My current practice is based on the diagnosis and study of neoplastic and non-neoplastic diseases in children. My main interest is in pediatric solid tumors, gastrointestinal and liver pathology, and sudden infant death pathology.
Vasoactive Intestinal Polypeptide Promotes Intestinal Barrier Homeostasis and Protection Against Colitis in Mice PLOS ONE Xiujuan Wu and Victoria S. Conlin and Vijay Morampudi and Natasha R. Ryz and Yasmin Nasser and Ganive Bhinder and Kirk S. Bergstrom and Hong B. Yu and Chris C. M. Waterhouse and Allison M. J. Buchan and Oana E. Popescu and William T. Gibson and James A. Waschek and Bruce A. Vallance and Kevan Jacobson DOI: 10.1371/journal.pone.0125225 05/2015
Prenatal and postnatal findings in serpentine fibula polycystic kidney syndrome and a review of the NOTCH2 spectrum disorders American Journal of Medical Genetics Part A Brett M. Martin and Margarita H. Ivanova and Anna Sarukhanov and Ashley Kim and Patricia Power and Denise Pugash and Oana-Eugenia Popescu and Ralph S. Lachman and Deborah Krakow and Millan S. Patel DOI: 10.1002/ajmg.a.36656 07/2014
Carnitine Palmitoyltransferase I and Sudden Unexpected Infant Death in British Columbia First Nations PEDIATRICS G. B. Sinclair and S. Collins and O. Popescu and D. McFadden and L. Arbour and H. D. Vallance DOI: 10.1542/peds.2011-2924 10/2012
SHIP-Deficient Mice Develop Spontaneous Intestinal Inflammation and Arginase-Dependent Fibrosis The American Journal of Pathology Keith W. McLarren and Alexandra E. Cole and Shelley B. Weisser and Nicole S. Voglmaier and Victoria S. Conlin and Kevan Jacobson and Oana Popescu and Jean-Luc Boucher and Laura M. Sly DOI: 10.1016/j.ajpath.2011.03.018 07/2011
Current Projects The project I am working now is about liver and renal histopathology in sudden infant death cases in aboriginal children homozygous for CPT1AP479L mutation. This mutation is associated with recurrent attacks of hypoketotic hypoglycemia during fasting, fever, and intercurrent illnesses. Clinical presentation of CPT1A deficiency is variable and ranges from sudden death in infancy to liver disease with hepatomegaly later in life. It appears to have specific histological findings in sudden death cases of homozygous infants homozygous for CPT1AP479L mutation compared with heterozygous and wild type cases.
Human DNA testing could improve outcomes for patients with COVID-19.
That’s the key idea put forth in preliminary research posted this month to bioRxiv that highlights the potential benefits of testing COVID-19 patients for genetic variants of ACE2—the protein identified as the point-of-entry for the SARS-COV-2 virus into human cells.
Congratulations to the BC Children's and BC Women's investigators who were awarded funding through the highly competitive Canadian Institutes of Health Research (CIHR) Project Grant Fall 2019 competition.
A new study suggests that specialized immune cells that dampen inflammation and help repair the gut could be used as a potential therapy for children dealing with the painful symptoms of inflammatory bowel disease.
We believe there’s nothing we can’t do with your support. It can take years to turn scientific breakthrough into new interventions and treatments. Funding helps speed the pace of change. When given the resources, we can bring transformative therapies – and hope – out of the laboratory and into the clinic to save and improve children’s lives.