Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion
Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.2219086120
2023

Human A2-CAR T Cells Reject HLA-A2⁺Human Islets Transplanted into Mice Without Inducing Graft-versus-host Disease
Transplantation
DOI: 10.1097/TP.0000000000004709
2023

A Century-long Journey From the Discovery of Insulin to the Implantation of Stem Cell–derived Islets
Endocrine Reviews
DOI: 10.1210/endrev/bnac021
2023

Targeting regulatory T cell metabolism in disease: Novel therapeutic opportunities
European Journal of Immunology
DOI: 10.1002/eji.202250002
2023

Strategies for optimizing CITE-seq for human islets and other tissues
Frontiers in Immunology
DOI: 10.3389/fimmu.2023.1107582
2023

Flagellin-specific human CAR Tregs for immune regulation in IBD
Journal of Autoimmunity
Boardman, D.A. and Wong, M.Q. and Rees, W.D. and Wu, D. and Himmel, M.E. and Orban, P.C. and Vent-Schmidt, J. and Zachos, N.C. and Steiner, T.S. and Levings, M.K.
DOI: 10.1016/j.jaut.2022.102961
2023

3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity
medRxiv
DOI: 10.1101/2023.08.30.23294092
2023

T-cell activation–induced marker assays in health and disease
Immunology and Cell Biology
DOI: 10.1111/imcb.12636
2023

Regulatory T Cell Biomarkers Identify Patients at Risk of Developing Acute Cellular Rejection in the First Year Following Heart Transplantation
Transplantation
DOI: 10.1097/TP.0000000000004607
2023

First-in-human therapy with Treg produced from thymic tissue (thyTreg) in a heart transplant infant
The Journal of experimental medicine
DOI: 10.1084/jem.20231045
2023

Alleviating graft-versus-host disease by directing regulatory T cells to the gut … It is all about location, location, location
American Journal of Transplantation
DOI: 10.1016/j.ajt.2023.04.010
2023

Omicron BA.4/5 Neutralization and T-Cell Responses in Organ Transplant Recipients after Booster Messenger RNA Vaccine: A Multicenter Cohort Study
Clinical Infectious Diseases
DOI: 10.1093/cid/ciad175
2023

Human A2-CAR T cells reject HLA-A2+ human islets transplanted into mice without inducing graft versus host disease
bioRxiv
DOI: 10.1101/2023.02.23.529741
2023

Eras of designer Tregs: Harnessing synthetic biology for immune suppression
Immunological Reviews
DOI: 10.1111/imr.13254
2023

A germline heterozygous dominant negative IKZF2 variant causing syndromic primary immune regulatory disorder and ICHAD
medRxiv
DOI: 10.1101/2023.09.09.23295301
2023

Tregs with an MHC class II peptide-specific chimeric antigen receptor prevent autoimmune diabetes in mice
The Journal of clinical investigation
DOI: 10.1172/JCI168601
2023

SARS-CoV-2 variants Omicron BA.4/5 and XBB.1.5 significantly escape T cell recognition in solid organ transplant recipients vaccinated against the ancestral strain
medRxiv
DOI: 10.1101/2023.08.14.23293991
2023

Insulin B peptide-MHC class II-specific chimeric antigen receptor-Tregs prevent autoimmune diabetes
bioRxiv
DOI: 10.1101/2023.02.23.529737
2023

Tregs integrate native and CAR-mediated costimulatory signals for control of allograft rejection
JCI Insight
DOI: 10.1172/jci.insight.167215
2023

Sex biased human thymic architecture guides T cell development through spatially defined niches
bioRxiv
DOI: 10.1101/2023.04.13.536804
2023

Preclinical assessment of antigen-specific chimeric antigen receptor regulatory T cells for use in solid organ transplantation
Gene Therapy
DOI: 10.1038/s41434-022-00358-x
2023

CD56^brightCD16^- natural killer cells as an important regulatory mechanism in chronic graft-versus-host disease
Haematologica
DOI: 10.3324/haematol.2022.280653
2023

Acidity promotes the differentiation of immunosuppressive regulatory T cells
European Journal of Immunology
DOI: 10.1002/eji.202350511
2023

A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes
Immunotherapy Advances
DOI: 10.1093/immadv/ltab022
2022

Emerging strategies for treating autoimmune disorders with genetically modified Treg cells
Journal of Allergy and Clinical Immunology
Boardman, D.A. and Levings, M.K.
DOI: 10.1016/j.jaci.2021.11.007
2022

Modelling Graft-Versus-Host Disease in Mice Using Human Peripheral Blood Mononuclear Cells
Bio-protocol
DOI: 10.21769/BioProtoc.4566
2022

PTEN is required for human Treg suppression of costimulation
bioRxiv
Lam, A.J. and Haque, M. and Ward-Hartstonge, K.A. and Uday, P. and Wardell, C.M. and Gillies, J.K. and Speck, M. and Mojibian, M. and Klein Geltink, R.I. and Levings, M.K.
DOI: 10.1101/2022.03.06.483188
2022

PHLPP Signaling in Immune Cells
Current Topics in Microbiology and Immunology
DOI: 10.1007/978-3-031-06566-8_5
2022

The Women of FOCIS: Promoting Equality and Inclusiveness in a Professional Federation of Clinical Immunology Societies
Frontiers in Immunology
Reed, E.F. and Chong, A.S. and Levings, M.K. and Mutrie, C. and Laufer, T.M. and Roncarolo, M.G. and Sykes, M.
DOI: 10.3389/fimmu.2022.816535
2022

Consequences of adjusting cell density and feed frequency on serum-free expansion of thymic regulatory T cells
Cytotherapy
MacDonald, K.N. and Hall, M.G. and Ivison, S. and Gandhi, S. and Klein Geltink, R.I. and Piret, J.M. and Levings, M.K.
DOI: 10.1016/j.jcyt.2022.06.006
2022

Serum Analyte Profiles Associated with Crohn's Disease and Disease Location
Inflammatory Bowel Diseases
Boucher, G. and Paradis, A. and Chabot-Roy, G. and Coderre, L. and Hillhouse, E.E. and Bitton, A. and Des Rosiers, C. and Levings, M.K. and Philip Schumm, L. and Lazarev, M. and Brant, S.R. and Duerr, R. and McGovern, D. and Silverberg, M.S. and Cho, J. and Lesage, S. and Rioux, J.D. and Charron, G. and Forest, A. and Goyette, P. and Ivinson, S. and Joseph, L. and Kohen, R. and Lachaine, J. and Levings, M. and Thompson-Legault, J. and Vachon, L. and Veilleux, S. and White-Guay, B. and Bajpai, M. and Birch, S. and Borowski, K. and Botwin, G. and Brant, S.R. and Chen, W. and Cho, J.H. and Cordero, R. and Côté-Daigneault, J. and Daly, M.J. and Datta, L. and Duerr, R.H. and Filice, M. and Fleshner, P. and Gettler, K. and Giri, M. and Goytte, P. and Hao, K. and Haritunians, T. and Itan, Y. and Johnston, E. and Konnikova, L. and Landers, C. and Li, D. and McGovern, D.P.B. and Mengesha, E. and Merad, M. and Miladinova, V. and Nayeri, S. and Proksell, S. and Raquel, M. and Rymaszewski, K. and Sabic, K. and Sands, B. and Schumm, L.P. and Schwartz, M.B. and Simpson, C.L. and Stempak, J.M. and Stevens, C. and Targan, S.R. and Xavier, R.
DOI: 10.1093/ibd/izab123
2022

Integration of exogenous and endogenous co-stimulatory signals by CAR-Tregs
bioRxiv
Rosado-S{\'a}nchez, I. and Haque, M. and Salim, K. and Speck, M. and Fung, V. and Boardman, D. and Mojibian, M. and Raimondi, G. and Levings, M.K.
DOI: 10.1101/2022.11.10.516049
2022

PTEN is required for human Treg suppression of costimulation in vitro
European Journal of Immunology
Lam, A.J. and Haque, M. and Ward-Hartstonge, K.A. and Uday, P. and Wardell, C.M. and Gillies, J.K. and Speck, M. and Mojibian, M. and Klein Geltink, R.I. and Levings, M.K.
DOI: 10.1002/eji.202249888
2022

Manufacturing next-generation regulatory T-cell therapies
Current Opinion in Biotechnology
MacDonald, K.N. and Salim, K. and Levings, M.K.
DOI: 10.1016/j.copbio.2022.102822
2022

Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes
European journal of immunology
Yang, J.H.M. and Ward-Hartstonge, K.A. and Perry, D.J. and Blanchfield, J.L. and Posgai, A.L. and Wiedeman, A.E. and Diggins, K. and Rahman, A. and Tree, T.I.M. and Brusko, T.M. and Levings, M.K. and James, E.A. and Kent, S.C. and Speake, C. and Homann, D. and Long, S.A.
DOI: 10.1002/eji.202049067
2022

mRNA vaccines take on immune tolerance
Nature Biotechnology
Christine M. Wardell and Megan K. Levings
DOI: 10.1038/s41587-021-00880-0
04/2021

Helios is a marker, not a driver, of human Treg stability
Avery J. Lam and Prakruti Uday and Jana K. Gillies and Megan K. Levings
DOI: 10.1101/2021.04.27.441702
04/2021

Identifying the ‘Achilles heel’ of type 1 diabetes
Clinical and Experimental Immunology
M Battaglia and J H Buckner and M K Levings and S J Richardson and F S Wong and T I Tree
DOI: 10.1111/cei.13570
04/2021

Fecal microbiota transplant treatment for recurrent Clostridioides difficile infection enhances adaptive immunity to TcdB.
Gastroenterology
Cook L and Rees WD and Wong MQ and Peters H and Levings MK and Steiner TS
DOI: 10.1053/j.gastro.2021.01.009
PubMed: 33444574
01/2021

Optimized CRISPR-mediated gene knock-in reveals FOXP3-independent control of human Treg identity
Avery J. Lam and David T.S. Lin and Jana K. Gillies and Prakruti Uday and Anne M. Pesenacker and Michael S. Kobor and Megan K. Levings
DOI: 10.1101/2021.01.16.426937
01/2021

Cross talk between human regulatory T cells and antigen-presenting cells: Lessons for clinical applications
European Journal of Immunology
Christine M Wardell and Katherine N MacDonald and Megan K Levings and Laura Cook
DOI: 10.1002/eji.202048746
01/2021

Functional screen of inflammatory bowel disease genes reveals key epithelial functions
Genome Medicine
Ntunzwenimana, J.C. and Boucher, G. and Paquette, J. and Gosselin, H. and Alikashani, A. and Morin, N. and Beauchamp, C. and Thauvette, L. and Rivard, M.-?. and Dupuis, F. and Desch{\^e}nes, S. and Foisy, S. and Latour, F. and Lavall{\'e}e, G. and Daly, M.J. and Xavier, R.J. and Bitton, A. and Rosiers, C.D. and Forest, A. and Ivison, S. and Joseph, L. and Kohen, R. and Lachaine, J. and Lesage, S. and Levings, M.K. and Rioux, J.D. and Legault, J.T. and Vachon, L. and Veilleux, S. and White-Guay, B. and Charron, G. and Goyette, P. and Rioux, J.D.
DOI: 10.1186/s13073-021-00996-7
2021

