Infections in children are still a major cause of early morbidity and mortality throughout the world, despite the advances made in preventive care. Infections are often a reason for children to become critically ill, and often occur in the critically ill child. My research focuses upon stemming this burden through optimizing their management in a variety of settings. Additionally, the ability of various settings and healthcare systems to cost-effectively manage critically ill children, especially those with infection, is an area of focus.


The Potential Harm of Cytomegalovirus Infection in Immunocompetent Critically Ill Children
Frontiers in Pediatrics
Raidan Alyazidi and Srinivas Murthy and Jennifer A. Slyker and Soren Gantt
DOI: 10.3389/fped.2018.00096

Dopamine and the Risk for Hospital-Acquired Infections*
Pediatric Critical Care Medicine
Srinivas Murthy
DOI: 10.1097/pcc.0000000000001446

Evidence-based guidelines for supportive care of patients with Ebola virus disease
The Lancet
François Lamontagne and Robert A Fowler and Neill K Adhikari and Srinivas Murthy and David M Brett-Major and Michael Jacobs and Timothy M Uyeki and Constanza Vallenas and Susan L Norris and William A Fischer and Thomas E Fletcher and Adam C Levine and Paul Reed and Daniel G Bausch and Sandy Gove and Andrew Hall and Susan Shepherd and Reed A Siemieniuk and Marie-Claude Lamah and Rashida Kamara and Phiona Nakyeyune and Moses J Soka and Ama Edwin and Afeez A Hazzan and Shevin T Jacob and Mubarak Mustafa Elkarsany and Takuya Adachi and Lynda Benhadj and Christophe Clément and Ian Crozier and Armando Garcia and Steven J Hoffman and Gordon H Guyatt
DOI: 10.1016/s0140-6736(17)31795-6

Non-invasive ventilation in children and adults in low- and low-middle income countries: A systematic review and meta-analysis
Journal of Critical Care
Keren Mandelzweig and Aleksandra Leligdowicz and Srinivas Murthy and Rejani Lalitha and Robert A. Fowler and Neill K.J. Adhikari
DOI: 10.1016/j.jcrc.2018.01.007

Recommendations on infrastructure and organization of adult ICUs in resource-limited settings
Intensive Care Medicine
Alfred Papali and for the European Society of Intensive Care Medicine (ESICM) Global Intensive Care working group and The Mahidol–Oxford Research Unit (MORU) in Bangkok and Thailand and Marcus J. Schultz and Martin W. Dünser
DOI: 10.1007/s00134-017-4972-0

The Young Investigator Retreat of the Canadian Critical Care Trials Group: mentorship and self-discovery
Canadian Journal of Anesthesia/Journal canadien d'anesthésie
Ian M. Ball and for the Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group and Lisa Burry and Peter Dodek and Jamie S. Hutchison and Jeanna Parsons Leigh and Victoria McCredie and Srinivas Murthy and Bram Rochwerg and Deborah Cook
DOI: 10.1007/s12630-017-1016-8

Outcome Measures in Sepsis, Revisited*
Pediatric Critical Care Medicine
Srinivas Murthy
DOI: 10.1097/pcc.0000000000001209

Burden of diarrhea in the Eastern Mediterranean Region, 1990–2015: Findings from the Global Burden of Disease 2015 study
International Journal of Public Health
Ali H. Mokdad and GBD 2015 Eastern Mediterranean Region Diarrhea Collaborators
DOI: 10.1007/s00038-017-1008-z

Selective digestive decontamination in critically ill children: A survey of Canadian providers
Journal of Critical Care
Srinivas Murthy and Nazima Pathan and Brian H. Cuthbertson
DOI: 10.1016/j.jcrc.2017.02.024

Perioperative antibiotics in pediatric cardiac surgery: protocol for a systematic review
Systematic Reviews
Vijay Anand and Angela Bates and Robin Featherstone and Srinivas Murthy
DOI: 10.1186/s13643-017-0502-y

