Overview

Infections in children are still a major cause of early morbidity and mortality throughout the world, despite the advances made in preventive care. Infections are often a reason for children to become critically ill, and often occur in the critically ill child. My research focuses upon stemming this burden through optimizing their management in a variety of settings. Additionally, the ability of various settings and healthcare systems to cost-effectively manage critically ill children, especially those with infection, is an area of focus.

Publications

Global, regional, and national burden of meningitis, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
The Lancet Neurology
DOI: 10.1016/s1474-4422(18)30387-9
12/2018

Global, regional, and national age-sex-specific mortality and life expectancy, 1950–2017: a systematic analysis for the Global Burden of Disease Study 2017
The Lancet
DOI: 10.1016/s0140-6736(18)31891-9
11/2018

Global, regional, and national age-sex-specific mortality and life expectancy, 1950-2017: a systematic analysis for the Global Burden of Disease Study 2017.
Lancet (London, England)
DOI: 10.1016/S0140-6736(18)31891-9
PubMed: 30496102
11/2018

Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017.
Lancet (London, England)
DOI: 10.1016/S0140-6736(18)32281-5
PubMed: 30496107
11/2018

Global, regional, and national burden of meningitis, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.
The Lancet. Neurology
DOI: 10.1016/S1474-4422(18)30387-9
PubMed: 30507391
11/2018

Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017
The Lancet
DOI: 10.1016/s0140-6736(18)32281-5
11/2018

Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
The Lancet Infectious Diseases
DOI: 10.1016/s1473-3099(18)30310-4
11/2018

Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016
The Lancet Infectious Diseases
DOI: 10.1016/s1473-3099(18)30362-1
11/2018

Barriers to supportive care during the Ebola virus disease outbreak in West Africa: Results of a qualitative study
PLOS ONE
Christine Loignon and Elysée Nouvet and François Couturier and Lynda Benhadj and Neill K. J. Adhikari and Srinivas Murthy and Rob A. Fowler and François Lamontagne
DOI: 10.1371/journal.pone.0201091
09/2018

Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.
The Lancet. Infectious diseases
DOI: 10.1016/S1473-3099(18)30310-4
PubMed: 30243584
09/2018

Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016.
The Lancet. Infectious diseases
DOI: 10.1016/S1473-3099(18)30362-1
PubMed: 30243583
09/2018

Platelet Transfusion Practices in Critically Ill Children
Critical Care Medicine
DOI: 10.1097/ccm.0000000000003192
08/2018

Mortality Risk Using a Pediatric Quick Sequential (Sepsis-Related) Organ Failure Assessment Varies With Vital Sign Thresholds*
Pediatric Critical Care Medicine
Cheryl Peters and Srinivas Murthy and Rollin Brant and Niranjan Kissoon and Matthias Görges
DOI: 10.1097/pcc.0000000000001598
08/2018

Hyperferritinemia in Sepsis in Children
Pediatric Critical Care Medicine
Srinivas Murthy and Niranjan Kissoon
DOI: 10.1097/pcc.0000000000001585
07/2018

Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016
The Lancet
DOI: 10.1016/s0140-6736(18)30994-2
06/2018

Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016.
Lancet (London, England)
DOI: 10.1016/S0140-6736(18)30994-2
PubMed: 29893224
06/2018

The Potential Harm of Cytomegalovirus Infection in Immunocompetent Critically Ill Children
Frontiers in Pediatrics
Raidan Alyazidi and Srinivas Murthy and Jennifer A. Slyker and Soren Gantt
DOI: 10.3389/fped.2018.00096
04/2018

Dopamine and the Risk for Hospital-Acquired Infections*
Pediatric Critical Care Medicine
Srinivas Murthy
DOI: 10.1097/pcc.0000000000001446
03/2018

Evidence-based guidelines for supportive care of patients with Ebola virus disease
The Lancet
François Lamontagne and Robert A Fowler and Neill K Adhikari and Srinivas Murthy and David M Brett-Major and Michael Jacobs and Timothy M Uyeki and Constanza Vallenas and Susan L Norris and William A Fischer and Thomas E Fletcher and Adam C Levine and Paul Reed and Daniel G Bausch and Sandy Gove and Andrew Hall and Susan Shepherd and Reed A Siemieniuk and Marie-Claude Lamah and Rashida Kamara and Phiona Nakyeyune and Moses J Soka and Ama Edwin and Afeez A Hazzan and Shevin T Jacob and Mubarak Mustafa Elkarsany and Takuya Adachi and Lynda Benhadj and Christophe Clément and Ian Crozier and Armando Garcia and Steven J Hoffman and Gordon H Guyatt
DOI: 10.1016/s0140-6736(17)31795-6
02/2018

