Evaluating the Heterogeneity of T Cell Phenotypes in PediatricRenal Transplant Recipients: Associations with Patient andTransplant Factors, and Alloimmune Activity

Project Summary

Some children following kidney transplant have stable kidney function whilst others experience rejection and reduced function. Knowing which children are at risk would help identify who may benefit from new treatments, but we lack tests soon after transplant that can tell us. A possible early marker is the balance between two white blood cell types – those that attack foreign cells (e.g. transplant cells) and those that help accept foreign cells. We will test this balance of white blood cells following transplant relates to kidney function. This study will help to design research of treatments that may improve kidney transplant acceptance.

This is a database registry being built by Dr. Tom Blydt-Hansen's research team at BC Children's Hospital Research Institute. Dr. Tom Blydt-Hansen is the Principal Investigator.

Project Status

Status: Closed
Study Start Date: June 2, 2020
Study End Date: March 31, 2022

Study Enrollment Status: Closed

Project Team

Principal Investigator

Tom Blydt-Hansen
 
Co-Investigators

Suzanne Vercauteren, Clinical Professor, UBC Faculty of Medicine, Department of Pathology & Laboratory Medicine
Shirin Kalyan, Adjunct Professor, UBC Faculty of Medicine, Department of Endocrinology and Metabolism
Megan Levings, Professor, UBC Faculty of Medicine, Department of Surgery
Suzanne Vercauteren, Clinical Professor, UBC Faculty of Medicine, Department of Pathology & Laboratory Medicine
Samantha Lang, Graduate Student, UBC Faculty of Medicine, BC Children's Hospital Research Insititute 
Li Wang, Clinical Associate Professor, UBC Faculty of Medicine, Department of Pathology & Laboratory Medicine
Micheal Alastair Irvine, Adjunct Professor, UBC Faculty of Science, Department of Statistics

Research Team Members

Candice Wiedman, Research Assistant

Enrollment Eligibility Criteria
  1. Renal transplant recipients followed at BC Children's Hospital
  2. At least 12 months post transplant
  3. Kidney function stable for the previous 1 month

For more information, please email sotresearch@bcchr.ca.