Dr. Crystal Karakochuk is an Assistant Professor in the Faculty of Land and Food Systems at UBC. Her research program focuses on the links of nutritional status and anemia, including the role of nutritional supplementation and of hemoglobinopathies in children, women, and families in Canada and globally.
Her team performs comprehensive measurement and interpretation of indicators of anemia (hematological and nutritional biomarkers) and genetic polymorphisms associated with hemoglobin in individuals, families, and populations. She also studies the benefits and potential harms of nutrition supplementation policies and programs designed to treat anemia, including untargeted iron and folic acid supplementation in women and children globally.
Dr. Karakochuk's research program combines two distinct fields of research – nutrition and hematology. This program brings together clinicians, researchers, and policy makers to advance and apply knowledge in nutritional hematology. Dr. Karakochuk’s research program addresses two key objectives:
-To improve diagnostic methods and investigate new biomarkers for anemia and iron deficiency for individual- and population-level assessment
-To evaluate the risk-benefit of Canadian and global micronutrient supplementation policies to advance clinical practice and to inform safe, effective nutrition therapy worldwide
The Effect of Daily Iron Supplementation with 60 mg Ferrous Sulfate for 12 Weeks on Non-Transferrin Bound Iron Concentrations in Women with a High Prevalence of Hemoglobinopathies
Journal of Clinical Medicine
Shannon L. Steele and Hou Kroeun and Crystal Karakochuk
Measurement and interpretation of hemoglobin concentration in clinical and field settings: a narrative review
Annals of the New York Academy of Sciences
Crystal D. Karakochuk and Sonja Y. Hess and Denish Moorthy and Sorrel Namaste and Megan E. Parker and Aviva I. Rappaport and Rita Wegmüller and Omar Dary
Comparison of a New Multiplex Immunoassay for Measurement of Ferritin, Soluble Transferrin Receptor, Retinol-Binding Protein, C-Reactive Protein and a1-Acid-glycoprotein Concentrations against a Widely-Used s-ELISA Method
Mean hemoglobin concentrations in fasting venous and non-fasting capillary blood of Cambodian women using a hemoglobinometer and an automated hematology analyzer.
Clinical chemistry and laboratory medicine
Serum Soluble Transferrin Receptor Concentrations Are Elevated in Congolese Children with Glucose-6-Phosphate Dehydrogenase Variants, but Not Sickle Cell Variants or a-Thalassemia.
The Journal of nutrition
High prevalence of thiamine (vitamin B1) deficiency in early childhood among a nationally representative sample of Cambodian women of childbearing age and their children.
PLoS Neglected Tropical Diseases
The effect of inflammation on serum zinc concentrations and the prevalence estimates of population-level zinc status among Congolese children aged 6-59 months.
European journal of clinical nutrition
The effect of oral iron with or without multiple micronutrients on hemoglobin concentration and hemoglobin response among nonpregnant Cambodian women of reproductive age: a 2 x 2 factorial, double-blind, randomized controlled supplementation trial
The American Journal of Clinical Nutrition
Crystal D Karakochuk and Mikaela K Barker and Kyly C Whitfield and Susan I Barr and Suzanne M Vercauteren and Angela M Devlin and Jennifer A Hutcheon and Lisa A Houghton and Sophonneary Prak and Kroeun Hou and Tze Lin Chai and Ame Stormer and Sokhoing Ly and Robyn Devenish and Christian Oberkanins and Helene Pühringer and Kimberly B Harding and Luz M De-Regil and Klaus Kraemer and Tim J Green
Correlations between Maternal, Breast Milk, and Infant Vitamin B12 Concentrations among Mother–Infant Dyads in Vancouver, Canada and Prey Veng, Cambodia: An Exploratory Analysis
Comparison of four immunoassays to measure serum ferritin concentrations and iron deficiency prevalence among non-pregnant Cambodian women and Congolese children
Clinical Chemistry and Laboratory Medicine
Karakochuk, C.D. and Whitfield, K.C. and Rappaport, A.I. and Barr, S.I. and Vercauteren, S.M. and McLean, J. and Hou, K. and Talukder, A. and Houghton, L.A. and Bailey, K.B. and Boy, E. and Green, T.J.