Non-invasive ventilation in children and adults in low- and low-middle income countries: A systematic review and meta-analysis
Journal of Critical Care
Keren Mandelzweig and Aleksandra Leligdowicz and Srinivas Murthy and Rejani Lalitha and Robert A. Fowler and Neill K.J. Adhikari
DOI: 10.1016/j.jcrc.2018.01.007
01/2018

External Validation of the “Quick” Pediatric Logistic Organ Dysfunction-2 Score Using a Large North American Cohort of Critically Ill Children With Suspected Infection
Pediatric Critical Care Medicine
Matthias Görges and Cheryl Peters and Srinivas Murthy and Shanshan Pi and Niranjan Kissoon
DOI: 10.1097/pcc.0000000000001729
2018

Recommendations on infrastructure and organization of adult ICUs in resource-limited settings
Intensive Care Medicine
Alfred Papali and for the European Society of Intensive Care Medicine (ESICM) Global Intensive Care working group and The Mahidol–Oxford Research Unit (MORU) in Bangkok and Thailand and Marcus J. Schultz and Martin W. Dünser
DOI: 10.1007/s00134-017-4972-0
11/2017

Early vasopressor use following traumatic injury: a systematic review.
BMJ open
DOI: 10.1136/bmjopen-2017-017559
PubMed: 29151048
11/2017

The Young Investigator Retreat of the Canadian Critical Care Trials Group: mentorship and self-discovery
Canadian Journal of Anesthesia/Journal canadien d'anesthésie
Ian M. Ball and for the Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group and Lisa Burry and Peter Dodek and Jamie S. Hutchison and Jeanna Parsons Leigh and Victoria McCredie and Srinivas Murthy and Bram Rochwerg and Deborah Cook
DOI: 10.1007/s12630-017-1016-8
11/2017

Evidence-based guidelines for supportive care of patients with Ebola virus disease.
Lancet (London, England)
DOI: 10.1016/S0140-6736(17)31795-6
PubMed: 29054555
10/2017

Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: a systematic analysis for the Global Burden of Disease Study 2016.
Lancet (London, England)
DOI: 10.1016/S0140-6736(17)31833-0
PubMed: 28919115
09/2017

Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016.
Lancet (London, England)
DOI: 10.1016/S0140-6736(17)32130-X
PubMed: 28919118
09/2017

Outcome Measures in Sepsis, Revisited*
Pediatric Critical Care Medicine
Srinivas Murthy
DOI: 10.1097/pcc.0000000000001209
08/2017

Burden of diarrhea in the Eastern Mediterranean Region, 1990–2015: Findings from the Global Burden of Disease 2015 study
International Journal of Public Health
Ali H. Mokdad and GBD 2015 Eastern Mediterranean Region Diarrhea Collaborators
DOI: 10.1007/s00038-017-1008-z
08/2017

Selective digestive decontamination in critically ill children: A survey of Canadian providers
Journal of Critical Care
Srinivas Murthy and Nazima Pathan and Brian H. Cuthbertson
DOI: 10.1016/j.jcrc.2017.02.024
06/2017

Perioperative antibiotics in pediatric cardiac surgery: protocol for a systematic review
Systematic Reviews
Vijay Anand and Angela Bates and Robin Featherstone and Srinivas Murthy
DOI: 10.1186/s13643-017-0502-y
05/2017

Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: a novel analysis from the Global Burden of Disease Study 2015.
Lancet (London, England)
DOI: 10.1016/S0140-6736(17)30818-8
PubMed: 28528753
05/2017

Current challenges in the management of sepsis in ICUs in resource-poor settings and suggestions for the future.
Intensive care medicine
DOI: 10.1007/s00134-017-4750-z
PubMed: 28349179
03/2017

Vasopressor use following traumatic injury: protocol for a systematic review
BMJ Open
Mathieu Hylands and Augustin Toma and Nicolas Beaudoin and Anne-Julie Frenette and Frederick D'Aragon and Emilie Belley-Côté and Morten Hylander and François Lauzier and Reed Alexander Siemieniuk and Emmanuel Charbonney and Joey Kwong and Jon Henrik Laake and Gordon Guyatt and Per Olav Vandvik and Bram Rochwerg and Robert Green and Ian Ball and Damon Scales and Srinivas Murthy and Sandro Rizoli and Pierre Asfar and François Lamontagne
DOI: 10.1136/bmjopen-2016-014166
02/2017

