Overview

Research in my laboratory is focused on a novel subset of CD4+ T cells, termed T regulatory (Treg) cells, which control immune homeostasis. Although we know that Treg cells have a fundamental role in regulating immunity to both self and foreign proteins, little is known about how they function. Current work is focused on determining how Treg cells differ from normal CD4+ T cells at both the biochemical and molecular levels, and elucidating their role in transplantation tolerance, cancer and inflammatory bowel disease. A long-term goal is to develop methods to generate Treg cells in vitro for use as a cellular therapy to replace standard immunosuppression in the context of organ transplantation or to restore tolerance in the context of autoimmunity.

Publications

Pharmacological inhibition of RORC2 enhances human Th17-Treg stability and function
European Journal of Immunology
Dominic A. Boardman and Rosa V. Garcia and Sabine M. Ivison and Brian Bressler and TG Murali Dhar and Qihong Zhao and Megan K. Levings
DOI: 10.1002/eji.201948435
09/2020

Building a CAR-Treg: going from the basic to the luxury model
Cellular Immunology
Isaac Rosado-Sánchez and Megan K. Levings
DOI: 10.1016/j.cellimm.2020.104220
09/2020

T reg–specific insulin receptor deletion prevents diet-induced and age-associated metabolic syndrome
Journal of Experimental Medicine
Dan Wu and Chi Kin Wong and Jonathan M. Han and Paul C. Orban and Qing Huang and Jana Gillies and Majid Mojibian and William T. Gibson and Megan K. Levings
DOI: 10.1084/jem.20191542
08/2020

Donor-specific chimeric antigen receptor Tregs limit rejection in naive but not sensitized allograft recipients
American Journal of Transplantation
Antoine Sicard and Caroline Lamarche and Madeleine Speck and May Wong and Isaac Rosado-Sánchez and Mathilde Blois and Nicolas Glaichenhaus and Majid Mojibian and Megan K. Levings
DOI: 10.1111/ajt.15787
06/2020

Repeated stimulation or tonic-signaling chimeric antigen receptors drive regulatory T cell exhaustion
Caroline Lamarche and German E. Novakovsky and Christopher N. Qi and Evan W. Weber and Crystal L. Mackall and Megan K Levings
DOI: 10.1101/2020.06.27.175158
06/2020

Ectopic germline recombination activity of the widely used Foxp3-YFP-Cre mouse: a case report
Immunology
Dan Wu and Qing Huang and Paul C. Orban and Megan K. Levings
DOI: 10.1111/imm.13153
02/2020

Analysis of Flagellin-Specific Adaptive Immunity Reveals Links to Dysbiosis in Patients With Inflammatory Bowel Disease
Cellular and Molecular Gastroenterology and Hepatology
Cook, L. and Lisko, D.J. and Wong, M.Q. and Garcia, R.V. and Himmel, M.E. and Seidman, E.G. and Bressler, B. and Levings, M.K. and Steiner, T.S.
DOI: 10.1016/j.jcmgh.2019.11.012
2020

T-Cell Specificity Matters in IBD: Impaired IL10 Production Revealed by OmpC-Tetramers
Cellular and Molecular Gastroenterology and Hepatology
Cook, L. and Levings, M.K.
DOI: 10.1016/j.jcmgh.2020.06.007
2020

A New Mechanism of Action in Human and Mouse Treg Cells: The Ke(y)to Suppression.
Immunity
Wu D and Levings MK
DOI: 10.1016/j.immuni.2019.04.008
PubMed: 31117006
05/2019

Innate Control of Tissue-Reparative Human Regulatory T Cells
The Journal of Immunology
Avery J. Lam and Katherine N. MacDonald and Anne M. Pesenacker and Stephen C. Juvet and Kimberly A. Morishita and Brian Bressler and James G. Pan and Sachdev S. Sidhu and John D. Rioux and Megan K. Levings
DOI: 10.4049/jimmunol.1801330
04/2019

Cancer immunotherapies repurposed for use in autoimmunity.
Nature biomedical engineering
Boardman DA and Levings MK
DOI: 10.1038/s41551-019-0359-6
PubMed: 30952977
04/2019

Methods to manufacture regulatory T cells for cell therapy
Clinical & Experimental Immunology
K. N. MacDonald and J. M. Piret and M. K. Levings
DOI: 10.1111/cei.13297
04/2019

Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells.
JCI insight
Dawson NA and Lamarche C and Hoeppli RE and Bergqvist P and Fung VC and McIver E and Huang Q and Gillies J and Speck M and Orban PC and Bush JW and Mojibian M and Levings MK
DOI: 10.1172/jci.insight.123672
PubMed: 30753169
03/2019

Treg gene signatures predict and measure type 1 diabetes trajectory.
JCI insight
Pesenacker AM and Chen V and Gillies J and Speake C and Marwaha AK and Sun A and Chow S and Tan R and Elliott T and Dutz JP and Tebbutt SJ and Levings MK
DOI: 10.1172/jci.insight.123879
PubMed: 30730852
03/2019

Evaluating the role of Tregs in the progression of multiple myeloma.
Leukemia & lymphoma
Lad D and Huang Q and Hoeppli R and Garcia R and Xu L and Levings M and Song K and Broady R
DOI: 10.1080/10428194.2019.1579324
PubMed: 30773086
02/2019

Characterization of regulatory T cells in obese omental adipose tissue in humans.
European journal of immunology
Wu D and Han JM and Yu X and Lam AJ and Hoeppli RE and Pesenacker AM and Huang Q and Chen V and Speake C and Yorke E and Nguyen N and Sampath S and Harris D and Levings MK
DOI: 10.1002/eji.201847570
PubMed: 30566246
01/2019

Cryopreservation timing is a critical process parameter in a thymic regulatory T-cell therapy manufacturing protocol
Cytotherapy
MacDonald, K.N. and Ivison, S. and Hippen, K.L. and Hoeppli, R.E. and Hall, M. and Zheng, G. and Dijke, I.E. and Aklabi, M.A. and Freed, D.H. and Rebeyka, I. and Gandhi, S. and West, L.J. and Piret, J.M. and Blazar, B.R. and Levings, M.K.
DOI: 10.1016/j.jcyt.2019.10.011
2019

Suppressive and Gut-Reparative Functions of Human Type 1 T Regulatory Cells
Gastroenterology
Cook, L. and Stahl, M. and Han, X. and Nazli, A. and MacDonald, K.N. and Wong, M.Q. and Tsai, K. and Dizzell, S. and Jacobson, K. and Bressler, B. and Kaushic, C. and Vallance, B.A. and Steiner, T.S. and Levings, M.K.
DOI: 10.1053/j.gastro.2019.09.002
2019

Tailoring the homing capacity of human Tregs for directed migration to sites of Th1-inflammation or intestinal regions
American Journal of Transplantation
Hoeppli, R.E. and MacDonald, K.N. and Leclair, P. and Fung, V.C.W. and Mojibian, M. and Gillies, J. and Rahavi, S.M.R. and Campbell, A.I.M. and Gandhi, S.K. and Pesenacker, A.M. and Reid, G. and Lim, C.J. and Levings, M.K.
DOI: 10.1111/ajt.14936
2019