Vasopressor use following traumatic injury: protocol for a systematic review
BMJ Open
Mathieu Hylands and Augustin Toma and Nicolas Beaudoin and Anne-Julie Frenette and Frederick D'Aragon and Emilie Belley-Côté and Morten Hylander and François Lauzier and Reed Alexander Siemieniuk and Emmanuel Charbonney and Joey Kwong and Jon Henrik Laake and Gordon Guyatt and Per Olav Vandvik and Bram Rochwerg and Robert Green and Ian Ball and Damon Scales and Srinivas Murthy and Sandro Rizoli and Pierre Asfar and François Lamontagne
DOI: 10.1136/bmjopen-2016-014166

Who Says There Is No “I” in Team? Achieving Individual Success in Collaborative Clinical Research in Critical Care
American Journal of Respiratory and Critical Care Medicine
Raquel R. Bartz and Dashiell Gantner and Anthony C. Gordon and Aleksandra Leligdowicz and James J. McNamee and Srinivas Murthy and Alistair Nichol and Steve Webb
DOI: 10.1164/rccm.201602-0405le

Design and a-testing of an electronic rounding tool (CERTAINp) to improve process of care in pediatric intensive care unit
Journal of Clinical Monitoring and Computing
Manasi Hulyalkar and Stephen J. Gleich and Rahul Kashyap and Amelia Barwise and Harsheen Kaur and Yue Dong and Lei Fan and Srinivas Murthy and Grace M. Arteaga and Sandeep Tripathi
DOI: 10.1007/s10877-016-9946-1

Pediatric sepsis and septic shock management in resource-limited settings
Intensive Care Medicine
Ndidiamaka Musa and Srinivas Murthy and Niranjan Kissoon
DOI: 10.1007/s00134-016-4382-8

A survey on the resources and practices in pediatric critical care of resource-rich and resource-limited countries
Journal of Intensive Care
Sandeep Tripathi and Harsheen Kaur and Rahul Kashyap and Yue Dong and Ognjen Gajic and Srinivas Murthy
DOI: 10.1186/s40560-015-0106-3

Management of severe viral infections in the pediatric intensive care unit
Journal of Pediatric Intensive Care
Srinivas Murthy and Niranjan Kissoon
DOI: 10.3233/pic-14103

Industry-sponsored clinical research outside high-income countries: an empirical analysis of registered clinical trials from 2006 to 2013
Health Research Policy and Systems
Srinivas Murthy and Kenneth D. Mandl and Florence T. Bourgeois
DOI: 10.1186/s12961-015-0019-6

Ebola and provision of critical care
The Lancet
Srinivas Murthy
DOI: 10.1016/s0140-6736(15)60712-7

Ebola Virus Disease among Children in West Africa
New England Journal of Medicine
WHO Ebola Response Team
DOI: 10.1056/nejmc1415318

Being Ready to Treat Ebola Virus Disease Patients
The American Journal of Tropical Medicine and Hygiene
David M. Brett-Major and Shevin T. Jacob and Barbara J. Shea and Frederique A. Jacquerioz and Henry Kyobe Bosa and John S. Schieffelin and Tim O'Dempsey and Gary G. Kuniyoshi and Sara K. Hurley and John C. Carlson and David T. Porembka and Takuya Adachi and William A. Fischer and Catherine F. Houlihan and Daniel G. Bausch and Robert A. Fowler and Susan L. McLellan and Thomas E. Fletcher and Lewis Rubinson and Francois Lamontagne and James V. Lawler and George F. Risi and Srinivas G. Murthy and Suzanne M. Donovan and Nicola Petrosillo and Mauricio Ferri and Louise E. Berry and Thomas. C. Button and Yasuyuki Kato and Ian Crozier
DOI: 10.4269/ajtmh.14-0746

Intensive Care Unit Capacity in Low-Income Countries: A Systematic Review
Srinivas Murthy and Aleksandra Leligdowicz and Neill K. J. Adhikari
DOI: 10.1371/journal.pone.0116949

Critical Care in Low-Resource Settings
The Organization of Critical Care
Srinivas Murthy and Sadath A. Sayeed and Neill K. J. Adhikari
DOI: 10.1007/978-1-4939-0811-0_16

Global Health Care of the Critically Ill in Low-Resource Settings
Annals of the American Thoracic Society
Srinivas Murthy and Neill K. Adhikari
DOI: 10.1513/annalsats.201307-246ot