Optimized CRISPR-mediated gene knockin reveals FOXP3-independent maintenance of human Treg identity
Cell Reports
Lam, A.J. and Lin, D.T.S. and Gillies, J.K. and Uday, P. and Pesenacker, A.M. and Kobor, M.S. and Levings, M.K.
DOI: 10.1016/j.celrep.2021.109494
2021

Lasting changes to circulating leukocytes in people with mild SARS-CoV-2 infections
medRxiv
Kennedy, A.E. and Cook, L. and Breznik, J.A. and Cowbrough, B. and Wallace, J.G. and Huynh, A. and Smith, J.W. and Son, K. and Stacey, H. and Ang, J. and McGeer, A. and Coleman, B.L. and Larch{\'e}, M. and Larch{\'e}, M. and Hambly, N. and Nair, P. and Ask, K. and Miller, M.S. and Bramson, J. and Levings, M.K. and Nazy, I. and Svenningsen, S. and Mukherjee, M. and Bowdish, D.M.E.
DOI: 10.1101/2021.09.25.21264117
2021

Interactions between islets and regulatory immune cells in health and type 1 diabetes
Diabetologia
Budd, M.A. and Monajemi, M. and Colpitts, S.J. and Crome, S.Q. and Verchere, C.B. and Levings, M.K.
DOI: 10.1007/s00125-021-05565-6
2021

Induction of stable human FOXP3⁺ Tregs by a parasite-derived TGF-ß mimic
Immunology and Cell Biology
Cook, L. and Reid, K.T. and Häkkinen, E. and de Bie, B. and Tanaka, S. and Smyth, D.J. and White, M.P.J. and Wong, M.Q. and Huang, Q. and Gillies, J.K. and Ziegler, S.F. and Maizels, R.M. and Levings, M.K.
DOI: 10.1111/imcb.12475
2021

The parasite cytokine mimic Hp-TGM potently replicates the regulatory effects of TGF-ß on murine CD4⁺ T cells
Immunology and Cell Biology
White, M.P.J. and Smyth, D.J. and Cook, L. and Ziegler, S.F. and Levings, M.K. and Maizels, R.M.
DOI: 10.1111/imcb.12479
2021

Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
European Journal of Immunology
Cossarizza, A. and Chang, H.-D. and Radbruch, A. and Abrignani, S. and Addo, R. and Akdis, M. and Andrä, I. and Andreata, F. and Annunziato, F. and Arranz, E. and Bacher, P. and Bari, S. and Barnaba, V. and Barros-Martins, J. and Baumjohann, D. and Beccaria, C.G. and Bernardo, D. and Boardman, D.A. and Borger, J. and Böttcher, C. and Brockmann, L. and Burns, M. and Busch, D.H. and Cameron, G. and Cammarata, I. and Cassotta, A. and Chang, Y. and Chirdo, F.G. and Christakou, E. and ?i?in-?ain, L. and Cook, L. and Corbett, A.J. and Cornelis, R. and Cosmi, L. and Davey, M.S. and De Biasi, S. and De Simone, G. and del Zotto, G. and Delacher, M. and Di Rosa, F. and Santo, J.D. and Diefenbach, A. and Dong, J. and Dörner, T. and Dress, R.J. and Dutertre, C.-A. and Eckle, S.B.G. and Eede, P. and Evrard, M. and Falk, C.S. and Feuerer, M. and Fillatreau, S. and Fiz-Lopez, A. and Follo, M. and Foulds, G.A. and Fröbel, J. and Gagliani, N. and Galletti, G. and Gangaev, A. and Garbi, N. and Garrote, J.A. and Geginat, J. and Gherardin, N.A. and Gibellini, L. and Ginhoux, F. and Godfrey, D.I. and Gruarin, P. and Haftmann, C. and Hansmann, L. and Harpur, C.M. and Hayday, A.C. and Heine, G. and Hernández, D.C. and Herrmann, M. and Hoelsken, O. and Huang, Q. and Huber, S. and Huber, J.E. and Huehn, J. and Hundemer, M. and Hwang, W.Y.K. and Iannacone, M. and Ivison, S.M. and Jäck, H.-M. and Jani, P.K. and Keller, B. and Kessler, N. and Ketelaars, S. and Knop, L. and Knopf, J. and Koay, H.-F. and Kobow, K. and Kriegsmann, K. and Kristyanto, H. and Krueger, A. and Kuehne, J.F. and Kunze-Schumacher, H. and Kvistborg, P. and Kwok, I. and Latorre, D. and Lenz, D. and Levings, M.K. and Lino, A.C. and Liotta, F. and Long, H.M. and Lugli, E. and MacDonald, K.N. and Maggi, L. and Maini, M.K. and Mair, F. and Manta, C. and Manz, R.A. and Mashreghi, M.-F. and Mazzoni, A. and McCluskey, J. and Mei, H.E. and Melchers, F. and Melzer, S. and Mielenz, D. and Monin, L. and Moretta, L. and Multhoff, G. and Muñoz, L.E. and Muñoz-Ruiz, M. and Muscate, F. and Natalini, A. and Neumann, K. and Ng, L.G. and Niedobitek, A. and Niemz, J. and Almeida, L.N. and Notarbartolo, S. and Ostendorf, L. and Pallett, L.J. and Patel, A.A. and Percin, G.I. and Peruzzi, G. and Pinti, M. and Pockley, A.G. and Pracht, K. and Prinz, I. and Pujol-Autonell, I. and Pulvirenti, N. and Quatrini, L. and Quinn, K.M. and Radbruch, H. and Rhys, H. and Rodrigo, M.B. and Romagnani, C. and Saggau, C. and Sakaguchi, S. and Sallusto, F. and Sanderink, L. and Sandrock, I. and Schauer, C. and Scheffold, A. and Scherer, H.U. and Schiemann, M. and Schildberg, F.A. and Schober, K. and Schoen, J. and Schuh, W. and Schüler, T. and Schulz, A.R. and Schulz, S. and Schulze, J. and Simonetti, S. and Singh, J. and Sitnik, K.M. and Stark, R. and Starossom, S. and Stehle, C. and Szelinski, F. and Tan, L. and Tarnok, A. and Tornack, J. and Tree, T.I.M. and van Beek, J.J.P. and van de Veen, W. and van Gisbergen, K. and Vasco, C. and Verheyden, N.A. and von Borstel, A. and Ward-Hartstonge, K.A. and Warnatz, K. and Waskow, C. and Wiedemann, A. and Wilharm, A. and Wing, J. and Wirz, O. and Wittner, J. and Yang, J.H.M. and Yang, J.
DOI: 10.1002/eji.202170126
2021

Suppression of human dendritic cells by regulatory t cells
Bio-protocol
Huang, Q. and Lam, A.J. and Boardman, D.A. and Dawson, N.A.J. and Levings, M.K.
DOI: 10.21769/BioProtoc.4217
2021

Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes
Cell Stem Cell
Ramzy, A. and Thompson, D.M. and Ward-Hartstonge, K.A. and Ivison, S. and Cook, L. and Garcia, R.V. and Loyal, J. and Kim, P.T.W. and Warnock, G.L. and Levings, M.K. and Kieffer, T.J.
DOI: 10.1016/j.stem.2021.10.003
2021

Transduction of human T cell subsets with lentivirus
Methods in Molecular Biology
DOI: 10.1007/978-1-0716-1311-5_19
2021

Prevention of vascular-allograft rejection by protecting the endothelial glycocalyx with immunosuppressive polymers
Nature Biomedical Engineering
Siren, E.M.J. and Luo, H.D. and Tam, F. and Montgomery, A. and Enns, W. and Moon, H. and Sim, L. and Rey, K. and Guan, Q. and Wang, J.-J. and Wardell, C.M. and Monajemi, M. and Mojibian, M. and Levings, M.K. and Zhang, Z.J. and Du, C. and Withers, S.G. and Choy, J.C. and Kizhakkedathu, J.N.
DOI: 10.1038/s41551-021-00777-y
2021

Novel T regulatory cells come of age: The curious incident of a mouse in Tennessee, delayed thymectomy and chimeric receptors!
Cellular immunology
Scott DW and Levings MK
DOI: 10.1016/j.cellimm.2020.104253
PubMed: 33307362
12/2020

Building a CAR-Treg: Going from the basic to the luxury model
Cellular Immunology
Isaac Rosado-Sánchez and Megan K. Levings
DOI: 10.1016/j.cellimm.2020.104220
12/2020

A method for expansion and retroviral transduction of mouse regulatory T cells.
Journal of immunological methods
Wu D and Wong MQ and Vent-Schmidt J and Boardman DA and Steiner TS and Levings MK
DOI: 10.1016/j.jim.2020.112931
PubMed: 33221458
11/2020

Recurrent Clostridioides difficile infection is associated with impaired Th17 immunity to TcdB.
Gastroenterology
Cook L and Rees WD and Wong MQ and Kwok WW and Levings MK and Steiner TS
DOI: 10.1053/j.gastro.2020.11.043
PubMed: 33253683
11/2020

What is the Optimal Design-Build-Test Cycle for Clinically Relevant Synthetic CAR T Cell Therapies?
Cell systems
Chen YY and Lim W and Levings M and Blazar B and Krenciute G and Wong W and Lehner M
DOI: 10.1016/j.cels.2020.08.017
PubMed: 32970992
09/2020

Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells.
Science translational medicine
Dawson NAJ and Rosado-Sánchez I and Novakovsky GE and Fung VCW and Huang Q and McIver E and Sun G and Gillies J and Speck M and Orban PC and Mojibian M and Levings MK
DOI: 10.1126/scitranslmed.aaz3866
PubMed: 32817364
08/2020

Impaired Th17 immunity in recurrent C. difficile infection is ameliorated by fecal microbial transplantation
Cook L and Rees WD and Wong MQ and Wang X and Peters H and Oliveira L and Lau T and Mah R and Bressler B and Gomez R and Chow I and James EA and Kwok WW and Levings MK and Steiner TS
DOI: 10.1101/2020.06.05.20114876
06/2020

Repeated stimulation or tonic-signaling chimeric antigen receptors drive regulatory T cell exhaustion
Caroline Lamarche and German E. Novakovsky and Christopher N. Qi and Evan W. Weber and Crystal L. Mackall and Megan K Levings
DOI: 10.1101/2020.06.27.175158
06/2020

Ectopic germline recombination activity of the widely used Foxp3-YFP-Cre mouse: a case report
Immunology
Wu, D. and Huang, Q. and Orban, P.C. and Levings, M.K.
DOI: 10.1111/imm.13153
2020

T-Cell Specificity Matters in IBD: Impaired IL10 Production Revealed by OmpC-Tetramers
Cellular and Molecular Gastroenterology and Hepatology
Cook, L. and Levings, M.K.
DOI: 10.1016/j.jcmgh.2020.06.007
2020

Analysis of Flagellin-Specific Adaptive Immunity Reveals Links to Dysbiosis in Patients With Inflammatory Bowel Disease
Cellular and Molecular Gastroenterology and Hepatology
Cook, L. and Lisko, D.J. and Wong, M.Q. and Garcia, R.V. and Himmel, M.E. and Seidman, E.G. and Bressler, B. and Levings, M.K. and Steiner, T.S.
DOI: 10.1016/j.jcmgh.2019.11.012
2020