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
European Journal of Immunology
Cossarizza, A. and Chang, H.-D. and Radbruch, A. and Acs, A. and Adam, D. and Adam-Klages, S. and Agace, W.W. and Aghaeepour, N. and Akdis, M. and Allez, M. and Almeida, L.N. and Alvisi, G. and Anderson, G. and Andr{\"a}, I. and Annunziato, F. and Anselmo, A. and Bacher, P. and Baldari, C.T. and Bari, S. and Barnaba, V. and Barros-Martins, J. and Battistini, L. and Bauer, W. and Baumgart, S. and Baumgarth, N. and Baumjohann, D. and Baying, B. and Bebawy, M. and Becher, B. and Beisker, W. and Benes, V. and Beyaert, R. and Blanco, A. and Boardman, D.A. and Bogdan, C. and Borger, J.G. and Borsellino, G. and Boulais, P.E. and Bradford, J.A. and Brenner, D. and Brinkman, R.R. and Brooks, A.E.S. and Busch, D.H. and B{\"u}scher, M. and Bushnell, T.P. and Calzetti, F. and Cameron, G. and Cammarata, I. and Cao, X. and Cardell, S.L. and Casola, S. and Cassatella, M.A. and Cavani, A. and Celada, A. and Chatenoud, L. and Chattopadhyay, P.K. and Chow, S. and Christakou, E. and ?i?in-?ain, L. and Clerici, M. and Colombo, F.S. and Cook, L. and Cooke, A. and Cooper, A.M. and Corbett, A.J. and Cosma, A. and Cosmi, L. and Coulie, P.G. and Cumano, A. and Cvetkovic, L. and Dang, V.D. and Dang-Heine, C. and Davey, M.S. and Davies, D. and De Biasi, S. and Del Zotto, G. and Dela Cruz, G.V. and Delacher, M. and Della Bella, S. and Dellabona, P. and Deniz, G. and Dessing, M. and Di Santo, J.P. and Diefenbach, A. and Dieli, F. and Dolf, A. and D{\"o}rner, T. and Dress, R.J. and Dudziak, D. and Dustin, M. and Dutertre, C.-A. and Ebner, F. and Eckle, S.B.G. and Edinger, M. and Eede, P. and Ehrhardt, G.R.A. and Eich, M. and Engel, P. and Engelhardt, B. and Erdei, A. and Esser, C. and Everts, B. and Evrard, M. and Falk, C.S. and Fehniger, T.A. and Felipo-Benavent, M. and Ferry, H. and Feuerer, M. and Filby, A. and Filkor, K. and Fillatreau, S. and Follo, M. and F{\"o}rster, I. and Foster, J. and Foulds, G.A. and Frehse, B. and Frenette, P.S. and Frischbutter, S. and Fritzsche, W. and Galbraith, D.W. and Gangaev, A. and Garbi, N. and Gaudilliere, B. and Gazzinelli, R.T. and Geginat, J. and Gerner, W. and Gherardin, N.A. and Ghoreschi, K. and Gibellini, L. and Ginhoux, F. and Goda, K. and Godfrey, D.I. and Goettlinger, C. and Gonz{\'a}lez-Navajas, J.M. and Goodyear, C.S. and Gori, A. and Grogan, J.L. and Grummitt, D. and Gr{\"u}tzkau, A. and Haftmann, C. and Hahn, J. and Hammad, H. and H{\"a}mmerling, G. and Hansmann, L. and Hansson, G. and Harpur, C.M. and Hartmann, S. and Hauser, A. and Hauser, A.E. and Haviland, D.L. and Hedley, D. and Hern{\'a}ndez, D.C. and Herrera, G. and Herrmann, M. and Hess, C. and H{\"o}fer, T. and Hoffmann, P. and Hogquist, K. and Holland, T. and H{\"o}llt, T. and Holmdahl, R. and Hombrink, P. and Houston, J.P. and Hoyer, B.F. and Huang, B. and Huang, F.-P. and Huber, J.E. and Huehn, J. and Hundemer, M. and Hunter, C.A. and Hwang, W.Y.K. and Iannone, A. and Ingelfinger, F. and Ivison, S.M. and J{\"a}ck, H.-M. and Jani, P.K. and J{\'a}vega, B. and Jonjic, S. and Kaiser, T. and Kalina, T. and Kamradt, T. and Kaufmann, S.H.E. and Keller, B. and Ketelaars, S.L.C. and Khalilnezhad, A. and Khan, S. and Kisielow, J. and Klenerman, P. and Knopf, J. and Koay, H.-F. and Kobow, K. and Kolls, J.K. and Kong, W.T. and Kopf, M. and Korn, T. and Kriegsmann, K. and Kristyanto, H. and Kroneis, T. and Krueger, A. and K{\"u}hne, J. and Kukat, C. and Kunkel, D. and Kunze-Schumacher, H. and Kurosaki, T. and Kurts, C. and Kvistborg, P. and Kwok, I. and Landry, J. and Lantz, O. and Lanuti, P. and LaRosa, F. and Lehuen, A. and LeibundGut-Landmann, S. and Leipold, M.D. and Leung, L.Y.T. and Levings, M.K. and Lino, A.C. and Liotta, F. and Litwin, V. and Liu, Y. and Ljunggren, H.-G. and Lohoff, M. and Lombardi, G. and Lopez, L. and L{\'o}pez-Botet, M. and Lovett-Racke, A.E. and Lubberts, E. and Luche, H. and Ludewig, B. and Lugli, E. and Lunemann, S. and Maecker, H.T. and Maggi, L. and Maguire, O. and Mair, F. and Mair, K.H. and Mantovani, A. and Manz, R.A. and Marshall, A.J. and Mart{\'i}nez-Romero, A. and Martrus, G. and Marventano, I. and Maslinski, W. and Matarese, G. and Mattioli, A.V. and Mauer{\"o}der, C. and Mazzoni, A. and McCluskey, J. and McGrath, M. and McGuire, H.M. and McInnes, I.B. and Mei, H.E. and Melchers, F. and Melzer, S. and Mielenz, D. and Miller, S.D. and Mills, K.H.G. and Minderman, H. and Mj{\"o}sberg, J. and Moore, J. and Moran, B. and Moretta, L. and Mosmann, T.R. and M{\"u}ller, S. and Multhoff, G. and Mu{\~n}oz, L.E. and M{\"u}nz, C. and Nakayama, T. and Nasi, M. and Neumann, K. and Ng, L.G. and Niedobitek, A. and Nourshargh, S. and N{\'u}{\~n}ez, G. and O{'}Connor, J.-E. and Ochel, A. and Oja, A. and Ordonez, D. and Orfao, A. and Orlowski-Oliver, E. and Ouyang, W. and Oxenius, A. and Palankar, R. and Panse, I. and Pattanapanyasat, K. and Paulsen, M. and Pavlinic, D. and Penter, L. and Peterson, P. and Peth, C. and Petriz, J. and Piancone, F. and Pickl, W.F. and Piconese, S. and Pinti, M. and Pockley, A.G. and Podolska, M.J. and Poon, Z. and Pracht, K. and Prinz, I. and Pucillo, C.E.M. and Quataert, S.A. and Quatrini, L. and Quinn, K.M. and Radbruch, H. and Radstake, T.R.D.J. and Rahmig, S. and Rahn, H.-P. and Rajwa, B. and Ravichandran, G. and Raz, Y. and Rebhahn, J.A. and Recktenwald, D. and Reimer, D. and Reis e Sousa, C. and Remmerswaal, E.B.M. and Richter, L. and Rico, L.G. and Riddell, A. and Rieger, A.M. and Robinson, J.P. and Romagnani, C. and Rubartelli, A. and Ruland, J. and Saalm{\"u}ller, A. and Saeys, Y. and Saito, T. and Sakaguchi, S. and Sala-de-Oyanguren, F. and Samstag, Y. and Sanderson, S. and Sandrock, I. and Santoni, A. and Sanz, R.B. and Saresella, M. and Sautes-Fridman, C. and Sawitzki, B. and Schadt, L. and Scheffold, A. and Scherer, H.U. and Schiemann, M. and Schildberg, F.A. and Schimisky, E. and Schlitzer, A. and Schlosser, J. and Schmid, S. and Schmitt, S. and Schober, K. and Schraivogel, D. and Schuh, W. and Sch{\"u}ler, T. and Schulte, R. and Schulz, A.R. and Schulz, S.R. and Scott{\'a}, C. and Scott-Algara, D. and Sester, D.P. and Shankey, T.V. and Silva-Santos, B. and Simon, A.K. and Sitnik, K.M. and Sozzani, S. and Speiser, D.E. and Spidlen, J. and Stahlberg, A. and Stall, A.M. and Stanley, N. and Stark, R. and Stehle, C. and Steinmetz, T. and Stockinger, H. and Takahama, Y. and Takeda, K. and Tan, L. and T{\'a}rnok, A. and Tiegs, G. and Toldi, G. and Tornack, J. and Traggiai, E. and Trebak, M. and Tree, T.I.M. and Trotter, J. and Trowsdale, J. and Tsoumakidou, M. and Ulrich, H. and Urbanczyk, S. and van de Veen, W. and van den Broek, M. and van der Pol, E. and Van Gassen, S. and Van Isterdael, G. and van Lier, R.A.W. and Veldhoen, M. and Vento-Asturias, S. and Vieira, P. and Voehringer, D. and Volk, H.-D. and von Borstel, A. and von Volkmann, K. and Waisman, A. and Walker, R.V. and Wallace, P.K. and Wang, S.A. and Wang, X.M. and Ward, M.D. and Ward-Hartstonge, K.A. and Warnatz, K. and Warnes, G. and Warth, S. and Waskow, C. and Watson, J.V. and Watzl, C. and Wegener, L. and Weisenburger, T. and Wiedemann, A. and Wienands, J. and Wilharm, A. and Wilkinson, R.J. and Willimsky, G. and Wing, J.B. and Winkelmann, R. and Winkler, T.H. and Wirz, O.F. and Wong, A. and Wurst, P. and Yang, J.H.M. and Yang, J. and Yazdanbakhsh, M. and Yu, L. and Yue, A. and Zhang, H. and Zhao, Y. and Ziegler, S.M. and Zielinski, C. and Zimmermann, J. and Zychlinsky, A.
DOI: 10.1002/eji.201970107
2019

A composite immune signature parallels disease progression across T1D subjects
JCI Insight
Speake, C. and Skinner, S.O. and Berel, D. and Whalen, E. and Dufort, M.J. and Young, W.C. and Odegard, J.M. and Pesenacker, A.M. and Gorus, F.K. and James, E.A. and Levings, M.K. and Linsley, P.S. and Akirav, E.M. and Pugliese, A. and Hessner, M.J. and Nepom, G.T. and Gottardo, R. and Alice Long, S.
DOI: 10.1172/jci.insight.126917
2019

A standardized immune phenotyping and automated data analysis platform for multicenter biomarker studies.
JCI insight
Ivison S and Malek M and Garcia RV and Broady R and Halpin A and Richaud M and Brant RF and Wang SI and Goupil M and Guan Q and Ashton P and Warren J and Rajab A and Urschel S and Kumar D and Levings MK
DOI: 10.1172/jci.insight.121867
PubMed: 30518691
12/2018

Taking regulatory T-cell therapy one step further.
Current opinion in organ transplantation
Sicard A and Boardman DA and Levings MK
DOI: 10.1097/mot.0000000000000566
PubMed: 30063480
10/2018

An optimized method to measure human FOXP3+ regulatory T cells from multiple tissue types using mass cytometry
European Journal of Immunology
Nicholas A. J. Dawson and Avery J. Lam and Laura Cook and Romy E. Hoeppli and Raewyn Broady and Anne M. Pesenacker and Megan K. Levings
DOI: 10.1002/eji.201747407
08/2018

Megadose Bone Marrow and Regulatory T cells for the Induction of Immune Tolerance in Non-Human Primates Through Durable Mixed Hematopoietic Chimerism Across MHC-barriers
Transplantation
Paula Alonso-Guallart and Raimon Duran-Struuck and Jeffrey Stern and Erik Berglund and Nathaly Llore and Jonah Zitsman and Genevieve Pierre and Sigal Kofman and Makenzie Danton and Samanta Gokova and Emily Lopes and Alicia McMurchy and Qizhi Tang and Megan Levings and Megan Sykes and Adam Griesemer
DOI: 10.1097/01.tp.0000542954.80179.6b
07/2018