Who Says There Is No “I” in Team? Achieving Individual Success in Collaborative Clinical Research in Critical Care
American Journal of Respiratory and Critical Care Medicine
Raquel R. Bartz and Dashiell Gantner and Anthony C. Gordon and Aleksandra Leligdowicz and James J. McNamee and Srinivas Murthy and Alistair Nichol and Steve Webb
DOI: 10.1164/rccm.201602-0405le
10/2016

Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015.
Lancet (London, England)
DOI: 10.1016/S0140-6736(16)31575-6
PubMed: 27733285
10/2016

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015.
Lancet (London, England)
DOI: 10.1016/S0140-6736(16)31012-1
PubMed: 27733281
10/2016

Global, regional, and national levels of maternal mortality, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015.
Lancet (London, England)
DOI: 10.1016/S0140-6736(16)31470-2
PubMed: 27733286
10/2016

Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015
The Lancet
DOI: 10.1016/s0140-6736(16)31575-6
10/2016

Design and a-testing of an electronic rounding tool (CERTAINp) to improve process of care in pediatric intensive care unit
Journal of Clinical Monitoring and Computing
Manasi Hulyalkar and Stephen J. Gleich and Rahul Kashyap and Amelia Barwise and Harsheen Kaur and Yue Dong and Lei Fan and Srinivas Murthy and Grace M. Arteaga and Sandeep Tripathi
DOI: 10.1007/s10877-016-9946-1
10/2016

Measuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease Study 2015.
Lancet (London, England)
DOI: 10.1016/S0140-6736(16)31467-2
PubMed: 27665228
09/2016

Ebola virus disease and critical illness.
Critical care (London, England)
DOI: 10.1186/s13054-016-1325-2
PubMed: 27468829
07/2016

Pediatric sepsis and septic shock management in resource-limited settings
Intensive Care Medicine
Ndidiamaka Musa and Srinivas Murthy and Niranjan Kissoon
DOI: 10.1007/s00134-016-4382-8
05/2016

A survey on the resources and practices in pediatric critical care of resource-rich and resource-limited countries
Journal of Intensive Care
Sandeep Tripathi and Harsheen Kaur and Rahul Kashyap and Yue Dong and Ognjen Gajic and Srinivas Murthy
DOI: 10.1186/s40560-015-0106-3
10/2015

Management of severe viral infections in the pediatric intensive care unit
Journal of Pediatric Intensive Care
Srinivas Murthy and Niranjan Kissoon
DOI: 10.3233/pic-14103
07/2015

Industry-sponsored clinical research outside high-income countries: an empirical analysis of registered clinical trials from 2006 to 2013
Health Research Policy and Systems
Srinivas Murthy and Kenneth D. Mandl and Florence T. Bourgeois
DOI: 10.1186/s12961-015-0019-6
06/2015

Ebola and provision of critical care
The Lancet
Srinivas Murthy
DOI: 10.1016/s0140-6736(15)60712-7
04/2015

Ebola Virus Disease among Children in West Africa
New England Journal of Medicine
WHO Ebola Response Team
DOI: 10.1056/nejmc1415318
03/2015

Being Ready to Treat Ebola Virus Disease Patients
The American Journal of Tropical Medicine and Hygiene
David M. Brett-Major and Shevin T. Jacob and Barbara J. Shea and Frederique A. Jacquerioz and Henry Kyobe Bosa and John S. Schieffelin and Tim O'Dempsey and Gary G. Kuniyoshi and Sara K. Hurley and John C. Carlson and David T. Porembka and Takuya Adachi and William A. Fischer and Catherine F. Houlihan and Daniel G. Bausch and Robert A. Fowler and Susan L. McLellan and Thomas E. Fletcher and Lewis Rubinson and Francois Lamontagne and James V. Lawler and George F. Risi and Srinivas G. Murthy and Suzanne M. Donovan and Nicola Petrosillo and Mauricio Ferri and Louise E. Berry and Thomas. C. Button and Yasuyuki Kato and Ian Crozier
DOI: 10.4269/ajtmh.14-0746
02/2015

Intensive Care Unit Capacity in Low-Income Countries: A Systematic Review
PLOS ONE
Srinivas Murthy and Aleksandra Leligdowicz and Neill K. J. Adhikari
DOI: 10.1371/journal.pone.0116949
01/2015

Critical Care in Low-Resource Settings
The Organization of Critical Care
Srinivas Murthy and Sadath A. Sayeed and Neill K. J. Adhikari
DOI: 10.1007/978-1-4939-0811-0_16
2014

