Overview

Infections in children are still a major cause of early morbidity and mortality throughout the world, despite the advances made in preventive care. Infections are often a reason for children to become critically ill, and often occur in the critically ill child. My research focuses upon stemming this burden through optimizing their management in a variety of settings. Additionally, the ability of various settings and healthcare systems to cost-effectively manage critically ill children, especially those with infection, is an area of focus.

Publications

Moral Distress and Other Wellness Measures in Canadian Critical Care Physicians.
Annals of the American Thoracic Society
Dodek PM and Cheung EO and Burns KE and Martin CM and Archambault PM and Lauzier F and Sarti AJ and Mehta S and Fox-Robichaud AE and Seely AJE and Parshuram C and Garros D and Canadian Critical Care Trials Group
DOI: 10.1513/annalsats.202009-1118oc
PubMed: 33356972
12/2020

Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results.
The New England journal of medicine
WHO Solidarity Trial Consortium and Pan H and Peto R and Henao-Restrepo AM and Preziosi MP and Sathiyamoorthy V and Abdool Karim Q and Alejandria MM and Hernández García C and Swaminathan S
DOI: 10.1056/nejmoa2023184
PubMed: 33264556
12/2020

Study protocol for a multicentre, prospective cohort study of the association of angiotensin II type 1 receptor blockers on outcomes of coronavirus infection.
BMJ open
Russell JA and Marshall JC and Slutsky A and Murthy S and Sweet D and Lee T and Singer J and Patrick DM and Du B and Peng Z and Cheng M and Burns KD and Harhay MO
DOI: 10.1136/bmjopen-2020-040768
PubMed: 33293316
12/2020

Fungal infections should be part of the core outcome set for COVID-19 - Authors' reply.
The Lancet. Infectious diseases
Marshall JC and Murthy S and Diaz J and WHO Working Group on the Clinical Characterisation and Management of COVID-19 infection
DOI: 10.1016/s1473-3099(20)30681-2
PubMed: 33301729
12/2020

Clinician-researcher's perspectives on clinical research during the COVID19 pandemic.
PloS one
Silverberg SL and Puchalski Ritchie LM and Gobat N and Nichol A and Murthy S
DOI: 10.1371/journal.pone.0243525
PubMed: 33296427
12/2020

An Appraisal of Respiratory System Compliance In Mechanically Ventilated Covid-19 Patients
Bassi GL and Suen J and Dalton H and White N and Shrapnel S and Fanning JP and Liquet B and Hinton S and Vuorinem A and Booth G and Millar J and Forsyth S and Panigada M and Laffey J and Fraser J
DOI: 10.21203/rs.3.rs-125428/v1
12/2020

Post-exposure Prophylaxis Against SARS-CoV-2 in Close Contacts of Confirmed COVID-19 Cases (CORIPREV): Study Protocol for a Cluster-randomised Trial
Tan D and Chan AK and Jüni P and Tomlinson G and Daneman N and Walmsley S and Muller M and Fowler R and Murthy S and Press N and Cooper C and Lee T and Mazzulli T and McGeer A
DOI: 10.21203/rs.3.rs-56125/v1
12/2020

Outcomes for patients with COVID-19 admitted to Australian intensive care units during the first four months of the pandemic.
The Medical journal of Australia
Burrell AJ and Pellegrini B and Salimi F and Begum H and Broadley T and Campbell LT and Cheng AC and Cheung W and Cooper DJ and Earnest A and Erickson SJ and French CJ and Kaldor JM and Udy AA
DOI: 10.5694/mja2.50883
PubMed: 33325070
12/2020

Pediatric Emergency and Critical Care Resources and Infrastructure in Resource-Limited Settings: A Multicountry Survey.
Critical care medicine
Muttalib F and González-Dambrauskas S and Lee JH and Steere M and Agulnik A and Murthy S and Adhikari NKJ and PALISI Global Health Subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI)
DOI: 10.1097/ccm.0000000000004769
PubMed: 33337665
12/2020

Clinical Trials in COVID-19 Management & Prevention: A Meta-epidemiological Study examining methodological quality
Honarmand K and Penn J and Agarwal A and Siemieniuk R and Brignardello-Petersen R and Bartoszko JJ and Zeraatkar D and Agoritsas T and Burns K and Fernando SM and Foroutan F and Rochwerg B
DOI: 10.1101/2020.11.29.20237875
11/2020

Leveraging a Cloud-Based Critical Care Registry for COVID-19 Pandemic Surveillance and Research in Low- and Middle-Income Countries.
JMIR public health and surveillance
CRIT Care Asia and Hashmi M and Beane A and Murthy S and Dondorp AM and Haniffa R
DOI: 10.2196/21939
PubMed: 33147162
11/2020

Prevalence of Acute Rehabilitation for Kids in the PICU: A Canadian Multicenter Point Prevalence Study.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Choong K and Zorko DJ and Awojoodu R and Ducharme-Crevier L and Fontela PS and Lee LA and Guerguerian AM and Garcia Guerra G and Krmpotic K and McKelvie B and Menon K and Murthy S and Kudchadkar SR
DOI: 10.1097/pcc.0000000000002601
PubMed: 33116069
10/2020

Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis.
JAMA
WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group and Sterne JAC and Murthy S and Diaz JV and Slutsky AS and Villar J and Angus DC and Annane D and Marshall JC
DOI: 10.1001/jama.2020.17023
PubMed: 32876694
10/2020

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.
JAMA
Angus DC and Derde L and Al-Beidh F and Annane D and Arabi Y and Beane A and van Bentum-Puijk W and Berry L and Bhimani Z and Bonten M and Bradbury C and Brunkhorst F and Buxton M and Carr-Knott L
DOI: 10.1001/jama.2020.17022
PubMed: 32876697
10/2020

Repurposed antiviral drugs for COVID-19 –interim WHO SOLIDARITY trial results
WHO Solidarity trial consortium and Pan H and Peto R and Karim QA and Alejandria M and Henao-Restrepo AM and García CH and Kieny M and Malekzadeh R and Murthy S and Preziosi M and assume responsibility for the content and integrity of this article
DOI: 10.1101/2020.10.15.20209817
10/2020

A national cross-sectional survey of public perceptions of the COVID-19 pandemic: Self-reported beliefs, knowledge, and behaviors.
PloS one
Parsons Leigh J and Fiest K and Brundin-Mather R and Plotnikoff K and Soo A and Sypes EE and Whalen-Browne L and Ahmed SB and Burns KEA and Fox-Robichaud A and Kupsch S and Stelfox HT
DOI: 10.1371/journal.pone.0241259
PubMed: 33095836
10/2020

Pregnancy and COVID-19: Pharmacologic Considerations.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
D'Souza R and Ashraf R and Rowe H and Zipursky J and Clarfield L and Maxwell C and Arzola C and Lapinsky S and Paquette K and Murthy S and Cheng MP and Malhamé I
DOI: 10.1002/uog.23116
PubMed: 32959455
09/2020

Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19: an international collaborative meta-analysis of randomized trials
Axfors C and Schmitt AM and Janiaud P and van ’t Hooft J and Abd-Elsalam S and Abdo EF and Abella BS and Akram J and Amaravadi RK and Angus DC and Arabi YM and Azhar S and Baden LR and Hemkens LG
DOI: 10.1101/2020.09.16.20194571
09/2020

A minimal common outcome measure set for COVID-19 clinical research
The Lancet Infectious Diseases
DOI: 10.1016/s1473-3099(20)30483-7
08/2020

Robust, reproducible clinical patterns in hospitalised patients with COVID-19
Millar JE and Neyton L and Seth S and Dunning J and Merson L and Murthy S and Russell CD and Keating S and Swets M and Sudre CH and Spector TD and Ourselin S and Steves CJ and Wolf J and ISARIC4C Investigators
DOI: 10.1101/2020.08.14.20168088
08/2020

Anti-Thrombotic Therapy to Ameliorate Complications of COVID-19 (ATTACC): Study design and methodology for an international, adaptive Bayesian randomized controlled trial.
Clinical trials (London, England)
Houston BL and Lawler PR and Goligher EC and Farkouh ME and Bradbury C and Carrier M and Dzavik V and Fergusson DA and Fowler RA and Galanaud JP and Gross PL and McDonald EG and Zarychanski R
DOI: 10.1177/1740774520943846
PubMed: 32815416
08/2020

Pediatric Critical Care and the Climate Emergency: Our Responsibilities and a Call for Change.
Frontiers in pediatrics
Wooldridge G and Murthy S
DOI: 10.3389/fped.2020.00472
PubMed: 32974244
08/2020

Corticosteroid therapy for critically ill patients with COVID-19: A structured summary of a study protocol for a prospective meta-analysis of randomized trials.
Trials
Sterne JAC and Diaz J and Villar J and Murthy S and Slutsky AS and Perner A and Jüni P and Angus DC and Annane D and Azevedo LCP and Du B and Dequin PF and Gordon AC and Green C and WHO COVID-19 Clinical Management and Characterization Working Group
DOI: 10.1186/s13063-020-04641-3
PubMed: 32831155
08/2020

Effectiveness of a Daily Rounding Checklist on Processes of Care and Outcomes in Diverse Pediatric Intensive Care Units Across the World.
Journal of tropical pediatrics
Kashyap R and Murthy S and Arteaga GM and Dong Y and Cooper L and Kovacevic T and Basavaraja C and Ren H and Qiao L and Zhang G and Sridharan K and Jin P and Wang T and Tuibeqa I and Kang A and SCCM Discovery CERTAINp Collaborative Investigators
DOI: 10.1093/tropej/fmaa058
PubMed: 32853362
08/2020

The importance of airway and lung microbiome in the critically ill.
Critical care (London, England)
Martin-Loeches I and Dickson R and Torres A and Hanberger H and Lipman J and Antonelli M and de Pascale G and Bozza F and Vincent JL and Murthy S and Bauer M and Marshall J and Cilloniz C and Bos LD
DOI: 10.1186/s13054-020-03219-4
PubMed: 32867808
08/2020