Engineering therapeutic T cells to suppress alloimmune responses using TCRs, CARs, or BARs
American Journal of Transplantation
Antoine Sicard and Megan K. Levings and David W. Scott
DOI: 10.1111/ajt.14747
04/2018

Minimum information about T regulatory cells: A step toward reproducibility and standardization
Frontiers in Immunology
Fuchs, A. and Gliwinski, M. and Grageda, N. and Spiering, R. and Abbas, A.K. and Appel, S. and Bacchetta, R. and Battaglia, M. and Berglund, D. and Blazar, B. and Bluestone, J.A. and Bornh{\"a}user, M. and Brinke, A. and Brusko, T.M. and Cools, N. and Cuturi, M.C. and Geissler, E. and Giannoukakis, N. and Golab, K. and Hafler, D.A. and van Ham, S.M. and Hester, J. and Hippen, K. and Di Ianni, M. and Ilic, N. and Isaacs, J. and Issa, F. and Iwaszkiewicz-Grzes, D. and Jaeckel, E. and Joosten, I. and Klatzmann, D. and Koenen, H. and Kooten, C. and Korsgren, O. and Kretschmer, K. and Levings, M. and Marek-Trzonkowska, N.M. and Martinez-Llordella, M. and Miljkovic, D. and Mills, K.H.G. and Miranda, J.P. and Piccirillo, C.A. and Putnam, A.L. and Ritter, T. and Roncarolo, M.G. and Sakaguchi, S. and S{\'a}nchez-Ram{\'o}n, S. and Sawitzki, B. and Sofronic-Milosavljevic, L. and Sykes, M. and Tang, Q. and Vives-Pi, M. and Waldmann, H. and Witkowski, P. and Wood, K.J. and Gregori, S. and Hilkens, C.M.U. and Lombardi, G. and Lord, P. and Martinez-Caceres, E.M. and Trzonkowski, P.
DOI: 10.3389/fimmu.2017.01844
2018

The outstanding questions in transplantation: It's about time…
American Journal of Transplantation
Azzi, J. and Raimondi, G. and Mas, V. and Riella, L.V. and Elfadawy, N. and Safa, K. and Wojciechowski, D. and Kanak, M. and Nog, R. and Maltzman, J.S. and Ford, M.L. and Pober, J.S. and Luo, X.-R. and Rothstein, D. and Miller, M.L. and Matthews, D. and Burlingham, W. and Levings, M. and Heeger, P. and Higdon, L. and Gill, J. and Gill, R.G. and Alegre, M.-L.
DOI: 10.1111/ajt.14450
2018

Taking regulatory T-cell therapy one step further
Current Opinion in Organ Transplantation
Sicard, A. and Boardman, D.A. and Levings, M.K.
DOI: 10.1097/MOT.0000000000000566
2018

Guiding regulatory T cells to the allograft
Current Opinion in Organ Transplantation
Lamarche, C. and Levings, M.K.
DOI: 10.1097/MOT.0000000000000483
2018

Regulatory T-cells drive immune dysfunction in CLL
Leukemia and Lymphoma
Lad, D. and Hoeppli, R. and Huang, Q. and Garcia, R. and Xu, L. and Toze, C. and Broady, R. and Levings, M.
DOI: 10.1080/10428194.2017.1330475
2018

Guiding regulatory T cells to the allograft
Current Opinion in Organ Transplantation
Caroline Lamarche and Megan K. Levings
DOI: 10.1097/mot.0000000000000483
11/2017

Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells
Frontiers in Immunology
Nicholas A. J. Dawson and Jens Vent-Schmidt and Megan K. Levings
DOI: 10.3389/fimmu.2017.01460
11/2017

Harnessing Advances in T Regulatory Cell Biology for Cellular Therapy in Transplantation
Transplantation
Avery J. Lam and Romy E. Hoeppli and Megan K. Levings
DOI: 10.1097/tp.0000000000001757
10/2017

Guidelines for the use of flow cytometry and cell sorting in immunological studies.
European journal of immunology
Cossarizza A and Chang HD and Radbruch A and Akdis M and Andrä I and Annunziato F and Bacher P and Barnaba V and Battistini L and Bauer WM and Baumgart S and Becher B and Beisker W and Zimmermann J
DOI: 10.1002/eji.201646632
PubMed: 29023707
10/2017

Antigen-specific regulatory T cells: are police CARs the answer?
Translational Research
Nicholas A.J. Dawson and Megan K. Levings
DOI: 10.1016/j.trsl.2017.06.009
09/2017

CD56bright natural killer regulatory cells in filgrastim primed donor blood or marrow products regulate chronic graft-versus-host disease: the Canadian Blood and Marrow Transplant Group randomized 0601 study results.
Haematologica
Kariminia A and Ivison S and Ng B and Rozmus J and Sung S and Varshney A and Aljurf M and Lachance S and Walker I and Toze C and Lipton J and Lee SJ and Szer J and Doocey R and Lewis I and Schultz KR
DOI: 10.3324/haematol.2017.170928
PubMed: 28935847
09/2017

Adipose-tissue regulatory T cells: Critical players in adipose-immune crosstalk
European Journal of Immunology
Maike Becker and Megan K. Levings and Carolin Daniel
DOI: 10.1002/eji.201646739
09/2017

OR42 Expanded thymic regulatory T cells (Tregs) have low class I HLA expression levels and are HLA-DR negative – Potential for ‘Off-The-Shelf’ Cellular Therapy?
Human Immunology
Esme Dijke and Romy Hoeppli and Ingrid Larsen and Ivan Rebeyka and David Ross and Megan Levings and Lori West
DOI: 10.1016/j.humimm.2017.06.048
09/2017

Thymic progenitors of TCRaß + CD8aa intestinal intraepithelial lymphocytes require RasGRP1 for development
The Journal of Experimental Medicine
Dominic P. Golec and Romy E. Hoeppli and Laura M. Henao Caviedes and Jillian McCann and Megan K. Levings and Troy A. Baldwin
DOI: 10.1084/jem.20170844
06/2017

Migration Capacity of Thymic Regulatory T Cells can be Tuned by Expansion in Cytokine-Enriched Culture Conditions
Transplantation
Romy E. Hoeppli and Esmé Dijke and Andrew Campbell and Lori J. West and Megan K. Levings
DOI: 10.1097/01.tp.0000520352.47820.13
05/2017

Standardized Immunophenotyping in the Canadian National Transplant Research Program
Transplantation
Sabine Ivison and Salima Janmohamed and Mehrnoush Malek and Rosa Garcia and Raewyn Broady and Anne Halpin and Manon Richaud and Rollin Brant and Jean-Sebastien Delisle and Lori West and Ryan R. Brinkman and Megan Levings
DOI: 10.1097/01.tp.0000520396.84839.9b
05/2017

Thymus-Derived Treg Infusion to Prevent Graft Rejection in Heart-Transplanted Children
Transplantation
Esther Bernaldo de Quirós and Verónica A. Pérez and Maribel Clemente and Juan Miguel Gil-Jaurena and María Teresa González and Marjorie Pion and Giovanna Lombardi and Lori J. West and Megan Levings and Rafael Correa-Rocha
DOI: 10.1097/01.tp.0000520350.40197.6b
05/2017

Development of GMP-Compatible Protocols for Thymus-Derived Regulatory T Cell Expansion
Transplantation
Katherine MacDonald and Romy Hoeppli and James Piret and Esmé Dijke and Lori West and Megan Levings
DOI: 10.1097/01.tp.0000520303.10595.5e
05/2017

A Novel Whole Blood Assay Detects Flagellin-Specific CD4 + T Cells in Patients with Inflammatory Bowel Disease
Gastroenterology
Laura Cook and May Q. Wong and Rosa Garcia and Megan E. Himmel and Brian Bressler and Ernest G. Seidman and Theodore S. Steiner and Megan K. Levings
DOI: 10.1016/s0016-5085(17)32185-6
04/2017

Evaluating the Role of Tregs in the Progression of Multiple Myeloma
Clinical Lymphoma Myeloma and Leukemia
Deeepesh Lad and Raewyn Broady and Jessica Huang and Romy Hoeppli and Anne Pesenacker and Rosa Garcia and Lixin Xu and Megan Levings and Kevin Song
DOI: 10.1016/j.clml.2017.03.075
02/2017

Effect of Ex Vivo–Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance Across MHC Barriers in Cynomolgus Macaques
Transplantation
Raimon Duran-Struuck and Hugo P. Sondermeijer and Leo Bühler and Paula Alonso-Guallart and Jonah Zitsman and Yojiro Kato and Anette Wu and Alicia N. McMurchy and David Woodland and Adam Griesemer and Mercedes Martinez and Svetlan Boskovic and Tatsuo Kawai and A. Benedict Cosimi and Cheng-Shie Wuu and Andrea Slate and Markus Y. Mapara and Sam Baker and Rafal Tokarz and Vivette D'Agati and Scott Hammer and Marcus Pereira and W. Ian Lipkin and Thomas Wekerle and Megan K. Levings and Megan Sykes
DOI: 10.1097/tp.0000000000001559
02/2017

CD4+ T Cells Specific for C. difficile Toxins are a Marker of Patients with Active Relapsing Disease
Open Forum Infectious Diseases
Laura Cook and May Wong and William Rees and Torey Lau and Megan Levings and Theodore Steiner
DOI: 10.1093/ofid/ofx163.948
2017