Global Health Care of the Critically Ill in Low-Resource Settings
Annals of the American Thoracic Society
Srinivas Murthy and Neill K. Adhikari
DOI: 10.1513/annalsats.201307-246ot
10/2013

Innominate artery aneurysm after cannulation for extracorporeal membrane oxygenation via the right carotid artery
Intensive Care Medicine
Srinivas Murthy and Cathy MacDonald and Osami Honjo and Alejandro A. Floh and Tilman Humpl
DOI: 10.1007/s00134-013-3070-1
08/2013

Infections of the Developing World
Critical Care Clinics
Srinivas Murthy and Jay Keystone and Niranjan Kissoon
DOI: 10.1016/j.ccc.2013.03.005
07/2013

Analysis of Pediatric Clinical Drug Trials for Neuropsychiatric Conditions
PEDIATRICS
S. Murthy and K. D. Mandl and F. Bourgeois
DOI: 10.1542/peds.2012-2694
05/2013

Access to urban acute care services in high- vs. middle-income countries: an analysis of seven cities
Intensive Care Medicine
Shamly Austin and On behalf of the International Forum of Acute Care Trialists and Srinivas Murthy and Hannah Wunsch and Neill K. J. Adhikari and Veena Karir and Kathryn Rowan and Shevin T. Jacob and Jorge Salluh and Fernando A. Bozza and Bin Du and Youzhong An and Bruce Lee and Felicia Wu and Yen-Lan Nguyen and Chris Oppong and Ramesh Venkataraman and Vimalraj Velayutham and Carmelo Dueñas and Derek C. Angus
DOI: 10.1007/s00134-013-3174-7
2013

Network Analysis of Transcriptional Responses Induced by Mesenchymal Stem Cell Treatment of Experimental Sepsis
The American Journal of Pathology
Claudia C. dos Santos and Srinivas Murthy and Pingzhao Hu and Yuexin Shan and Jack J. Haitsma and Shirley H.J. Mei and Duncan J. Stewart and W. Conrad Liles
DOI: 10.1016/j.ajpath.2012.08.009
11/2012

After the FEAST—Fluid Resuscitation in Pediatric Sepsis
The Indian Journal of Pediatrics
Srinivas Murthy and Niranjan Kissoon
DOI: 10.1007/s12098-012-0845-2
07/2012

Pediatric Versus Adult Drug Trials for Conditions With High Pediatric Disease Burden
PEDIATRICS
F. T. Bourgeois and S. Murthy and C. Pinto and K. L. Olson and J. P. A. Ioannidis and K. D. Mandl
DOI: 10.1542/peds.2012-0139
07/2012

The Role and Impact of Research Agendas on the Comparative-Effectiveness Research Among Antihyperlipidemics
Clinical Pharmacology & Therapeutics
A G Dunn and F T Bourgeois and S Murthy and K D Mandl and R O Day and E Coiera
DOI: 10.1038/clpt.2011.279
02/2012

Comparative Effectiveness Research: An Empirical Study of Trials Registered in ClinicalTrials.gov
PLoS ONE
Florence T. Bourgeois and Srinivas Murthy and Kenneth D. Mandl
DOI: 10.1371/journal.pone.0028820
01/2012

Clinical review: International comparisons in critical care - lessons learned
Critical Care
Srinivas Murthy and Hannah Wunsch
DOI: 10.1186/cc11140
2012

Clinical utility of biomarkers of endothelial activation in sepsis-a systematic review
Critical Care
Katharine Xing and Srinivas Murthy and W Conrad Liles and Jeffrey M Singh
DOI: 10.1186/cc11145
2012

Infectious Diseases Following Disasters
Disaster Medicine and Public Health Preparedness
Srinivas Murthy and Michael D. Christian
DOI: 10.1001/dmp.2010.hcn10005
10/2010

Outcome Reporting Among Drug Trials Registered in ClinicalTrials.gov
Annals of Internal Medicine
Florence T. Bourgeois
DOI: 10.7326/0003-4819-153-3-201008030-00006
08/2010

Research

Biomarkers in pediatric sepsis
Being able to stratify children with severe sepsis, so as to better triage their care and predict their outcome, is a long-standing challenge. I am investigating the role of a panel of novel biomarkers, detected in blood, in predicting the outcome of children. This will be of tremendous help for research purposes, for front-line providers assessing the severity of illness, and for improving the understanding of the mechanism of the complex septic reaction.

Grants

2011 University of Toronto Elizabeth Arbuthnot Dyson Fellowship

2011 University of Toronto Joseph M. West Family Memorial Fund Fellowship

Research Group Members

Kira Genise, Student
Tina Madani Kia, Co-op Student