

Kawasaki disease in the older child.
Pediatrics
Momenah T and Sanatani S and Potts J and Sandor GG and Human DG and Patterson MW
DOI: 10.1542/peds.102.1.e7
PubMed: 9651459
07/1998

Research

Supraventricular tachycardia (SVT)
Supraventricular tachycardia remains the most common chronic rhythm disturbance. I was the Principal Investigator on a Heart and Stroke funded multi-site study examining two antiarrhythmia medications in infants with this rhythm disturbance. This study was among very few prospective controlled studies in pediatric electrophysiology. This study led to the creation of the International SVT Pediatric SVT Research Interest group, which continues to support pediatric SVT research.

In the realm of SVT, CIHR-funded collaborations with the cardiac basic science group are ongoing, examining mechanisms of post-operative arrhythmias. This group has isolated cells from a neonatal rabbit’s cardiac conduction system. To our knowledge, the isolation of neonatal AV nodal cells had not been done before.

Sudden unexpected death (SUD)
Sudden death affects about 500000 individuals each year in North America. The vast majority of these cases occur in older individuals with coronary artery disease. An important number of cases, however, are due to hidden heart disease, either latent structural disease or primary electrical heart disease. These disorders are typically due to mutations in the genes responsible for the electrical heart beat and corresponding muscle contraction. The abnormalities predispose the individual to potentially lethal cardiac rhythm abnormalities.

I am part of a national research collaboration examining families of SUD victims to identify the cause of SUD in these families. We have many active research collaborations on sudden death in the young. My clinical work in SUD substrates has led to multidisciplinary collaboration with basic scientists, geneticists, genetic counselors and lay personnel. We have described a novel mutation in a Northern British Columbia community predisposing many individuals to SUD. This work has led to further collaboration, grants and ongoing research. We currently lead an international registry on pediatric catecholaminergic polymorphic ventricular tachycardia, a rare, but lethal heart condition.

Working with a group of anesthetists, we examined the effects of anesthetic agents on cardiac repolarization. Abnormalities of repolarization have been linked to sudden death and arrhythmias. This project was one of several projects dealing with cardiac repolarization.

I am a member of the medical advisory for the Sudden Arrhythmia Death Syndromes (SADS) Foundation and serve on the scientific advisory board of the American SADS Foundation. I was the Vice-President of Research for the international Pediatric and Congenital Electrophysiology Society (PACES) prior to serving as president in 2016-17.

Honours & Awards

Resident Research Faculty Mentor of the Year Award, UBC Department of Pediatrics. 2011-2012

Canadian Pacific Has Heart Cardiovascular Award. Heart and Stroke Foundation. Oct 2015

Research Group Members

Jeff Chen
Valerie Chu, Undergraduate Student
Sonia Franciosi
Dallas Kallas, Graduate Student
Christopher Li
Michelle Liu, Research Assistant