Circulating gluten-specific FOXP3+CD39+ regulatory T cells have impaired suppressive function in patients with celiac disease
Journal of Allergy and Clinical Immunology
Cook, L. and Munier, C.M.L. and Seddiki, N. and van Bockel, D. and Ontiveros, N. and Hardy, M.Y. and Gillies, J.K. and Levings, M.K. and Reid, H.H. and Petersen, J. and Rossjohn, J. and Anderson, R.P. and Zaunders, J.J. and Tye-Din, J.A. and Kelleher, A.D.
DOI: 10.1016/j.jaci.2017.02.015
2017

Erratum to “Filgrastim-Stimulated Bone Marrow Compared with Filgrastim-Mobilized Peripheral Blood in Myeloablative Sibling Allografting for Patients with Hematologic Malignancies: A Randomized Canadian Blood and Marrow Transplant Group Study” [Biol Blood Marrow Transplant 2016 22 (1410–1415)] (S1083879116300362)(10.1016/j.bbmt.2016.04.017)
Biology of Blood and Marrow Transplantation
Couban, S. and Aljurf, M. and Lachance, S. and Walker, I. and Toze, C. and Rubinger, M. and Lipton, J.H. and Lee, S.J. and Szer, J. and Doocey, R. and Lewis, I.D. and Huebsch, L. and Howson-Jan, K. and Lalancette, M. and Almohareb, F. and Chaudhri, N. and Ivison, S. and Broady, R. and Levings, M. and Fairclough, D. and Devins, G. and Szwajcer, D. and Foley, R. and Smith, C. and Panzarella, T. and Kerr, H. and Kariminia, A. and Schultz, K.R.
DOI: 10.1016/j.bbmt.2016.09.021
2017

Biomarker-guided stratification of autoimmune patients for biologic therapy
Current Opinion in Immunology
Ivison, S. and des Rosiers, C. and Lesage, S. and Rioux, J.D. and Levings, M.K.
DOI: 10.1016/j.coi.2017.09.006
2017

Harnessing Advances in T Regulatory Cell Biology for Cellular Therapy in Transplantation
Transplantation
Lam, A.J. and Hoeppli, R.E. and Levings, M.K.
DOI: 10.1097/TP.0000000000001757
2017

Effect of Ex Vivo-Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance Across MHC Barriers in Cynomolgus Macaques
Transplantation
Duran-Struuck, R. and Sondermeijer, H.P. and B{\"u}hler, L. and Alonso-Guallart, P. and Zitsman, J. and Kato, Y. and Wu, A. and McMurchy, A.N. and Woodland, D. and Griesemer, A. and Martinez, M. and Boskovic, S. and Kawai, T. and Cosimi, A.B. and Wuu, C.-S. and Slate, A. and Mapara, M.Y. and Baker, S. and Tokarz, R. and D{'}Agati, V. and Hammer, S. and Pereira, M. and Lipkin, W.I. and Wekerle, T. and Levings, M.K. and Sykes, M.
DOI: 10.1097/TP.0000000000001559
2017

Filgrastim-Stimulated Bone Marrow Compared with Filgrastim-Mobilized Peripheral Blood in Myeloablative Sibling Allografting for Patients with Hematologic Malignancies: A Randomized Canadian Blood and Marrow Transplant Group Study
Biology of Blood and Marrow Transplantation
Stephen Couban and Mahmoud Aljurf and Sylvie Lachance and Irwin Walker and Cynthia Toze and Morel Rubinger and Jeffrey H. Lipton and Stephanie J. Lee and Jeff Szer and Richard Doocey and Ian D. Lewis and Lothar Huebsch and Kang Howson-Jan and Michel Lalancette and Fahad Almohareb and Nadeem Chaudhri and Sabine Ivison and Raewyn Broady and Megan Levings and Diane Fairclough and Gerald Devins and David Szwajcer and Ronan Foley and Clayton Smith and Tony Panzarella and Holly Kerr and Amina Kariminia and Kirk R. Schultz
DOI: 10.1016/j.bbmt.2016.04.017
08/2016

How antigen specificity directs regulatory T-cell function: self, foreign and engineered specificity
HLA
R. E. Hoeppli and K. G. MacDonald and M. K. Levings and L. Cook
DOI: 10.1111/tan.12822
06/2016

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor
Journal of Clinical Investigation
Katherine G. MacDonald and Romy E. Hoeppli and Qing Huang and Jana Gillies and Dan S. Luciani and Paul C. Orban and Raewyn Broady and Megan K. Levings
DOI: 10.1172/jci82771
03/2016

Heterogeneity of chronic graft-versus-host disease biomarkers: association with CXCL10 and CXCR3+ NK cells.
Blood
Kariminia A and Holtan SG and Ivison S and Rozmus J and Hebert MJ and Martin PJ and Lee SJ and Wolff D and Subrt P and Abdossamadi S and Sung S and Storek J and Levings M and Aljurf M and Schultz KR
DOI: 10.1182/blood-2015-09-668251
PubMed: 27020088
03/2016

T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression
Journal of Clinical Investigation
Scott J. Patterson and Anne M. Pesenacker and Adele Y. Wang and Jana Gillies and Majid Mojibian and Kim Morishita and Rusung Tan and Timothy J. Kieffer and C. Bruce Verchere and Constadina Panagiotopoulos and Megan K. Levings
DOI: 10.1172/jci83987
02/2016

A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes
Diabetes
Anne M. Pesenacker and Adele Y. Wang and Amrit Singh and Jana Gillies and Youngwoong Kim and Ciriaco A. Piccirillo and Duc Nguyen and W. Nicholas Haining and Scott J. Tebbutt and Constadina Panagiotopoulos and Megan K. Levings
DOI: 10.2337/db15-0572
01/2016

Obesity-Associated Adipose Tissue Inflammation and Transplantation
American Journal of Transplantation
D. Wu and N. A. J. Dawson and M. K. Levings
DOI: 10.1111/ajt.13578
01/2016

The role of FOXP3 in autoimmunity
Current Opinion in Immunology
Anne M Pesenacker and Laura Cook and Megan K Levings
DOI: 10.1016/j.coi.2016.07.004
2016

T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression
Journal of Clinical Investigation
Patterson, S.J. and Pesenacker, A.M. and Wang, A.Y. and Gillies, J. and Mojibian, M. and Morishita, K. and Tan, R. and Kieffer, T.J. and Verchere, C.B. and Panagiotopoulos, C. and Levings, M.K.
DOI: 10.1172/JCI83987
2016

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor
Journal of Clinical Investigation
MacDonald, K.G. and Hoeppli, R.E. and Huang, Q. and Gillies, J. and Luciani, D.S. and Orban, P.C. and Broady, R. and Levings, M.K.
DOI: 10.1172/JCI82771
2016

Discarded human thymus is a novel source of stable and long-lived therapeutic regulatory T cells
American Journal of Transplantation
Dijke, I.E. and Hoeppli, R.E. and Ellis, T. and Pearcey, J. and Huang, Q. and McMurchy, A.N. and Boer, K. and Peeters, A.M.A. and Aubert, G. and Larsen, I. and Ross, D.B. and Rebeyka, I. and Campbell, A. and Baan, C.C. and Levings, M.K. and West, L.J.
DOI: 10.1111/ajt.13456
2016

CCL22 Prevents Rejection of Mouse Islet Allografts and Induces Donor-Specific Tolerance
Cell Transplantation
Joel Montane and Merce Obach and Sigrid Alvarez and Loraine Bischoff and Derek L. Dai and Galina Soukhatcheva and John J. Priatel and Gijs Hardenberg and Megan K. Levings and Rusung Tan and Paul C. Orban and C. Bruce Verchere
DOI: 10.3727/096368914x685249
10/2015

Tr1 Cells, but Not Foxp3+Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10–Dependent Mechanism
The Journal of Immunology
Yu Yao and Jens Vent-Schmidt and Matthew D. McGeough and May Wong and Hal M. Hoffman and Theodore S. Steiner and Megan K. Levings
DOI: 10.4049/jimmunol.1403225
06/2015

IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance
The Journal of Immunology
Jonathan M. Han and Dan Wu and Heather C. Denroche and Yu Yao and C. Bruce Verchere and Megan K. Levings
DOI: 10.4049/jimmunol.1500020
04/2015

Regulatory T cells produce profibrotic cytokines in the skin of patients with systemic sclerosis
Journal of Allergy and Clinical Immunology
Katherine G. MacDonald and Nicholas A.J. Dawson and Qing Huang and James V. Dunne and Megan K. Levings and Raewyn Broady
DOI: 10.1016/j.jaci.2014.12.1932
04/2015

The Environment of Regulatory T Cell Biology: Cytokines, Metabolites, and the Microbiome
Frontiers in Immunology
Romy E. Hoeppli and Dan Wu and Laura Cook and Megan K. Levings
DOI: 10.3389/fimmu.2015.00061
02/2015

Restimulation After Cryopreservation and Thawing Preserves the Phenotype and Function of Expanded Baboon Regulatory T Cells
Transplantation Direct
Joshua Weiner and Raimon Duran-Struuck and Jonah Zitsman and Leo Buhler and Hugo Sondermeijer and Alicia N. McMurchy and Megan K. Levings and Megan Sykes and Adam Griesemer
DOI: 10.1097/txd.0000000000000511
02/2015

Phenotype, Function and Expansion of Regulatory T Cells in the Cynomolgus Macaque (Macaca fascicularis)
Biology of Blood and Marrow Transplantation
Paula Alonso Guallart and Jonah Zitsman and Hugo Sondermeijer and Leo Bühler and Christopher Ovanez and Alicia McMurchy and Megan Levings and Megan Sykes and Raimon Duran-Struuck
DOI: 10.1016/j.bbmt.2014.11.445
02/2015