How Canada can better embed randomized trials into clinical care.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
Murthy S and Fowler RA and Laupacis A
DOI: 10.1503/cmaj.201764
PubMed: 32732228
07/2020

A national cross-sectional survey of public perceptions, knowledge, and behaviors during the COVID-19 pandemic
Parsons Leigh J and Fiest K and Brundin-Mather R and Plonikoff K and Soo A and Sypes EE and Whalen-Browne L and Ahmed SB and Burns KE and Fox-Robichaud A and Kupsch S and Longmore S and Stelfox HT
DOI: 10.1101/2020.07.07.20147413
07/2020

The REMAP-CAP (Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia) Study. Rationale and Design.
Annals of the American Thoracic Society
Angus DC and Berry S and Lewis RJ and Al-Beidh F and Arabi Y and van Bentum-Puijk W and Bhimani Z and Bonten M and Broglio K and Brunkhorst F and Cheng AC and Chiche JD and De Jong M and Webb SA
DOI: 10.1513/annalsats.202003-192sd
PubMed: 32267771
07/2020

Drug treatments for covid-19: living systematic review and network meta-analysis.
BMJ (Clinical research ed.)
Siemieniuk RA and Bartoszko JJ and Ge L and Zeraatkar D and Izcovich A and Pardo-Hernandez H and Rochwerg B and Lamontagne F and Han MA and Kum E and Liu Q and Agarwal A and Brignardello-Petersen R
DOI: 10.1136/bmj.m2980
PubMed: 32732190
07/2020

Remdesivir for severe covid-19: a clinical practice guideline.
BMJ (Clinical research ed.)
Rochwerg B and Agarwal A and Zeng L and Leo YS and Appiah JA and Agoritsas T and Bartoszko J and Brignardello-Petersen R and Ergan B and Ge L and Geduld H and Gershengorn HB and Guyatt G
DOI: 10.1136/bmj.m2924
PubMed: 32732352
07/2020

High-flow nasal cannula for acute hypoxemic respiratory failure in patients with COVID-19: systematic reviews of effectiveness and its risks of aerosolization, dispersion, and infection transmission.
Canadian journal of anaesthesia = Journal canadien d'anesthesie
Agarwal A and Basmaji J and Muttalib F and Granton D and Chaudhuri D and Chetan D and Hu M and Fernando SM and Honarmand K and Bakaa L and Brar S and Rochwerg B and Adhikari NK and Vandvik PO
DOI: 10.1007/s12630-020-01740-2
PubMed: 32542464
06/2020

Global outbreak research: harmony not hegemony.
The Lancet. Infectious diseases
ISARIC clinical characterisation group
DOI: 10.1016/s1473-3099(20)30440-0
PubMed: 32502433
06/2020

Treatment of patients with nonsevere and severe coronavirus disease 2019: an evidence-based guideline
Canadian Medical Association Journal
DOI: 10.1503/cmaj.200648
05/2020

Global injury morbidity and mortality from 1990 to 2017: results from the Global Burden of Disease Study 2017
Injury Prevention
DOI: 10.1136/injuryprev-2019-043494
04/2020

Misinformation During the Coronavirus Disease 2019 Outbreak: How Knowledge Emerges From Noise.
Critical care explorations
Rochwerg B and Parke R and Murthy S and Fernando SM and Leigh JP and Marshall J and Adhikari NKJ and Fiest K and Fowler R and Lamontagne F and Sevransky JE
DOI: 10.1097/cce.0000000000000098
PubMed: 32426740
04/2020

Current Challenges in the Management of Sepsis in ICUs in Resource-Poor Settings and Suggestions for the Future
Schultz MJ and Dünser MW and Dondorp AM and Adhikari NKJ and Iyer S and Kwizera A and Lubell Y and Papali A and Pisani L and Riviello ED and Angus DC and Azevedo LC and Baker T and Thwaites CL
PubMed: 32091691
02/2020

Infection Management in Patients with Sepsis and Septic Shock in Resource-Limited Settings
Thwaites CL and Lundeg G and Dondorp AM and Adhikari NKJ and Nakibuuka J and Jawa R and Mer M and Murthy S and Schultz MJ and Thien BN and Kwizera A
PubMed: 32091696
02/2020

Pediatric Sepsis and Septic Shock Management in Resource-Limited Settings
Musa N and Murthy S and Kissoon N and Lodha R and Ranjit S
PubMed: 32091689
02/2020

Burden of injury along the development spectrum: associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017.
Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention
Haagsma JA and James SL and Castle CD and Dingels ZV and Fox JT and Hamilton EB and Liu Z and Lucchesi LR and Roberts NLS and Sylte DO and Adebayo OM and Ahmadi A and Ahmed MB and Vos T
DOI: 10.1136/injuryprev-2019-043296
PubMed: 31915273
01/2020

Generating randomized trial evidence to optimize treatment in the COVID-19 pandemic
CMAJ
Cheng, M.P. and Lee, T.C. and Tan, D.H.S. and Murthy, S.
DOI: 10.1503/cmaj.200438
2020