Pharmacological inhibition of RORC2 enhances human Th17-Treg stability and function
European Journal of Immunology
Boardman, D.A. and Garcia, R.V. and Ivison, S.M. and Bressler, B. and Dhar, T.G.M. and Zhao, Q. and Levings, M.K.
DOI: 10.1002/eji.201948435
2020

T reg–specific insulin receptor deletion prevents diet-induced and age-associated metabolic syndrome
Journal of Experimental Medicine
Wu, D. and Wong, C.K. and Han, J.M. and Orban, P.C. and Huang, Q. and Gillies, J. and Mojibian, M. and Gibson, W.T. and Levings, M.K.
DOI: 10.1084/jem.20191542
2020

Donor-specific chimeric antigen receptor Tregs limit rejection in naive but not sensitized allograft recipients
American Journal of Transplantation
Sicard, A. and Lamarche, C. and Speck, M. and Wong, M. and Rosado-Sánchez, I. and Blois, M. and Glaichenhaus, N. and Mojibian, M. and Levings, M.K.
DOI: 10.1111/ajt.15787
2020

Functional effects of chimeric antigen receptor co-receptor signaling domains in human Tregs
Dawson NA and Rosado-Sánchez I and Novakovsky GE and Fung VC and Huang Q and McIver E and Sun G and Gillies J and Speck M and Orban PC and Mojibian M and Levings MK
DOI: 10.1101/749721
08/2019

Evaluating the role of Tregs in the progression of multiple myeloma.
Leukemia & lymphoma
Lad D and Huang Q and Hoeppli R and Garcia R and Xu L and Levings M and Song K and Broady R
DOI: 10.1080/10428194.2019.1579324
PubMed: 30773086
02/2019

Cancer immunotherapies repurposed for use in autoimmunity
Nature Biomedical Engineering
Boardman, D.A. and Levings, M.K.
DOI: 10.1038/s41551-019-0359-6
2019

Characterization of regulatory T cells in obese omental adipose tissue in humans
European Journal of Immunology
Wu, D. and Han, J.M. and Yu, X. and Lam, A.J. and Hoeppli, R.E. and Pesenacker, A.M. and Huang, Q. and Chen, V. and Speake, C. and Yorke, E. and Nguyen, N. and Sampath, S. and Harris, D. and Levings, M.K.
DOI: 10.1002/eji.201847570
2019

Tailoring the homing capacity of human Tregs for directed migration to sites of Th1-inflammation or intestinal regions
American Journal of Transplantation
Hoeppli, R.E. and MacDonald, K.N. and Leclair, P. and Fung, V.C.W. and Mojibian, M. and Gillies, J. and Rahavi, S.M.R. and Campbell, A.I.M. and Gandhi, S.K. and Pesenacker, A.M. and Reid, G. and Lim, C.J. and Levings, M.K.
DOI: 10.1111/ajt.14936
2019

A New Mechanism of Action in Human and Mouse Treg Cells: The Ke(y)to Suppression
Immunity
Wu, D. and Levings, M.K.
DOI: 10.1016/j.immuni.2019.04.008
2019

A composite immune signature parallels disease progression across T1D subjects
JCI Insight
Speake, C. and Skinner, S.O. and Berel, D. and Whalen, E. and Dufort, M.J. and Young, W.C. and Odegard, J.M. and Pesenacker, A.M. and Gorus, F.K. and James, E.A. and Levings, M.K. and Linsley, P.S. and Akirav, E.M. and Pugliese, A. and Hessner, M.J. and Nepom, G.T. and Gottardo, R. and Alice Long, S.
DOI: 10.1172/jci.insight.126917
2019

Treg gene signatures predict and measure type 1 diabetes trajectory
JCI Insight
Pesenacker, A.M. and Chen, V. and Gillies, J. and Speake, C. and Marwaha, A.K. and Sun, A. and Chow, S. and Tan, R. and Elliott, T. and Dutz, J.P. and Tebbutt, S.J. and Levings, M.K.
DOI: 10.1172/jci.insight.123879
2019

Suppressive and Gut-Reparative Functions of Human Type 1 T Regulatory Cells
Gastroenterology
Cook, L. and Stahl, M. and Han, X. and Nazli, A. and MacDonald, K.N. and Wong, M.Q. and Tsai, K. and Dizzell, S. and Jacobson, K. and Bressler, B. and Kaushic, C. and Vallance, B.A. and Steiner, T.S. and Levings, M.K.
DOI: 10.1053/j.gastro.2019.09.002
2019

Cryopreservation timing is a critical process parameter in a thymic regulatory T-cell therapy manufacturing protocol
Cytotherapy
MacDonald, K.N. and Ivison, S. and Hippen, K.L. and Hoeppli, R.E. and Hall, M. and Zheng, G. and Dijke, I.E. and Aklabi, M.A. and Freed, D.H. and Rebeyka, I. and Gandhi, S. and West, L.J. and Piret, J.M. and Blazar, B.R. and Levings, M.K.
DOI: 10.1016/j.jcyt.2019.10.011
2019

Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells
JCI Insight
Dawson, N.A.J. and Lamarche, C. and Hoeppli, R.E. and Bergqvist, P. and Fung, V.C.W. and McIver, E. and Huang, Q. and Gillies, J. and Speck, M. and Orban, P.C. and Bush, J.W. and Mojibian, M. and Levings, M.K.
DOI: 10.1172/jci.insight.123672
2019

Methods to manufacture regulatory T cells for cell therapy
Clinical and Experimental Immunology
MacDonald, K.N. and Piret, J.M. and Levings, M.K.
DOI: 10.1111/cei.13297
2019

Innate control of tissue-reparative human regulatory T cells
Journal of Immunology
Lam, A.J. and MacDonald, K.N. and Pesenacker, A.M. and Juvet, S.C. and Morishita, K.A. and Bressler, B. and Pan, J.G. and Sidhu, S.S. and Rioux, J.D. and Levings, M.K.
DOI: 10.4049/jimmunol.1801330
2019

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
European Journal of Immunology
Cossarizza, A. and Chang, H.-D. and Radbruch, A. and Acs, A. and Adam, D. and Adam-Klages, S. and Agace, W.W. and Aghaeepour, N. and Akdis, M. and Allez, M. and Almeida, L.N. and Alvisi, G. and Anderson, G. and Andrä, I. and Annunziato, F. and Anselmo, A. and Bacher, P. and Baldari, C.T. and Bari, S. and Barnaba, V. and Barros-Martins, J. and Battistini, L. and Bauer, W. and Baumgart, S. and Baumgarth, N. and Baumjohann, D. and Baying, B. and Bebawy, M. and Becher, B. and Beisker, W. and Benes, V. and Beyaert, R. and Blanco, A. and Boardman, D.A. and Bogdan, C. and Borger, J.G. and Borsellino, G. and Boulais, P.E. and Bradford, J.A. and Brenner, D. and Brinkman, R.R. and Brooks, A.E.S. and Busch, D.H. and Büscher, M. and Bushnell, T.P. and Calzetti, F. and Cameron, G. and Cammarata, I. and Cao, X. and Cardell, S.L. and Casola, S. and Cassatella, M.A. and Cavani, A. and Celada, A. and Chatenoud, L. and Chattopadhyay, P.K. and Chow, S. and Christakou, E. and ?i?in-?ain, L. and Clerici, 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Silva-Santos, B. and Simon, A.K. and Sitnik, K.M. and Sozzani, S. and Speiser, D.E. and Spidlen, J. and Stahlberg, A. and Stall, A.M. and Stanley, N. and Stark, R. and Stehle, C. and Steinmetz, T. and Stockinger, H. and Takahama, Y. and Takeda, K. and Tan, L. and Tárnok, A. and Tiegs, G. and Toldi, G. and Tornack, J. and Traggiai, E. and Trebak, M. and Tree, T.I.M. and Trotter, J. and Trowsdale, J. and Tsoumakidou, M. and Ulrich, H. and Urbanczyk, S. and van de Veen, W. and van den Broek, M. and van der Pol, E. and Van Gassen, S. and Van Isterdael, G. and van Lier, R.A.W. and Veldhoen, M. and Vento-Asturias, S. and Vieira, P. and Voehringer, D. and Volk, H.-D. and von Borstel, A. and von Volkmann, K. and Waisman, A. and Walker, R.V. and Wallace, P.K. and Wang, S.A. and Wang, X.M. and Ward, M.D. and Ward-Hartstonge, K.A. and Warnatz, K. and Warnes, G. and Warth, S. and Waskow, C. and Watson, J.V. and Watzl, C. and Wegener, L. and Weisenburger, T. and Wiedemann, A. and Wienands, J. and Wilharm, A. and Wilkinson, R.J. and Willimsky, G. and Wing, J.B. and Winkelmann, R. and Winkler, T.H. and Wirz, O.F. and Wong, A. and Wurst, P. and Yang, J.H.M. and Yang, J. and Yazdanbakhsh, M. and Yu, L. and Yue, A. and Zhang, H. and Zhao, Y. and Ziegler, S.M. and Zielinski, C. and Zimmermann, J. and Zychlinsky, A.
DOI: 10.1002/eji.201970107
2019

Megadose Bone Marrow and Regulatory T cells for the Induction of Immune Tolerance in Non-Human Primates Through Durable Mixed Hematopoietic Chimerism Across MHC-barriers
Transplantation
Paula Alonso-Guallart and Raimon Duran-Struuck and Jeffrey Stern and Erik Berglund and Nathaly Llore and Jonah Zitsman and Genevieve Pierre and Sigal Kofman and Makenzie Danton and Samanta Gokova and Emily Lopes and Alicia McMurchy and Qizhi Tang and Megan Levings and Megan Sykes and Adam Griesemer
DOI: 10.1097/01.tp.0000542954.80179.6b
07/2018

Guiding regulatory T cells to the allograft
Current Opinion in Organ Transplantation
Lamarche, C. and Levings, M.K.
DOI: 10.1097/MOT.0000000000000483
2018

Regulatory T-cells drive immune dysfunction in CLL
Leukemia and Lymphoma
Lad, D. and Hoeppli, R. and Huang, Q. and Garcia, R. and Xu, L. and Toze, C. and Broady, R. and Levings, M.
DOI: 10.1080/10428194.2017.1330475
2018

An optimized method to measure human FOXP3 ⁺ regulatory T cells from multiple tissue types using mass cytometry
European Journal of Immunology
Dawson, N.A.J. and Lam, A.J. and Cook, L. and Hoeppli, R.E. and Broady, R. and Pesenacker, A.M. and Levings, M.K.
DOI: 10.1002/eji.201747407
2018

The outstanding questions in transplantation: It's about time…
American Journal of Transplantation
Azzi, J. and Raimondi, G. and Mas, V. and Riella, L.V. and Elfadawy, N. and Safa, K. and Wojciechowski, D. and Kanak, M. and Nog, R. and Maltzman, J.S. and Ford, M.L. and Pober, J.S. and Luo, X.-R. and Rothstein, D. and Miller, M.L. and Matthews, D. and Burlingham, W. and Levings, M. and Heeger, P. and Higdon, L. and Gill, J. and Gill, R.G. and Alegre, M.-L.
DOI: 10.1111/ajt.14450
2018