Innominate artery aneurysm after cannulation for extracorporeal membrane oxygenation via the right carotid artery
Intensive Care Medicine
Srinivas Murthy and Cathy MacDonald and Osami Honjo and Alejandro A. Floh and Tilman Humpl
DOI: 10.1007/s00134-013-3070-1

Infections of the Developing World
Critical Care Clinics
Srinivas Murthy and Jay Keystone and Niranjan Kissoon
DOI: 10.1016/j.ccc.2013.03.005

Analysis of Pediatric Clinical Drug Trials for Neuropsychiatric Conditions
S. Murthy and K. D. Mandl and F. Bourgeois
DOI: 10.1542/peds.2012-2694

Access to urban acute care services in high- vs. middle-income countries: an analysis of seven cities
Intensive Care Medicine
Shamly Austin and On behalf of the International Forum of Acute Care Trialists and Srinivas Murthy and Hannah Wunsch and Neill K. J. Adhikari and Veena Karir and Kathryn Rowan and Shevin T. Jacob and Jorge Salluh and Fernando A. Bozza and Bin Du and Youzhong An and Bruce Lee and Felicia Wu and Yen-Lan Nguyen and Chris Oppong and Ramesh Venkataraman and Vimalraj Velayutham and Carmelo Dueñas and Derek C. Angus
DOI: 10.1007/s00134-013-3174-7

Network Analysis of Transcriptional Responses Induced by Mesenchymal Stem Cell Treatment of Experimental Sepsis
The American Journal of Pathology
Claudia C. dos Santos and Srinivas Murthy and Pingzhao Hu and Yuexin Shan and Jack J. Haitsma and Shirley H.J. Mei and Duncan J. Stewart and W. Conrad Liles
DOI: 10.1016/j.ajpath.2012.08.009

After the FEAST—Fluid Resuscitation in Pediatric Sepsis
The Indian Journal of Pediatrics
Srinivas Murthy and Niranjan Kissoon
DOI: 10.1007/s12098-012-0845-2

Pediatric Versus Adult Drug Trials for Conditions With High Pediatric Disease Burden
F. T. Bourgeois and S. Murthy and C. Pinto and K. L. Olson and J. P. A. Ioannidis and K. D. Mandl
DOI: 10.1542/peds.2012-0139

The Role and Impact of Research Agendas on the Comparative-Effectiveness Research Among Antihyperlipidemics
Clinical Pharmacology & Therapeutics
A G Dunn and F T Bourgeois and S Murthy and K D Mandl and R O Day and E Coiera
DOI: 10.1038/clpt.2011.279

Comparative Effectiveness Research: An Empirical Study of Trials Registered in ClinicalTrials.gov
Florence T. Bourgeois and Srinivas Murthy and Kenneth D. Mandl
DOI: 10.1371/journal.pone.0028820

Clinical review: International comparisons in critical care - lessons learned
Critical Care
Srinivas Murthy and Hannah Wunsch
DOI: 10.1186/cc11140

Clinical utility of biomarkers of endothelial activation in sepsis-a systematic review
Critical Care
Katharine Xing and Srinivas Murthy and W Conrad Liles and Jeffrey M Singh
DOI: 10.1186/cc11145

Infectious Diseases Following Disasters
Disaster Medicine and Public Health Preparedness
Srinivas Murthy and Michael D. Christian
DOI: 10.1001/dmp.2010.hcn10005

Outcome Reporting Among Drug Trials Registered in ClinicalTrials.gov
Annals of Internal Medicine
Florence T. Bourgeois
DOI: 10.7326/0003-4819-153-3-201008030-00006


Biomarkers in pediatric sepsis
Being able to stratify children with severe sepsis, so as to better triage their care and predict their outcome, is a long-standing challenge. I am investigating the role of a panel of novel biomarkers, detected in blood, in predicting the outcome of children. This will be of tremendous help for research purposes, for front-line providers assessing the severity of illness, and for improving the understanding of the mechanism of the complex septic reaction.


2011 University of Toronto Elizabeth Arbuthnot Dyson Fellowship

2011 University of Toronto Joseph M. West Family Memorial Fund Fellowship

Research Group Members

Kira Genise, Student
Tina Madani Kia, Co-op Student