Cytomegalovirus in pediatric sepsis: Should we care?
Pediatric Critical Care Medicine
Wooldridge, G. and Murthy, S.
DOI: 10.1097/PCC.0000000000002209
2020

Core outcome set in paediatric sepsis in low-and middle-income countries: a study protocol
BMJ Open
Wooldridge, G. and Murthy, S. and Kissoon, N.
DOI: 10.1136/bmjopen-2019-034960
2020

Stakeholder perspectives on adaptive clinical trials: A scoping review
Trials
Madani Kia, T. and Marshall, J.C. and Murthy, S.
DOI: 10.1186/s13063-020-04466-0
2020

COVID-19: a novel coronavirus and a novel challenge for critical care
Intensive Care Medicine
Arabi, Y.M. and Murthy, S. and Webb, S.
DOI: 10.1007/s00134-020-05955-1
2020

Coronavirus Disease 2019 in Critically Ill Children: A Narrative Review of the Literature
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Ong, J.S.M. and Tosoni, A. and Kim, Y. and Kissoon, N. and Murthy, S.
DOI: 10.1097/PCC.0000000000002376
2020

Third-generation cephalosporin-resistant urinary tract infections in children presenting to the paediatric emergency department
Paediatrics and Child Health (Canada)
Kang, K.T. and Ng, K. and Kendrick, J. and Tilley, P. and Ting, J. and Rassekh, S. and Murthy, S. and Roberts, A.
DOI: 10.1093/pch/pxy175
2020

Correction to: COVID-19: a novel coronavirus and a novel challenge for critical care (Intensive Care Medicine, (2020), 46, 5, (833-836), 10.1007/s00134-020-05955-1)
Intensive Care Medicine
Arabi, Y.M. and Murthy, S. and Webb, S.
DOI: 10.1007/s00134-020-06009-2
2020

Care for Critically Ill Patients with COVID-19
JAMA - Journal of the American Medical Association
Murthy, S. and Gomersall, C.D. and Fowler, R.A.
DOI: 10.1001/jama.2020.3633
2020

Defining Optimal Empirical Antibiotic Regimens in a Rapidly Changing Landscape of Resistance
JAMA network open
Park, J.J.H. and Murthy, S.
DOI: 10.1001/jamanetworkopen.2019.21150
2020

Data initiatives supporting critical care research and quality improvement in Canada: an environmental scan and narrative review,Bases de données étayant la recherche et l’amélioration de la qualité des soins intensifs au Canada: une étude générale de la situation et revue narrative
Canadian Journal of Anesthesia
Jackson Chornenki, N. and Liaw, P. and Bagshaw, S. and Burns, K. and Dodek, P. and English, S. and Fan, E. and Ferrari, N. and Fowler, R. and Fox-Robichaud, A. and Garland, A. and Green, R. and Hebert, P. and Kho, M. and Martin, C. and Maslove, D. and McDonald, E. and Menon, K. and Murthy, S. and Muscedere, J. and Scales, D. and Stelfox, H.T. and Wang, H.T. and Weiss, M.
DOI: 10.1007/s12630-020-01571-1
2020

Academic careers in global pulmonary and critical care medicine
Journal of Global Health
Papali, A. and Diaz, J.V. and Carter, E.J. and Ferreira, J.C. and Fowler, R. and Gebremariam, T.H. and Gordon, S.B. and Lee, B.W. and Murthy, S. and Riviello, E.D. and West, T.E. and Adhikari, N.K.J.
DOI: 10.7189/jogh.10.010313
2020

Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017.
The Lancet. Infectious diseases
GBD 2017 Diarrhoeal Disease Collaborators
DOI: 10.1016/s1473-3099(19)30401-3
PubMed: 31678029
10/2019

Quantifying risks and interventions that have affected the burden of lower respiratory infections among children younger than 5 years: an analysis for the Global Burden of Disease Study 2017.
The Lancet. Infectious diseases
GBD 2017 Lower Respiratory Infections Collaborators
DOI: 10.1016/s1473-3099(19)30410-4
PubMed: 31678026
10/2019

International Study of the Epidemiology of Platelet Transfusions in Critically Ill Children With an Underlying Oncologic Diagnosis.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Nellis ME and Goel R and Karam O and Cushing MM and Davis PJ and Steiner ME and Tucci M and Stanworth SJ and Spinella PC and and the Point Prevalence Study of Platelet Transfusions in Critically Ill Children (P3T) Investigators
DOI: 10.1097/pcc.0000000000001987
PubMed: 31107379
07/2019

New filovirus disease classification and nomenclature
Nature Reviews Microbiology
DOI: 10.1038/s41579-019-0187-4
05/2019

Effects of ABO Matching of Platelet Transfusions in Critically Ill Children*
Pediatric Critical Care Medicine
DOI: 10.1097/pcc.0000000000001779
02/2019

Pediatric sepsis and septic shock management in resource-limited settings
Sepsis Management in Resource-limited Settings
Musa, N. and Murthy, S. and Kissoon, N. and Lodha, R. and Ranjit, S.
DOI: 10.1007/978-3-030-03143-5_10
2019