A standardized immune phenotyping and automated data analysis platform for multicenter biomarker studies
JCI insight
Ivison, S. and Malek, M. and Garcia, R.V. and Broady, R. and Halpin, A. and Richaud, M. and Brant, R.F. and Wang, S.-I. and Goupil, M. and Guan, Q. and Ashton, P. and Warren, J. and Rajab, A. and Urschel, S. and Kumar, D. and Streitz, M. and Sawitzki, B. and Schlickeiser, S. and Bijl, J.J. and Wall, D.A. and Delisle, J.-S. and West, L.J. and Brinkman, R.R. and Levings, M.K.
DOI: 10.1172/jci.insight.121867
2018

Engineering therapeutic T cells to suppress alloimmune responses using TCRs, CARs, or BARs
American Journal of Transplantation
Sicard, A. and Levings, M.K. and Scott, D.W.
DOI: 10.1111/ajt.14747
2018

Taking regulatory T-cell therapy one step further
Current Opinion in Organ Transplantation
Sicard, A. and Boardman, D.A. and Levings, M.K.
DOI: 10.1097/MOT.0000000000000566
2018

Minimum information about T regulatory cells: A step toward reproducibility and standardization
Frontiers in Immunology
Fuchs, A. and Gliwinski, M. and Grageda, N. and Spiering, R. and Abbas, A.K. and Appel, S. and Bacchetta, R. and Battaglia, M. and Berglund, D. and Blazar, B. and Bluestone, J.A. and Bornhäuser, M. and Brinke, A. and Brusko, T.M. and Cools, N. and Cuturi, M.C. and Geissler, E. and Giannoukakis, N. and Golab, K. and Hafler, D.A. and van Ham, S.M. and Hester, J. and Hippen, K. and Di Ianni, M. and Ilic, N. and Isaacs, J. and Issa, F. and Iwaszkiewicz-Grzes, D. and Jaeckel, E. and Joosten, I. and Klatzmann, D. and Koenen, H. and Kooten, C. and Korsgren, O. and Kretschmer, K. and Levings, M. and Marek-Trzonkowska, N.M. and Martinez-Llordella, M. and Miljkovic, D. and Mills, K.H.G. and Miranda, J.P. and Piccirillo, C.A. and Putnam, A.L. and Ritter, T. and Roncarolo, M.G. and Sakaguchi, S. and Sánchez-Ramón, S. and Sawitzki, B. and Sofronic-Milosavljevic, L. and Sykes, M. and Tang, Q. and Vives-Pi, M. and Waldmann, H. and Witkowski, P. and Wood, K.J. and Gregori, S. and Hilkens, C.M.U. and Lombardi, G. and Lord, P. and Martinez-Caceres, E.M. and Trzonkowski, P.
DOI: 10.3389/fimmu.2017.01844
2018

CD4+ T Cells Specific for C. difficile Toxins are a Marker of Patients with Active Relapsing Disease.
Open forum infectious diseases
Cook L and Wong M and Rees W and Lau T and Levings M and Steiner T
10/2017

OR42 Expanded thymic regulatory T cells (Tregs) have low class I HLA expression levels and are HLA-DR negative – Potential for ‘Off-The-Shelf’ Cellular Therapy?
Human Immunology
Esme Dijke and Romy Hoeppli and Ingrid Larsen and Ivan Rebeyka and David Ross and Megan Levings and Lori West
DOI: 10.1016/j.humimm.2017.06.048
09/2017

Development of GMP-Compatible Protocols for Thymus-Derived Regulatory T Cell Expansion
Transplantation
Katherine MacDonald and Romy Hoeppli and James Piret and Esmé Dijke and Lori West and Megan Levings
DOI: 10.1097/01.tp.0000520303.10595.5e
05/2017

Migration Capacity of Thymic Regulatory T Cells can be Tuned by Expansion in Cytokine-Enriched Culture Conditions
Transplantation
Romy E. Hoeppli and Esmé Dijke and Andrew Campbell and Lori J. West and Megan K. Levings
DOI: 10.1097/01.tp.0000520352.47820.13
05/2017

Standardized Immunophenotyping in the Canadian National Transplant Research Program
Transplantation
Sabine Ivison and Salima Janmohamed and Mehrnoush Malek and Rosa Garcia and Raewyn Broady and Anne Halpin and Manon Richaud and Rollin Brant and Jean-Sebastien Delisle and Lori West and Ryan R. Brinkman and Megan Levings
DOI: 10.1097/01.tp.0000520396.84839.9b
05/2017

Thymus-Derived Treg Infusion to Prevent Graft Rejection in Heart-Transplanted Children
Transplantation
Esther Bernaldo de Quirós and Verónica A. Pérez and Maribel Clemente and Juan Miguel Gil-Jaurena and María Teresa González and Marjorie Pion and Giovanna Lombardi and Lori J. West and Megan Levings and Rafael Correa-Rocha
DOI: 10.1097/01.tp.0000520350.40197.6b
05/2017

A Novel Whole Blood Assay Detects Flagellin-Specific CD4 + T Cells in Patients with Inflammatory Bowel Disease
Gastroenterology
Laura Cook and May Q. Wong and Rosa Garcia and Megan E. Himmel and Brian Bressler and Ernest G. Seidman and Theodore S. Steiner and Megan K. Levings
DOI: 10.1016/s0016-5085(17)32185-6
04/2017

Evaluating the Role of Tregs in the Progression of Multiple Myeloma
Clinical Lymphoma Myeloma and Leukemia
Deeepesh Lad and Raewyn Broady and Jessica Huang and Romy Hoeppli and Anne Pesenacker and Rosa Garcia and Lixin Xu and Megan Levings and Kevin Song
DOI: 10.1016/j.clml.2017.03.075
02/2017

Adipose-tissue regulatory T cells: Critical players in adipose-immune crosstalk
European Journal of Immunology
Becker, M. and Levings, M.K. and Daniel, C.
DOI: 10.1002/eji.201646739
2017

Effect of Ex Vivo-Expanded Recipient Regulatory T Cells on Hematopoietic Chimerism and Kidney Allograft Tolerance Across MHC Barriers in Cynomolgus Macaques
Transplantation
Duran-Struuck, R. and Sondermeijer, H.P. and Bühler, L. and Alonso-Guallart, P. and Zitsman, J. and Kato, Y. and Wu, A. and McMurchy, A.N. and Woodland, D. and Griesemer, A. and Martinez, M. and Boskovic, S. and Kawai, T. and Cosimi, A.B. and Wuu, C.-S. and Slate, A. and Mapara, M.Y. and Baker, S. and Tokarz, R. and D'Agati, V. and Hammer, S. and Pereira, M. and Lipkin, W.I. and Wekerle, T. and Levings, M.K. and Sykes, M.
DOI: 10.1097/TP.0000000000001559
2017

Guidelines for the use of flow cytometry and cell sorting in immunological studies
European Journal of Immunology
Cossarizza, A. and Chang, H.-D. and Radbruch, A. and Akdis, M. and Andrä, I. and Annunziato, F. and Bacher, P. and Barnaba, V. and Battistini, L. and Bauer, W.M. and Baumgart, S. and Becher, B. and Beisker, W. and Berek, C. and Blanco, A. and Borsellino, G. and Boulais, P.E. and Brinkman, R.R. and Büscher, M. and Busch, D.H. and Bushnell, T.P. and Cao, X. and Cavani, A. and Chattopadhyay, P.K. and Cheng, Q. and Chow, S. and Clerici, M. and Cooke, A. and Cosma, A. and Cosmi, L. and Cumano, A. and Dang, V.D. and Davies, D. and De Biasi, S. and Del Zotto, G. and Della Bella, S. and Dellabona, P. and Deniz, G. and Dessing, M. and Diefenbach, A. and Di Santo, J. and Dieli, F. and Dolf, A. and Donnenberg, V.S. and Dörner, T. and Ehrhardt, G.R.A. and Endl, E. and Engel, P. and Engelhardt, B. and Esser, C. and Everts, B. and Dreher, A. and Falk, C.S. and Fehniger, T.A. and Filby, A. and Fillatreau, S. and Follo, M. and Förster, I. and Foster, J. and Foulds, G.A. and Frenette, P.S. and Galbraith, D. and Garbi, N. and García-Godoy, M.D. and Geginat, J. and Ghoreschi, K. and Gibellini, L. and Goettlinger, C. and Goodyear, C.S. and Gori, A. and Grogan, J. and Gross, M. and Grützkau, A. and Grummitt, D. and Hahn, J. and Hammer, Q. and Hauser, A.E. and Haviland, D.L. and Hedley, D. and Herrera, G. and Herrmann, M. and Hiepe, F. and Holland, T. and Hombrink, P. and Houston, J.P. and Hoyer, B.F. and Huang, B. and Hunter, C.A. and Iannone, A. and Jäck, H.-M. and Jávega, B. and Jonjic, S. and Juelke, K. and Jung, S. and Kaiser, T. and Kalina, T. and Keller, B. and Khan, S. and Kienhöfer, D. and Kroneis, T. and Kunkel, D. and Kurts, C. and Kvistborg, P. and Lannigan, J. and Lantz, O. and Larbi, A. and LeibundGut-Landmann, S. and Leipold, M.D. and Levings, M.K. and Litwin, V. and Liu, Y. and Lohoff, M. and Lombardi, G. and Lopez, L. and Lovett-Racke, A. and Lubberts, E. and Ludewig, B. and Lugli, E. and Maecker, H.T. and Martrus, G. and Matarese, G. and Maueröder, C. and McGrath, M. and McInnes, I. and Mei, H.E. and Melchers, F. and Melzer, S. and Mielenz, D. and Mills, K. and Mirrer, D. and Mjösberg, J. and Moore, J. and Moran, B. and Moretta, A. and Moretta, L. and Mosmann, T.R. and Müller, S. and Müller, W. and Münz, C. and Multhoff, G. and Munoz, L.E. and Murphy, K.M. and Nakayama, T. and Nasi, M. and Neudörfl, C. and Nolan, J. and Nourshargh, S. and O'Connor, J.-E. and Ouyang, W. and Oxenius, A. and Palankar, R. and Panse, I. and Peterson, P. and Peth, C. and Petriz, J. and Philips, D. and Pickl, W. and Piconese, S. and Pinti, M. and Pockley, A.G. and Podolska, M.J. and Pucillo, C. and Quataert, S.A. and Radstake, T.R.D.J. and Rajwa, B. and Rebhahn, J.A. and Recktenwald, D. and Remmerswaal, E.B.M. and Rezvani, K. and Rico, L.G. and Robinson, J.P. and Romagnani, C. and Rubartelli, A. and Ruckert, B. and Ruland, J. and Sakaguchi, S. and Sala-de-Oyanguren, F. and Samstag, Y. and Sanderson, S. and Sawitzki, B. and Scheffold, A. and Schiemann, M. and Schildberg, F. and Schimisky, E. and Schmid, S.A. and Schmitt, S. and Schober, K. and Schüler, T. and Schulz, A.R. and Schumacher, T. and Scotta, C. and Shankey, T.V. and Shemer, A. and Simon, A.-K. and Spidlen, J. and Stall, A.M. and Stark, R. and Stehle, C. and Stein, M. and Steinmetz, T. and Stockinger, H. and Takahama, Y. and Tarnok, A. and Tian, Z. and Toldi, G. and Tornack, J. and Traggiai, E. and Trotter, J. and Ulrich, H. and van der Braber, M. and van Lier, R.A.W. and Veldhoen, M. and Vento-Asturias, S. and Vieira, P. and Voehringer, D. and Volk, H.-D. and von Volkmann, K. and Waisman, A. and Walker, R. and Ward, M.D. and Warnatz, K. and Warth, S. and Watson, J.V. and Watzl, C. and Wegener, L. and Wiedemann, A. and Wienands, J. and Willimsky, G. and Wing, J. and Wurst, P. and Yu, L. and Yue, A. and Zhang, Q. and Zhao, Y. and Ziegler, S. and Zimmermann, J.
DOI: 10.1002/eji.201646632
2017