Anemia and micronutrient status ofwomen of childbearing age and children 6–59 months in the Democratic Republic of the Congo
Harvey-Leeson, S. and Karakochuk, C.D. and Hawes, M. and Tugirimana, P.L. and Bahizire, E. and Akilimali, P.Z. and Michaux, K.D. and Lynd, L.D. and Whitfield, K.C. and Moursi, M. and Boy, E. and Foley, J. and McLean, J. and Houghton, L.A. and Gibson, R.S. and Green, T.J.
Household Consumption of Thiamin-Fortified Fish Sauce Increases Erythrocyte Thiamin Concentrations among Rural Cambodian Women and Their Children Younger Than 5 Years of Age: A Randomized Controlled Efficacy Trial
Journal of Pediatrics
Whitfield, K.C. and Karakochuk, C.D. and Kroeun, H. and Sokhoing, L. and Chan, B.B. and Borath, M. and Sophonneary, P. and Moore, K. and Tong, J.K.T. and McLean, J. and Talukder, A. and Lynd, L.D. and Li-Chan, E.C.Y. and Kitts, D.D. and Green, T.J.
Perinatal consumption of thiamine-fortified fish sauce in rural Cambodia: A randomized clinical trial
Whitfield, K.C. and Karakochuk, C.D. and Kroeun, H. and Hampel, D. and Sokhoing, L. and Chan, B.B. and Borath, M. and Sophonneary, P. and McLean, J. and Talukder, A. and Lynd, L.D. and Li-Chan, E.C.Y. and Kitts, D.D. and Allen, L.H. and Green, T.J.
Improved sanitation facilities are associated with higher body mass index and higher hemoglobin concentration among rural cambodian women in the first trimester of pregnancy
American Journal of Tropical Medicine and Hygiene
Janmohamed, A. and Karakochuk, C.D. and McLean, J. and Green, T.J.
A method comparison study between two hemoglobinometer models (Hemocue Hb 301 and Hb 201+) to measure hemoglobin concentrations and estimate anemia prevalence among women in Preah Vihear, Cambodia
International Journal of Laboratory Hematology
Rappaport, A.I. and Karakochuk, C.D. and Whitfield, K.C. and Kheang, K.M. and Green, T.J.
Factors affecting the acceptability and consumption of Corn Soya Blend Plus as a prenatal dietary supplement among pregnant women in rural Cambodia
Public Health Nutrition
Janmohamed, A. and Karakochuk, C.D. and Boungnasiri, S. and Whitfield, K.C. and Chapman, G.E. and Janssen, P. and McLean, J. and Green, T.J.
Anthropometric measures are simple and accurate paediatric weight-prediction proxies in resource-poor settings with a high HIV prevalence
Archives of Disease in Childhood
Whitfield, K.C. and Wozniak, R. and Pradinuk, M. and Karakochuk, C.D. and Anabwani, G. and Daly, Z. and MacLeod, S.M. and Larson, C.P. and Green, T.J.
Prenatal supplementation with Corn Soya Blend Plus reduces the risk of maternal anemia in late gestation and lowers the rate of preterm birth but does not significantly improve maternal weight gain and birth anthropometric measurements in rural Cambodian women: A randomized trial
American Journal of Clinical Nutrition
Janmohamed, A. and Karakochuk, C.D. and Boungnasiri, S. and Chapman, G.E. and Janssen, P.A. and Brant, R. and Green, T.J. and McLean, J.
Folic acid fortified milk increases blood folate to concentrations associated with a very low risk of neural tube defects in Singaporean women of childbearing age
Asia Pacific Journal of Clinical Nutrition
Cheong, M. and Xiao, H.Y. and Tay, V. and Karakochuk, C.D. and Liu, Y.A. and Harvey, S. and Lamers, Y. and Houghton, L.A. and Kitts, D.D. and Green, T.J.
Median urinary iodine concentrations are indicative of adequate iodine status among women of reproductive age in prey veng, Cambodia
Karakochuk, C.D. and Michaux, K.D. and Chai, T.L. and Chan, B.B. and Whit?eld, K.C. and Barr, S.I. and McLean, J. and Talukder, A. and Hou, K. and Ly, S. and Green, T.J.
Evaluation of two methods to measure hemoglobin concentration among women with genetic hemoglobin disorders in Cambodia: A method-comparison study
Clinica Chimica Acta
Karakochuk, C.D. and Janmohamed, A. and Whitfield, K.C. and Barr, S.I. and Vercauteren, S.M. and Kroeun, H. and Talukder, A. and McLean, J. and Green, T.J.