Priorities, barriers, and facilitators towards international guidelines for the delivery of supportive clinical care during an ebola outbreak: A cross-sectional survey
Viruses
Battista, M.-C. and Loignon, C. and Benhadj, L. and Nouvet, E. and Murthy, S. and Fowler, R. and Adhikari, N.K.J. and Haj-Moustafa, A. and Salam, A.P. and Chan, A.K. and Mishra, S. and Couturier, F. and Hudon, C. and Horby, P. and Bedell, R. and Rekart, M. and Hajek, J. and Lamontagne, F.
DOI: 10.3390/v11020194
2019

Feasibility of Automated Vital Sign Instability Detection in Children Admitted to the Pediatric Intensive Care Unit
Computing in Cardiology
Seidel, G. and Murthy, S. and Peters, C. and Rostalski, P. and Görges, M.
DOI: 10.23919/CinC49843.2019.9005547
2019

Clinical research networks and assessing pandemic severity
The Lancet Global Health
Murthy, S. and Carson, G. and Horby, P. and Merson, L. and Webb, S.
DOI: 10.1016/S2214-109X(18)30413-3
2019

Anti-Ebola therapy for patients with Ebola virus disease: A systematic review
BMC Infectious Diseases
Lee, J.S. and Adhikari, N.K.J. and Kwon, H.Y. and Teo, K. and Siemieniuk, R. and Lamontagne, F. and Chan, A. and Mishra, S. and Murthy, S. and Kiiza, P. and Hajek, J. and Bah, E.I. and Lamah, M.-C. and Kao, R. and Fowler, R.A.
DOI: 10.1186/s12879-019-3980-9
2019

Using research to prepare for outbreaks of severe acute respiratory infection
BMJ Global Health
Murthy, S.
DOI: 10.1136/bmjgh-2018-001061
2019

Editorial: Pediatric critical care in resource-limited settings
Frontiers in Pediatrics
Murthy, S. and Chugh, K. and Musa, N. and Ouellette, Y. and Phan, P.H.
DOI: 10.3389/fped.2019.00080
2019

Infection management in patients with sepsis and septic shock in resource-limited settings
Sepsis Management in Resource-limited Settings
Thwaites, C.L. and Lundeg, G. and Dondorp, A.M. and Adhikari, N.K.J. and Nakibuuka, J. and Jawa, R. and Mer, M. and Murthy, S. and Schultz, M.J. and Thien, B.N. and Kwizera, A.
DOI: 10.1007/978-3-030-03143-5_8
2019

Global, regional, and national burden of meningitis, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
The Lancet Neurology
DOI: 10.1016/s1474-4422(18)30387-9
12/2018

External Validation of the "Quick" Pediatric Logistic Organ Dysfunction-2 Score Using a Large North American Cohort of Critically Ill Children With Suspected Infection.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Görges M and Peters C and Murthy S and Pi S and Kissoon N
DOI: 10.1097/pcc.0000000000001729
PubMed: 30234742
12/2018

Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the Global Burden of Disease Study 2017.
The Lancet. Respiratory medicine
GBD 2017 Influenza Collaborators
DOI: 10.1016/s2213-2600(18)30496-x
PubMed: 30553848
12/2018

Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017
The Lancet
DOI: 10.1016/s0140-6736(18)31891-9
11/2018

Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.
The Lancet. Neurology
GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators
DOI: 10.1016/s1474-4422(18)30415-0
PubMed: 30497965
11/2018

Global, regional, and national age-sex-specific mortality and life expectancy, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017.
Lancet (London, England)
DOI: 10.1016/S0140-6736(18)31891-9
PubMed: 30496102
11/2018

Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017.
Lancet (London, England)
DOI: 10.1016/S0140-6736(18)32281-5
PubMed: 30496107
11/2018

Global, regional, and national burden of meningitis, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.
The Lancet. Neurology
DOI: 10.1016/S1474-4422(18)30387-9
PubMed: 30507391
11/2018

Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017
The Lancet
DOI: 10.1016/s0140-6736(18)32281-5
11/2018

Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
The Lancet Infectious Diseases
DOI: 10.1016/s1473-3099(18)30310-4
11/2018

Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016
The Lancet Infectious Diseases
DOI: 10.1016/s1473-3099(18)30362-1
11/2018

Barriers to supportive care during the Ebola virus disease outbreak in West Africa: Results of a qualitative study
PLOS ONE
Christine Loignon and Elysée Nouvet and François Couturier and Lynda Benhadj and Neill K. J. Adhikari and Srinivas Murthy and Rob A. Fowler and François Lamontagne
DOI: 10.1371/journal.pone.0201091
09/2018

Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.
The Lancet. Infectious diseases
DOI: 10.1016/S1473-3099(18)30310-4
PubMed: 30243584
09/2018

Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016.
The Lancet. Infectious diseases
DOI: 10.1016/S1473-3099(18)30362-1
PubMed: 30243583
09/2018

Mortality Risk Using a Pediatric Quick Sequential (Sepsis-Related) Organ Failure Assessment Varies With Vital Sign Thresholds*
Pediatric Critical Care Medicine
Cheryl Peters and Srinivas Murthy and Rollin Brant and Niranjan Kissoon and Matthias Görges
DOI: 10.1097/pcc.0000000000001598
08/2018