Engineered tolerance: Tailoring development, function, and antigen-specificity of regulatory T cells
Frontiers in Immunology
Dawson, N.A.J. and Vent-Schmidt, J. and Levings, M.K.
DOI: 10.3389/fimmu.2017.01460
2017

Thymic progenitors of TCRaß⁺ CD8aa intestinal intraepithelial lymphocytes require RasGRP1 for development
Journal of Experimental Medicine
Golec, D.P. and Hoeppli, R.E. and Caviedes, L.M.H. and McCann, J. and Levings, M.K. and Baldwin, T.A.
DOI: 10.1084/jem.20170844
2017

Biomarker-guided stratification of autoimmune patients for biologic therapy
Current Opinion in Immunology
Ivison, S. and des Rosiers, C. and Lesage, S. and Rioux, J.D. and Levings, M.K.
DOI: 10.1016/j.coi.2017.09.006
2017

Erratum to “Filgrastim-Stimulated Bone Marrow Compared with Filgrastim-Mobilized Peripheral Blood in Myeloablative Sibling Allografting for Patients with Hematologic Malignancies: A Randomized Canadian Blood and Marrow Transplant Group Study” [Biol Blood Marrow Transplant 2016 22 (1410–1415)] (S1083879116300362)(10.1016/j.bbmt.2016.04.017)
Biology of Blood and Marrow Transplantation
Couban, S. and Aljurf, M. and Lachance, S. and Walker, I. and Toze, C. and Rubinger, M. and Lipton, J.H. and Lee, S.J. and Szer, J. and Doocey, R. and Lewis, I.D. and Huebsch, L. and Howson-Jan, K. and Lalancette, M. and Almohareb, F. and Chaudhri, N. and Ivison, S. and Broady, R. and Levings, M. and Fairclough, D. and Devins, G. and Szwajcer, D. and Foley, R. and Smith, C. and Panzarella, T. and Kerr, H. and Kariminia, A. and Schultz, K.R.
DOI: 10.1016/j.bbmt.2016.09.021
2017

Circulating gluten-specific FOXP3⁺CD39⁺ regulatory T cells have impaired suppressive function in patients with celiac disease
Journal of Allergy and Clinical Immunology
Cook, L. and Munier, C.M.L. and Seddiki, N. and van Bockel, D. and Ontiveros, N. and Hardy, M.Y. and Gillies, J.K. and Levings, M.K. and Reid, H.H. and Petersen, J. and Rossjohn, J. and Anderson, R.P. and Zaunders, J.J. and Tye-Din, J.A. and Kelleher, A.D.
DOI: 10.1016/j.jaci.2017.02.015
2017

CD56 ^bright natural killer regulatory cells in filgrastim primed donor blood or marrow products regulate chronic graft-versus-host disease: The Canadian blood and marrow transplant group randomized 0601 study results
Haematologica
Kariminia, A. and Ivison, S. and Ng, B. and Rozmus, J. and Sung, S. and Varshney, A. and Aljurf, M. and Lachance, S. and Walker, I. and Toze, C. and Lipton, J. and Lee, S.J. and Szer, J. and Doocey, R. and Lewis, I. and Smith, C. and Chaudhri, N. and Levings, M.K. and Broady, R. and Devins, G. and Szwajcer, D. and Foley, R. and Mostafavi, S. and Pavletic, S. and Wall, D.A. and Couban, S. and Panzarella, T. and Schultz, K.R.
DOI: 10.3324/haematol.2017.170928
2017

CD4+ T Cells Specific for C. difficile Toxins are a Marker of Patients with Active Relapsing Disease
Open Forum Infectious Diseases
Laura Cook and May Wong and William Rees and Torey Lau and Megan Levings and Theodore Steiner
DOI: 10.1093/ofid/ofx163.948
2017

Antigen-specific regulatory T cells: are police CARs the answer?
Translational Research
Dawson, N.A.J. and Levings, M.K.
DOI: 10.1016/j.trsl.2017.06.009
2017

Harnessing Advances in T Regulatory Cell Biology for Cellular Therapy in Transplantation
Transplantation
Lam, A.J. and Hoeppli, R.E. and Levings, M.K.
DOI: 10.1097/TP.0000000000001757
2017

Discarded human thymus is a novel source of stable and long-lived therapeutic regulatory T cells
American Journal of Transplantation
Dijke, I.E. and Hoeppli, R.E. and Ellis, T. and Pearcey, J. and Huang, Q. and McMurchy, A.N. and Boer, K. and Peeters, A.M.A. and Aubert, G. and Larsen, I. and Ross, D.B. and Rebeyka, I. and Campbell, A. and Baan, C.C. and Levings, M.K. and West, L.J.
DOI: 10.1111/ajt.13456
2016

Heterogeneity of chronic graft-versus-host disease biomarkers: Association with CXCL10 and CXCR3⁺ NK cells
Blood
Kariminia, A. and Holtan, S.G. and Ivison, S. and Rozmus, J. and Hebert, M.-J. and Martin, P.J. and Lee, S.J. and Wolff, D. and Subrt, P. and Abdossamadi, S. and Sung, S. and Storek, J. and Levings, M. and Aljurf, M. and Arora, M. and Cutler, C. and Gallagher, G. and Kuruvilla, J. and Lipton, J. and Nevill, T.J. and Newell, L.F. and Panzarella, T. and Pidala, J. and Popradi, G. and Szwajcer, D. and Tay, J. and Toze, C.L. and Walker, I. and Couban, S. and Storer, B.E. and Schultz, K.R.
DOI: 10.1182/blood-2015-09-668251
2016

Filgrastim-Stimulated Bone Marrow Compared with Filgrastim-Mobilized Peripheral Blood in Myeloablative Sibling Allografting for Patients with Hematologic Malignancies: A Randomized Canadian Blood and Marrow Transplant Group Study
Biology of Blood and Marrow Transplantation
Couban, S. and Aljurf, M. and Lachance, S. and Walker, I. and Toze, C. and Rubinger, M. and Lipton, J.H. and Lee, S.J. and Szer, R. and Doocey, R. and Lewis, I.D. and Huebsch, L. and Howson-Jan, K. and Lalancette, M. and Almohareb, F. and Chaudhri, N. and Ivison, S. and Broady, R. and Levings, M. and Fairclough, D. and Devins, G. and Szwajcer, D. and Foley, R. and Smith, C. and Panzarella, T. and Kerr, H. and Kariminia, A. and Schultz, K.R.
DOI: 10.1016/j.bbmt.2016.04.017
2016

The role of FOXP3 in autoimmunity
Current Opinion in Immunology
Pesenacker, A.M. and Cook, L. and Levings, M.K.
DOI: 10.1016/j.coi.2016.07.004
2016

How antigen specificity directs regulatory T-cell function: Self, foreign and engineered specificity
HLA
Hoeppli, R.E. and Macdonald, K.G. and Levings, M.K. and Cook, L.
DOI: 10.1111/tan.12822
2016

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor
Journal of Clinical Investigation
MacDonald, K.G. and Hoeppli, R.E. and Huang, Q. and Gillies, J. and Luciani, D.S. and Orban, P.C. and Broady, R. and Levings, M.K.
DOI: 10.1172/JCI82771
2016

Obesity-Associated Adipose Tissue Inflammation and Transplantation
American Journal of Transplantation
Wu, D. and Dawson, N.A.J. and Levings, M.K.
DOI: 10.1111/ajt.13578
2016

T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression
Journal of Clinical Investigation
Patterson, S.J. and Pesenacker, A.M. and Wang, A.Y. and Gillies, J. and Mojibian, M. and Morishita, K. and Tan, R. and Kieffer, T.J. and Verchere, C.B. and Panagiotopoulos, C. and Levings, M.K.
DOI: 10.1172/JCI83987
2016

A Regulatory T-cell gene signature is a specific and sensitive biomarker to identify children with new-onset type 1 diabetes
Diabetes
Pesenacker, A.M. and Wang, A.Y. and Singh, A. and Gillies, J. and Kim, Y. and Piccirillo, C.A. and Nguyen, D. and Haining, W.N. and Tebbutt, S.J. and Panagiotopoulos, C. and Levings, M.K.
DOI: 10.2337/db15-0572
2016

Induction of Durable Mixed Hematopoietic Chimerism and Immune Tolerance in Monkeys
Biology of Blood and Marrow Transplantation
Paula Alonso Guallart and Jonah Zitsman and Hugo Sondermeijer and David Woodland and Yojiro Kato and Joshua Weiner and Adam Griesemer and Leo Bühler and Alicia McMurchy and Megan Levings and Megan Sykes and Raimon Duran-Struuck
DOI: 10.1016/j.bbmt.2014.11.040
02/2015

Phenotype, Function and Expansion of Regulatory T Cells in the Cynomolgus Macaque (Macaca fascicularis)
Biology of Blood and Marrow Transplantation
Paula Alonso Guallart and Jonah Zitsman and Hugo Sondermeijer and Leo Bühler and Christopher Ovanez and Alicia McMurchy and Megan Levings and Megan Sykes and Raimon Duran-Struuck
DOI: 10.1016/j.bbmt.2014.11.445
02/2015

Restimulation After Cryopreservation and Thawing Preserves the Phenotype and Function of Expanded Baboon Regulatory T Cells
Transplantation Direct
Joshua Weiner and Raimon Duran-Struuck and Jonah Zitsman and Leo Buhler and Hugo Sondermeijer and Alicia N. McMurchy and Megan K. Levings and Megan Sykes and Adam Griesemer
DOI: 10.1097/txd.0000000000000511
02/2015

CCL22 prevents rejection of mouse islet allografts and induces donor-specific tolerance
Cell Transplantation
Montane, J. and Obach, M. and Alvarez, S. and Bischoff, L. and Dai, D.L. and Soukhatcheva, G. and Priatel, J.J. and Hardenberg, G. and Levings, M.K. and Tan, R. and Orban, P.C. and Verchere, C.B.
DOI: 10.3727/096368914X685249
2015