Induction of Durable Mixed Hematopoietic Chimerism and Immune Tolerance in Monkeys
Biology of Blood and Marrow Transplantation
Paula Alonso Guallart and Jonah Zitsman and Hugo Sondermeijer and David Woodland and Yojiro Kato and Joshua Weiner and Adam Griesemer and Leo Bühler and Alicia McMurchy and Megan Levings and Megan Sykes and Raimon Duran-Struuck
DOI: 10.1016/j.bbmt.2014.11.040
02/2015

CCL22 prevents rejection of mouse islet allografts and induces donor-specific tolerance
Cell Transplantation
Montane, J. and Obach, M. and Alvarez, S. and Bischoff, L. and Dai, D.L. and Soukhatcheva, G. and Priatel, J.J. and Hardenberg, G. and Levings, M.K. and Tan, R. and Orban, P.C. and Verchere, C.B.
DOI: 10.3727/096368914X685249
2015

Control of tissue-localized immune responses by human regulatory T cells
European Journal of Immunology
Pesenacker, A.M. and Broady, R. and Levings, M.K.
DOI: 10.1002/eji.201344205
2015

Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation
Journal of Clinical Investigation
Frann Antignano and Kyle Burrows and Michael R. Hughes and Jonathan M. Han and Ken J. Kron and Nadia M. Penrod and Menno J. Oudhoff and Steven Kai Hao Wang and Paul H. Min and Matthew J. Gold and Alistair L. Chenery and Mitchell J.S. Braam and Thomas C. Fung and Fabio M.V. Rossi and Kelly M. McNagny and Cheryl H. Arrowsmith and Mathieu Lupien and Megan K. Levings and Colby Zaph
DOI: 10.1172/jci69592
03/2014

Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation
Journal of Clinical Investigation
Antignano, F. and Burrows, K. and Hughes, M.R. and Han, J.M. and Kron, K.J. and Penrod, N.M. and Oudhoff, M.J. and Wang, S.K.H. and Min, P.H. and Gold, M.J. and Chenery, A.L. and Braam, M.J.S. and Fung, T.C. and Rossi, F.M.V. and McNagny, K.M. and Arrowsmith, C.H. and Lupien, M. and Levings, M.K. and Zaph, C.
DOI: 10.1172/JCI69592
2014

Insulin inhibits IL-10-mediated regulatory T cell function: Implications for obesity
Journal of Immunology
Han, J.M. and Patterson, S.J. and Speck, M. and Ehses, J.A. and Levings, M.K.
DOI: 10.4049/jimmunol.1302181
2014

The role of FOXP3 in regulating immune responses
International Reviews of Immunology
Vent-Schmidt, J. and Han, J.M. and Macdonald, K.G. and Levings, M.K.
DOI: 10.3109/08830185.2013.811657
2014

Immune Regulation in Obesity-Associated Adipose Inflammation
The Journal of Immunology
J. M. Han and M. K. Levings
DOI: 10.4049/jimmunol.1301035
07/2013

Response to Comment on "Helios+ and Helios- Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans"
The Journal of Immunology
K. G. MacDonald and J. M. Han and M. E. Himmel and Q. Huang and B. Kan and A. I. M. Campbell and P. M. Lavoie and M. K. Levings
DOI: 10.4049/jimmunol.1390019
04/2013

Autologous transplant for autoimmune disease: optimizing the regulatory T cells
Cytotherapy
T.D. Prestidge and J.H. Davis and J. Huang and M. Himmel and M. Levings
DOI: 10.1016/j.jcyt.2013.01.161
04/2013

Pediatric thymic tissue as a source of CD25+FOXP3+ regulatory T cells (Tregs) for cellular therapy
Cytotherapy
E. Dijke and M. Levings and A. McMurchy and I. Larsen and I. Rebeyka and D. Ross and L. West
DOI: 10.1016/j.jcyt.2013.01.160
04/2013

Helios+ and Helios- Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans
The Journal of Immunology
M. E. Himmel and K. G. MacDonald and R. V. Garcia and T. S. Steiner and M. K. Levings
DOI: 10.4049/jimmunol.1201379
01/2013

Th-2 cytokine producing Tregs in the skin of patients with systemic sclerosis
Frontiers in Immunology
Broady Raewyn and Huang Qing and MacDonald Katherine and Dunne James and Levings Megan
DOI: 10.3389/conf.fimmu.2013.02.01011
2013

Anovel function for FOXP3 in humans: Intrinsic regulation of conventional T cells
Blood
McMurchy, A.N. and Gillies, J. and Gizzi, M.C. and Riba, M. and Garcia-Manteiga, J.M. and Cittaro, D. and Lazarevic, D. and Di Nunzio, S. and Piras, I.S. and Bulfone, A. and Roncarolo, M.G. and Stupka, E. and Bacchetta, R. and Levings, M.K.
DOI: 10.1182/blood-2012-05-431023
2013

Erratum: Transcriptome analysis reveals markers of aberrantly activated innate immunity in vitiligo lesional and non-lesional skin (PLoS ONE (2013) 8:7 DOI:10.1371/annotation/fbf9e317-e3ab-4f9a-b317-3de6abff890f)
PLoS ONE
Yu, R. and Broady, R. and Huang, Y. and Wang, Y. and Yu, J. and Gao, M. and Levings, M. and Wei, S. and Zhang, S. and Xu, A. and Su, M. and Dutz, J. and Zhang, X. and Zhou, Y.
DOI: 10.1371/annotation/fbf9e317-e3ab-4f9a-b317-3de6abff890f
2013

In vitro generation of human T regulatory cells: Generation, culture, and analysis of FOXP3-transduced t cells
Methods in Molecular Biology
McMurchy, A.N. and Levings, M.K.
DOI: 10.1007/978-1-62703-128-8-8
2013

Insulin impairs regulatory T cell function: implications for obesity
Frontiers in Immunology
Han Jonathan and Patterson Scott and Ehses Jan and Levings Megan
DOI: 10.3389/conf.fimmu.2013.02.00587
2013

Expansion of Highly Suppressive FOXP3+ Regulatory T Cells from Pediatric Thymic Tissue
Transplantation Journal
E. Dijke and A. McMurchy and M. Levings and I. Larsen and I. Rebeyka and D. Ross and L. West
DOI: 10.1097/00007890-201211271-02368
11/2012

In Vitro Generation of Human T Regulatory Cells: Generation, Culture, and Analysis of FOXP3-Transduced T Cells
Basic Cell Culture Protocols
Alicia N. McMurchy and Megan K. Levings
DOI: 10.1007/978-1-62703-128-8_8
10/2012

Chemokine Induced Tolerance in Mouse Islet Allografts
Canadian Journal of Diabetes
Joel Montane and Merce Obach and Loraine Bischoff and Galina Soukhatcheva and Paul C. Orban and Gijs Hardenberg and Megan K. Levings and Rusung Tan and C. Bruce Verchere
DOI: 10.1016/j.jcjd.2012.07.468
10/2012

ATP conditions intestinal epithelial cells to an inflammatory state that promotes components of DC maturation
European Journal of Immunology
Yu Yao and Megan K. Levings and Theodore S. Steiner
DOI: 10.1002/eji.201142213
10/2012

Active vitamin D (1,25-dihydroxyvitamin D3) increases host susceptibility to Citrobacter rodentium by suppressing mucosal Th17 responses
AJP: Gastrointestinal and Liver Physiology
N. R. Ryz and S. J. Patterson and Y. Zhang and C. Ma and T. Huang and G. Bhinder and X. Wu and J. Chan and A. Glesby and H. P. Sham and J. P. Dutz and M. K. Levings and K. Jacobson and B. A. Vallance
DOI: 10.1152/ajpgi.00320.2012
09/2012

T regulatory cell therapy in transplantation
Current Opinion in Organ Transplantation
Katherine G. MacDonald and Paul C. Orban and Megan K. Levings
DOI: 10.1097/mot.0b013e328355aaaf
08/2012

Regulatory T-cell therapy for inflammatory bowel disease: more questions than answers
Immunology
Megan E. Himmel and Yu Yao and Paul C. Orban and Theodore S. Steiner and Megan K. Levings
DOI: 10.1111/j.1365-2567.2012.03572.x
04/2012

Inflammation-Driven Reprogramming of CD4+Foxp3+ Regulatory T Cells into Pathogenic Th1/Th17 T Effectors Is Abrogated by mTOR Inhibition in vivo
PLoS ONE
Ekaterina Yurchenko and Marina T. Shio and Tony C. Huang and Maria Da Silva Martins and Moshe Szyf and Megan K. Levings and Martin Olivier and Ciriaco A. Piccirillo
DOI: 10.1371/journal.pone.0035572
04/2012

Toll-like receptor 5 deficiency protects from wasting disease in a T cell transfer colitis model in T cell receptor-ß-deficient mice
Inflammatory Bowel Diseases
Gijs Hardenberg and Yu Yao and Ciriaco A. Piccirillo and Megan K. Levings and Theodore S. Steiner
DOI: 10.1002/ibd.21738
01/2012

TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?
Frontiers in Immunology
Ashish K. Marwaha and Nicole J. Leung and Alicia N. McMurchy and Megan K. Levings
DOI: 10.3389/fimmu.2012.00129
2012

Suppression assays with human T regulatory cells: A technical guide
European Journal of Immunology
Mcmurchy, A.N. and Levings, M.K.
DOI: 10.1002/eji.201141651
2012