Platelet Transfusion Practices in Critically Ill Children
Critical Care Medicine
DOI: 10.1097/ccm.0000000000003192
08/2018

Hyperferritinemia in Sepsis in Children
Pediatric Critical Care Medicine
Srinivas Murthy and Niranjan Kissoon
DOI: 10.1097/pcc.0000000000001585
07/2018

Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016
The Lancet
DOI: 10.1016/s0140-6736(18)30994-2
06/2018

Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016.
Lancet (London, England)
DOI: 10.1016/S0140-6736(18)30994-2
PubMed: 29893224
06/2018

The Potential Harm of Cytomegalovirus Infection in Immunocompetent Critically Ill Children
Frontiers in Pediatrics
Raidan Alyazidi and Srinivas Murthy and Jennifer A. Slyker and Soren Gantt
DOI: 10.3389/fped.2018.00096
04/2018

Dopamine and the Risk for Hospital-Acquired Infections*
Pediatric Critical Care Medicine
Srinivas Murthy
DOI: 10.1097/pcc.0000000000001446
03/2018

Evidence-based guidelines for supportive care of patients with Ebola virus disease
The Lancet
DOI: 10.1016/s0140-6736(17)31795-6
02/2018

Non-invasive ventilation in children and adults in low- and low-middle income countries: A systematic review and meta-analysis
Journal of Critical Care
Keren Mandelzweig and Aleksandra Leligdowicz and Srinivas Murthy and Rejani Lalitha and Robert A. Fowler and Neill K.J. Adhikari
DOI: 10.1016/j.jcrc.2018.01.007
01/2018

Mortality Risk Using a Pediatric Quick Sequential (Sepsis-Related) Organ Failure Assessment Varies With Vital Sign Thresholds
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
Peters, C. and Murthy, S. and Brant, R. and Kissoon, N. and Görges, M.
DOI: 10.1097/PCC.0000000000001598
2018

Dopamine and the Risk for Hospital-Acquired Infections*
Pediatric Critical Care Medicine
Murthy, S.
DOI: 10.1097/PCC.0000000000001446
2018

Hyperferritinemia in sepsis in children: Ironing out the global details
Pediatric Critical Care Medicine
Murthy, S. and Kissoon, N.
DOI: 10.1097/PCC.0000000000001585
2018

The Young Investigator Retreat of the Canadian Critical Care Trials Group: mentorship and self-discovery,La Retraite pour jeunes chercheurs du Groupe canadien de recherche en soins intensifs : mentorat et introspection
Canadian Journal of Anesthesia
Ball, I.M. and Burry, L. and Dodek, P. and Hutchison, J.S. and Leigh, J.P. and McCredie, V. and Murthy, S. and Rochwerg, B. and Cook, D.
DOI: 10.1007/s12630-017-1016-8
2018

Recommendations on infrastructure and organization of adult ICUs in resource-limited settings
Intensive Care Medicine
Alfred Papali and for the European Society of Intensive Care Medicine (ESICM) Global Intensive Care working group and The Mahidol–Oxford Research Unit (MORU) in Bangkok and Thailand and Marcus J. Schultz and Martin W. Dünser
DOI: 10.1007/s00134-017-4972-0
11/2017

Early vasopressor use following traumatic injury: a systematic review.
BMJ open
DOI: 10.1136/bmjopen-2017-017559
PubMed: 29151048
11/2017

Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016.
Lancet (London, England)
DOI: 10.1016/S0140-6736(17)31833-0
PubMed: 28919115
09/2017

Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.
Lancet (London, England)
DOI: 10.1016/S0140-6736(17)32130-X
PubMed: 28919118
09/2017

Outcome Measures in Sepsis, Revisited*
Pediatric Critical Care Medicine
Srinivas Murthy
DOI: 10.1097/pcc.0000000000001209
08/2017

Burden of diarrhea in the Eastern Mediterranean Region, 1990-2015: Findings from the Global Burden of Disease 2015 study.
International journal of public health
GBD 2015 Eastern Mediterranean Region Diarrhea Collaborators
DOI: 10.1007/s00038-017-1008-z
PubMed: 28776239
08/2017

Selective digestive decontamination in critically ill children: A survey of Canadian providers
Journal of Critical Care
Srinivas Murthy and Nazima Pathan and Brian H. Cuthbertson
DOI: 10.1016/j.jcrc.2017.02.024
06/2017

Perioperative antibiotics in pediatric cardiac surgery: protocol for a systematic review
Systematic Reviews
Vijay Anand and Angela Bates and Robin Featherstone and Srinivas Murthy
DOI: 10.1186/s13643-017-0502-y
05/2017

Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: a novel analysis from the Global Burden of Disease Study 2015.
Lancet (London, England)
DOI: 10.1016/S0140-6736(17)30818-8
PubMed: 28528753
05/2017

Current challenges in the management of sepsis in ICUs in resource-poor settings and suggestions for the future.
Intensive care medicine
DOI: 10.1007/s00134-017-4750-z
PubMed: 28349179
03/2017