Tr1 cells, but not foxp3⁺ regulatory T cells, suppress NLRP3 inflammasome activation via an IL-10-dependent mechanism
Journal of Immunology
Yao, Y. and Vent-Schmidt, J. and McGeough, M.D. and Wong, M. and Hoffman, H.M. and Steiner, T.S. and Levings, M.K.
DOI: 10.4049/jimmunol.1403225
2015

The environment of regulatory T cell biology: Cytokines, metabolites, and the microbiome
Frontiers in Immunology
Hoeppli, R.E. and Wu, D. and Cook, L. and Levings, M.K.
DOI: 10.3389/fimmu.2015.00061
2015

IL-33 reverses an obesity-induced deficit in visceral adipose tissue ST2⁺ T regulatory cells and ameliorates adipose tissue inflammation and insulin resistance
Journal of Immunology
Han, J.M. and Wu, D. and Denroche, H.C. and Yao, Y. and Verchere, C.B. and Levings, M.K.
DOI: 10.4049/jimmunol.1500020
2015

Regulatory T cells produce profibrotic cytokines in the skin of patients with systemic sclerosis
Journal of Allergy and Clinical Immunology
Macdonald, K.G. and Dawson, N.A.J. and Huang, Q. and Dunne, J.V. and Levings, M.K. and Broady, R.
DOI: 10.1016/j.jaci.2014.12.1932
2015

Control of tissue-localized immune responses by human regulatory T cells
European Journal of Immunology
Pesenacker, A.M. and Broady, R. and Levings, M.K.
DOI: 10.1002/eji.201344205
2015

The role of FOXP3 in regulating immune responses
International Reviews of Immunology
Vent-Schmidt, J. and Han, J.M. and Macdonald, K.G. and Levings, M.K.
DOI: 10.3109/08830185.2013.811657
2014

Insulin inhibits IL-10-mediated regulatory T cell function: Implications for obesity
Journal of Immunology
Han, J.M. and Patterson, S.J. and Speck, M. and Ehses, J.A. and Levings, M.K.
DOI: 10.4049/jimmunol.1302181
2014

Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation
Journal of Clinical Investigation
Antignano, F. and Burrows, K. and Hughes, M.R. and Han, J.M. and Kron, K.J. and Penrod, N.M. and Oudhoff, M.J. and Wang, S.K.H. and Min, P.H. and Gold, M.J. and Chenery, A.L. and Braam, M.J.S. and Fung, T.C. and Rossi, F.M.V. and McNagny, K.M. and Arrowsmith, C.H. and Lupien, M. and Levings, M.K. and Zaph, C.
DOI: 10.1172/JCI69592
2014

Autologous transplant for autoimmune disease: optimizing the regulatory T cells
Cytotherapy
T.D. Prestidge and J.H. Davis and J. Huang and M. Himmel and M. Levings
DOI: 10.1016/j.jcyt.2013.01.161
04/2013

Pediatric thymic tissue as a source of CD25+FOXP3+ regulatory T cells (Tregs) for cellular therapy
Cytotherapy
E. Dijke and M. Levings and A. McMurchy and I. Larsen and I. Rebeyka and D. Ross and L. West
DOI: 10.1016/j.jcyt.2013.01.160
04/2013

In vitro generation of human T regulatory cells: Generation, culture, and analysis of FOXP3-transduced t cells
Methods in Molecular Biology
McMurchy, A.N. and Levings, M.K.
DOI: 10.1007/978-1-62703-128-8-8
2013

Th-2 cytokine producing Tregs in the skin of patients with systemic sclerosis
Frontiers in Immunology
Broady Raewyn and Huang Qing and MacDonald Katherine and Dunne James and Levings Megan
DOI: 10.3389/conf.fimmu.2013.02.01011
2013

Immune regulation in obesity-associated adipose inflammation
Journal of Immunology
Jonathan M, H. and Levings, M.K.
DOI: 10.4049/jimmunol.1301035
2013

Helios⁺ and Helios^- cells coexist within the natural Foxp3⁺ T regulatory cell subset in humans
Journal of Immunology
Himmel, M.E. and MacDonald, K.G. and Garcia, R.V. and Steiner, T.S. and Levings, M.K.
DOI: 10.4049/jimmunol.1201379
2013

Insulin impairs regulatory T cell function: implications for obesity
Frontiers in Immunology
Han Jonathan and Patterson Scott and Ehses Jan and Levings Megan
DOI: 10.3389/conf.fimmu.2013.02.00587
2013

Erratum: Transcriptome analysis reveals markers of aberrantly activated innate immunity in vitiligo lesional and non-lesional skin (PLoS ONE (2013) 8:7 DOI:10.1371/annotation/fbf9e317-e3ab-4f9a-b317-3de6abff890f)
PLoS ONE
Yu, R. and Broady, R. and Huang, Y. and Wang, Y. and Yu, J. and Gao, M. and Levings, M. and Wei, S. and Zhang, S. and Xu, A. and Su, M. and Dutz, J. and Zhang, X. and Zhou, Y.
DOI: 10.1371/annotation/fbf9e317-e3ab-4f9a-b317-3de6abff890f
2013

Anovel function for FOXP3 in humans: Intrinsic regulation of conventional T cells
Blood
McMurchy, A.N. and Gillies, J. and Gizzi, M.C. and Riba, M. and Garcia-Manteiga, J.M. and Cittaro, D. and Lazarevic, D. and Di Nunzio, S. and Piras, I.S. and Bulfone, A. and Roncarolo, M.G. and Stupka, E. and Bacchetta, R. and Levings, M.K.
DOI: 10.1182/blood-2012-05-431023
2013

Response to Comment on "helios⁺ and helios^- cells coexist within the natural FOXP31 T regulatory cell subset in humans"
Journal of Immunology
MacDonald, K.G. and Han, J.M. and Himmel, M.E. and Huang, Q. and Kan, B. and Campbell, A.I.M. and Lavoie, P.M. and Levings, M.K.
DOI: 10.4049/jimmunol.1390019
2013

Expansion of Highly Suppressive FOXP3+ Regulatory T Cells from Pediatric Thymic Tissue
Transplantation Journal
E. Dijke and A. McMurchy and M. Levings and I. Larsen and I. Rebeyka and D. Ross and L. West
DOI: 10.1097/00007890-201211271-02368
11/2012

Chemokine Induced Tolerance in Mouse Islet Allografts
Canadian Journal of Diabetes
Joel Montane and Merce Obach and Loraine Bischoff and Galina Soukhatcheva and Paul C. Orban and Gijs Hardenberg and Megan K. Levings and Rusung Tan and C. Bruce Verchere
DOI: 10.1016/j.jcjd.2012.07.468
10/2012

ATP conditions intestinal epithelial cells to an inflammatory state that promotes components of DC maturation
European Journal of Immunology
Yao, Y. and Levings, M.K. and Steiner, T.S.
DOI: 10.1002/eji.201142213
2012

TH17 cells in autoimmunity and immunodeficiency : Protective orpathogenic?
Frontiers in Immunology
Marwaha, A.K. and Leung, N.J. and McMurchy, A.N. and Levings, M.K.
DOI: 10.3389/fimmu.2012.00129
2012

T regulatory cell therapy in transplantation: Stability, localization and functional specialization
Current Opinion in Organ Transplantation
MacDonald, K.G. and Orban, P.C. and Levings, M.K.
DOI: 10.1097/MOT.0b013e328355aaaf
2012

Suppression assays with human T regulatory cells: A technical guide
European Journal of Immunology
Mcmurchy, A.N. and Levings, M.K.
DOI: 10.1002/eji.201141651
2012

Inflammation-driven reprogramming of CD4 ⁺foxp3 ⁺ regulatory T cells into pathogenic Th1/Th17 t effectors is abrogated by mTOR inhibition in vivo
PLoS ONE
Yurchenko, E. and Shio, M.T. and Huang, T.C. and da Silva Martins, M. and Szyf, M. and Levings, M.K. and Olivier, M. and Piccirillo, C.A.
DOI: 10.1371/journal.pone.0035572
2012

Active vitamin D (1,25-dihydroxyvitamin D3) increases host susceptibility to Citrobacter rodentium by suppressing mucosal Th17 responses
American Journal of Physiology - Gastrointestinal and Liver Physiology
Ryz, N.R. and Patterson, S.J. and Zhang, Y. and Ma, C. and Huang, T. and Bhinder, G. and Wu, X. and Chan, J. and Glesby, A. and Sham, H.P. and Dutz, J.P. and Levings, M.K. and Jacobson, K. and Vallance, B.A.
DOI: 10.1152/ajpgi.00320.2012
2012

Toll-like receptor 5 deficiency protects from wasting disease in a T cell transfer colitis model in T cell receptor-ß-deficient mice
Inflammatory Bowel Diseases
Hardenberg, G. and Yao, Y. and Piccirillo, C.A. and Levings, M.K. and Steiner, T.S.
DOI: 10.1002/ibd.21738
2012

The Role of the PI3K Signaling Pathway in CD4+ T Cell Differentiation and Function
Frontiers in Immunology
Jonathan M. Han and Scott J. Patterson and Megan K. Levings
DOI: 10.3389/fimmu.2012.00245
2012

Transcriptome Analysis Reveals Markers of Aberrantly Activated Innate Immunity in Vitiligo Lesional and Non-Lesional Skin
PLoS ONE
Yu, R. and Broady, R. and Huang, Y. and Wang, Y. and Yu, J. and Gao, M. and Levings, M. and Wei, S. and Zhang, S. and Xu, A. and Su, M. and Dutz, J. and Zhang, X. and Zhou, Y.
DOI: 10.1371/journal.pone.0051040
2012

Regulatory T-cell therapy for inflammatory bowel disease: More questions than answers
Immunology
Himmel, M.E. and Yao, Y. and Orban, P.C. and Steiner, T.S. and Levings, M.K.
DOI: 10.1111/j.1365-2567.2012.03572.x
2012

CD4 ⁺Foxp3 ⁺ regulatory T cells suppress ¿d T-cell effector functions in a model of T-cell-induced mucosal inflammation
European Journal of Immunology
Yurchenko, E. and Levings, M.K. and Piccirillo, C.A.
DOI: 10.1002/eji.201141814
2011

Cellular magnetic resonance imaging of monocyte-derived dendritic cell migration from healthy donors and cancer patients as assessed in a scid mouse model
Cytotherapy
Zhang, X. and De Chickera, S.N. and Willert, C. and Economopoulos, V. and Noad, J. and Rohani, R. and Wang, A.Y. and Levings, M.K. and Scheid, E. and Foley, R. and Foster, P.J. and Dekaban, G.A.
DOI: 10.3109/14653249.2011.605349
2011

Ship-deficient dendritic cells, unlike wild type dendritic cells, suppress t cell proliferation via a nitric oxide-independent mechanism
PLoS ONE
Antignano, F. and Hamilton, M. and Patterson, S. and Ho, V. and Cohen, C. and Levings, M.K. and Krystal, G.
DOI: 10.1371/journal.pone.0021893
2011

Moving to tolerance: Clinical application of T regulatory cells
Seminars in Immunology
McMurchy, A.N. and Bushell, A. and Levings, M.K. and Wood, K.J.
DOI: 10.1016/j.smim.2011.04.001
2011