The homozygous hemoglobin EE genotype and chronic inflammation are associated with high serum ferritin and soluble transferrin receptor concentrations among women in rural Cambodia
Journal of Nutrition
Karakochuk, C.D. and Whitfield, K.C. and Rappaport, A.I. and Barr, S.I. and Vercauteren, S.M. and McLean, J. and Prak, S. and Hou, K. and Talukder, A. and Devenish, R. and Green, T.J.
Genetic hemoglobin disorders rather than iron deficiency are a major predictor of hemoglobin concentration in women of reproductive age in rural prey veng, Cambodia
Journal of Nutrition
Karakochuk, C.D. and Whitfield, K.C. and Barr, S.I. and Lamers, Y. and Devlin, A.M. and Vercauteren, S.M. and Kroeun, H. and Talukder, A. and McLean, J. and Green, T.J.
Maternal vitamin D3 supplementation at 50 mg/d protects against low serum 25-hydroxyvitamin D in infants at 8 wk of age: A randomized controlled trial of 3 doses of vitamin D beginning in gestation and continued in lactation
American Journal of Clinical Nutrition
March, K.M. and Chen, N.N. and Karakochuk, C.D. and Shand, A.W. and Innis, S.M. and Von Dadelszen, P. and Barr, S.I. and Lyon, M.R. and Whiting, S.J. and Weiler, H.A. and Green, T.J.
Poor thiamin and riboflavin status is common among women of childbearing age in rural and urban Cambodia
Journal of Nutrition
Whitfield, K.C. and Karakochuk, C.D. and Liu, Y. and McCann, A. and Talukder, A. and Kroeun, H. and Ward, M. and McNulty, H. and Lynd, L.D. and Kitts, D.D. and Li-Chan, E.C.Y. and McLean, J. and Green, T.J.
Elevated levels of iron in groundwater in Prey Veng province in Cambodia: A possible factor contributing to high iron stores in women
Journal of Water and Health
Karakochuk, C.D. and Murphy, H.M. and Whitfield, K.C. and Barr, S.I. and Vercauteren, S.M. and Talukder, A. and Porter, K. and Kroeun, H. and Eath, M. and McLean, J. and Green, T.J.
Food Sharing Practices in Households Receiving Supplemental Foods for the Treatment of Moderate Acute Malnutrition in Ethiopian Children
Journal of Hunger and Environmental Nutrition
Karakochuk, C.D. and van den Briel, T. and Stephens, D. and Zlotkin, S.
Treatment of moderate acute malnutrition with ready-to-use supplementary food results in higher overall recovery rates compared with a corn-soya blend in children in southern Ethiopia: An operations research trial
American Journal of Clinical Nutrition
Karakochuk, C. and Van Den Briel, T. and Stephens, D. and Zlotkin, S.
CIHR Project Grant 2018: Is iron supplementation harmful in populations where iron deficiency is not the cause of anemia? A 12 week RCT in Cambodia. $187,424.
The Thrasher Research Fund Early Career Award 2018. High-dose folic acid supplementation in sickle cell disease: Friend or foe? $26,750 USD.
Canadian Foundation for Innovation John R. Evans Leaders Fund. The Nutritional Hematology (NUTRI-HEME) Laboratory at UBC. $125,000.
BC Children’s Hospital Research Institute - Healthy Starts Catalyst Grant.Is natural folate as effective as synthetic folic acid in increasing plasma and red blood cell folate concentrations during pregnancy? A proof-of-concept pilot study. $40,000.
International Life Sciences Institute (ILSI North America) Future Leader Award. Investigating the potential risk of iron supplementation in Cambodian women. $30,000 USD.Honours & Awards
2018, International Life Sciences Institute (ILSI North America) Future Leader Award.
2015, Emerging Leaders in Nutrition Science Poster Competition Award, sponsored by the Global Nutrition Council of the American Society of Nutrition
2016, Outstanding Achievements for a Doctoral Candidate Award, BC Children’s Hospital Research Institute, Vancouver, Canada.
2016, Early Career Award for Contribution to Alleviation of Micronutrient Malnutrition International Life Sciences Institute.Research Group Members
Mikaela Barker, Volunteer
Kelsey Cochrane, Masters Student
Jordie Fischer, Masters Student
Cara Mayer, Work Learn Student
Kaitlyn Samson, Masters Student
Brock Williams, Doctoral Student, Clinical Dietitian