Vasopressor use following traumatic injury: protocol for a systematic review
BMJ Open
DOI: 10.1136/bmjopen-2016-014166
02/2017

Erratum: Global, regional, and national levels of maternal mortality, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015
The Lancet
DOI: 10.1016/s0140-6736(16)32609-5
01/2017

Global, Regional, and National Levels of Maternal Mortality, 1990–2015
Obstetrical & Gynecological Survey
DOI: 10.1097/01.ogx.0000511935.64476.66
01/2017

Erratum: Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015
The Lancet
DOI: 10.1016/s0140-6736(16)32608-3
01/2017

Outcome measures in sepsis, revisited
Pediatric Critical Care Medicine
Murthy, S.
DOI: 10.1097/PCC.0000000000001209
2017

Design and a-testing of an electronic rounding tool (CERTAINp) to improve process of care in pediatric intensive care unit
Journal of Clinical Monitoring and Computing
Hulyalkar, M. and Gleich, S.J. and Kashyap, R. and Barwise, A. and Kaur, H. and Dong, Y. and Fan, L. and Murthy, S. and Arteaga, G.M. and Tripathi, S.
DOI: 10.1007/s10877-016-9946-1
2017

Who Says There Is No “I” in Team? Achieving Individual Success in Collaborative Clinical Research in Critical Care
American Journal of Respiratory and Critical Care Medicine
Raquel R. Bartz and Dashiell Gantner and Anthony C. Gordon and Aleksandra Leligdowicz and James J. McNamee and Srinivas Murthy and Alistair Nichol and Steve Webb
DOI: 10.1164/rccm.201602-0405le
10/2016

Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015.
Lancet (London, England)
DOI: 10.1016/S0140-6736(16)31575-6
PubMed: 27733285
10/2016

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015.
Lancet (London, England)
DOI: 10.1016/S0140-6736(16)31012-1
PubMed: 27733281
10/2016

Global, regional, and national levels of maternal mortality, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.
Lancet (London, England)
DOI: 10.1016/S0140-6736(16)31470-2
PubMed: 27733286
10/2016

Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015
The Lancet
DOI: 10.1016/s0140-6736(16)31575-6
10/2016

Measuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease Study 2015.
Lancet (London, England)
DOI: 10.1016/S0140-6736(16)31467-2
PubMed: 27665228
09/2016

Ebola virus disease and critical illness.
Critical care (London, England)
DOI: 10.1186/s13054-016-1325-2
PubMed: 27468829
07/2016

Pediatric sepsis and septic shock management in resource-limited settings
Intensive Care Medicine
Ndidiamaka Musa and Srinivas Murthy and Niranjan Kissoon
DOI: 10.1007/s00134-016-4382-8
05/2016

Who says there is no "i" in team? Achieving individual success in collaborative clinical research in critical care
American Journal of Respiratory and Critical Care Medicine
Bartz, R.R. and Gantner, D. and Gordon, A.C. and Leligdowicz, A. and McNamee, J.J. and Murthy, S. and Nichol, A. and Webb, S.
DOI: 10.1164/rccm.201602-0405LE
2016

A survey on the resources and practices in pediatric critical care of resource-rich and resource-limited countries
Journal of Intensive Care
Sandeep Tripathi and Harsheen Kaur and Rahul Kashyap and Yue Dong and Ognjen Gajic and Srinivas Murthy
DOI: 10.1186/s40560-015-0106-3
10/2015

Management of severe viral infections in the pediatric intensive care unit
Journal of Pediatric Intensive Care
Srinivas Murthy and Niranjan Kissoon
DOI: 10.3233/pic-14103
07/2015

Industry-sponsored clinical research outside high-income countries: an empirical analysis of registered clinical trials from 2006 to 2013
Health Research Policy and Systems
Srinivas Murthy and Kenneth D. Mandl and Florence T. Bourgeois
DOI: 10.1186/s12961-015-0019-6
06/2015

Ebola and provision of critical care
The Lancet
Srinivas Murthy
DOI: 10.1016/s0140-6736(15)60712-7
04/2015

Ebola Virus Disease among Children in West Africa
New England Journal of Medicine
DOI: 10.1056/nejmc1415318
03/2015

Being Ready to Treat Ebola Virus Disease Patients
The American Journal of Tropical Medicine and Hygiene
DOI: 10.4269/ajtmh.14-0746
02/2015

Intensive Care Unit Capacity in Low-Income Countries: A Systematic Review
PLOS ONE
Srinivas Murthy and Aleksandra Leligdowicz and Neill K. J. Adhikari
DOI: 10.1371/journal.pone.0116949
01/2015

Ebola and provision of critical care (II)
The Lancet
Murthy, S.
DOI: 10.1016/S0140-6736(15)60712-7
2015

Access to urban acute care services in high- vs. middle-income countries: an analysis of seven cities
Intensive Care Medicine
DOI: 10.1007/s00134-013-3174-7
03/2014

Critical Care in Low-Resource Settings
The Organization of Critical Care
Srinivas Murthy and Sadath A. Sayeed and Neill K. J. Adhikari
DOI: 10.1007/978-1-4939-0811-0_16
2014