Human CD4⁺FOXP3⁺ regulatory T cells produce CXCL8 and recruit neutrophils
European Journal of Immunology
Himmel, M.E. and Crome, S.Q. and Ivison, S. and Piccirillo, C. and Steiner, T.S. and Levings, M.K.
DOI: 10.1002/eji.201040459
2011

Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets
Journal of Clinical Investigation
Montane, J. and Bischoff, L. and Soukhatcheva, G. and Dai, D.L. and Hardenberg, G. and Levings, M.K. and Orban, P.C. and Kieffer, T.J. and Tan, R. and Verchere, C.B.
DOI: 10.1172/JCI43048
2011

Adenoviral-transduced dendritic cells are susceptible to suppression by T regulatory cells and promote interleukin 17 production
Cancer Immunology, Immunotherapy
Wang, A.Y. and Crome, S.Q. and Jenkins, K.M. and Medin, J.A. and Bramson, J.L. and Levings, M.K.
DOI: 10.1007/s00262-010-0948-4
2011

T regulatory cells and cancer immunotherapy
Experimental and Applied Immunotherapy
DOI: 10.1007/978-1-60761-980-2_10
2011

Human Th1 and Th17 cells exhibit epigenetic stability at signature cytokine and transcription factor loci
Journal of Immunology
Cohen, C.J. and Crome, S.Q. and MacDonald, K.G. and Dai, E.L. and Mager, D.L. and Levings, M.K.
DOI: 10.4049/jimmunol.1101058
2011

Environmental influences on T regulatory cells in inflammatory bowel disease
Seminars in Immunology
Hardenberg, G. and Steiner, T.S. and Levings, M.K.
DOI: 10.1016/j.smim.2011.01.012
2011

Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells
Journal of Immunology
Patterson, S.J. and Han, J.M. and Garcia, R. and Assi, K. and Gao, T. and O'Neill, A. and Newton, A.C. and Levings, M.K.
DOI: 10.4049/jimmunol.1002126
2011

The Stress signal extracellular ATP modulates antiflagellin immune responses in intestinal epithelial cells
Inflammatory Bowel Diseases
Ivison, S.M. and Himmel, M.E. and Mayer, M. and Yao, Y. and Kifayet, A. and Levings, M.K. and Steiner, T.S.
DOI: 10.1002/ibd.21428
2011

Role of epithelial integrin-linked kinase in promoting intestinal inflammation: Effects on CCL2, fibronectin and the T cell repertoire
BMC Immunology
Assi, K. and Patterson, S. and Dedhar, S. and Owen, D. and Levings, M. and Salh, B.
DOI: 10.1186/1471-2172-12-42
2011

The Inflammatory Effects of ex vivo Human T Helper 17 Cells are Suppressed by T Regulatory Cells
Clinical Immunology
Sarah Crome and Breanna Clive and Adele Wang and Christine Kang and Vickie Chow and Jessie Yiu and Raewyn Broady and Megan Levings
DOI: 10.1016/j.clim.2010.03.361
01/2010

PHLPP Regulates the Development, Function and Molecular Signaling Pathways of T Regulatory Cells
Clinical Immunology
Scott Patterson and Rosa Garcia and Audrey O'Neill and Tianyan Gao and Alexandra Newton and Megan Levings
DOI: 10.1016/j.clim.2010.03.025
01/2010

Constitutive Expression of CD25 on the Surface of Neonatal (invariant) Natural Killer T Cells Primes Them to Proliferate with Lower Antigenic Stimulation
Clinical Immunology
Ashish Sharma and Mihoko Whalen and Qing Huang and Adele Wang and Lixin Xu and Indira Genowati and Meghan Levings and Pascal Lavoie
DOI: 10.1016/j.clim.2010.03.151
01/2010

Increased Fraction of IL-17 Secreting Cells in Type 1 Diabetes
Clinical Immunology
Ashish Marwaha and Megan Levings and Sarah Crome and Constadina Panagiotopoulos and John Priatel and Rusung Tan
DOI: 10.1016/j.clim.2010.03.398
01/2010

CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC
European Journal of Immunology
Maggi, L. and Santarlasci, V. and Capone, M. and Peired, A. and Frosali, F. and Crome, S.Q. and Querci, V. and Fambrini, M. and Liotta, F. and Levings, M.K. and Maggi, E. and Cosmi, L. and Romagnani, S. and Annunziato, F.
DOI: 10.1002/eji.200940257
2010

TLR5 is not required for flagellin-mediated exacerbation of DSS colitis
Inflammatory Bowel Diseases
Ivison, S.M. and Himmel, M.E. and Hardenberg, G. and Wark, P.A.J. and Kifayet, A. and Levings, M.K. and Steiner, T.S.
DOI: 10.1002/ibd.21097
2010

Deconvolution and chromatic aberration corrections in quantifying colocalization of a transcription factor in three-dimensional cellular space
Micron
Abraham, T. and Allan, S.E. and Levings, M.K.
DOI: 10.1016/j.micron.2010.03.005
2010

Point mutants of forkhead box P3 that cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked have diverse abilities to reprogram T cells into regulatory T cells
Journal of Allergy and Clinical Immunology
Mcmurchy, A.N. and Gillies, J. and Allan, S.E. and Passerini, L. and Gambineri, E. and Roncarolo, M.G. and Bacchetta, R. and Levings, M.K.
DOI: 10.1016/j.jaci.2010.09.001
2010

Natural killer T cells constitutively expressing the interleukin-2 receptor a chain early in life are primed to respond to lower antigenic stimulation
Immunology
Ladd, M. and Sharma, A. and Huang, Q. and Wang, A.Y. and Xu, L. and Genowati, I. and Levings, M.K. and Lavoie, P.M.
DOI: 10.1111/j.1365-2567.2010.03304.x
2010

Cutaneous GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells
Blood
Broady, R. and Yu, J. and Chow, V. and Tantiworawit, A. and Kang, C. and Berg, K. and Martinka, M. and Ghoreishi, M. and Dutz, J. and Levings, M.K.
DOI: 10.1182/blood-2010-07-295436
2010

Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes
Journal of Immunology
Marwaha, A.K. and Crome, S.Q. and Panagiotopoulos, C. and Berg, K.B. and Qin, H. and Ouyang, Q. and Xu, L. and Priatel, J.J. and Levings, M.K. and Tan, R.
DOI: 10.4049/jimmunol.1001860
2010

Translational mini-review series on Th17 cells: Function and regulation of human T helper 17 cells in health and disease
Clinical and Experimental Immunology
Crome, S.Q. and Wang, A.Y. and Levings, M.K.
DOI: 10.1111/j.1365-2249.2009.04037.x
2010

Inflammatory effects of ex vivo human Th17 cells are suppressed by regulatory T cells
Journal of Immunology
Crome, S.Q. and Clive, B. and Wang, A.Y. and Kang, C.Y. and Chow, V. and Yu, J. and Lai, A. and Ghahary, A. and Broady, R. and Levings, M.K.
DOI: 10.4049/jimmunol.1000557
2010

Leishmania exosomes modulate innate and adaptive immune responses through effects on monocytes and dendritic cells
Journal of Immunology
Silverman, J.M. and Clos, J. and Horakova, E. and Wang, A.Y. and Wiesgigl, M. and Kelly, I. and Lynn, M.A. and McMaster, W.R. and Foster, L.J. and Levings, M.K. and Reiner, N.E.
DOI: 10.4049/jimmunol.1000541
2010

Molecular regulation of cellular immunity by FOXP3.
Advances in experimental medicine and biology
McMurchy AN and Di Nunzio S and Roncarolo MG and Bacchetta R and Levings MK
PubMed: 20429414
01/2009

ATG-induced expression of FOXP3 in human CD4⁺ T cells in vitro is associated with T-cell activation and not the induction of FOXP3⁺ T regulatory cells
Blood
Broady, R. and Yu, J. and Levings, M.K.
DOI: 10.1182/blood-2009-04-214437
2009

SHIP regulates the reciprocal development of T regulatory and Th17 cells
Journal of Immunology
Locke, N.R. and Patterson, S.J. and Hamilton, M.J. and Sly, L.M. and Krystal, G. and Levings, M.K.
DOI: 10.4049/jimmunol.0803749
2009

3rd Keystone Symposium on T regulatory cells: 1-6 March 2009, Keystone, CO, USA
Immunotherapy
DOI: 10.2217/IMT.09.33
2009

Wild-type FOXP3 is selectively active in CD4⁺CD25^hi regulatory T cells of healthy female carriers of different FOXP3 mutations
Blood
Di Nunzio, S. and Cecconi, M. and Passerini, L. and McMurchy, A.N. and Baron, U. and Turbachova, I. and Vignola, S. and Valencic, E. and Tommasini, A. and Junker, A. and Cazzola, G. and Olek, S. and Levings, M.K. and Perroni, L. and Roncarolo, M.G. and Bacchetta, R.
DOI: 10.1182/blood-2009-04-214593
2009

Molecular regulation of cellular immunity by FOXP3
Advances in Experimental Medicine and Biology
McMurchy, A.N. and Di Nunzio, S. and Roncarolo, M.G. and Bacchetta, R. and Levings, M.K.
DOI: 10.1007/978-1-4419-1599-3_3
2009

Quantifying colocalization of a conditionally active transcription factor foxp3 in three-dimensional cellular space
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Abraham, T. and Allanb, S.E. and Levings, M.K.
DOI: 10.1117/12.808049
2009

The role of retinoic acid-related orphan receptor variant 2 and IL-17 in the development and function of human CD4⁺ T cells
European Journal of Immunology
Crome, S.Q. and Wang, A.Y. and Kang, C.Y. and Levings, M.K.
DOI: 10.1002/eji.200838908
2009

Editorial: MASTering treg function to promote tolerance
American Journal of Transplantation
Levings, M.K. and Thomson, A.W.
DOI: 10.1111/j.1600-6143.2009.02810.x
2009

Molecular and Functional Studies in T Cells from Healthy Carriers of FOXP3 Mutations
Clinical Immunology
DOI: 10.1016/j.clim.2008.03.187
01/2008

Expression of RORC2 Controls the Development of Human Th17 Cells
Clinical Immunology
Sarah Crome and Adele Wang and Megan Levings
DOI: 10.1016/j.clim.2008.03.043
01/2008

CD4⁺ T-regulatory cells: Toward therapy for human diseases
Immunological Reviews
Allan, S.E. and Broady, R. and Gregori, S. and Himmel, M.E. and Locke, N. and Roncarolo, M.G. and Bacchetta, R. and Levings, M.K.
DOI: 10.1111/j.1600-065X.2008.00634.x
2008

Pro-tolerogenic effects of photodynamic therapy with TH9402 on dendritic cells
Journal of Clinical Apheresis
Broady, R. and Yu, J. and Levings, M.K.
DOI: 10.1002/jca.20162
2008

STAT5-signaling cytokines regulate the expression of FOXP3 in CD4⁺CD25⁺ regulatory T cells and CD4⁺ CD25^- effector T cells
International Immunology
Passerini, L. and Allan, S.E. and Battaglia, M. and Di Nunzio, S. and Alstad, A.N. and Levings, M.K. and Roncarolo, M.G. and Bacchetta, R.
DOI: 10.1093/intimm/dxn002
2008