Transcriptome Analysis Reveals Markers of Aberrantly Activated Innate Immunity in Vitiligo Lesional and Non-Lesional Skin
PLoS ONE
Yu, R. and Broady, R. and Huang, Y. and Wang, Y. and Yu, J. and Gao, M. and Levings, M. and Wei, S. and Zhang, S. and Xu, A. and Su, M. and Dutz, J. and Zhang, X. and Zhou, Y.
DOI: 10.1371/journal.pone.0051040
2012

T regulatory cell therapy in transplantation: Stability, localization and functional specialization
Current Opinion in Organ Transplantation
MacDonald, K.G. and Orban, P.C. and Levings, M.K.
DOI: 10.1097/MOT.0b013e328355aaaf
2012

The Role of the PI3K Signaling Pathway in CD4+ T Cell Differentiation and Function
Frontiers in Immunology
Jonathan M. Han and Scott J. Patterson and Megan K. Levings
DOI: 10.3389/fimmu.2012.00245
2012

Cellular magnetic resonance imaging of monocyte-derived dendritic cell migration from healthy donors and cancer patients as assessed in a scid mouse model
Cytotherapy
Xizhong Zhang and Sonali N. de Chickera and Christy Willert and Vasliki Economopoulos and Jennifer Noad and Roja Rohani and Adele Y. Wang and Megan K. Levings and Elizabeth Scheid and Ronan Foley and Paula J. Foster and Gregory A. Dekaban
DOI: 10.3109/14653249.2011.605349
11/2011

Human Th1 and Th17 Cells Exhibit Epigenetic Stability at Signature Cytokine and Transcription Factor Loci
The Journal of Immunology
C. J. Cohen and S. Q. Crome and K. G. MacDonald and E. L. Dai and D. L. Mager and M. K. Levings
DOI: 10.4049/jimmunol.1101058
11/2011

CD4+Foxp3+ regulatory T cells suppress ¿d T-cell effector functions in a model of T-cell-induced mucosal inflammation
European Journal of Immunology
Ekaterina Yurchenko and Megan K. Levings and Ciriaco A. Piccirillo
DOI: 10.1002/eji.201141814
11/2011

Moving to tolerance: Clinical application of T regulatory cells
Seminars in Immunology
Alicia N. McMurchy and Andrew Bushell and Megan K. Levings and Kathryn J. Wood
DOI: 10.1016/j.smim.2011.04.001
08/2011

Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets
Journal of Clinical Investigation
Joel Montane and Loraine Bischoff and Galina Soukhatcheva and Derek L. Dai and Gijs Hardenberg and Megan K. Levings and Paul C. Orban and Timothy J. Kieffer and Rusung Tan and C. Bruce Verchere
DOI: 10.1172/jci43048
08/2011

SHIP-Deficient Dendritic Cells, Unlike Wild Type Dendritic Cells, Suppress T Cell Proliferation via a Nitric Oxide-Independent Mechanism
PLoS ONE
Frann Antignano and Melisa Hamilton and Scott Patterson and Victor Ho and Carla Cohen and Megan K. Levings and Gerald Krystal
DOI: 10.1371/journal.pone.0021893
07/2011

Environmental influences on T regulatory cells in inflammatory bowel disease
Seminars in Immunology
Gijs Hardenberg and Theodore S. Steiner and Megan K. Levings
DOI: 10.1016/j.smim.2011.01.012
04/2011

Human CD4+FOXP3+ regulatory T cells produce CXCL8 and recruit neutrophils
European Journal of Immunology
Megan E. Himmel and Sarah Q. Crome and Sabine Ivison and Ciriaco Piccirillo and Theodore S. Steiner and Megan K. Levings
DOI: 10.1002/eji.201040459
01/2011

The Stress signal extracellular ATP modulates antiflagellin immune responses in intestinal epithelial cells
Inflammatory Bowel Diseases
Sabine M. Ivison and Megan E. Himmel and Matt Mayer and Yu Yao and Arnawaz Kifayet and Megan K. Levings and Theodore S. Steiner
DOI: 10.1002/ibd.21428
01/2011

Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire
BMC Immunology
Kiran Assi and Scott Patterson and Shoukat Dedhar and David Owen and Megan Levings and Baljinder Salh
DOI: 10.1186/1471-2172-12-42
2011

Adenoviral-transduced dendritic cells are susceptible to suppression by T regulatory cells and promote interleukin 17 production
Cancer Immunology, Immunotherapy
Wang, A.Y. and Crome, S.Q. and Jenkins, K.M. and Medin, J.A. and Bramson, J.L. and Levings, M.K.
DOI: 10.1007/s00262-010-0948-4
2011

Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells
Journal of Immunology
Patterson, S.J. and Han, J.M. and Garcia, R. and Assi, K. and Gao, T. and O{'}Neill, A. and Newton, A.C. and Levings, M.K.
DOI: 10.4049/jimmunol.1002126
2011

Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets
Journal of Clinical Investigation
Montane, J. and Bischoff, L. and Soukhatcheva, G. and Dai, D.L. and Hardenberg, G. and Levings, M.K. and Orban, P.C. and Kieffer, T.J. and Tan, R. and Verchere, C.B.
DOI: 10.1172/JCI43048
2011

T regulatory cells and cancer immunotherapy
Experimental and Applied Immunotherapy
Wang, A.Y. and Levings, M.K.
DOI: 10.1007/978-1-60761-980-2_10
2011

Natural killer T cells constitutively expressing the interleukin-2 receptor a chain early in life are primed to respond to lower antigenic stimulation
Immunology
Mihoko Ladd and Ashish Sharma and Qing Huang and Adele Y. Wang and Lixin Xu and Indira Genowati and Megan K. Levings and Pascal M. Lavoie
DOI: 10.1111/j.1365-2567.2010.03304.x
09/2010

Cutaneous GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells.
Blood
Broady R and Yu J and Chow V and Tantiworawit A and Kang C and Berg K and Martinka M and Ghoreishi M and Dutz J and Levings MK
DOI: 10.1182/blood-2010-07-295436
PubMed: 20864580
09/2010

Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes.
Journal of immunology (Baltimore, Md. : 1950)
Marwaha AK and Crome SQ and Panagiotopoulos C and Berg KB and Qin H and Ouyang Q and Xu L and Priatel JJ and Levings MK and Tan R
DOI: 10.4049/jimmunol.1001860
PubMed: 20810982
09/2010

Leishmania Exosomes Modulate Innate and Adaptive Immune Responses through Effects on Monocytes and Dendritic Cells
The Journal of Immunology
J. M. Silverman and J. Clos and E. Horakova and A. Y. Wang and M. Wiesgigl and I. Kelly and M. A. Lynn and W. R. McMaster and L. J. Foster and M. K. Levings and N. E. Reiner
DOI: 10.4049/jimmunol.1000541
09/2010

Deconvolution and chromatic aberration corrections in quantifying colocalization of a transcription factor in three-dimensional cellular space
Micron
Thomas Abraham and Sarah E. Allan and Megan K. Levings
DOI: 10.1016/j.micron.2010.03.005
08/2010

Inflammatory Effects of Ex Vivo Human Th17 Cells Are Suppressed by Regulatory T Cells
The Journal of Immunology
S. Q. Crome and B. Clive and A. Y. Wang and C. Y. Kang and V. Chow and J. Yu and A. Lai and A. Ghahary and R. Broady and M. K. Levings
DOI: 10.4049/jimmunol.1000557
08/2010

CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC
European Journal of Immunology
Laura Maggi and Veronica Santarlasci and Manuela Capone and Anna Peired and Francesca Frosali and Sarah Q. Crome and Valentina Querci and Massimiliano Fambrini and Francesco Liotta and Megan K. Levings and Enrico Maggi and Lorenzo Cosmi and Sergio Romagnani and Francesco Annunziato
DOI: 10.1002/eji.200940257
05/2010

TLR5 is not required for flagellin-mediated exacerbation of DSS colitis
Inflammatory Bowel Diseases
Sabine M. Ivison and Megan E. Himmel and Gijs Hardenberg and Paige A.J. Wark and Arnawaz Kifayet and Megan K. Levings and Theodore S. Steiner
DOI: 10.1002/ibd.21097
03/2010

PHLPP Regulates the Development, Function and Molecular Signaling Pathways of T Regulatory Cells
Clinical Immunology
Scott Patterson and Rosa Garcia and Audrey O'Neill and Tianyan Gao and Alexandra Newton and Megan Levings
DOI: 10.1016/j.clim.2010.03.025
01/2010

Constitutive Expression of CD25 on the Surface of Neonatal (invariant) Natural Killer T Cells Primes Them to Proliferate with Lower Antigenic Stimulation
Clinical Immunology
Ashish Sharma and Mihoko Whalen and Qing Huang and Adele Wang and Lixin Xu and Indira Genowati and Meghan Levings and Pascal Lavoie
DOI: 10.1016/j.clim.2010.03.151
01/2010

The Inflammatory Effects of ex vivo Human T Helper 17 Cells are Suppressed by T Regulatory Cells
Clinical Immunology
Sarah Crome and Breanna Clive and Adele Wang and Christine Kang and Vickie Chow and Jessie Yiu and Raewyn Broady and Megan Levings
DOI: 10.1016/j.clim.2010.03.361
01/2010

Increased Fraction of IL-17 Secreting Cells in Type 1 Diabetes
Clinical Immunology
Ashish Marwaha and Megan Levings and Sarah Crome and Constadina Panagiotopoulos and John Priatel and Rusung Tan
DOI: 10.1016/j.clim.2010.03.398
01/2010

Translational mini-review series on Th17 cells: Function and regulation of human T helper 17 cells in health and disease
Clinical and Experimental Immunology
Crome, S.Q. and Wang, A.Y. and Levings, M.K.
DOI: 10.1111/j.1365-2249.2009.04037.x
2010