Global Health Care of the Critically Ill in Low-Resource Settings
Annals of the American Thoracic Society
Srinivas Murthy and Neill K. Adhikari
DOI: 10.1513/annalsats.201307-246ot
10/2013

Innominate artery aneurysm after cannulation for extracorporeal membrane oxygenation via the right carotid artery
Intensive Care Medicine
Srinivas Murthy and Cathy MacDonald and Osami Honjo and Alejandro A. Floh and Tilman Humpl
DOI: 10.1007/s00134-013-3070-1
08/2013

Infections of the Developing World
Critical Care Clinics
Srinivas Murthy and Jay Keystone and Niranjan Kissoon
DOI: 10.1016/j.ccc.2013.03.005
07/2013

Analysis of Pediatric Clinical Drug Trials for Neuropsychiatric Conditions
PEDIATRICS
S. Murthy and K. D. Mandl and F. Bourgeois
DOI: 10.1542/peds.2012-2694
05/2013

After the FEAST - Fluid resuscitation in pediatric sepsis
Indian Journal of Pediatrics
Murthy, S. and Kissoon, N.
DOI: 10.1007/s12098-012-0845-2
2013

Global health care of the critically ill in low-resource settings
Annals of the American Thoracic Society
Murthy, S. and Adhikari, N.K.
DOI: 10.1513/AnnalsATS.201307-246OT
2013

Network Analysis of Transcriptional Responses Induced by Mesenchymal Stem Cell Treatment of Experimental Sepsis
The American Journal of Pathology
Claudia C. dos Santos and Srinivas Murthy and Pingzhao Hu and Yuexin Shan and Jack J. Haitsma and Shirley H.J. Mei and Duncan J. Stewart and W. Conrad Liles
DOI: 10.1016/j.ajpath.2012.08.009
11/2012

Pediatric Versus Adult Drug Trials for Conditions With High Pediatric Disease Burden
PEDIATRICS
F. T. Bourgeois and S. Murthy and C. Pinto and K. L. Olson and J. P. A. Ioannidis and K. D. Mandl
DOI: 10.1542/peds.2012-0139
07/2012

The Role and Impact of Research Agendas on the Comparative-Effectiveness Research Among Antihyperlipidemics
Clinical Pharmacology & Therapeutics
A G Dunn and F T Bourgeois and S Murthy and K D Mandl and R O Day and E Coiera
DOI: 10.1038/clpt.2011.279
02/2012

Comparative Effectiveness Research: An Empirical Study of Trials Registered in ClinicalTrials.gov
PLoS ONE
Florence T. Bourgeois and Srinivas Murthy and Kenneth D. Mandl
DOI: 10.1371/journal.pone.0028820
01/2012

Clinical review: International comparisons in critical care - lessons learned
Critical Care
Srinivas Murthy and Hannah Wunsch
DOI: 10.1186/cc11140
2012

Clinical utility of biomarkers of endothelial activation in sepsis-a systematic review
Critical Care
Xing, K. and Murthy, S. and Liles, W.C. and Singh, J.M.
DOI: 10.1186/cc11145
2012

The effect of funding source on outcome reporting among drug trials
Annals of Internal Medicine
Bourgeois, F.T. and Mandl, K.D. and Murthy, S.
DOI: 10.7326/0003-4819-154-2-201101180-00021
2011

Infectious Diseases Following Disasters
Disaster Medicine and Public Health Preparedness
Srinivas Murthy and Michael D. Christian
DOI: 10.1001/dmp.2010.hcn10005
10/2010

Outcome Reporting Among Drug Trials Registered in ClinicalTrials.gov
Annals of Internal Medicine
Florence T. Bourgeois
DOI: 10.7326/0003-4819-153-3-201008030-00006
08/2010

Pseudomigraine with prolonged aphasia in a child with cranial irradiation for medulloblastoma
Journal of Child Neurology
Murthy, S.N.K. and Cohen, M.E.
DOI: 10.1177/088307380201700209
2002

Acute disseminated encephalomyelitis in children.
Pediatrics
Murthy, S.N. and Faden, H.S. and Cohen, M.E. and Bakshi, R.
DOI: 10.1542/peds.110.2.e21
2002

Influencing spermicide use among low-income minority women.
Journal of the American Medical Women's Association
Cohen, D. and Reardon, K. and Alleyne, D. and Murthy, S. and Linton, K.
1995

Research

Biomarkers in pediatric sepsis
Being able to stratify children with severe sepsis, so as to better triage their care and predict their outcome, is a long-standing challenge. I am investigating the role of a panel of novel biomarkers, detected in blood, in predicting the outcome of children. This will be of tremendous help for research purposes, for front-line providers assessing the severity of illness, and for improving the understanding of the mechanism of the complex septic reaction.

Grants

2011 University of Toronto Elizabeth Arbuthnot Dyson Fellowship

2011 University of Toronto Joseph M. West Family Memorial Fund Fellowship

Research Group Members

Jasjot Deol
Ethan Rajkumar, INSPIRE Student