Generation of potent and stable human CD4⁺ T regulatory cells by activation-independent expression of FOXP3
Molecular Therapy
Allan, S.E. and Alstad, A.N. and Merindol, N. and Crellin, N.K. and Amendola, M. and Bacchetta, R. and Naldini, L. and Roncarolo, M.G. and Soudeyns, H. and Levings, M.K.
DOI: 10.1038/sj.mt.6300341
2008

Molecular Signalling in T Regulatory Cells
Regulatory T Cells and Clinical Application
DOI: 10.1007/978-0-387-77909-6_8
2008

Graft versus host disease: Suppression by statins
Nature Medicine
Broady, R. and Levings, M.K.
DOI: 10.1038/nm1108-1155
2008

Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3
European Journal of Immunology
Allan, S.E. and Song-Zhao, G.X. and Abraham, T. and McMurchy, A.N. and Levings, M.K.
DOI: 10.1002/eji.200838373
2008

The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease
Immunology
Himmel, M.E. and Hardenberg, G. and Piccirillo, C.A. and Steiner, T.S. and Levings, M.K.
DOI: 10.1111/j.1365-2567.2008.02939.x
2008

27 Effects of IL-17 On Effector and Regultory T Cell Subsets
Cytokine
Sarah Q. Crome and Adele Wang and Megan K. Levings
DOI: 10.1016/j.cyto.2007.07.032
07/2007

Altered activation of AKT is required for the suppressive function of human CD4⁺CD25⁺ T regulatory cells
Blood
Crellin, N.K. and Garcia, R.V. and Levings, M.K.
DOI: 10.1182/blood-2006-07-035279
2007

Flow cytometry-based methods for studying signaling in human CD4⁺CD25⁺FOXP3⁺ T regulatory cells
Journal of Immunological Methods
Crellin, N.K. and Garcia, R.V. and Levings, M.K.
DOI: 10.1016/j.jim.2007.05.008
2007

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production
International Immunology
Allan, S.E. and Crome, S.Q. and Crellin, N.K. and Passerini, L. and Steiner, T.S. and Bacchetta, R. and Roncarolo, M.G. and Levings, M.K.
DOI: 10.1093/intimm/dxm014
2007

Isolation, expansion, and characterization of human natural and adaptive regulatory T cells
Methods in Molecular Biology
Gregori, S. and Bacchetta, R. and Passerini, L. and Levings, M.K. and Roncarolo, M.G.
DOI: 10.1385/1-59745-395-1:83
2007

Foxp3 Mutations in Children: Different Degrees of Impairment in Regulatory and Effector T-Cell Functions in Patients with Distinct Genotypes and Phenotypes
Clinical Immunology
DOI: 10.1016/j.clim.2006.04.196
01/2006

Human CD4+CD25+ T Regulatory Cells Have Altered PKB Signalling Which Correlates with Suppressive Function
Clinical Immunology
DOI: 10.1016/j.clim.2006.04.009
01/2006

Defining a Role for FOXP3 in Human Cd4+ T-Cells
Clinical Immunology
DOI: 10.1016/j.clim.2006.04.525
01/2006

Interleukin-10-secreting type 1 regulatory T cells in rodents and humans
Immunological Reviews
Roncarolo, M.G. and Gregori, S. and Battaglia, M. and Bacchetta, R. and Fleischhauer, K. and Levings, M.K.
DOI: 10.1111/j.0105-2896.2006.00420.x
2006

Gliadin-specific type 1 regulatory T cells from the intestinal mucosa of treated celiac patients inhibit pathogenic T cells
Journal of Immunology
Gianfrani, C. and Levings, M.K. and Sartirana, C. and Mazzarella, G. and Barba, G. and Zanzi, D. and Camarca, A. and Iaquinto, G. and Giardullo, N. and Auricchio, S. and Troncone, R. and Roncarolo, M.-G.
DOI: 10.4049/jimmunol.177.6.4178
2006

Erratum: Interleukin-10- secreting type 1 regulatory T cells in rodents and humans (Immunological Reviews (2006) 212, (28-50))
Immunological Reviews
Roncarolo, M.G. and Gregori, S. and Battaglia, M. and Bacchetta, R. and Fleischhauer, K. and Levings, M.K.
DOI: 10.1111/j.1600-065X.2006.00448.x
2006

Defective regulatory and effector T cell functions in patients with FOXP3 mutations
Journal of Clinical Investigation
Bacchetta, R. and Passerini, L. and Gambineri, E. and Dai, M. and Allan, S.E. and Perroni, L. and Dagna-Bricarelli, F. and Sartirana, C. and Matthes-Martin, S. and Lawitschka, A. and Azzari, C. and Ziegler, S.F. and Levings, M.K. and Roncarolo, M.G.
DOI: 10.1172/JCI25112
2006

Functional Dynamics of Naturally Occurring Regulatory T Cells in Health and Autoimmunity
Advances in Immunology
Levings, M.K. and Allan, S. and d'Hennezel, E. and Piccirillo, C.A.
DOI: 10.1016/S0065-2776(06)92003-3
2006

The role of 2 FOXP3 isoforms in the generation of human CD4⁺ Tregs
Journal of Clinical Investigation
Allan, S.E. and Passerini, L. and Bacchetta, R. and Crellin, N. and Dai, M. and Orban, P.C. and Ziegler, S.F. and Roncarolo, M.G. and Levings, M.K.
DOI: 10.1172/JCI24685
2005

Recombinant human interleukin 10 suppresses gliadin dependent T cell activation in ex vivo cultured coeliac intestinal mucosa
Gut
Salveti, V.M. and Mazzarella, G. and Gianfrani, C. and Levings, M.K. and Stefanile, R. and De Giulio, B. and Iaquinto, G. and Giardullo, N. and Auricchio, S. and Roncarolo, M.G. and Troncone, R.
DOI: 10.1136/gut.2003.023150
2005

Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25⁺CD4⁺ Tr cells
Blood
Levings, M.K. and Gregori, S. and Tresoldi, E. and Cazzaniga, S. and Bonini, C. and Roncarolo, M.G.
DOI: 10.1182/blood-2004-03-1211
2005

Phenotypic and functional differences between human CD4 ⁺CD25⁺ and type 1 regulatory T cells
Current Topics in Microbiology and Immunology
Levings, M.K. and Roncarolo, M.G.
DOI: 10.1007/3-540-27702-1_14
2005

Human CD4⁺ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4 ⁺CD25⁺ T regulatory cells
Journal of Immunology
Crellin, N.K. and Garcia, R.V. and Hadisfar, O. and Allan, S.E. and Steiner, T.S. and Levings, M.K.
DOI: 10.4049/jimmunol.175.12.8051
2005

Can we throw the master-switch in autoimmune disease?
Clinical Genetics
Paul C Orban and Megan K Levings
DOI: 10.1034/j.1399-0004.2003.t01-2-00121.x
06/2003

Discoveries in sphingolipid metabolism, spinocerebellar ataxia and autoimmune disease
Clinical Genetics
Liam R Brunham and Edmond YW Chan and Paul C Orban and Megan K Levings
DOI: 10.1034/j.1399-0004.2003.00121.x
06/2003

Type 1 T regulatory cells and their relationship with CD4 ⁺CD25⁺ T regulatory cells
Novartis Foundation Symposium
Roncarolo, M.G. and Gregori, S. and Levings, M. and Bluestone and Shevach and Hafler
2003

The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells.
International archives of allergy and immunology
Levings, M.K. and Bacchetta, R. and Schulz, U. and Roncarolo, M.G.
DOI: 10.1159/000067596
2002

Human CD25⁺CD4⁺ T suppressor cell clones produce transforming growth factor ß, but not interleukin 10, and are distinct from type 1 T regulatory cells
Journal of Experimental Medicine
Levings, M.K. and Sangregorio, R. and Sartirana, C. and Moschin, A.L. and Battaglia, M. and Orban, P.C. and Roncarolo, M.-G.
DOI: 10.1084/jem.20021139
2002

Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines
European Journal of Immunology
Bacchetta, R. and Sartirana, C. and Levings, M.K. and Bordignon, C. and Narula, S. and Roncarolo, M.-G.
DOI: 10.1002/1521-4141(200208)32:83.0.CO;2-2
2002

Human CD25⁺CD4⁺ T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
Journal of Experimental Medicine
Levings, M.K. and Sangregorio, R. and Roncarolo, M.-G.
DOI: 10.1084/jem.193.11.1295
2001

Type 1 T regulatory cells
Immunological Reviews
Roncarolo, M.G. and Bacchetta, R. and Bordignon, C. and Narula, S. and Levings, M.K.
DOI: 10.1034/j.1600-065X.2001.1820105.x
2001

Ifn-a and il-10 induce the differentiation of human type 1 t regulatory cells¹
Journal of Immunology
Levings, M.K. and Sangregorio, R. and Galbiati, F. and Squadrone, S. and De Waal Malefyt, R. and Roncarolo, M.-G.
DOI: 10.4049/jimmunol.166.9.5530
2001

Differentiation of T regulatory cells by immature dendritic cells
Journal of Experimental Medicine
Roncarolo, M.-G. and Levings, M.K. and Traversari, C.
DOI: 10.1084/jem.193.2.f5
2001

T-regulatory 1 cells: A novel subset of CD4⁺T cells with immunoregulatory properties
Journal of Allergy and Clinical Immunology
Levings, M.K. and Roncarolo, M.-G.
DOI: 10.1067/mai.2000.106635
2000

The role of different subsets of T regulatory cells in controlling autoimmunity
Current Opinion in Immunology
Roncarolo, M.-G. and Levings, M.K.
DOI: 10.1016/S0952-7915(00)00162-X
2000

Interleukin-4 synergizes with Raf-1 to promote long-term proliferation and activation of c-jun N-terminal kinase
Blood
Levings, M.K. and Bessette, D.C. and Schrader, J.W.
DOI: 10.1182/blood.v93.11.3694
1999

Heterodimerization of the a and ß chains of the interleukin-3 (IL-3) receptor is necessary and sufficient for IL-3-induced mitogenesis
Blood
Orban, P.C. and Levings, M.K. and Schrader, J.W.
DOI: 10.1182/blood.v94.5.1614.417k22_1614_1622
1999

IL-4 inhibits the production of TNF-a and IL-12 by STAT6-dependent and -independent mechanisms
Journal of Immunology
Levings, M.K. and Schrader, J.W.
1999

Interleukin-4 synergizes with the raf kinase cascade to stimulate proliferation
Experimental Hematology
Levings, M.K.
1998

Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells
Journal of Biological Chemistry
Welham, M.J. and Bone, H. and Levings, M. and Learmonth, L. and Wang, L.-M. and Leslie, K.B. and Pierce, J.H. and Schrader, J.W.
DOI: 10.1074/jbc.272.2.1377
1997

Type 1 T Regulatory Cells and Their Relationship with CD4+CD25+ T Regulatory Cells
Generation and Effector Functions of Regulatory Lymphocytes
DOI: 10.1002/0470871628.ch9