Point mutants of forkhead box P3 that cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked have diverse abilities to reprogram T cells into regulatory T cells
Journal of Allergy and Clinical Immunology
Mcmurchy, A.N. and Gillies, J. and Allan, S.E. and Passerini, L. and Gambineri, E. and Roncarolo, M.G. and Bacchetta, R. and Levings, M.K.
DOI: 10.1016/j.jaci.2010.09.001
2010

ATG-induced expression of FOXP3 in human CD4(+) T cells in vitro is associated with T-cell activation and not the induction of FOXP3(+) T regulatory cells.
Blood
Broady R and Yu J and Levings MK
DOI: 10.1182/blood-2009-04-214437
PubMed: 19822903
10/2009

MASTering Treg function to promote tolerance.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Levings MK and Thomson AW
DOI: 10.1111/j.1600-6143.2009.02810.x
PubMed: 19764946
10/2009

Wild-type FOXP3 is selectively active in CD4+CD25(hi) regulatory T cells of healthy female carriers of different FOXP3 mutations.
Blood
Di Nunzio S and Cecconi M and Passerini L and McMurchy AN and Baron U and Turbachova I and Vignola S and Valencic E and Tommasini A and Junker A and Cazzola G and Olek S and Levings MK and Bacchetta R
DOI: 10.1182/blood-2009-04-214593
PubMed: 19738030
09/2009

3rd Keystone Symposium on T regulatory cells.
Immunotherapy
McMurchy AN and Levings MK
DOI: 10.2217/imt.09.33
PubMed: 20635985
07/2009

The role of retinoic acid‐related orphan receptor variant 2 and IL‐17 in the development and function of human CD4+T cells
European Journal of Immunology
Sarah Q. Crome and Adele Y. Wang and Christine Y. Kang and Megan K. Levings
DOI: 10.1002/eji.200838908
06/2009

SHIP Regulates the Reciprocal Development of T Regulatory and Th17 Cells
The Journal of Immunology
N. R. Locke and S. J. Patterson and M. J. Hamilton and L. M. Sly and G. Krystal and M. K. Levings
DOI: 10.4049/jimmunol.0803749
06/2009

Quantifying colocalization of a conditionally active transcription factor FOXP3 in three-dimensional cellular space
Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XVI
Thomas Abraham and Sarah E. Allan and Megan K. Levings
DOI: 10.1117/12.808049
02/2009

Molecular regulation of cellular immunity by FOXP3.
Advances in experimental medicine and biology
McMurchy AN and Di Nunzio S and Roncarolo MG and Bacchetta R and Levings MK
PubMed: 20429414
01/2009

Molecular Regulation ofCellular Immunity by FOXP3
Forkhead Transcription Factors
Alicia N. McMurchy and Sara Di Nunzio and Maria Grazia Roncarolo and Rosa Bacchetta and Megan K. Levings
DOI: 10.1007/978-1-4419-1599-3_3
2009

3rd Keystone Symposium on T regulatory cells: 1-6 March 2009, Keystone, CO, USA
Immunotherapy
McMurchy, A.N. and Levings, M.K.
DOI: 10.2217/IMT.09.33
2009

Graft versus host disease: suppression by statins
Nature Medicine
Raewyn Broady and Megan K Levings
DOI: 10.1038/nm1108-1155
11/2008

Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3
European Journal of Immunology
Sarah E. Allan and George X. Song-Zhao and Thomas Abraham and Alicia N. McMurchy and Megan K. Levings
DOI: 10.1002/eji.200838373
11/2008

The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease
Immunology
Megan E. Himmel and Gijs Hardenberg and Ciriaco A. Piccirillo and Theodore S. Steiner and Megan K. Levings
DOI: 10.1111/j.1365-2567.2008.02939.x
10/2008

CD4+T-regulatory cells: toward therapy for human diseases
Immunological Reviews
Sarah E. Allan and Raewyn Broady and Silvia Gregori and Megan E. Himmel and Natasha Locke and Maria Grazia Roncarolo and Rosa Bacchetta and Megan K. Levings
DOI: 10.1111/j.1600-065x.2008.00634.x
06/2008

STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells
International Immunology
Laura Passerini and Sarah E. Allan and Manuela Battaglia and Sara Di Nunzio and Alicia N. Alstad and Megan K. Levings and Maria G. Roncarolo and Rosa Bacchetta
DOI: 10.1093/intimm/dxn002
02/2008

Expression of RORC2 Controls the Development of Human Th17 Cells
Clinical Immunology
Sarah Crome and Adele Wang and Megan Levings
DOI: 10.1016/j.clim.2008.03.043
01/2008

Molecular and Functional Studies in T Cells from Healthy Carriers of FOXP3 Mutations
Clinical Immunology
DOI: 10.1016/j.clim.2008.03.187
01/2008

Generation of Potent and Stable Human CD4+ T Regulatory Cells by Activation-independent Expression of FOXP3
Molecular Therapy
Sarah E Allan and Alicia N Alstad and Natacha Merindol and Natasha K Crellin and Mario Amendola and Rosa Bacchetta and Luigi Naldini and Maria Grazia Roncarolo and Hugo Soudeyns and Megan K Levings
DOI: 10.1038/sj.mt.6300341
01/2008

Molecular Signalling in T Regulatory Cells
Regulatory T Cells and Clinical Application
Natasha R. Locke and Natasha K. Crellin and Megan K. Levings
DOI: 10.1007/978-0-387-77909-6_8
2008

Pro-tolerogenic effects of photodynamic therapy with TH9402 on dendritic cells
Journal of Clinical Apheresis
Broady, R. and Yu, J. and Levings, M.K.
DOI: 10.1002/jca.20162
2008

CD4+ T-regulatory cells: Toward therapy for human diseases
Immunological Reviews
Allan, S.E. and Broady, R. and Gregori, S. and Himmel, M.E. and Locke, N. and Roncarolo, M.G. and Bacchetta, R. and Levings, M.K.
DOI: 10.1111/j.1600-065X.2008.00634.x
2008

27 Effects of IL-17 On Effector and Regultory T Cell Subsets
Cytokine
Sarah Q. Crome and Adele Wang and Megan K. Levings
DOI: 10.1016/j.cyto.2007.07.032
07/2007

Flow cytometry-based methods for studying signaling in human CD4+CD25+FOXP3+ T regulatory cells
Journal of Immunological Methods
Natasha K. Crellin and Rosa V. Garcia and Megan K. Levings
DOI: 10.1016/j.jim.2007.05.008
07/2007

Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells
Blood
N. K. Crellin and R. V. Garcia and M. K. Levings
DOI: 10.1182/blood-2006-07-035279
03/2007

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production
International Immunology
S. E. Allan and S. Q. Crome and N. K. Crellin and L. Passerini and T. S. Steiner and R. Bacchetta and M. G. Roncarolo and M. K. Levings
DOI: 10.1093/intimm/dxm014
02/2007

Isolation, Expansion, and Characterization of Human Natural and Adaptive Regulatory T Cells
Immunological Tolerance
Silvia Gregori and Rosa Bacchetta and Laura Passerini and Megan K. Levings and Maria Grazia Roncarolo
DOI: 10.1007/978-1-59745-395-0_6
2007

Isolation, expansion, and characterization of human natural and adaptive regulatory T cells
Methods in Molecular Biology
Gregori, S. and Bacchetta, R. and Passerini, L. and Levings, M.K. and Roncarolo, M.G.
DOI: 10.1385/1-59745-395-1:83
2007

Gliadin-Specific Type 1 Regulatory T Cells from the Intestinal Mucosa of Treated Celiac Patients Inhibit Pathogenic T Cells
The Journal of Immunology
C. Gianfrani and M. K. Levings and C. Sartirana and G. Mazzarella and G. Barba and D. Zanzi and A. Camarca and G. Iaquinto and N. Giardullo and S. Auricchio and R. Troncone and M.-G. Roncarolo
DOI: 10.4049/jimmunol.177.6.4178
09/2006

Interleukin-10-secreting type 1 regulatory T cells in rodents and humans
Immunological Reviews
Maria Grazia Roncarolo and Silvia Gregori and Manuela Battaglia and Rosa Bacchetta and Katharina Fleischhauer and Megan K. Levings
DOI: 10.1111/j.0105-2896.2006.00420.x
08/2006

Su.98. Defining a Role for FOXP3 in Human Cd4+ T-Cells
Clinical Immunology
Sarah Allan and Laura Passerini and Rosa Bacchetta and Mario Amendola and Luigi Naldini and Maria Grazia Roncarolo and Megan Levings
DOI: 10.1016/j.clim.2006.04.525
01/2006

Human CD4+CD25+ T Regulatory Cells Have Altered PKB Signalling Which Correlates with Suppressive Function
Clinical Immunology
DOI: 10.1016/j.clim.2006.04.009
01/2006

Foxp3 Mutations in Children: Different Degrees of Impairment in Regulatory and Effector T-Cell Functions in Patients with Distinct Genotypes and Phenotypes
Clinical Immunology
DOI: 10.1016/j.clim.2006.04.196
01/2006

Functional Dynamics of Naturally Occurring Regulatory T Cells in Health and Autoimmunity
Advances in Immunology
DOI: 10.1016/s0065-2776(06)92003-3
2006

Erratum: Interleukin-10- secreting type 1 regulatory T cells in rodents and humans (Immunological Reviews (2006) 212, (28-50))
Immunological Reviews
Roncarolo, M.G. and Gregori, S. and Battaglia, M. and Bacchetta, R. and Fleischhauer, K. and Levings, M.K.
DOI: 10.1111/j.1600-065X.2006.00448.x
2006

Functional Dynamics of Naturally Occurring Regulatory T Cells in Health and Autoimmunity
Advances in Immunology
Levings, M.K. and Allan, S. and d{'}Hennezel, E. and Piccirillo, C.A.
DOI: 10.1016/S0065-2776(06)92003-3
2006

Defective regulatory and effector T cell functions in patients with FOXP3 mutations
Journal of Clinical Investigation
Bacchetta, R. and Passerini, L. and Gambineri, E. and Dai, M. and Allan, S.E. and Perroni, L. and Dagna-Bricarelli, F. and Sartirana, C. and Matthes-Martin, S. and Lawitschka, A. and Azzari, C. and Ziegler, S.F. and Levings, M.K. and Roncarolo, M.G.
DOI: 10.1172/JCI25112
2006

Human CD4+ T Cells Express TLR5 and Its Ligand Flagellin Enhances the Suppressive Capacity and Expression of FOXP3 in CD4+CD25+ T Regulatory Cells
The Journal of Immunology
N. K. Crellin and R. V. Garcia and O. Hadisfar and S. E. Allan and T. S. Steiner and M. K. Levings
DOI: 10.4049/jimmunol.175.12.8051
2005

The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs
Journal of Clinical Investigation
Allan, S.E. and Passerini, L. and Bacchetta, R. and Crellin, N. and Dai, M. and Orban, P.C. and Ziegler, S.F. and Roncarolo, M.G. and Levings, M.K.
DOI: 10.1172/JCI24685
2005

Phenotypic and functional differences between human CD4 +CD25+ and type 1 regulatory T cells
Current Topics in Microbiology and Immunology
Levings, M.K. and Roncarolo, M.G.
DOI: 10.1007/3-540-27702-1_14
2005

Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells
Blood
Levings, M.K. and Gregori, S. and Tresoldi, E. and Cazzaniga, S. and Bonini, C. and Roncarolo, M.G.
DOI: 10.1182/blood-2004-03-1211
2005

Recombinant human interleukin 10 suppresses gliadin dependent T cell activation in ex vivo cultured coeliac intestinal mucosa
Gut
Salveti, V.M. and Mazzarella, G. and Gianfrani, C. and Levings, M.K. and Stefanile, R. and De Giulio, B. and Iaquinto, G. and Giardullo, N. and Auricchio, S. and Roncarolo, M.G. and Troncone, R.
DOI: 10.1136/gut.2003.023150
2005

Can we throw the master-switch in autoimmune disease?
Clinical Genetics
Paul C Orban and Megan K Levings
DOI: 10.1034/j.1399-0004.2003.t01-2-00121.x
06/2003

Discoveries in sphingolipid metabolism, spinocerebellar ataxia and autoimmune disease
Clinical Genetics
Liam R Brunham and Edmond YW Chan and Paul C Orban and Megan K Levings
DOI: 10.1034/j.1399-0004.2003.00121.x
06/2003

Type 1 T regulatory cells and their relationship with CD4 +CD25+ T regulatory cells
Novartis Foundation Symposium
Roncarolo, M.G. and Gregori, S. and Levings, M. and Bluestone and Shevach and Hafler
2003

Human CD25+CD4+T Suppressor Cell Clones Produce Transforming Growth Factor ß, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells
The Journal of Experimental Medicine
Megan K. Levings and Romina Sangregorio and Claudia Sartirana and Anna Lisa Moschin and Manuela Battaglia and Paul C. Orban and Maria-Grazia Roncarolo
DOI: 10.1084/jem.20021139
11/2002

Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines
European Journal of Immunology
Rosa Bacchetta and Claudia Sartirana and Megan K. Levings and Claudio Bordignon and Satwant Narula and Maria-Grazia Roncarolo
DOI: 10.1002/1521-4141(200208)32:83.0.co;2-2
08/2002

The Role of IL-10 and TGF-ß in the Differentiation and Effector Function of T Regulatory Cells
International Archives of Allergy and Immunology
Megan K. Levings and Rosa Bacchetta and Ute Schulz and Maria Grazia Roncarolo
DOI: 10.1159/000067596
2002

Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines
European Journal of Immunology
Bacchetta, R. and Sartirana, C. and Levings, M.K. and Bordignon, C. and Narula, S. and Roncarolo, M.-G.
DOI: 10.1002/1521-4141(200208)32:83.0.CO;2-2
2002

Type 1 T regulatory cells
Immunological Reviews
Maria Grazia Roncarolo and Rosa Bacchetta and Claudio Bordignon and Satwant Narula and Megan K. Levings
DOI: 10.1034/j.1600-065x.2001.1820105.x
08/2001

Human Cd25+Cd4+T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function
The Journal of Experimental Medicine
Megan K. Levings and Romina Sangregorio and Maria-Grazia Roncarolo
DOI: 10.1084/jem.193.11.1295
06/2001

IFN-  and IL-10 Induce the Differentiation of Human Type 1 T Regulatory Cells
The Journal of Immunology
M. K. Levings and R. Sangregorio and F. Galbiati and S. Squadrone and R. de Waal Malefyt and M.-G. Roncarolo
DOI: 10.4049/jimmunol.166.9.5530
05/2001

Differentiation of T regulatory cells by immature dendritic cells
Journal of Experimental Medicine
Roncarolo, M.-G. and Levings, M.K. and Traversari, C.
DOI: 10.1084/jem.193.2.f5
2001

Type 1 T regulatory cells
Immunological Reviews
Roncarolo, M.G. and Bacchetta, R. and Bordignon, C. and Narula, S. and Levings, M.K.
DOI: 10.1034/j.1600-065X.2001.1820105.x
2001

T-regulatory 1 cells: A novel subset of CD4+ T cells with immunoregulatory properties
Journal of Allergy and Clinical Immunology
Megan K Levings and Maria-Grazia Roncarolo
DOI: 10.1067/mai.2000.106635
07/2000

The role of different subsets of T regulatory cells in controlling autoimmunity
Current Opinion in Immunology
Maria-Grazia Roncarolo and Megan K Levings
DOI: 10.1016/s0952-7915(00)00162-x
2000

The role of different subsets of T regulatory cells in controlling autoimmunity
Current Opinion in Immunology
Roncarolo, M.-G. and Levings, M.K.
DOI: 10.1016/S0952-7915(00)00162-X
2000

IL-4 inhibits the production of TNF-a and IL-12 by STAT6-dependent and -independent mechanisms
Journal of Immunology
Levings, M.K. and Schrader, J.W.
1999

Heterodimerization of the a and ß chains of the interleukin-3 (IL-3) receptor is necessary and sufficient for IL-3-induced mitogenesis
Blood
Orban, P.C. and Levings, M.K. and Schrader, J.W.
DOI: 10.1182/blood.v94.5.1614.417k22_1614_1622
1999

Interleukin-4 synergizes with Raf-1 to promote long-term proliferation and activation of c-jun N-terminal kinase
Blood
Levings, M.K. and Bessette, D.C. and Schrader, J.W.
DOI: 10.1182/blood.v93.11.3694
1999

Interleukin-4 synergizes with the raf kinase cascade to stimulate proliferation
Experimental Hematology
Levings, M.K.
1998

Insulin Receptor Substrate-2 Is the Major 170-kDa Protein Phosphorylated on Tyrosine in Response to Cytokines in Murine Lymphohemopoietic Cells
Journal of Biological Chemistry
Melanie J. Welham and Heather Bone and Megan Levings and Leslie Learmonth and Ling-Mei Wang and Kevin B. Leslie and Jacalyn H. Pierce and John W. Schrader
DOI: 10.1074/jbc.272.2.1377
01/1997

Type 1 T Regulatory Cells and Their Relationship with CD4+CD25+ T Regulatory Cells
Generation and Effector Functions of Regulatory Lymphocytes
Maria Grazia Roncarolo and Silvia Gregori and Megan Levings
DOI: 10.1002/0470871628.ch9

Research

Current Projects
Studying the interaction between Tregs and IL-17-producing cells
Developing biomarkers to track the function of Tregs
Studying the unique cell-signalling pathways in human and mouse Tregs

Grants

Genome Canada and CIHR

Applied Research Project Competition in Genomics and Personalized Health (2013)

Canadian Cancer Society Research Institute

"Generation of antigen specific T regulatory cells to treat GVHD post allogeneic stem cell transplant" (2013)

CIHR and Genome BC

Canadian National Transplant Research Program (2013)

Honours & Awards

2012 Genome Canada-CIHR Competition in Personalized Health

2016 UBC Killam Research Prize in Applied Science & Sciences

2003-2013 CRC in Transplantation Tier II; Canada Research Chairs

Research Group Members

Dominic Boardman, Postdoctoral Fellow
Andrew Brown
Matt Budd
Laura Cook, Postdoctoral Fellow
Vivian Fung, MSc Student, Masters Student
Rosa Garcia, Lab Manager
Jana Gillies, Research Technician
Michael Hall, Co-op Student:
Manjurul Haque
Jessica Huang, Research Technician
Sabine Ivison, Clinical Research and Development Project Manager
Avery Lam, Doctoral Student
Katie MacDonald, Doctoral Student
Emma McIver, Research Technician
Majid Mojibian, Research & Development Manager
Mahdis Monajemi, Doctoral Student
Uyen Nguyen, Masters Student
Isaac Rosado Sanchez, Postdoctoral Fellow
Madeleine Speck, Research Technician
Prakruti Uday, Co-op Student
Kirsten Ward Harstonge, Postdoctoral Fellow
Christine Wardell, Graduate student
May Wong, Research Technician
Dan Wu, Doctoral Student
Lisa Xu, Research Asst/Tech 5